Patents by Inventor Michelle Luo

Michelle Luo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR CLL1 MODIFICATION
    Publication number: 20240110189
    Abstract: This disclosure provides, e.g., novel cells having a modification (e.g., insertion or deletion) in the endogenous CLL1 gene. The disclosure also provides compositions, e.g., gRNAs, that can be used to make such a modification.
    Type: Application
    Filed: August 27, 2021
    Publication date: April 4, 2024
    Applicant: VOR BIOPHARMA INC.
    Inventors: John Lydeard, Chong Luo, Michelle Lin, Jessica Evelyn Lisle
  • Methods and compositions for RNA-directed repression of transcription using CRISPR-associated genes
    Patent number: 11439712
    Abstract: The present invention is directed to methods and compositions for targeted gene silencing that provide the ability to not only repress expression but to modulate the repression of expression of one or more target genes. In one aspect, a recombinant nucleic acid molecule is provided comprising a nucleotide sequence encoding a subset of CRISPR-cas polypeptides, or functional fragments thereof, from a type-I CRISPR-cas system. In some aspects, a recombinant nucleic acid of the invention comprises a nucleotide sequence encoding three or more Type I Cascade polypeptides having substantial identity to a type I Cascade polypeptide.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: September 13, 2022
    Assignee: North Carolina State University
    Inventors: Chase Beisel, Michelle Luo
  • METHODS AND COMPOSITIONS FOR EFFICIENT DELIVERY OF NUCLEIC ACIDS AND RNA-BASED ANTIMICROBIALS
    Publication number: 20210403926
    Abstract: The invention relates to the methods for modifying the methylation pattern of bacteriophage DNA and phagemid DNA and to methods for selective killing of bacteria using lysogenic bacteriophages comprising bacteriophage DNA or phagemid DNA comprising components of an engineered CRISPR-Cas system.
    Type: Application
    Filed: September 10, 2021
    Publication date: December 30, 2021
    Inventors: Chase Lawrence Beisel, Ahmed Abdelshafy Mahmoud Gomaa, Michelle Luo
  • Methods and compositions for efficient delivery of nucleic acids and RNA-based antimicrobials
    Patent number: 11155823
    Abstract: The invention relates to the methods for modifying the methylation pattern of bacteriophage DNA and phagemid DNA and to methods for selective killing of bacteria using lysogenic bacteriophages comprising bacteriophage DNA or phagemid DNA comprising components of an engineered CRISPR-Cas system.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: October 26, 2021
    Assignee: NORTH CAROLINA STATE UNIVERSITY
    Inventors: Chase Lawrence Beisel, Ahmed Abdelshafy Mahmoud Gomaa, Michelle Luo
  • METHODS AND COMPOSITIONS FOR EFFICIENT DELIVERY OF NUCLEIC ACIDS AND RNA-BASED ANTIMICROBIALS
    Publication number: 20180155729
    Abstract: The invention relates to the methods for modifying the methylation pattern of bacteriophage DNA and phagemid DNA and to methods for selective killing of bacteria using lysogenic bacteriophages comprising bacteriophage DNA or phagemid DNA comprising components of an engineered CRISPR-Cas system.
    Type: Application
    Filed: June 15, 2016
    Publication date: June 7, 2018
    Inventors: Chase Lawrence Beisel, Ahmed Abdeishafy Mahmoud Gomaa, Michelle Luo
  • Methods and Compositions for RNA-Directed Repression of Transcription Using CRISPR-Associated Genes
    Publication number: 20170028083
    Abstract: The present invention is directed to methods and compositions for targeted gene silencing that provide the ability to not only repress expression but to modulate the repression of expression of one or more target genes. In one aspect, a recombinant nucleic acid molecule is provided comprising a nucleotide sequence encoding a subset of CRISPR-cas polypeptides, or functional fragments thereof, from a type-I CRISPR-cas system. In some aspects, a recombinant nucleic acid of the invention comprises a nucleotide sequence encoding three or more Type I Cascade polypeptides having substantial identity to a type I Cascade polypeptide.
    Type: Application
    Filed: April 7, 2015
    Publication date: February 2, 2017
    Inventors: Chase Beisel, Michelle Luo