Patents by Inventor Michel Schalk
Michel Schalk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10337031Abstract: Provided herein is an isolated polypeptide from Juniperus virginiana, Platycladus orientalis ‘Beverleyensis’ or Platycladus orientalis comprising a (+)-cedrol or a (?)-thujopsene synthase. Further provided herein is an isolated nucleic acid molecule from Juniperus virginiana, Platycladus orientalis ‘Beverleyensis’ or Platycladus orientalis encoding a (+)-cedrol or (?)-thujopsene synthase. Further provided herein are methods of producing (+)-cedrol or (?)-thujopsene.Type: GrantFiled: April 11, 2016Date of Patent: July 2, 2019Assignee: Firmenich SAInventors: Michel Schalk, Fabienne Deguerry, Pan Li, Xiufeng He, Qi Wang
-
Patent number: 10253335Abstract: The present invention provides a method of producing ?-santalene, said method comprising contacting at least one polypeptide with farnesyl pyrophosphate (FPP). In particular, said method may be carried out in vitro or in vivo to produce ?-santalene, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of a polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing said nucleic acid are also part of the present invention. A non-human host organism or a cell transformed to be used in the method of producing ?-santalene is also an object of the present invention.Type: GrantFiled: August 29, 2017Date of Patent: April 9, 2019Assignee: Firmenich SAInventor: Michel Schalk
-
Publication number: 20190002925Abstract: Provided herein are methods of producing (+)-manool comprising: contacting geranylgeranyl diphosphate with an copalyl diphosphate (CPP) synthase to form a (9S, 10S)-copalyl diphosphate wherein the CPP synthase comprises an amino acid sequence having at least 90%, 95%, 98%, 99% and 100% sequence identity to a polypeptide selected from the group consisting of SEQ ID NO: 1 and SEQ ID NO:2; and contacting the CPP with a sclareol synthase enzyme to form (+)-manool.Type: ApplicationFiled: June 30, 2016Publication date: January 3, 2019Applicant: Firmenich SAInventors: Michel SCHALK, Letizia ROCCI
-
Publication number: 20180251797Abstract: The present invention relates to a method of producing drimenol and/or drimenol derivatives by contacting at least one polypeptide with farnesyl diphosphate. The method may be performed in vitro or in vivo. The present invention also provides amino acid sequences of polypeptides useful in the method of the invention and nucleic acid encoding the polypeptides of the invention. The method further provides host cells or organisms genetically modified to express the polypeptides of the invention and useful to produce drimenol and/or drimenol derivatives.Type: ApplicationFiled: May 6, 2015Publication date: September 6, 2018Applicant: Firmenich SAInventors: Yu-Hua ZHANG, Michel SCHALK, Olivier HAEFLIGER, Xiu-Feng HE, Fabienne DEGUERRY
-
Publication number: 20180208946Abstract: This invention relates generally to methods and compositions for producing a sesquiterpene alcohol comprising contacting a sesquiterpene with a P450 polypeptide with monooxygenase activity.Type: ApplicationFiled: January 22, 2018Publication date: July 26, 2018Applicant: FIRMENICH SAInventors: Laurent DAVIET, Letizia ROCCI, Michel SCHALK
-
Patent number: 10000773Abstract: The present invention provides the nucleic acid and the amino acid sequences of a cytochrome P450 capable of oxidizing terpene molecules. It also provides a method of oxidizing terpene molecules comprising contacting the cytochrome P450 of the invention with the terpene molecule intended to be oxidized. In particular, said method may be carried out in vitro or in vivo to produce oxidized terpene molecules, which may be used in different technical fields such as for example perfumery and flavoring. The present invention also provides an expression vector containing the nucleic acid. A non-human host organism or a cell transformed with the nucleic acid is also an object of the invention.Type: GrantFiled: October 25, 2012Date of Patent: June 19, 2018Assignee: FIRMENICH SAInventors: Michel Schalk, Fabienne Deguerry
-
Patent number: 9969999Abstract: The present invention provides a method of producing ?-santalene by contacting at least one polypeptide with farnesyl phyrophosphate (fpp). In particular, the method may be carried out in vitro or in vivo to produce ?-santalene, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of a polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing the nucleic acid represent part of the present invention. A non-human host organism and a cell transformed to be used in the method of producing ? santalene are also part of the present invention.Type: GrantFiled: March 3, 2016Date of Patent: May 15, 2018Assignee: Firmenich SAInventor: Michel Schalk
-
Publication number: 20180105837Abstract: The present invention provides a method of producing ?-santalene, said method comprising contacting at least one polypeptide with farnesyl pyrophosphate (FPP). In particular, said method may be carried out in vitro or in vivo to produce ?-santalene, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of a polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing said nucleic acid are also part of the present invention. A non-human host organism or a cell transformed to be used in the method of producing ?-santalene is also an object of the present invention.Type: ApplicationFiled: August 29, 2017Publication date: April 19, 2018Applicant: Firmenich SAInventor: Michel SCHALK
-
Publication number: 20180094281Abstract: Provided herein is an isolated polypeptide from Juniperus virginiana, Platycladus orientalis ‘Beverleyensis’ or Platycladus orientalis comprising a (+)-cedrol or a (?)-thujopsene synthase. Further provided herein is an isolated nucleic acid molecule from Juniperus virginiana, Platycladus orientalis ‘Beverleyensis’ or Platycladus orientalis encoding a (+)-cedrol or (?)-thujopsene synthase. Further provided herein are methods of producing (+)-cedrol or (?)-thujopsene.Type: ApplicationFiled: April 11, 2016Publication date: April 5, 2018Applicant: Firmenich SAInventors: Michel SCHALK, Fabienne DEGUERRY, Pan LI, Xiufeng HE, Qi WANG
-
Patent number: 9909145Abstract: This invention relates generally to methods and compositions for producing a sesquiterpene alcohol comprising contacting a sesquiterpene with a p450 polypeptide with monooxygenase activity.Type: GrantFiled: September 19, 2014Date of Patent: March 6, 2018Assignee: FIRMENICH SAInventors: Laurent Daviet, Letizia Rocci, Michel Schalk
-
Publication number: 20170283841Abstract: The present invention provides a method of producing patchoulol and 7-epi-?-selinene, said method comprising contacting at least one polypeptide with farnesyl phyrophosphate (FPP). In particular, said method may be carried out in vitro or in vivo to produce patchoulol and 7-epi-?-selinene, compounds which can be useful in the field of perfumery. The present invention also provides the amino acid sequence of a polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing said nucleic acid are also part of the present invention. A non-human host organism or a cell transformed to be used in the method of producing patchoulol and 7-epi-?-selinene is also an object of the present invention.Type: ApplicationFiled: June 12, 2017Publication date: October 5, 2017Applicant: FIRMENICH SAInventors: Michel SCHALK, Fabienne DEGUERRY
-
Patent number: 9777293Abstract: The present invention provides a method of producing ?-santalene, said method comprising contacting at least one polypeptide with farnesyl pyrophosphate (FPP). In particular, said method may be carried out in vitro or in vivo to produce ?-santalene, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of a polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing said nucleic acid are also part of the present invention. A non-human host organism or a cell transformed to be used in the method of producing ?-santalene is also an object of the present invention.Type: GrantFiled: October 31, 2014Date of Patent: October 3, 2017Assignee: FIRMENICH SAInventor: Michel Schalk
-
Patent number: 9745602Abstract: The present invention relates to the control of gene expression by a heterologous glucose-regulated promoter, to microorganisms in which gene expression is controlled by a heterologous glucose-regulated promoter and to methods using said microorganisms for the production of terpenes during glucose-limited fed-batch fermentation.Type: GrantFiled: June 1, 2012Date of Patent: August 29, 2017Assignee: FIRMENICH SAInventors: Laurent Daviet, Michel Schalk, Jens Nielsen, Verena Siewers, Christoph Knuf, Gionata Scalcinati
-
Patent number: 9714440Abstract: The present invention provides a method of producing patchoulol and 7-epi-?-selinene, said method comprising contacting at least one polypeptide with famesyl phyrophosphate (FPP). In particular, said method may be carried out in vitro or in vivo to produce patchoulol and 7-epi-?-seline, compounds which can be useful in the field of perfumery. The present invention also provides the amino acid sequence of polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing said nucleic acid are also part of the present invention. A non-human host organism or a cell transformed to be used in the method of producing patchoul and 7-epi-?-selinene is also an object of the present invention.Type: GrantFiled: December 19, 2014Date of Patent: July 25, 2017Assignee: FIRMENICH SAInventors: Michel Schalk, Fabienne Deguerry
-
Patent number: 9670494Abstract: The present invention relates to yeast cells producing high levels of acetoacetyl-CoA. It also relates to a method for making such yeast cells and to the use of such yeast cells in a method for producing acetyl-CoA derived products.Type: GrantFiled: December 17, 2012Date of Patent: June 6, 2017Assignee: FIRMENICH SAInventors: Jens Nielsen, Verena Siewers, Yun Chen, Laurent Daviet, Michel Schalk
-
Publication number: 20160215301Abstract: Methods and compositions for producing a sesquiterpene alcohol comprising contacting a sesquiterpene with a p450 polypeptide with monooxygenase activity.Type: ApplicationFiled: September 19, 2014Publication date: July 28, 2016Applicant: FIRMENICH SAInventors: Laurent DAVIET, Letizia ROCCI, Michel SCHALK
-
Publication number: 20160177288Abstract: The present invention provides a method of producing ?-santalene by contacting at least one polypeptide with farnesyl phyrophosphate (fpp). In particular, the method may be carried out in vitro or in vivo to produce ?-santalene, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of a polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing the nucleic acid represent part of the present invention. A non-human host organism and a cell transformed to be used in the method of producing ? santalene are also part of the present invention.Type: ApplicationFiled: March 3, 2016Publication date: June 23, 2016Inventor: Michel SCHALK
-
Patent number: 9297004Abstract: The present invention provides a method of producing ?-santalene by contacting at least one polypeptide with farnesyl phyrophosphate (fpp). In particular, the method may be carried out in vitro or in vivo to produce ?-santalene, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of a polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing the nucleic acid represent part of the present invention. A non-human host organism and a cell transformed to be used in the method of producing ?-santalene are also part of the present invention.Type: GrantFiled: March 4, 2009Date of Patent: March 29, 2016Assignee: FIRMENICH SAInventor: Michel Schalk
-
Patent number: 9267155Abstract: The present invention provides a method of producing sclareol, the method comprising contacting a particular polypeptide having a sclareol synthase activity with labdenediol diphosphate (LPP). In particular, the method may be carried out in vitro or in vivo to produce sclareol, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of the polypeptide used in the method. A nucleic acid derived from Salvia sclarea and encoding the polypeptide of the invention, an expression vector containing the nucleic acid, as well as a non-human organism or a cell transformed to harbor the same nucleic acid, are also part of the present invention.Type: GrantFiled: December 20, 2013Date of Patent: February 23, 2016Assignee: FIRMENICH SAInventor: Michel Schalk
-
Publication number: 20150218588Abstract: The present invention provides the nucleic acid and the amino acid sequences of a cytochrome P450 capable of oxidizing terpene molecules. It also provides a method of oxidizing terpene molecules comprising contacting the cytochrome P450 of the invention with the terpene molecule intended to be oxidized. In particular, said method may be carried out in vitro or in vivo to produce oxidized terpene molecules, which may be used in different technical fields such as for example perfumery and flavoring. The present invention also provides an expression vector containing the nucleic acid. A non-human host organism or a cell transformed with the nucleic acid is also an object of the invention.Type: ApplicationFiled: October 25, 2012Publication date: August 6, 2015Applicant: FIRMENICH SAInventors: Michel Schalk, Fabienne Deguerry