Patents by Inventor Miguel A. Ondetti

Miguel A. Ondetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for rehabilitating the vasorelaxant action of the coronary arteries impaired through atherosclerosis or hypercholesterolemia employing an ACE inhibitor
    Patent number: 5212165
    Abstract: A method is provided for rehabilitating or restoring the vasorelaxant action of the endothelium impaired by atherosclerosis and/or hypercholesterolemia, thereby preventing arteriospasm in the coronary arteries using an angiotensin converting enzyme inhibitor such as captopril, fosinopril, ceranapril, enalapril or lisinopril, which may be administered by oral or parenteral dosage forms.
    Type: Grant
    Filed: October 23, 1989
    Date of Patent: May 18, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: A. K. Gunnar Aberg, Miguel A. Ondetti
  • Method for preventing onset of restenosis after angioplasty employing an ace inhibitor
    Patent number: 5166143
    Abstract: A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering an ACE inhibitor such as fosinopril or ceranapril, prior to, during and/or after angioplasty.
    Type: Grant
    Filed: June 13, 1991
    Date of Patent: November 24, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, A. K. Gunnar Aberg, Patricia Ferrer
  • Method for preventing onset of restenosis after angioplasty employing pravastatin
    Patent number: 5140012
    Abstract: A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering pravastatin alone or in combination with an ACE inhibitor such as captopril or ceranapril, prior to, during and/or after angioplasty.
    Type: Grant
    Filed: May 31, 1990
    Date of Patent: August 18, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Mark E. McGovern, Miguel A. Ondetti, Henry Y. Pan
  • Method for stabilizing or causing regression of atherosclerosis in coronary arteries employing an ace inhibitor
    Patent number: 5061694
    Abstract: A method is provided for slowing the progression of atherosclerosis in coronary arteries in hypertensive or normotensive patients and reducing or eliminating atherosclerotic lesions in such patients in a mammalian species by administering an ACE inhibitor, especially one containing a mercapto moiety, such as captopril or zofenopril.
    Type: Grant
    Filed: October 23, 1989
    Date of Patent: October 29, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: A. K. Gunnar Aberg, Patricia Ferrer, Miguel A. Ondetti
  • Certain [(lower alkanoyl-thio)methyl-1-oxo-3-phenyl propyl amino]benzene lower alkanoic acid or ester derivatives which inhibit enkephalinase
    Patent number: 4798904
    Abstract: Acylmercaptoalkanoyl compounds of the formula ##STR1## wherein n is an integer from one to fifteen possess enkephalinase inhibition activity and are useful as analgesic agents.
    Type: Grant
    Filed: November 13, 1987
    Date of Patent: January 17, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Norma G. Delaney, Eric M. Gordon, Miguel A. Ondetti
  • Use of enkephalinase inhibitors as analgesic agents
    Patent number: 4774256
    Abstract: Mercaptoalkanoyl and acylmercaptoalkanoyl compounds of the formula ##STR1## wherein n is an integer from one to fifteen possess enkephalinase inhibition activity and are useful as analgesic agents.
    Type: Grant
    Filed: November 13, 1987
    Date of Patent: September 27, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Norma G. Delaney, Eric M. Gordon, Miguel A. Ondetti
  • Enkephalinase inhibitors
    Patent number: 4722810
    Abstract: Mercaptoalkanoyl and acylmercaptoalkanoyl compounds of the formula ##STR1## wherein n is an integer from one to fifteen possess enkephalinase inhibition activity and are useful as analgesic agents.
    Type: Grant
    Filed: August 13, 1986
    Date of Patent: February 2, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Norma G. Delaney, Eric M. Gordon, Miguel A. Ondetti
  • Carboxymethyl esters of mercaptopropanoic acids as enkephalinase inhibitors
    Patent number: 4611002
    Abstract: New carboxymethyl esters of mercaptopropanoic acids, and salts thereof, have the formula ##STR1## wherein R is hydrogen or lower alkanoyl;R.sub.1 is hydrogen, lower alkyl, phenylalkyl and phenyl;R.sub.2 is hydrogen, lower alkyl, phenyl, phenyl-lower alkyl, 4-hydroxyphenyl-lower alkyl or indolyl-lower alkyl.These compounds are useful as enkephalinase inhibitors and hypotensive agents.
    Type: Grant
    Filed: June 8, 1984
    Date of Patent: September 9, 1986
    Assignee: E. R. Squibb and Sons, Inc.
    Inventor: Miguel A. Ondetti
  • Antibacterial O-sulfated .beta.-lactam hydroxamic acids
    Patent number: 4533660
    Abstract: Antibacterial activity is exhibited by .beta.-lactams having a sulfate substituent in the 1-position and an acylamino substituent in the 3-position.
    Type: Grant
    Filed: November 12, 1981
    Date of Patent: August 6, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Miguel A. Ondetti
  • S-Acylation products of mercaptoacyl amino acids and carboxyl group containing diuretics
    Patent number: 4482725
    Abstract: The S-acylation of a mercaptoacyl amino acid having ACE inhibitory action with a diuretic containing a carboxyl group yields a product having both ACE inhibitory action and diuretic activity in vivo.
    Type: Grant
    Filed: April 3, 1980
    Date of Patent: November 13, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Denis E. Ryono
  • 4-Methylene-1-[[(alranoyl or arylcarbonyl)mercapto]acyl]proline and pipecolic acid
    Patent number: 4377701
    Abstract: Compounds having the formula ##STR1## and salts thereof, wherein R.sub.1 is a readily hydrolyzable acyl protecting group;R.sub.2 is hydrogen or alkyl;R.sub.3 is hydrogen, alkyl or arylalkyl;n is 1 or 2; andp is 1 or 2inhibit the action of angiotensin converting enzyme.
    Type: Grant
    Filed: September 21, 1981
    Date of Patent: March 22, 1983
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Miguel A. Ondetti
  • Compounds for alleviating angiotensin related hypertension
    Patent number: 4339600
    Abstract: Compounds for alleviating or reducing angiotensin related hypertension in hypertensive mammals comprising angiotensin converting enzyme inhibitors selected from a group of mercaptoacyl aminoacids.
    Type: Grant
    Filed: February 13, 1978
    Date of Patent: July 13, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, David W. Cushman
  • O-sulfated .beta.-lactam hydroxamic acids and intermediates
    Patent number: 4337197
    Abstract: Antibacterial activity is exhibited by .beta.-lactams having a sulfate substituent in the 1-position and an acylamino substituent in the 3-position.
    Type: Grant
    Filed: October 31, 1980
    Date of Patent: June 29, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Miguel A. Ondetti
  • Mercaptoacyl derivatives of keto substituted pipecolic acid
    Patent number: 4330548
    Abstract: This invention is directed to compounds of the formula ##STR1## which are useful in the treatment of hypertension.
    Type: Grant
    Filed: June 29, 1981
    Date of Patent: May 18, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Miguel A. Ondetti
  • Mixed disulfides
    Patent number: 4325944
    Abstract: This invention is directed to compounds of the formula ##STR1## wherein A and A.sub.1 are amino acid residues, X is an .alpha.-imino acid residue, and R.sub.1 is hydrogen, lower alkyl, or halo substituted lower alkyl. These compounds are useful as hypotensive agents.
    Type: Grant
    Filed: December 22, 1980
    Date of Patent: April 20, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Miguel A. Ondetti, Shih-jung Lan, Keith K. Wong
  • Mixed disulfides
    Patent number: 4325945
    Abstract: This invention is directed to compounds of the formula ##STR1## wherein A and A.sub.1 are amino acid residues, X is an .alpha.-imino acid residue, and R.sub.1 is hydrogen, lower alkyl, or halo substituted lower alkyl. These compounds are useful as hypotensive agents.
    Type: Grant
    Filed: December 22, 1980
    Date of Patent: April 20, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Miguel A. Ondetti, Shih-jung Lan, Keith K. Wong
  • Mixed disulfides
    Patent number: 4325943
    Abstract: This invention is directed to compounds of the formula ##STR1## wherein A and A.sub.1 are amino acid residues, X is an .alpha.-imino acid residue, and R.sub.1 is hydrogen, lower alkyl, or halo substituted lower alkyl. These compounds are useful as hypotensive agents.
    Type: Grant
    Filed: December 22, 1980
    Date of Patent: April 20, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Sesha I. Natarajan, Miguel A. Ondetti, Shih-jung Lan, Keith K. Wong
  • Mercaptoacyl derivatives of 4-oxazolidine-carboxylic acids
    Patent number: 4321392
    Abstract: This invention is directed to compounds of the formula ##STR1## which are useful as hypotensive agents.
    Type: Grant
    Filed: February 6, 1980
    Date of Patent: March 23, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Denis E. Ryono, Miguel A. Ondetti
  • Mercaptoacyl derivatives of substituted prolines
    Patent number: 4316906
    Abstract: New mercaptoacyl derivatives of substituted prolines which have the general formula ##STR1## are useful as hypotensive agents.
    Type: Grant
    Filed: October 31, 1980
    Date of Patent: February 23, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, John Krapcho
  • Hypotensive imidazole substituted mercapto-1-oxopropyl-L-prolines
    Patent number: 4313948
    Abstract: The invention relates to new compounds useful as hypotensive agents, of the formula: ##STR1## wherein R is hydrogen or lower alkyl;R.sub.1 is hydrogen, lower alkyl or halo substituted lower alkyl;R.sub.2 is hydrogen, ##STR2## or ##STR3## R.sub.3 is lower alkyl, phenyl or phenyl lower alkyl; Pr--COOR is a substituted or unsubstituted proline.
    Type: Grant
    Filed: November 20, 1980
    Date of Patent: February 2, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Denis E. Ryono