Patents by Inventor Milind Rajopadhye

Milind Rajopadhye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10442930
    Abstract: This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N, N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: October 15, 2019
    Assignee: VisEn Medical, Inc.
    Inventors: Narasimhachari Narayanan, Kevin Groves, Jeffrey D. Peterson, Milind Rajopadhye
  • Patent number: 10092188
    Abstract: The invention provides methods and compositions for determining whether a subject containing a stent immobilized in a blood vessel has asymptomatic stent thrombosis or is at risk of developing clinically symptomatic stent thrombosis. In one approach, the method involves imaging a region of the blood vessel that contains the stent using a probe that contains a fluorochrome, for example, a near-infrared fluorochrome, and a targeting moiety that binds a molecular marker indicative of the presence of asymptomatic stent thrombosis or the development of symptomatic stent thrombosis. To the extent that the subject displays one or more such markers, the probe binds to the markers and increases the local concentration of the probe in the vicinity of the stent. The imaging method identifies those patients that display a higher density of such markers in the vicinity of the stent. As a result, those patients can be monitored for, and/or treated to prevent, symptomatic stent thrombosis.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: October 9, 2018
    Assignee: VisEn Medical, Inc.
    Inventors: Farouc Jaffer, Milind Rajopadhye
  • Patent number: 9999687
    Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: June 19, 2018
    Assignee: VisEn Medical, Inc.
    Inventors: Milind Rajopadhye, Kevin Groves, Dorin V. Preda
  • Patent number: 9913917
    Abstract: The invention relates to highly fluorescent metal oxide nanoparticles to which biomolecules and other compounds can be chemically linked to form biocompatible, stable optical imaging agents for in vitro and in vivo applications. The fluorescent metal oxide nanoparticles may also be used for magnetic resonance imaging (MRI), thus providing a multi modality imaging agent.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: March 13, 2018
    Assignee: VisEn Medical, Inc.
    Inventors: Kevin Groves, Milind Rajopadhye
  • Publication number: 20170283617
    Abstract: This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N, N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
    Type: Application
    Filed: February 15, 2017
    Publication date: October 5, 2017
    Inventors: Narasimhachari Narayanan, Kevin Groves, Jeffrey D. Peterson, Milind Rajopadhye
  • Patent number: 9694089
    Abstract: The invention provides a family of agents that target integrins, which can be used as imaging agents and/or therapeutic agents. The agents can be used to image angiogenesis, inflammation or other physiological processes in a subject.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: July 4, 2017
    Assignees: Visen Medical, Inc., Merck Sharp & Dohme Corp.
    Inventors: Milind Rajopadhye, Guojie Ho, Bohumil Bednar, Le T. Duong, Paul J. Coleman
  • Publication number: 20170119908
    Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
    Type: Application
    Filed: August 29, 2016
    Publication date: May 4, 2017
    Inventors: Milind Rajopadhye, Kevin Groves, Dorin V. Preda
  • Patent number: 9574085
    Abstract: This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: February 21, 2017
    Assignee: VisEn Medical, Inc.
    Inventors: Narasimhachari Narayanan, Kevin Groves, Jeffrey D. Peterson, Milind Rajopadhye
  • Patent number: 9427481
    Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: August 30, 2016
    Assignee: VisEn Medical, Inc.
    Inventors: Milind Rajopadhye, Kevin Groves, Dorin V. Preda
  • Publication number: 20150133773
    Abstract: The invention provides methods and compositions for determining whether a subject containing a stent immobilized in a blood vessel has asymptomatic stent thrombosis or is at risk of developing clinically symptomatic stent thrombosis. In one approach, the method involves imaging a region of the blood vessel that contains the stent using a probe that contains a fluorochrome, for example, a near-infrared fluorochrome, and a targeting moiety that binds a molecular marker indicative of the presence of asymptomatic stent thrombosis or the development of symptomatic stent thrombosis. To the extent that the subject displays one or more such markers, the probe binds to the markers and increases the local concentration of the probe in the vicinity of the stent. The imaging method identifies those patients that display a higher density of such markers in the vicinity of the stent. As a result, those patients can be monitored for, and/or treated to prevent, symptomatic stent thrombosis.
    Type: Application
    Filed: September 30, 2014
    Publication date: May 14, 2015
    Applicant: VISEN MEDICAL, INC.
    Inventors: Farouc Jaffer, Milind Rajopadhye
  • Publication number: 20150018517
    Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
    Type: Application
    Filed: August 11, 2014
    Publication date: January 15, 2015
    Inventors: Milind Rajopadhye, Kevin Groves, Dorin V. Preda
  • Patent number: 8864821
    Abstract: The invention provides methods and compositions for determining whether a subject containing a stent immobilized in a blood vessel has asymptomatic stent thrombosis or is at risk of developing clinically symptomatic stent thrombosis. In one approach, the method involves imaging a region of the blood vessel that contains the stent using a probe that contains a fluorochrome, for example, a near-infrared fluorochrome, and a targeting moiety that binds a molecular marker indicative of the presence of asymptomatic stent thrombosis or the development of symptomatic stent thrombosis. To the extent that the subject displays one or more such markers, the probe binds to the markers and increases the local concentration of the probe in the vicinity of the stent. The imaging method identifies those patients that display a higher density of such markers in the vicinity of the stent. As a result, those patients can be monitored for, and/or treated to prevent, symptomatic stent thrombosis.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: October 21, 2014
    Assignee: VisEn Medical, Inc.
    Inventors: Farouc Jaffer, Milind Rajopadhye
  • Patent number: 8815214
    Abstract: Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
    Type: Grant
    Filed: January 17, 2009
    Date of Patent: August 26, 2014
    Assignee: VisEn Medical, Inc.
    Inventors: Milind Rajopadhye, Kevin Groves, Dorin V. Preda
  • Patent number: 8771646
    Abstract: This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: July 8, 2014
    Assignee: VisEn Medical, Inc.
    Inventors: Milind Rajopadhye, Narasimhachari Narayanan, Jeffrey D. Peterson
  • Publication number: 20140170066
    Abstract: The invention provides a family of agents that target integrins, which can be used as imaging agents and/or therapeutic agents. The agents can be used to image angiogenesis, inflammation or other physiological processes in a subject.
    Type: Application
    Filed: February 24, 2014
    Publication date: June 19, 2014
    Applicants: Merck & Co., Inc., Visen Medical, Inc.
    Inventors: Milind Rajopadhye, Guojie Ho, Bohumil Bednar, Le T. Duong, Paul J. Coleman
  • Patent number: 8685370
    Abstract: The invention provides a family of agents that target integrins, which can be used as imaging agents and/or therapeutic agents. The agents can be used to image angiogenesis, inflammation or other physiological processes in a subject.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: April 1, 2014
    Assignees: Visen Medical, Inc., Merck & Co., Inc.
    Inventors: Milind Rajopadhye, Guojie Ho, Bohumil Bednar, Le T. Duong, Paul J. Coleman
  • Publication number: 20130272967
    Abstract: This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 17, 2013
    Inventors: Milind Rajopadhye, Narasimhachari Narayanan, Jeffrey D. Peterson
  • Patent number: 8455651
    Abstract: This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: June 4, 2013
    Assignee: VisEn Medical, Inc.
    Inventors: Milind Rajopadhye, Narasimhachari Narayanan
  • Publication number: 20120321562
    Abstract: This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
    Type: Application
    Filed: April 18, 2012
    Publication date: December 20, 2012
    Inventors: Milind Rajopadhye, Narasimhachari Narayanan, Jeffrey D. Peterson
  • Patent number: 8173819
    Abstract: This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
    Type: Grant
    Filed: September 1, 2006
    Date of Patent: May 8, 2012
    Assignee: VisEn Medical, Inc.
    Inventors: Milind Rajopadhye, Narasimhachari Narayanan, Jeffrey D. Peterson