Patents by Inventor Miku Toyazaki
Miku Toyazaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11680279Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism that is able to produce the objective substance, which microorganism has been modified so that the activity of an enzyme involved in SAM cycle (SAM cycle enzyme) is increased.Type: GrantFiled: November 26, 2018Date of Patent: June 20, 2023Assignee: AJINOMOTO CO., INC.Inventors: Benjamin Mijts, Christine Roche, Rekha Murali, Sayaka Asari, Keita Fukui, Miku Toyazaki, Keiko Noguchi
-
Patent number: 11053519Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of S-adenosyl-L-homocysteine hydrolase is increased.Type: GrantFiled: April 24, 2019Date of Patent: July 6, 2021Assignee: AJINOMOTO CO., INC.Inventors: Benjamin Mijts, Christine Roche, Peter Kelly, Sayaka Asari, Keita Fukui, Miku Toyazaki
-
Patent number: 10883125Abstract: A method is described for producing an objective substance, for example, an aldehyde such as vanillin. The objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an ability to produce the objective substance, wherein the microorganism has been modified to have a specific carboxylic acid reductase (CAR) gene, such as a Gordonia CAR gene, Novosphingobium CAR gene, or Coccomyxa CAR gene.Type: GrantFiled: April 24, 2019Date of Patent: January 5, 2021Assignee: AJINOMOTO CO., INC.Inventors: Miku Toyazaki, Keita Fukui
-
Patent number: 10876138Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of enolase is reduced.Type: GrantFiled: April 24, 2019Date of Patent: December 29, 2020Assignee: AJINOMOTO CO., INC.Inventors: Benjamin Mijts, Christine Roche, Sayaka Asari, Miku Toyazaki, Keita Fukui
-
Patent number: 10858676Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so as to have a specific feature, such as a reduced activity of AICAR formyltransferase/IMP cyclohydrolase, an increased activity of 3-PGDH, and/or a reduced activity of L-serine deaminase.Type: GrantFiled: May 17, 2018Date of Patent: December 8, 2020Assignee: AJINOMOTO CO., INC.Inventors: Christine Roche, Benjamin Mijts, Peter Kelly, Matthew Davis, Sayaka Asari, Keita Fukui, Miku Toyazaki
-
Patent number: 10612006Abstract: A method is provided for producing an objective substance, for example, an aromatic aldehyde such as vanillin. The objective substance is produced from a carbon source or a precursor of the objective substance by using a coryneform bacterium that is able to produce the objective substance, wherein bacterium has been modified so that the activity of alcohol dehydrogenase is reduced.Type: GrantFiled: April 12, 2018Date of Patent: April 7, 2020Assignee: AJINOMOTO CO., INC.Inventors: Keita Fukui, Keiko Danjo, Junko Ito, Miku Toyazaki
-
Publication number: 20190249206Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of enolase is reduced.Type: ApplicationFiled: April 24, 2019Publication date: August 15, 2019Applicant: AJINOMOTO CO., INC.Inventors: Benjamin Mijts, Christine Roche, Sayaka Asari, Miku Toyazaki, Keita Fukui
-
Publication number: 20190249205Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of an L-cysteine biosynthesis enzyme is increased.Type: ApplicationFiled: April 24, 2019Publication date: August 15, 2019Inventors: Benjamin Mijts, Christine Roche, Peter Kelly, Sayaka Asari, Keita Fukui, Miku Toyazaki
-
Publication number: 20190249207Abstract: A method is described for producing an objective substance, for example, an aldehyde such as vanillin. The objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an ability to produce the objective substance, wherein the microorganism has been modified to have a specific carboxylic acid reductase (CAR) gene, such as a Gordonia CAR gene, Novosphingobium CAR gene, or Coccomyxa CAR gene.Type: ApplicationFiled: April 24, 2019Publication date: August 15, 2019Applicant: AJINOMOTO CO., INC.Inventors: Miku Toyazaki, Keita Fukui
-
Publication number: 20190241914Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so that the activity of NCgl2048 protein is reduced.Type: ApplicationFiled: April 24, 2019Publication date: August 8, 2019Applicant: AJINOMOTO CO., INC.Inventors: Benjamin Mijts, Christine Roche, Peter Kelly, Sayaka Asari, Miku Toyazaki, Keita Fukui
-
Publication number: 20190161776Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism that is able to produce the objective substance, which microorganism has been modified so that the activity of an enzyme involved in SAM cycle (SAM cycle enzyme) is increased.Type: ApplicationFiled: November 26, 2018Publication date: May 30, 2019Applicant: AJINOMOTO CO., INC.Inventors: Benjamin Mijts, Christine Roche, Rekha Murali, Sayaka Asari, Keita Fukui, Miku Toyazaki, Keiko Noguchi
-
Publication number: 20180334693Abstract: A method for producing an objective substance such as vanillin and vanillic acid is provided. An objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an objective substance-producing ability, which microorganism has been modified so as to have a specific feature, such as a reduced activity of AICAR formyltransferase/IMP cyclohydrolase, an increased activity of 3-PGDH, and/or a reduced activity of L-serine deaminase.Type: ApplicationFiled: May 17, 2018Publication date: November 22, 2018Applicant: AJINOMOTO CO., INC.Inventors: Christine Roche, Benjamin Mijts, Peter Kelly, Matthew Davis, Sayaka Asari, Keita Fukui, Miku Toyazaki
-
Publication number: 20180230441Abstract: A method is provided for producing an objective substance, for example, an aromatic aldehyde such as vanillin. The objective substance is produced from a carbon source or a precursor of the objective substance by using a coryneform bacterium that is able to produce the objective substance, wherein bacterium has been modified so that the activity of alcohol dehydrogenase is reduced.Type: ApplicationFiled: April 12, 2018Publication date: August 16, 2018Applicant: AJINOMOTO CO., INC.Inventors: Keita Fukui, Keiko Danjo, Junko Ito, Miku Toyazaki
-
Patent number: 9487806Abstract: A method for producing of an L-amino acid is provided. An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid-producing ability, which has been modified so that the acpP-fabF operon is attenuated, in a medium, and collecting the L-amino acid from the medium or cells of the bacterium.Type: GrantFiled: June 10, 2015Date of Patent: November 8, 2016Assignee: Ajinomoto Co., Inc.Inventors: Miku Toyazaki, Keiko Noguchi, Mika Moriya, Yuri Uehara
-
Publication number: 20150275246Abstract: A method for producing of an L-amino acid is provided. An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid-producing ability, which has been modified so that the acpP-fabF operon is attenuated, in a medium, and collecting the L-amino acid from the medium or cells of the bacterium.Type: ApplicationFiled: June 10, 2015Publication date: October 1, 2015Applicant: AJINOMOTO CO., INC.Inventors: Miku Toyazaki, Keiko Noguchi, Mika Moriya, Yuri Uehara