Abstract: The invention provides a method for monitoring a location of a tool in an ultrasound image. The method includes acquiring a plurality of 2D ultrasound images by way of an ultrasound transducer, wherein at least one of the plurality of 2D ultrasound images comprises a part of the tool and generating a 3D ultrasound image from said plurality of 2D ultrasound images. A first location of the tool is then identified within the 3D ultrasound image. An additional 2D ultrasound image, and location information relating to the location of the ultrasound transducer during capture of the additional 2D ultrasound image, is then acquired and the 3D ultrasound image updated based on the additional 2D ultrasound image and the location information. A location of the tool with respect to the additional 2D ultrasound image is then identified within the updated 3D ultrasound image based only on imaging data of the updated 3D ultrasound image.

Abstract: A tongue advancer system is for use in a tongue manipulation device, comprising a tissue anchor having a set of retractable fingers having a retracted configuration in which the tissue anchor is adapted to be loaded into a delivery tube and a deployed configuration in which the fingers are adapted for extending into tongue tissue in forward and lateral directions. The system further comprises a spacer which extends beyond the maximum forward extent of the retractable fingers. The spacer ensures that the fingers do not puncture the tongue surface.

Abstract: The invention provides a catheter (12) comprising longitudinally spaced acoustic emitters (S1, S2) and receivers (M1, M2, M3) for use in determining the locations of obstructions in an upper airway of a patient. A plurality of emitters and plurality of receivers are provided, such that, when inserted into an upper airway or oral cavity, the relative attenuation of signals received at each receiver from each emitter may be used to determine the existence and/or extent of obstructions located along the propagation path between each of the various emitter-receiver pairs. Also provided are methods for determining the locations of obstructions in an upper airway using signals received from acoustic receivers as comprised by catheter arrangements according to embodiments of the invention.

Abstract: A tongue advancer assembly for a tongue manipulation system includes a core mount and a tongue advancer for coupling to the core mount. The core mount includes a connection rod coupling for coupling the tongue advancer assembly to a distal end of a connection rod.

Abstract: A system for analysis of the upper airway has at least two sensors are provided along a flow path leading to the mouth and/or nose of a user. A relation is derived between the two sensor signals, and this is interpreted to detect at least the presence of upper airway obstructions, and preferably also the location and/or extent of such obstructions.

Abstract: The invention provides a catheter (12) comprising longitudinally spaced acoustic emitters (S1, S2) and receivers (M1, M2, M3) for use in determining the locations of obstructions in an upper airway of a patient. A plurality of emitters and plurality of receivers are provided, such that, when inserted into an upper airway or oral cavity, the relative attenuation of signals received at each receiver from each emitter may be used to determine the existence and/or extent of obstructions located along the propagation path between each of the various emitter-receiver pairs. Also provided are methods for determining the locations of obstructions in an upper airway using signals received from acoustic receivers as comprised by catheter arrangements according to embodiments of the invention.

Abstract: A tongue advancer system is for use in a tongue manipulation device, comprising a tissue anchor having a set of retractable fingers having a retracted configuration in which the tissue anchor is adapted to be loaded into a delivery tube and a deployed configuration in which the fingers are adapted for extending into tongue tissue in forward and lateral directions. The system further comprises a spacer which extends beyond the maximum forward extent of the retractable fingers. The spacer ensures that the fingers do not puncture the tongue surface.

Abstract: The invention relates to a nuclear magnetic resonance imaging radio frequency-receiver (112; 216; 308; 404), the receiver (112; 216; 308; 404) being adapted to receive analog signals from at least one radio frequency receiver coil unit (106; 200; 202; 300; 400; 402), the radio frequency receiver (112; 216; 308; 404) comprising: an analog-digital converter (118; 226) to convert the analog pre-amplified magnetic resonance signal into a digital signal, means (120; 230) for digital down converting the digital signal and a first communication interface (130; 252) adapted for transmitting the down converted digital signal via a communication link (e.g. wireless, optical or wire-bound).

Abstract: A tongue advancer assembly (305) for a tongue manipulation system, the tongue advancer assembly (305) comprising: a core mount (703) comprising a connection rod coupling configured to couple the tongue advancer assembly to a distal end of a connection rod (303); and a tongue advancer (701) configured to be coupled to the core mount (703).

Abstract: An electrode is provided for use as part of a tongue treatment. The electrode is for providing a permanent anchored implant in the tongue. The anchored implant may be used both for electrical therapy and mechanical (tongue remodeling) therapy.

Abstract: An optical sensor for operating along a catheter (103), the optical sensor comprising a light pattern generator configured to project at least one light pattern at a radial projection angle with respect to the optical sensor length onto the inner surface of an elongated volume into which the optical sensor is inserted, wherein the light pattern generator comprises an illumination system for providing a first light beam having a component of its direction along the sensor length and a first light redirection element (1007) configured to redirect the light beam to generate the at least one light pattern (1009) at an oblique and/or right angle to the optical sensor length, a second light redirection element (1012) for redirecting a reflected version of the light pattern from the inner surface of the elongated volume to provide a second light beam and- an imaging device (1013) having a field of view (1011) with a central axis substantially parallel to the length of the optical sensor for receiving the second ligh

Abstract: A catheter includes at least two optical sensors distributed along the catheter, each optical sensor comprising: a light pattern generator configured to project at a radial projection angle to the catheter at least one light pattern on the inner surface of an elongated volume into which the optical sensor is inserted; and an imaging device substantially aligned along a length of the optical sensor, the imaging device configured to observe the at least one light pattern on the inner surface of the elongated volume.

Abstract: A system for analysis of the upper airway has at least two sensors are provided along a flow path leading to the mouth and/or nose of a user. A relation is derived between the two sensor signals, and this is interpreted to detect at least the presence of upper airway obstructions, and preferably also the location and/or extent of such obstructions.

Abstract: A transducer device for detecting an environmental state within a biological material including a channel comprising a fluid, a hydrogel material, which is adapted to change its volume when getting into contact with an environmental material and/or when detecting an environmental change, and which is mechanically coupled to the channel such that the volume of the channel changes when the volume of the hydrogel material changes. The transducer device further includes a sensor, which is adapted to generate a signal upon detection of the change of a physical property of the fluid that is induced by the volume change of the channel. By applying the transducer device, an accurate monitoring of physiological parameters, for which the hydrogel material is sensitive is possible. It is also possible to apply the transducer device outside of the bodily lumen, for example to monitor the blood of a patient outside the bodily lumen.

Abstract: The invention relates to a device comprising an ingestible capsule which measures at least one body parameter and starts a drug release program upon predefined changes in the body parameter.

Abstract: The application is directed to a sensor element for use in a magnetochemical sensor, which comprises a first gel-like material (10), especially a swellable hydrogel such as polyacrylamide, and a magnetic second material (20) in the form of particles, especially magnetite (Fe304) nanoparticles, embedded in the first material along with a receptor for an alalyte, eg glucose. Changes in magnetic field due to interaction with the analyte are detected with GMR element (50). Applications include biosensors, DNA testing devices, and high throughput screening.

Abstract: The invention relates to a nuclear magnetic resonance imaging radio frequency—receiver (112; 216; 308; 404), the receiver (112; 216; 308; 404) being adapted to receive analogue signals from at least one radio frequency receiver coil unit (106; 200; 202; 300; 400; 402), the radio frequency receiver (112; 216; 308; 404) comprising: an analogue-digital converter (118; 226) to convert the analogue pre-amplified magnetic resonance signal into a digital signal, means (120; 230) for digital down converting the digital signal and a first communication interface (130; 252) adapted for transmitting the down converted digital signal via a communication link (e.g. wireless, optical or wire-bound).

Abstract: The invention relates to a transducer device (100,200,300,400) for detecting an environmental state or a change in the environmental state, in particular for detecting an environmental state within a biological material. The transducer device (100,200,300,400) comprises a channel (2,22,51) comprising a fluid, a hydrogel material (1,21,51), which is adapted to change its volume when getting into contact with an environmental material and/or when detecting an environmental change, and which is mechanically coupled to the channel (2,22,51) such that the volume of the channel (2,22,51) changes when the volume of the hydrogel material (1,21,51) changes. The transducer device (100,200,300,400) further comprises a sensor (11,12,25,35), which is adapted to generate a signal upon detection of the change of a physical property of the fluid that is induced by the volume change of the channel (2,22,51).

Abstract: Self-learning process for automatically adjusting a dosage of a substance administered to a person by a drug delivery device, a drug delivery device, wherein a dosage of a substance is adjusted by such a self-learning process and a drug delivery system comprising such a drug delivery device. Pain is experienced differently at certain times of day due to the origin causing the symptoms. Therefore, the medication providing pain relief should also be adjusted accordingly. The invention is to anticipate the pain experience and to deliver pain relief medication in such a way that Quality of Life is improved by appropriate timing of the right amount of medication and by appropriate timing of turning off the medication to reduce side effects.

Abstract: A light-source comprising at least one lighting unit (101) being arranged on a substrate (102) and a diffusing element (103) being arranged to receive and diffuse light emitted by said at least one lighting unit (101) is provided. The diffusing element (103) comprises a layer of non-woven fabric having a lower density at a side facing the lighting unit and a higher density at a side opposite to the lighting unit to obtain good diffusing properties.