Patents by Inventor Michihiro Yamaguchi

Michihiro Yamaguchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6360589
    Abstract: A liquid chromatograph and a column packing material effectively condensing cationic specimen and exhibiting a high resolution. The liquid chromatograph includes a pre-focusing column (30, 40) having a volume of less than 2.0 milliliters and packed with a column packing material, in which a porous support is coated by a silicone polymer having a Si—R—X (R is a spacer part, X is a sulfonic group) bond and a Si—R′ (R′ is a hydrophilic group) bond, wherein the specimen to be analyzed is supplied to the pre-focusing column in the state dispersed in a solvent for condensation. The condensed specimen is then separated in a separation column (16, 43) used for separating the specimen dispersed in the solvent, and the separated specimen is analyzed by a detector (17, 41).
    Type: Grant
    Filed: November 25, 1998
    Date of Patent: March 26, 2002
    Assignee: Shiseido Company, Ltd.
    Inventors: Taketoshi Kanda, Aya Ohkubo, Yutaka Ohtsu, Michihiro Yamaguchi
  • Patent number: 6323246
    Abstract: A fatty acid amphoteric surfactant complex obtained by mixing a) at least one imidazolinium ampholytic surfactant of the formula: wherein R1 represents an alkyl or alkenyl group having 9 to 17 carbon atoms on average; and Z is 1 or 2; with b) a higher fatty acid selected from the group consisting of oleic acid, isostearic acid and a mixture of oleic acid and isostearic acid; wherein the ratio of said higher fatty acid to the total amount of said imidazolinium ampholytic surfactant(s) in said complex ranges from about 25:75 to 90:10. The complex containing an ampholytic and/or semipolar surfactant and higher fatty acid may optionally contain a clay mineral. Said complex may be employed in making emulsions.
    Type: Grant
    Filed: September 16, 1998
    Date of Patent: November 27, 2001
    Assignee: Shiseido Company, Ltd.
    Inventors: Yasunari Nakama, Michihiro Yamaguchi, Kiyoshi Miyazawa, Takayuki Ohmura
  • Patent number: 6316647
    Abstract: Disclosed herein are a cation-exchanged clay mineral comprising a swelling clay mineral with the cations between layers substantially replaced by low-valence metal amine complexes and/or low-valence metal ammine complexes, and a packing material for chromatography using the same. Use of the packing material provides a sharp peak with respect to a highly unsaturated compound. Since the packing material is unlikely to be influenced by a solvent, it is usable for a long time with good stability.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: November 13, 2001
    Assignee: Shiseido Company, Ltd.
    Inventors: Yutaka Ohtsu, Isao Tanaka, Yasuhiko Kadota, Michihiro Yamaguchi
  • Patent number: 6231873
    Abstract: A cosmetic composition on an external treatment agent containing microcapsules, with an average particle size of 0.1 to 2000 &mgr;m, enclosing a hydrophobic component, wherein the microcapsules are composed of a gelatin film swollen with water.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: May 15, 2001
    Assignee: Shiseido Company, LTD
    Inventors: Akira Noda, Michihiro Yamaguchi, Masanori Aizawa, Yoshimaru Kumano
  • Patent number: 6150425
    Abstract: An O/W/O type multiple emulsion in which an O/W type emulsion is dispersed in the outer phase oil wherein the O/W type emulsion in the inner phase contains water, an oil based ingredient, a surfactant and an amphiphilic substance chosen from those which can form a gel at ordinal temperature or higher in an amphiphilic substance-surfactant-oil-water system or N-long chain acyl acidic amino acid monosalt and an amphiphilic substance chosen from those which can form a gel at ordinal temperature or higher in an amphiphilic substance-N-long chain acyl acidic amino acid monosalt-oil-water system, said outer phase oil contains organophilic modified clay minerals and an emulsifying agent with a HLB of 7 or lower, and the weight ratio of the O/W type emulsion and the outer phase oil is 2:3-19:1. An O/W/O type multiple emulsion with superior stability over time and good usability.
    Type: Grant
    Filed: March 15, 1999
    Date of Patent: November 21, 2000
    Assignee: Shiseido Company, Ltd.
    Inventors: Tomoko Sekine, Fumiaki Matsuzaki, Toshio Yanaki, Michihiro Yamaguchi
  • Patent number: 6063283
    Abstract: A liquid chromatograph includes pumps for supplying solvents, a mixer for mixing the solvents, a controller for controlling a mixing ratio of the solvents in the mixer, a chromatograph column for separating a sample carried with the solvents, a flow path control valve for supplying the sample together with the solvents to the chromatograph column, and a detector for detecting the sample supplied thereto, wherein the mixer includes a mixing chamber and a porous medium accommodated in the mixing chamber, the porous medium having a size and shape in conformity with a size and shape of said mixing chamber such that no substantial gap is formed between an outer surface of the porous medium and an inner surface of the mixing chamber.
    Type: Grant
    Filed: January 9, 1998
    Date of Patent: May 16, 2000
    Assignee: Shiseido Company, Ltd.
    Inventors: Osamu Shirota, Ayako Suzuki, Yutaka Ohtsu, Michihiro Yamaguchi, Hisao Tsuruta
  • Patent number: 5985177
    Abstract: This invention relates to an oil-in-water-in-oil (O/W/O) type multiple emulsion which contains an inner oil phase, a water phase, and an outer oil phase. The inner oil phase is first dispersed in water to form an oil-in-water (O/W) emulsion. Then, the O/W emulsion is further dispersed in the outer oil phase to form the O/W/O type multiple emulsion. The outer oil phase contains an organophilic clay mineral, which can effectively prevent the inter-mixing of the inner oil phase with the outer oil phase, thus, producing an O/W/O type multiple emulsion with excellent storage stability. Upon the using of an oil-soluble compound in the inner oil phase, this multiple emulsion system can prevent the oil-soluble compound from being oxidized.
    Type: Grant
    Filed: October 28, 1996
    Date of Patent: November 16, 1999
    Assignee: Shiseido Co., Ltd.
    Inventors: Katsunori Yoshida, Toshio Yanaki, Michihiro Yamaguchi, Hiroko Watanabe, Takafumi Kurosawa, Kenzo Ito
  • Patent number: 5866040
    Abstract: A novel complex containing an ampholytic and/or semi-polar surfactant as well as a higher fatty acid, and if necessary, a clay mineral, and an emulsified composition containing this complex.
    Type: Grant
    Filed: July 27, 1994
    Date of Patent: February 2, 1999
    Assignee: Shiseido Company, Ltd.
    Inventors: Yasunari Nakama, Michihiro Yamaguchi, Kiyoshi Miyazawa, Takayuki Ohmura
  • Patent number: 5849834
    Abstract: A W/O type emulsified composition comprising an oil phase containing ethyl cellulose and a solvent capable of swelling ethyl cellulose and a water phase containing a water soluble polymer(s) emulsified as a water-in-oil type (W/O type) emulsion. A W/O type emulsified composition comprising an oil phase containing ethyl cellulose and a solvent capable of swelling ethyl cellulose and a water phase containing a polyion complex comprising cationized cellulose and sodium hyaluronate emulsified as a water-in-oil type (W/O type) emulsion.
    Type: Grant
    Filed: March 10, 1997
    Date of Patent: December 15, 1998
    Assignee: Shiseido Co., Ltd.
    Inventors: Fumiaki Matsuzaki, Toshio Yanaki, Michihiro Yamaguchi
  • Patent number: 5817155
    Abstract: An emulsion for hair treatment is provided which is characterized by the following: the formulation (I) is composed of a W/O type emulsion, which allows the main agent to be stable, and contains preferably an oil soluble polymer compound for the emulsifier; the formulation (I), upon being mixed with formulation (II), can easily undergo demulsification and a phase inversion into an O/W type emulsion; and the emulsion has adequate viscosity to prevent dripping from the hair and a superior dyeing capability. Also, 2-formulation type oxidation hair dye with an excellent hair dyeing effect is provided by adding isostearyl alcohol.
    Type: Grant
    Filed: December 6, 1996
    Date of Patent: October 6, 1998
    Assignee: Shiseido Co., Ltd.
    Inventors: Masaaki Yasuda, Yasuhiro Arai, Fumiaki Matsuzaki, Toshio Yanaki, Hideo Nakajima, Michihiro Yamaguchi, Kimio Ohno
  • Patent number: 5785961
    Abstract: A hair-treating composition having convenient usability and excellent dyeability or hair-bleachability is provided. The composition having the above excellent properties contains at least one member selected from amphoteric surface active agents or semipolar surface active agents according to circumstances, and cationic polymers, in combination with an anionic surface active agent and a higher fatty acid, and further contains a dye or an alkalinizing agent.
    Type: Grant
    Filed: November 26, 1996
    Date of Patent: July 28, 1998
    Assignee: Shiseido Company, Ltd.
    Inventors: Yasunari Nakama, Yoko Takeshita, Yasuhiro Arai, Michihiro Yamaguchi, Masa'aki Yasuda
  • Patent number: 5738783
    Abstract: A liquid chromatograph includes pumps for supplying solvents, a mixer for mixing the solvents, a controller for controlling a mixing ratio of the solvents in the mixer, a chromatograph column for separating a sample carried with the solvents, a flow path control valve for supplying the sample together with the solvents to the chromatograph column, and a detector for detecting the sample supplied thereto, wherein the mixer includes a mixing chamber and a porous medium accommodated in the mixing chamber, the porous medium having a size and shape in conformity with a size and shape of said mixing chamber such that no substantial gap is formed between an outer surface of the porous medium and an inner surface of the mixing chamber.
    Type: Grant
    Filed: December 12, 1996
    Date of Patent: April 14, 1998
    Assignee: Shiseido Company, Ltd.
    Inventors: Osamu Shirota, Taketoshi Kanda, Ayako Suzuki, Yutaka Ohtsu, Michihiro Yamaguchi, Hisao Tsuruta, Ryujiro Namba
  • Patent number: 5679657
    Abstract: Low molecular weight acetylhyaluronate has the following characteristics:intrinsic viscosity: 50 to 200 cm.sup.3 /gsubstitution degree of acetyl group: 2.6 to 3.6 (excluding N-acetyl group)A skin-softening composition is mainly composed of this low molecular weight acetylhyaluronate. It can exhibit excellent skin-softening effect and moisturizing effect, while appropriately suppressing the thread-forming ability inherent in hyaluronic acid. A method of manufacturing acetylhyaluronate comprises the steps of suspending hyaluronic acid powder in an acetic anhydride solvent and then adding concentrated sulfuric acid thereto to effect acetylation. A method of purifying acetylhyaluronate comprises the steps of adding raw acetylhyaluronate to an aqueous acetone solution, adding and dissolving sodium lactate therein, and then adding highly concentrated acetone thereto to precipitate highly pure acetylhyaluronate. Acetylhyaluronate having highly purity can be obtained inexpensively.
    Type: Grant
    Filed: August 2, 1996
    Date of Patent: October 21, 1997
    Assignee: Shiseido Co., Ltd.
    Inventors: Takashi Oka, Toshio Yanaki, Michihiro Yamaguchi
  • Patent number: 5579769
    Abstract: A coupling medium for a probe of an ultrasonograph comprising a gel composed of .beta.-1,3 glucan as the main component, or a gel obtained by high pressure treatment or chemical cross-linking of the same, or a gel containing .beta.-1,3 glucan and a complex forming compound capable of forming a complex with .beta.-1,3 glucan.
    Type: Grant
    Filed: August 2, 1994
    Date of Patent: December 3, 1996
    Assignee: Shiseido Company, Ltd.
    Inventors: Katsunori Yoshida, Toshio Yanaki, . Michihiro Yamaguchi
  • Patent number: 5560965
    Abstract: A dry flower, and a process for producing the same, coated on its surface with a polymer film of (R.sup.1 HSiO).sub.a (R.sup.2 R.sup.3 SiO).sub.b (R.sup.4 R.sup.5 R.sup.6 SiO.sub.1/2).sub.c or (2) a film of one or more polymers selected from (i) photopolymerizable polymers, (ii) silane coupling agent polymers, and (iii) copolymers of photopolymerizable monomers and silane coupling agents.
    Type: Grant
    Filed: January 31, 1996
    Date of Patent: October 1, 1996
    Assignee: Shiseido Company, Ltd.
    Inventors: Hiroshi Fukui, Michihiro Yamaguchi, Naoto Okamoto, Yasushi Nishimura
  • Patent number: 5538728
    Abstract: A complex material of a hydrophilic polymer-silicate mineral comprising a carboxyl group containing hydrophilic polymer and a water swellable silicate mineral, and having a new absorption spectrum not existing in both starting materials in the IR-ray absorption spectrum within the range of 1000 to 1300 cm.sup.-1, and pharmaceutical and cosmetic compositions comprising same.
    Type: Grant
    Filed: April 14, 1993
    Date of Patent: July 23, 1996
    Assignee: Shiseido Company, Ltd.
    Inventors: Toshio Yanaki, Tadahito Takahashi, Yoko Nagasawa, Michihiro Yamaguchi
  • Patent number: 5532305
    Abstract: To provide a base suitable for a controlled release preparation and the controlled release preparation. A bioactive substance(s) is introduced in a poly-ion complex of hyaluronic acid and a cationic polyacrylic acid derivative(s).
    Type: Grant
    Filed: July 26, 1994
    Date of Patent: July 2, 1996
    Assignee: Shiseido Company Ltd.
    Inventors: Fumiaki Matsuzaki, Toshio Yanaki, Michihiro Yamaguchi
  • Patent number: 5219847
    Abstract: An antipruritic composition for an oral medicine, injection, and external medicine, comprising an effective amount of a chelated zinc (e.g., zinc picolinate) as an antipruritic agent.
    Type: Grant
    Filed: July 27, 1992
    Date of Patent: June 15, 1993
    Assignee: Shiseido Company, Ltd.
    Inventors: Shigeru Taguchi, Takashi Suzuki, Chikao Nishino, Yoshimori Fujinuma, Chuji Yanagawa, Michihiro Yamaguchi, Miwako Yamato, Noriko Nakajima, Mie Kitano, Tomomi Okazaki, Masaki Uemura, Ryuhei Inada, Yoshiko Tonomura
  • Patent number: 5203991
    Abstract: A packing material for liquid chromatography bears a polyalkylene polyamine moiety linked through a spacer moiety as the pendant group to a porous silica gel coated with a silicone polymer, and optionally is crosslinked by a crosslinking agent on two or more amino group of the different polyalkylene polyamine moieties, and a process for production thereof. Such a packing material is especially useful in the analysis of sugars.
    Type: Grant
    Filed: October 17, 1991
    Date of Patent: April 20, 1993
    Assignee: Shiseido Company, Ltd.
    Inventors: Hiroshi Kutsuna, Yoshihiro Shiojima, Tsuneo Suhara, Hiroshi Fukui, Yutaka Ohtsu, Michihiro Yamaguchi
  • Patent number: 5165915
    Abstract: A spherical clay mineral powder or spherical composite powder comprising water-swellable clay mineral with specific surface are of 100 m.sup.2 /g or more is provided, and the composite powder can contain an organic, inorganic or metal powder, an organic substance soluble in an organic solvent or a water-soluble substance, and these spherical powders can be formulated effectively in, for example, cosmetics.
    Type: Grant
    Filed: June 19, 1990
    Date of Patent: November 24, 1992
    Assignee: Shiseido Company Ltd.
    Inventors: Kazuo Tokubo, Michihiro Yamaguchi, Jyunko Suzuki, Toshio Yoshioka, Fujihiro Kanda, Minoru Fukuda, Toshihide Ikeda, Takeshi Kawaura, Yoshiaki Yagita