Patents by Inventor Michiko E. Taga

Michiko E. Taga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AI-2 compounds and analogs based on Salmonella typhimurium LsrB structure
    Publication number: 20090286873
    Abstract: This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in Salmonella typhimurium. The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.
    Type: Application
    Filed: March 13, 2009
    Publication date: November 19, 2009
    Inventors: Stephen T. Miller, Karina B. Xavier, Michiko E. Taga, Shawn R. Campagna, Martin F. Semmelhack, Bonnie L. Bassler, Frederick M. Hughson
  • AI-2 compounds and analogs based on LsrB structure
    Patent number: 7547726
    Abstract: This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in Salmonella typhimurium. The X-ray crystallographic data can be used in a drug discovery method. Additionally the invention provides AI-2 analogs based on this discovery as well as pharmaceutical compositions containing those analogs.
    Type: Grant
    Filed: September 16, 2005
    Date of Patent: June 16, 2009
    Assignee: The Trustees of Princeton University
    Inventors: Stephen T. Miller, Karina B. Xavier, Michiko E. Taga, Shawn R. Campagna, Martin F. Semmelhack, Bonnie L. Bassler, Frederick M. Hughson
  • Inhibitors of autoinducer transporters
    Patent number: 7183099
    Abstract: The present invention relates to the discovery of the lsr operon, the genes therein, and the polypeptides encoded by these genes. The present invention also includes strains with altered expression levels of the polypeptides encoded by the genes and the lsr operon relative to wild type cells. In some embodiments, the strains express a transporter that transports an autoinducer into the cell at a level higher than that of wild type cells. The present invention also includes methods for identifying compounds that modulate the transport of the autoinducer into cells.
    Type: Grant
    Filed: October 28, 2002
    Date of Patent: February 27, 2007
    Assignee: Princeton University
    Inventors: Michiko E. Taga, Bonnie L. Bassler, Douglas T. McKenzie
  • Inhibitors of autoinducer transporters
    Publication number: 20030165932
    Abstract: The present invention relates to the discovery of the lsr operon, the genes therein, and the polypeptides encoded by these genes. The present invention also includes strains with altered expression levels of the polypeptides encoded by the genes and the lsr operon relative to wild type cells. In some embodiments, the strains express a transporter that transports an autoinducer into the cell at a level higher than that of wild type cells. The present invention also includes methods for identifying compounds that modulate the transport of the autoinducer into cells.
    Type: Application
    Filed: October 28, 2002
    Publication date: September 4, 2003
    Inventors: Michiko E. Taga, Bonnie L. Bassler, Douglas T. McKenzie