Patents by Inventor Ming-Hsin Li

Ming-Hsin Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140378830
    Abstract: A method for stimulating a brain to form a cognitive reaction image is provided, which includes administrating 11C-isotope labeled glucose to a test recipient closing eyes, exposing the test recipient to visual stimulus, auditory stimulus and cognitive stimulus, respectively, and then monitoring the test recipient by a brain imaging device and collecting brain imaging data to compare variation between actions of the administrated 11C-isotope labeled glucose in the test recipient's brain before and after the test recipient being exposed to the stimulus. The brain images in correspondence with the brain reacting to the visual, auditory and cognitive stimuli are obtained by detecting the metabolic process of the 11C-isotope labeled glucose in brain.
    Type: Application
    Filed: June 24, 2013
    Publication date: December 25, 2014
    Inventor: Ming-Hsin Li
  • Publication number: 20140377169
    Abstract: An automated synthesis device to produce Re-188-BMEDA solution including: a plurality of reagent vials, three-way solenoid valves, gel filtration columns and micro pumps, and a reaction vial, a product vial, a temporary storage vial, a filter membrane, and a waste vial, wherein the plurality of reagent vials include first reagent vial and second reagent vials being connected to the reaction vial through first micro pump, the third reagent vial and fourth reagent vial being connected to the reaction vial through second micro pump, fifth reagent vial being connected to the reaction vial through third micro pump, and sixth reagent vial being connected to the temporary storage vial through fourth micro pump, wherein the reaction vial is connected to the plurality of gel filtration columns through the micro-pump, respectively. The automated synthesis device is operable with program to upgrade yield and avoid contamination.
    Type: Application
    Filed: June 19, 2013
    Publication date: December 25, 2014
    Inventors: Ming-Hsin Li, Shu-Pei Chiu, Chih-Hsien Chang, Te-Wei Lee
  • Publication number: 20140369928
    Abstract: The invention provides an automatic synthesizer apparatus and method for producing radiopharmaceutical tumor imaging agent Gallium-68-DOTATATE with one button control process to effectively isolate the medication in vials from the contamination of environment and manual operations, saving the costs of investment in production with alleviation of the critical standard required for the environmental equipments to be used for production.
    Type: Application
    Filed: June 13, 2013
    Publication date: December 18, 2014
    Inventor: Ming-Hsin Li
  • Patent number: 8894860
    Abstract: A Gallium-68 (Ga-68) radioisotope generator includes a generating column and a citrate eluent. The generating column is at least partially filled with an ion-exchange resin with glucamine groups to absorb germanium-68 (Ge-68) and Ga-68 radioisotopes. The citrate eluent is added into the generating column to desorb the Ga-68 radioisotope and form an eluent containing the Ga-68 radioisotope in the form of Ga-68 citrate. A method for generating Ga-68 radioisotope is also disclosed.
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: November 25, 2014
    Assignee: Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan
    Inventors: Ming-Hsin Li, Jin-Jenn Lin, Ther-Jen Ting, I-Lea Dai
  • Patent number: 8802014
    Abstract: The invention is related a novel structure for Ga-68 radionuclide generator. It allows two washing solutions to pass through two Ge-68 absorbents to wash out different chemical forms of Ga-68 nuclide. The invention comprises the first method that will withdraw hydrochloric acid solution from the washing bottle and pass it through inorganic resin absorbing column to produce the radioisotope solution of Ga-68 gallium chloride, and the second method that will allow the radioisotope solution of Ga-68 gallium citrate to pass the organic resin absorbing column and then the silica-gel cartridge, and be washed by the hydrochloric acid solution to obtain the radioisotope solution of Ga-68 gallium chloride.
    Type: Grant
    Filed: October 3, 2011
    Date of Patent: August 12, 2014
    Assignee: Institute of Nuclear Energy Research
    Inventors: Ming-Hsin Li, Jin-Jenn Lin, Ther-Jen Ting, I-Lea Dai
  • Publication number: 20140039237
    Abstract: A medication dispensing device includes a medication bottle, a perfusion device, a filter and a dispensing needle. The dispensing needle includes a lower end being shrill, smooth and seamless and puncturing into the plug of the medication bottle. The dispensing needle includes a passageway therein, and includes an opening and a groove on the side wall of the dispensing needle. The dispensing needle can puncture into the plug of the medication bottle without creating any scraps stuck in the opening of the passageway or dropping into the medication bottle. The groove can release the air and pressure of the medication bottle when the pressure in the medication bottle increases during the injection of the medication solution. Accordingly, the smoothness of the dispensation of the medication solution is improved, and the contamination of the medication solution can be avoided.
    Type: Application
    Filed: August 6, 2012
    Publication date: February 6, 2014
    Inventor: MING-HSIN LI
  • Publication number: 20130084220
    Abstract: The invention is related a novel structure for Ga-68 radionuclide generator. It allows two washing solutions to pass through two Ge-68 absorbents to wash out different chemical forms of Ga-68 nuclide. The invention comprises the first method that will withdraw hydrochloric acid solution from the washing bottle and pass it through inorganic resin absorbing column to produce the radioisotope solution of Ga-68 gallium chloride, and the second method that will allow the radioisotope solution of Ga-68 gallium citrate to pass the organic resin absorbing column and then the silica-gel cartridge, and be washed by the hydrochloric acid solution to obtain the radioisotope solution of Ga-68 gallium chloride.
    Type: Application
    Filed: October 3, 2011
    Publication date: April 4, 2013
    Inventors: MING-HSIN LI, JIN-JENN LIN, THER-JEN TING, I-LEA DAI
  • Patent number: 8347925
    Abstract: An automatic radiopharmaceuticals filling machine mainly comprises a main unit with an activation mechanism to perform three-dimensional reciprocal movement. The activation mechanism has a lateral slider that can be activated to move reciprocally along lateral X-axis. On the lateral slider, there is a vertical slider that can extend perpendicularly and move reciprocally along lateral Y-axis. An injection needle is located on the vertical slider and can be activated to move reciprocally along Z-axis perpendicular to the lateral slider. A syringe rack is located in the moving range of the injection needle to accommodate a plural number of syringes, on each of which there is an injection hole. A drug pump has an inlet and an outlet. The inlet connects to a high-dose radiopharmaceuticals drug bottle. The outlet connects to the injection needle.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: January 8, 2013
    Assignee: Institute of Nuclear Energy Research
    Inventor: Ming-Hsin Li
  • Patent number: 8239159
    Abstract: A method used to yield irradiation product with minimal impurity for the solid target for gallium (Ga)-68/germanium (Ge)-68 generator mainly consists of the procedures: first calculate the thickness d for the electroplated gallium (Ga)-69 on the solid target; and then through a graph of decay curves including 69Ga(p, 2n) 68Ge target thickness and incident energy with 5 different incident energy doses, derive the corresponding irradiation energy dose Yi for each group after decay; and through the graph including 69Ga(p,2n)68Ge incident energy and reaction cross-sectional area, derive the nuclear reaction cross-sectional area for each group for germanium(Ge)-68, gallium (Ga)-68, zinc (Zn)-65 and figure out the mean reaction area (MRA) from the reaction cross-sectional area of each group; and select the maximum germanium(Ge)-68 MRA value and the minimum gallium (Ga)-68 and zinc (Zn)-65 MRA values; and generate the required default irradiation energy for the MRA of each group.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: August 7, 2012
    Assignee: Institute of Nuclear Energy Research
    Inventors: Ming-Hsin Li, Ting Shien Duh, Wuu-Jyn Lin
  • Patent number: 8181677
    Abstract: An automated dispenser for radiopharmaceuticals is mainly for a platform to have a moving mechanism being able to move three-dimensionally back and forth, a syringe holder and a bottle holder. The syringe holder is for holding a plural number of syringes. The bottle holder has a reverse drug bottle. The moving mechanism has a syringe clamp rotatable around a horizontal axis and a syringe driving mechanism. The syringe clamp is activated to hold a syringe and move it to where the syringe needle is inserted to the drug bottle. The syringe driving mechanism and the syringe clamp are simultaneously associated with the syringe for drug-withdrawing action.
    Type: Grant
    Filed: October 8, 2007
    Date of Patent: May 22, 2012
    Assignee: Institute of Nuclear Energy Research
    Inventors: Ming-Hsin Li, Wuu-Jyh Lin, Tain-Shi Zen
  • Publication number: 20120011965
    Abstract: A Gallium-68 (Ga-68) radioisotope generator includes a generating column and a citrate eluent. The generating column is at least partially filled with an ion-exchange resin with glucamine groups to absorb germanium-68 (Ge-68) and Ga-68 radioisotopes. The citrate eluent is added into the generating column to desorb the Ga-68 radioisotope and form an eluent containing the Ga-68 radioisotope in the form of Ga-68 citrate. A method for generating Ga-68 radioisotope is also disclosed.
    Type: Application
    Filed: December 8, 2010
    Publication date: January 19, 2012
    Inventors: Ming-Hsin LI, Jin-Jenn Lin, Ther-Jen Ting, I-Lea Dai
  • Patent number: 8007730
    Abstract: An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: August 30, 2011
    Assignee: Institute of Nuclear Energy Research
    Inventors: Ming-Hsin Li, Hsin-EII Wang, Chun-Yi Wu, Wuu-Jyh Lin
  • Publication number: 20110077894
    Abstract: A process parameter assessment method for the solid target for gallium (Ga)-68/germanium (Ge)-68 generator mainly consists of the procedures: first calculate the thickness d for the electroplated gallium (Ga)-69 on the solid target; and then through a graph of decay curves comprising 69Ga(p, 2n) 68Ge target thickness and incident energy with 5 different incident energy doses (30, 26, 25, 24, 23 MeV), based on electroplating thickness d, derive the corresponding irradiation energy dose Yi for each group after decay; and through the graph comprising 69Ga(p, 2n) 68Ge incident energy and reaction cross-sectional area (containing corrected function graph of incident energy for germanium-68, gallium-68, or zinc-65 and reaction cross-sectional area), based on the defined range by irradiation energy dose Xi and the corresponding irradiation energy dose Yi, derive the nuclear reaction cross-sectional area for each group for germanium (Ge)-68, gallium (Ga)-68, zinc (Zn)-65 and figure out the mean reaction area (MRA) fr
    Type: Application
    Filed: September 30, 2009
    Publication date: March 31, 2011
    Inventors: Ming-Hsin Li, Ting Shien Duh, Wuu-Jyn Lin
  • Publication number: 20110041950
    Abstract: An automatic radiopharmaceuticals filling machine mainly comprises a main unit with an activation mechanism to perform three-dimensional reciprocal movement. The activation mechanism has a lateral slider that can be activated to move reciprocally along lateral X-axis. On the lateral slider, there is a vertical slider that can extend perpendicularly and move reciprocally along lateral Y-axis. An injection needle is located on the vertical slider and can be activated to move reciprocally along Z-axis perpendicular to the lateral slider. A syringe rack is located in the moving range of the injection needle to accommodate a plural number of syringes, on each of which there is an injection hole. A drug pump has an inlet and an outlet. The inlet connects to a high-dose radiopharmaceuticals drug bottle. The outlet connects to the injection needle.
    Type: Application
    Filed: August 19, 2009
    Publication date: February 24, 2011
    Inventor: Ming-Hsin Li
  • Publication number: 20100310428
    Abstract: An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.
    Type: Application
    Filed: June 5, 2009
    Publication date: December 9, 2010
    Inventors: MING-HSIN LI, HSIN-EII WANG, CHUN-YI WU, WUU-JYH LIN
  • Patent number: 7757724
    Abstract: An improved medication dispensing device includes an apyrexia receptacle, a transport pipeline, a perfusion device, a filter, and a dispensing needle, which operates in an environment in compliance with Class 100 laminar air ventilation. The perfusion device erected at the middle of the transport pipeline which has two ends linking to the apyrexia receptacle and the filter, respectively. In operation, the perfusion device pumps the prepared medication solution from the apyrexia receptacle to get through the filter to remove particles and bacterium, and a thin tubular dispensing needle which punctures the rubber plug of an aseptic bottle. An axial groove rendered in middle section of the dispensing needle forms a pressurized seal part with the rubber plug resiliently wrapped around at the middle of the dispensing needle to discharge redundant air pressure accumulating in the aseptic bottle while keeps outside air from entering.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: July 20, 2010
    Assignee: Institute of Nuclear Energy Research
    Inventors: Ming-Hsin Li, Wuu-Jyh Lin, Cheng-Hung Chien, Jun-Chieh Tsai, Wun-Shen Lan
  • Publication number: 20100087009
    Abstract: A method of automated formulation process for radiopharmaceutical injection medicine, including preparation for process control and calculation for formulation control, wherein the preparation steps for process control includes measuring radioactivity and size of radiopharmaceutical materials, determining measurement time and calibration time, measuring pH value and impurity percentage of radiopharmaceutical raw materials. By means of input of parameters measured and calculation of the volume of injection solvent and pH value, finished product of injection medicine is obtained when the pH value reaches 6.5, and the finished product is dispensed into the sterile bottles.
    Type: Application
    Filed: October 7, 2008
    Publication date: April 8, 2010
    Inventors: MING-HSIN LI, Wuu-Jyh Lin
  • Publication number: 20090108018
    Abstract: An automated dispenser for radiopharmaceuticals is mainly for a platform to have a moving mechanism being able to move three-dimensionally back and forth, a syringe holder and a bottle holder. The syringe holder is for holding a plural number of syringes. The bottle holder has a reverse drug bottle. The moving mechanism has a syringe clamp rotatable around a horizontal axis and a syringe driving mechanism. The syringe clamp is activated to hold a syringe and move it to where the syringe needle is inserted to the drug bottle. The syringe driving mechanism and the syringe clamp are simultaneously associated with the syringe for drug-withdrawing action.
    Type: Application
    Filed: October 8, 2007
    Publication date: April 30, 2009
    Inventors: MING-HSIN LI, WUU-JYH LIN, TAIN-SHI ZEN
  • Publication number: 20080097370
    Abstract: An improved medication dispensing device includes an apyrexia receptacle, a transport pipeline, a perfusion device, a filter, and a dispensing needle, which operates in an environment in compliance with Class 100 laminar air ventilation. The perfusion device erected at the middle of the transport pipeline which has two ends linking to the apyrexia receptacle and the filter, respectively. In operation, the perfusion device pumps the prepared medication solution from the apyrexia receptacle to get through the filter to remove particles and bacterium, and a thin tubular dispensing needle which punctures the rubber plug of an aseptic bottle. An axial groove rendered in middle section of the dispensing needle forms a pressurized seal part with the rubber plug resiliently wrapped around at the middle of the dispensing needle to discharge redundant air pressure accumulating in the aseptic bottle while keeps outside air from entering.
    Type: Application
    Filed: July 20, 2006
    Publication date: April 24, 2008
    Inventors: Ming-Hsin Li, Wuu-Jyh Lin, Cheng-Hung Chien, Jun-Chieh Tsai, Wun-Shen Lan
  • Publication number: 20070062865
    Abstract: The present invention relates to a novel flocculant comprising bacteria of the Bacillus genus cultivated in a culture medium comprising soybean protein, glucose, molasses, and yeast. Alternatively, the flocculant comprises soybean protein. The present invention also relates to methods of making the flocculant, including fermentation method for mass production, and methods of using the flocculant in water treatment.
    Type: Application
    Filed: November 20, 2006
    Publication date: March 22, 2007
    Inventors: Heng-Chuan Wang, Ming-Hsin Li, Hsu-Wen Tsang, Mei-Mao Wu, Hsui-Ping Lin