Abstract: Embodiments of the disclosure include methods and compositions for treating or preventing coronavirus infection using soluble vimentin of functional variant or derivative thereof. In specific embodiments, a vimentin derivative comprising the rod domain is utilized for treating or preventing any disease in which the blocking of viral particles from binding cell surface receptors is therapeutic. In specific embodiments, a fragment of vimentin that comprises part or all of the rod domain is employed.

Abstract: Embodiments of the disclosure encompass methods and compositions for maintaining a healthy fibrin network in an individual. The disclosure includes methods of targeting fibrin in an individual for the purpose of restoring fibrin that is subject to a level of fibrinolysis that is deleterious, such as excessive or reduced with respect to the general population. Such modifications of fibrin in an individual may include direct targeting of fibrin with the A2 domain of von Willebrand factor or a functional derivative or fragment thereof. In specific embodiments, the methods restore to a normal level any imbalance between coagulation and inflammation.

Abstract: The invention relates to a portable mixing platform for producing a heat-transfer fluid on site and on an industrial scale, said fluid consisting of a eutectic mixture of diphenyl (DP) and diphenyl oxide (DPO). The platform includes a device that stores DPO in liquid state, a device for supplying DP in solid state, a mixing device in which both components are mixed in liquid state and in the right amount for forming a eutectic mixture, and a device for inerting and treating gases which maintains the DPO and mixing devices under inert atmosphere, as well as drawing the gases vented from both devices to pass said gases through an activated-carbon filter prior to expelling same into the atmosphere. The present invention also relates to the method for producing the eutectic mixture of DP and DPO using the described portable mixing platform.