Patents by Inventor Mika Watanabe

Mika Watanabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11567033
    Abstract: A sensor element includes: an element base including: a ceramic body made of an oxygen-ion conductive solid electrolyte, and having an inlet at one end portion thereof; at least one internal chamber located inside the ceramic body, and communicating with the gas inlet; and an electrochemical pump cell including an outer electrode, an inner electrode facing the chamber, and a solid electrolyte therebetween, and a porous leading-end protective layer covering a leading end surface and four side surfaces in a predetermined range of the element base on the one end portion, wherein the protective layer has an extension extending into the gas inlet and fixed to an inner wall surface of the ceramic body demarcating the gas inlet, and a gap communicating with the gas inlet is located in the protective layer, with demarcated by a portion of the protective layer continuous with the extension.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: January 31, 2023
    Assignee: NGK INSULATORS, LTD.
    Inventors: Yusuke Watanabe, Takashi Hino, Mika Kai
  • Publication number: 20230025223
    Abstract: An R-T-B based permanent magnet including R2T14B main phase crystal grains and a grain boundary. R represents one or more rare earth elements, T represents one or more iron group elements essentially including Fe or Fe and Co, and B represents boron. In a cross-section parallel to the alignment direction of the R-T-B based permanent magnet, the coverage of the R2T14B main phase crystal grains is 50.0% or more, and the area ratio of the R2T14B main phase crystal grains is 92.0% or more.
    Type: Application
    Filed: November 26, 2020
    Publication date: January 26, 2023
    Applicant: TDK CORPORATION
    Inventors: Yoshinori FUJIKAWA, Atsushi KODA, Mika JINGU, Takashi WATANABE
  • Publication number: 20220356422
    Abstract: The present invention pertains to an alcoholic beverage that contains one or more types of steviol glycosides selected from rebaudioside D and rebaudioside M, and has a steviol glycoside content of 0.001-0.5 g/1,000 ml and an alcohol content of 0.5-40.0 v/v %.
    Type: Application
    Filed: April 19, 2021
    Publication date: November 10, 2022
    Applicant: SUNTORY HOLDINGS LIMITED
    Inventors: Yasuko FUJIWARA, Mika KONO, Yuriko WATANABE
  • Publication number: 20220341869
    Abstract: A sensor element includes: an element base including: a ceramic body made of an oxygen-ion conductive solid electrolyte, and having a gas inlet at one end portion thereof; at least two internal chambers located inside the ceramic body, and communicating with the gas inlet under predetermined diffusion resistance; an electrochemical pump cell including an electrode located on an outer surface of the ceramic body, an electrode facing the internal chambers, and solid electrolytes located therebetween; and a heater buried in the ceramic body; and a porous leading-end protective layer surrounding a first range at least including a part from a leading end surface to two internal chambers close to the gas inlet of the element base. A single heat insulating space is interposed between the leading-end protective layer and a portion of the element base in which the two internal chambers are located.
    Type: Application
    Filed: July 7, 2022
    Publication date: October 27, 2022
    Inventors: Yusuke WATANABE, Mika KAI, Ryo ONISHI, Saki SUZUKI
  • Patent number: 11435348
    Abstract: It is an object of the present invention to provide a tissue staining method that makes it possible to observe both information on the morphology of a tissue and information on a biological substance such as an antigen molecule to be detected on a single section and in a single view field. The present invention provides a tissue staining method, including carrying out (A) a HE (hematoxylin-eosin) staining, and (B) a histochemical staining, serially on a single tissue section, wherein the histochemical staining is defined as a histochemical technique for detecting a biological substance to be detected in a tissue in a visible manner by use of a binding reaction between the biological substance to be detected and a probe biological substance capable of binding specifically to the biological substance to be detected.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: September 6, 2022
    Assignee: KONICA MINOLTA, INC.
    Inventors: Hideki Gouda, Hisatake Okada, Yasushi Nakano, Kohsuke Gonda, Noriaki Ohuchi, Mika Watanabe
  • Publication number: 20220268727
    Abstract: A sensor element includes: an element base including: a ceramic body made of an oxygen-ion conductive solid electrolyte, and having an inlet at one end portion thereof; at least one internal chamber located inside the ceramic body, and communicating with the inlet under predetermined diffusion resistance; an electrochemical pump cell including an electrode located on an outer surface of the ceramic body, an electrode facing the internal chamber, and a solid electrolyte located therebetween; and a heater buried in the ceramic body; and a porous leading-end protective layer surrounding a first range at least including a leading end surface and a region to be coped with water-induced cracking specified in advance. A single heat insulating space is interposed between the leading-end protective layer and a whole side surface of the element base at least in the above region.
    Type: Application
    Filed: May 10, 2022
    Publication date: August 25, 2022
    Inventors: Yusuke WATANABE, Mika KAI, Ryo ONISHI, Saki SUZUKI
  • Patent number: 11415544
    Abstract: A sensor element includes: an element base including: a ceramic body made of an oxygen-ion conductive solid electrolyte, and having a gas inlet at one end portion thereof; at least two internal chambers located inside the ceramic body, and communicating with the gas inlet under predetermined diffusion resistance; an electrochemical pump cell including an electrode located on an outer surface of the ceramic body, an electrode facing the internal chambers, and solid electrolytes located therebetween; and a heater buried in the ceramic body; and a porous leading-end protective layer surrounding a first range at least including a part from a leading end surface to two internal chambers close to the gas inlet of the element base. A single heat insulating space is interposed between the leading-end protective layer and a portion of the element base in which the two internal chambers are located.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: August 16, 2022
    Assignee: NGK INSULATORS, LTD.
    Inventors: Yusuke Watanabe, Mika Kai, Ryo Onishi, Saki Suzuki
  • Patent number: 11385199
    Abstract: A sensor element includes: an element base including: a ceramic body made of an oxygen-ion conductive solid electrolyte, and having a gas inlet at one end portion thereof; at least one internal chamber located inside the ceramic body, and communicating with the gas inlet under predetermined diffusion resistance; an electrochemical pump cell including an electrode located on an outer surface of the ceramic body, an electrode facing the internal chamber, and a solid electrolyte located therebetween; and a heater buried in the ceramic body, and a leading-end protective layer being porous, and covering a leading end surface and four side surfaces in a predetermined range of the element base on the one end portion. The leading-end protective layer has an extension extending into a widened portion included in the gas inlet, and fixed to an inner wall surface of the widened portion.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: July 12, 2022
    Assignee: NGK INSULATORS, LTD.
    Inventors: Yusuke Watanabe, Mika Kai
  • Patent number: 11385197
    Abstract: A sensor element includes: an element base including: a ceramic body made of an oxygen-ion conductive solid electrolyte, and having a gas inlet at one end portion thereof; at least one internal chamber located inside the ceramic body, and communicating with the gas inlet under predetermined diffusion resistance; an electrochemical pump cell including an electrode located on an outer surface of the ceramic body, an electrode facing the chamber, and a solid electrolyte located therebetween; and a heater buried in the ceramic body, and an leading-end protective layer being porous, and covering a leading end surface and four side surfaces in a predetermined range of the element base on the one end portion. The leading-end protective layer has an extension extending into the gas inlet, and fixed to an inner wall surface of the ceramic body demarcating the gas inlet.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: July 12, 2022
    Assignee: NGK INSULATORS, LTD.
    Inventors: Yusuke Watanabe, Mika Kai, Tomoya Seimori, Takashi Hino
  • Patent number: 11275087
    Abstract: The present invention relates to a test support method which is a means for predicting whether or not pathological complete response (pCR) will be attained when a preoperative chemotherapy with an anticancer drug is performed, the method using a sample (breast cancer tissue section) collected from a breast cancer patient to be subjected to the preoperative chemotherapy. The test support method includes: [1] the step of acquiring a fluorescence image of a breast cancer tissue section, which fluorescence image shows bright spots of fluorescent nanoparticles labeling one or more kinds of breast cancer-related proteins; [2] the step of acquiring at least one index relating to the expression level(s) of the breast cancer-related protein(s) on the basis of the bright spots of the fluorescence image; and [3] the step of acquiring information for predicting pCR by performing an analysis using the above-described at least one index.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: March 15, 2022
    Assignee: KONICA MINOLTA, INC.
    Inventors: Hideki Gouda, Masaru Takahashi, Kensaku Takanashi, Hisatake Okada, Yuichi Ozaki, Yuka Yoshihara, Yasushi Nakano, Kohsuke Gonda, Noriaki Ohuchi, Mika Watanabe, Norikazu Masuda, Masakazu Toi, Hiroshi Tada, Minoru Miyashita
  • Patent number: 11035844
    Abstract: An image processing device (2A) comprises: an input means for inputting a brightfield image representing cell morphology in a tissue section, and a fluorescence image representing, by fluorescent bright spots, the expression of a specific protein in the same range of the tissue section; a first generation means for generating a cell image obtained by extracting a specific site of a cell from the brightfield image; a second generation means for generating an image obtained by extracting bright spot regions from the fluorescence image, creating a brightness profile for each bright spot region, and generating a fluorescent particle image obtained by extracting the fluorescent particles in the bright spot regions on the basis of the fluorescence profile for one fluorescent particle, which serves as a fluorescence bright spot source; and a calculation means for superimposing the cell image and the fluorescent particle image on one another.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: June 15, 2021
    Assignee: KONICA MINOLTA, INC.
    Inventors: Yasuhiro Watanabe, Shuji Ichitani, Kohsuke Gonda, Noriaki Ohuchi, Mika Watanabe
  • Patent number: 10746740
    Abstract: There is provided a biological substance quantitation method of quantitating a biological substance in a sample stained with a staining reagent including a fluorescent particle encapsulating a fluorescent substance, based on a fluorescence of the fluorescent substance. The method includes inputting a fluorescent image representing expression of the biological substance in the sample by a fluorescent bright spot; and quantitating an expression amount of the biological substance based on a fluorescence of the fluorescent bright spot. The biological substance is a nucleoprotein expressed at a cell nucleus. The fluorescent particle binds to the biological substance through a primary antibody which is directed against the biological substance as an antigen.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: August 18, 2020
    Assignee: Konica Minolta, Inc.
    Inventors: Takeshi Isoda, Naoko Furusawa, Yasuyuki Motokui, Kohsuke Gonda, Noriaki Ohuchi, Mika Watanabe
  • Publication number: 20200116718
    Abstract: It is an object of the present invention to provide a tissue staining method that makes it possible to observe both information on the morphology of a tissue and information on a biological substance such as an antigen molecule to be detected on a single section and in a single view field. The present invention provides a tissue staining method, including carrying out (A) a HE (hematoxylin-eosin) staining, and (B) a histochemical staining, serially on a single tissue section, wherein the histochemical staining is defined as a histochemical technique for detecting a biological substance to be detected in a tissue in a visible manner by use of a binding reaction between the biological substance to be detected and a probe biological substance capable of binding specifically to the biological substance to be detected.
    Type: Application
    Filed: December 16, 2019
    Publication date: April 16, 2020
    Inventors: Hideki GOUDA, Hisatake OKADA, Yasushi NAKANO, Kohsuke GONDA, Noriaki OHUCHI, Mika WATANABE
  • Patent number: 10551386
    Abstract: The present invention provides a biological substance detection method for specifically detecting a biological substance from a pathological specimen, by which method, when immunostaining using a fluorescent label and staining for morphological observation using a staining agent for morphological observation are simultaneously performed, the results of fluorescence observation and immunostaining can be assessed properly even if the fluorescent label and/or the staining agent is/are deteriorated by irradiation with an excitation light. The biological substance detection method according to the present invention is characterized in that the brightness retention rate of an immunostained part is in a range of 80% to 120% in relation to the brightness retention rate of a part stained for morphological observation when the fluorescent label used for the immunostaining is observed.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: February 4, 2020
    Assignee: KONICA MINOLTA, INC.
    Inventors: Kensaku Takanashi, Hisatake Okada, Yasushi Nakano, Kohsuke Gonda, Noriaki Ohuchi, Mika Watanabe
  • Patent number: 10551378
    Abstract: It is an object of the present invention to provide a tissue staining method that makes it possible to observe both information on the morphology of a tissue and information on a biological substance such as an antigen molecule to be detected on a single section and in a single view field. The present invention provides a tissue staining method, including carrying out (A) a HE (hematoxylin-eosin) staining, and (B) a histochemical staining, serially on a single tissue section, wherein the histochemical staining is defined as a histochemical technique for detecting a biological substance to be detected in a tissue in a visible manner by use of a binding reaction between the biological substance to be detected and a probe biological substance capable of binding specifically to the biological substance to be detected.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: February 4, 2020
    Assignee: KONICA MINOLTA, INC.
    Inventors: Hideki Gouda, Hisatake Okada, Yasushi Nakano, Kohsuke Gonda, Noriaki Ohuchi, Mika Watanabe
  • Patent number: 10502728
    Abstract: An image processing device (2A) comprises: an input means for inputting a brightfield image representing cell morphology in a tissue section, and a fluorescence image representing, by fluorescent bright spots, the expression of a specific protein in the same range of the tissue section; a first generation means for generating a cell image obtained by extracting a specific site of a cell from the brightfield image; a second generation means for generating an image obtained by extracting bright spot regions from the fluorescence image, creating a brightness profile for each bright spot region, and generating a fluorescent particle image obtained by extracting the fluorescent particles in the bright spot regions on the basis of the fluorescence profile for one fluorescent particle, which serves as a fluorescence bright spot source; and a calculation means for superimposing the cell image and the fluorescent particle image on one another.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: December 10, 2019
    Assignee: KONICA MINOLTA, INC.
    Inventors: Yasuhiro Watanabe, Shuji Ichitani, Kohsuke Gonda, Noriaki Ohuchi, Mika Watanabe
  • Publication number: 20190339251
    Abstract: An image processing device (2A) comprises: an input means for inputting a brightfield image representing cell morphology in a tissue section, and a fluorescence image representing, by fluorescent bright spots, the expression of a specific protein in the same range of the tissue section; a first generation means for generating a cell image obtained by extracting a specific site of a cell from the brightfield image; a second generation means for generating an image obtained by extracting bright spot regions from the fluorescence image, creating a brightness profile for each bright spot region, and generating a fluorescent particle image obtained by extracting the fluorescent particles in the bright spot regions on the basis of the fluorescence profile for one fluorescent particle, which serves as a fluorescence bright spot source; and a calculation means for superimposing the cell image and the fluorescent particle image on one another.
    Type: Application
    Filed: July 18, 2019
    Publication date: November 7, 2019
    Inventors: Yasuhiro WATANABE, Shuji ICHITANI, Kohsuke GONDA, Noriaki OHUCHI, Mika WATANABE
  • Patent number: 10458983
    Abstract: The present invention provides a staining method in which the fluorescent staining properties in a fluorescently-immunostained specimen are not reduced even when an oil-based mounting medium is used. The present invention also provides a method of preventing deterioration of a fluorescent label caused by irradiation with excitation light and improving the light resistance in a fluorescently-immunostained specimen obtained by the staining method. The biological substance detection method according to the present invention is a biological substance detection method for specifically detecting a biological substance from a pathological specimen, which includes the steps of: immunostaining the specimen with a fluorescent label; immobilizing the thus stained specimen; and mounting the thus immobilized specimen using a mounting medium including an organic solvent not freely miscible with water.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: October 29, 2019
    Assignee: KONICA MINOLTA, INC.
    Inventors: Kensaku Takanashi, Hideki Gouda, Keizou Takano, Hideki Hoshino, Yasushi Nakano, Kohsuke Gonda, Noriaki Ohuchi, Mika Watanabe
  • Patent number: 10352859
    Abstract: An object of the present invention is to provide a method of detecting a specific tissue or cell in a sample tissue section and accurately specifying both the position(s) and amount of a biological substance of interest that is expressed on the specific tissue or cell.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: July 16, 2019
    Assignee: KONICA MINOLTA, INC.
    Inventors: Fuminori Okada, Takuji Aimiya, Kohsuke Gonda, Noriaki Ohuchi, Mika Watanabe
  • Patent number: 10309900
    Abstract: A biological substance quantitation method includes the following. A fluorescent image is input, which represents an expression of a specific biological substance in a sample stained with a fluorescent substance by a florescent bright spot. A quantitative evaluation value of the florescent bright spot is calculated. A standard fluorescent image of a standard sample stained under a same condition as the sample and representing an expression of the biological substance in a standard sample, is input under a same condition as the fluorescent image. A quantitative evaluation value in the standard fluorescent image is calculated under a same condition as the fluorescent image. Based on a correlation between an expression amount of the biological substance in a standard sample measured in advance and the evaluation value in the standard fluorescent image, the evaluation value in the fluorescent image is converted to an expression amount of the biological substance in the sample.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: June 4, 2019
    Assignee: KONICA MINOLTA, INC.
    Inventors: Hideki Gouda, Kensaku Takanashi, Kohsuke Gonda, Noriaki Ohuchi, Mika Watanabe