Patents by Inventor Miguel ALCALDE GALEOTE

Miguel ALCALDE GALEOTE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotide, host cell and a method to recombinantly produce the protein encoded by said polynucleotide having peroxygenative activity
    Patent number: 10876098
    Abstract: The invention relates to an unspecific peroxygenase of the Agrocybe aegerita fungus, obtained by means of directed molecular evolution to facilitate the functional expression thereof in an active, soluble and stable form. The peroxygenase described in the invention shows a significant improvement in the functional expression thereof, improved monooxygenase activity and reduced peroxidase activity, in relation to the monooxygenase and peroxidase activities showed by the unspecific wild-type peroxygenase of A. aegerita. The peroxygenase of the invention is useful in chemical processes, including industrial transformations such as the selective oxyfunctionalisation of carbon-hydrogen bonds of various organic compounds.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: December 29, 2020
    Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)
    Inventors: Patricia Molina Espeja, Francisco José Plou Gasca, Miguel Alcalde Galeote, Patricia Gómez De Santos
  • MUTANTS OF UNSPECIFIC PEROXYGENASE WITH HIGH MONOOXYGENASE ACTIVITY AND USES THEREOF
    Publication number: 20190024058
    Abstract: The invention relates to an unspecific peroxygenase of the Agrocybe aegerita fungus, obtained by means of directed molecular evolution to facilitate the functional expression thereof in an active, soluble and stable form. The peroxygenase described in the invention shows a significant improvement in the functional expression thereof, improved monooxygenase activity and reduced peroxidase activity, in relation to the monooxygenase and peroxidase activities showed by the unspecific wild-type peroxygenase of A. aegerita. The peroxygenase of the invention is useful in chemical processes, including industrial transformations such as the selective oxyfunctionalisation of carbon-hydrogen bonds of various organic compounds.
    Type: Application
    Filed: November 14, 2016
    Publication date: January 24, 2019
    Applicant: CONSEJO SUPERIOR INVESTIGACIONES CIERNTIFICAS (CSIC)
    Inventors: Patricia MOLINA ESPEJA, Francisco José PLOU GASCA, Miguel ALCALDE GALEOTE, Patricia GÓMEZ DE SANTOS