Patents by Inventor Ming-Hsin Li

Ming-Hsin Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8347925
    Abstract: An automatic radiopharmaceuticals filling machine mainly comprises a main unit with an activation mechanism to perform three-dimensional reciprocal movement. The activation mechanism has a lateral slider that can be activated to move reciprocally along lateral X-axis. On the lateral slider, there is a vertical slider that can extend perpendicularly and move reciprocally along lateral Y-axis. An injection needle is located on the vertical slider and can be activated to move reciprocally along Z-axis perpendicular to the lateral slider. A syringe rack is located in the moving range of the injection needle to accommodate a plural number of syringes, on each of which there is an injection hole. A drug pump has an inlet and an outlet. The inlet connects to a high-dose radiopharmaceuticals drug bottle. The outlet connects to the injection needle.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: January 8, 2013
    Assignee: Institute of Nuclear Energy Research
    Inventor: Ming-Hsin Li
  • Patent number: 8239159
    Abstract: A method used to yield irradiation product with minimal impurity for the solid target for gallium (Ga)-68/germanium (Ge)-68 generator mainly consists of the procedures: first calculate the thickness d for the electroplated gallium (Ga)-69 on the solid target; and then through a graph of decay curves including 69Ga(p, 2n) 68Ge target thickness and incident energy with 5 different incident energy doses, derive the corresponding irradiation energy dose Yi for each group after decay; and through the graph including 69Ga(p,2n)68Ge incident energy and reaction cross-sectional area, derive the nuclear reaction cross-sectional area for each group for germanium(Ge)-68, gallium (Ga)-68, zinc (Zn)-65 and figure out the mean reaction area (MRA) from the reaction cross-sectional area of each group; and select the maximum germanium(Ge)-68 MRA value and the minimum gallium (Ga)-68 and zinc (Zn)-65 MRA values; and generate the required default irradiation energy for the MRA of each group.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: August 7, 2012
    Assignee: Institute of Nuclear Energy Research
    Inventors: Ming-Hsin Li, Ting Shien Duh, Wuu-Jyn Lin
  • Patent number: 8181677
    Abstract: An automated dispenser for radiopharmaceuticals is mainly for a platform to have a moving mechanism being able to move three-dimensionally back and forth, a syringe holder and a bottle holder. The syringe holder is for holding a plural number of syringes. The bottle holder has a reverse drug bottle. The moving mechanism has a syringe clamp rotatable around a horizontal axis and a syringe driving mechanism. The syringe clamp is activated to hold a syringe and move it to where the syringe needle is inserted to the drug bottle. The syringe driving mechanism and the syringe clamp are simultaneously associated with the syringe for drug-withdrawing action.
    Type: Grant
    Filed: October 8, 2007
    Date of Patent: May 22, 2012
    Assignee: Institute of Nuclear Energy Research
    Inventors: Ming-Hsin Li, Wuu-Jyh Lin, Tain-Shi Zen
  • Publication number: 20120011965
    Abstract: A Gallium-68 (Ga-68) radioisotope generator includes a generating column and a citrate eluent. The generating column is at least partially filled with an ion-exchange resin with glucamine groups to absorb germanium-68 (Ge-68) and Ga-68 radioisotopes. The citrate eluent is added into the generating column to desorb the Ga-68 radioisotope and form an eluent containing the Ga-68 radioisotope in the form of Ga-68 citrate. A method for generating Ga-68 radioisotope is also disclosed.
    Type: Application
    Filed: December 8, 2010
    Publication date: January 19, 2012
    Inventors: Ming-Hsin LI, Jin-Jenn Lin, Ther-Jen Ting, I-Lea Dai
  • Patent number: 8007730
    Abstract: An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: August 30, 2011
    Assignee: Institute of Nuclear Energy Research
    Inventors: Ming-Hsin Li, Hsin-EII Wang, Chun-Yi Wu, Wuu-Jyh Lin
  • Publication number: 20110077894
    Abstract: A process parameter assessment method for the solid target for gallium (Ga)-68/germanium (Ge)-68 generator mainly consists of the procedures: first calculate the thickness d for the electroplated gallium (Ga)-69 on the solid target; and then through a graph of decay curves comprising 69Ga(p, 2n) 68Ge target thickness and incident energy with 5 different incident energy doses (30, 26, 25, 24, 23 MeV), based on electroplating thickness d, derive the corresponding irradiation energy dose Yi for each group after decay; and through the graph comprising 69Ga(p, 2n) 68Ge incident energy and reaction cross-sectional area (containing corrected function graph of incident energy for germanium-68, gallium-68, or zinc-65 and reaction cross-sectional area), based on the defined range by irradiation energy dose Xi and the corresponding irradiation energy dose Yi, derive the nuclear reaction cross-sectional area for each group for germanium (Ge)-68, gallium (Ga)-68, zinc (Zn)-65 and figure out the mean reaction area (MRA) fr
    Type: Application
    Filed: September 30, 2009
    Publication date: March 31, 2011
    Inventors: Ming-Hsin Li, Ting Shien Duh, Wuu-Jyn Lin
  • Publication number: 20110041950
    Abstract: An automatic radiopharmaceuticals filling machine mainly comprises a main unit with an activation mechanism to perform three-dimensional reciprocal movement. The activation mechanism has a lateral slider that can be activated to move reciprocally along lateral X-axis. On the lateral slider, there is a vertical slider that can extend perpendicularly and move reciprocally along lateral Y-axis. An injection needle is located on the vertical slider and can be activated to move reciprocally along Z-axis perpendicular to the lateral slider. A syringe rack is located in the moving range of the injection needle to accommodate a plural number of syringes, on each of which there is an injection hole. A drug pump has an inlet and an outlet. The inlet connects to a high-dose radiopharmaceuticals drug bottle. The outlet connects to the injection needle.
    Type: Application
    Filed: August 19, 2009
    Publication date: February 24, 2011
    Inventor: Ming-Hsin Li
  • Publication number: 20100310428
    Abstract: An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.
    Type: Application
    Filed: June 5, 2009
    Publication date: December 9, 2010
    Inventors: MING-HSIN LI, HSIN-EII WANG, CHUN-YI WU, WUU-JYH LIN
  • Patent number: 7757724
    Abstract: An improved medication dispensing device includes an apyrexia receptacle, a transport pipeline, a perfusion device, a filter, and a dispensing needle, which operates in an environment in compliance with Class 100 laminar air ventilation. The perfusion device erected at the middle of the transport pipeline which has two ends linking to the apyrexia receptacle and the filter, respectively. In operation, the perfusion device pumps the prepared medication solution from the apyrexia receptacle to get through the filter to remove particles and bacterium, and a thin tubular dispensing needle which punctures the rubber plug of an aseptic bottle. An axial groove rendered in middle section of the dispensing needle forms a pressurized seal part with the rubber plug resiliently wrapped around at the middle of the dispensing needle to discharge redundant air pressure accumulating in the aseptic bottle while keeps outside air from entering.
    Type: Grant
    Filed: July 20, 2006
    Date of Patent: July 20, 2010
    Assignee: Institute of Nuclear Energy Research
    Inventors: Ming-Hsin Li, Wuu-Jyh Lin, Cheng-Hung Chien, Jun-Chieh Tsai, Wun-Shen Lan
  • Publication number: 20100087009
    Abstract: A method of automated formulation process for radiopharmaceutical injection medicine, including preparation for process control and calculation for formulation control, wherein the preparation steps for process control includes measuring radioactivity and size of radiopharmaceutical materials, determining measurement time and calibration time, measuring pH value and impurity percentage of radiopharmaceutical raw materials. By means of input of parameters measured and calculation of the volume of injection solvent and pH value, finished product of injection medicine is obtained when the pH value reaches 6.5, and the finished product is dispensed into the sterile bottles.
    Type: Application
    Filed: October 7, 2008
    Publication date: April 8, 2010
    Inventors: MING-HSIN LI, Wuu-Jyh Lin
  • Publication number: 20090108018
    Abstract: An automated dispenser for radiopharmaceuticals is mainly for a platform to have a moving mechanism being able to move three-dimensionally back and forth, a syringe holder and a bottle holder. The syringe holder is for holding a plural number of syringes. The bottle holder has a reverse drug bottle. The moving mechanism has a syringe clamp rotatable around a horizontal axis and a syringe driving mechanism. The syringe clamp is activated to hold a syringe and move it to where the syringe needle is inserted to the drug bottle. The syringe driving mechanism and the syringe clamp are simultaneously associated with the syringe for drug-withdrawing action.
    Type: Application
    Filed: October 8, 2007
    Publication date: April 30, 2009
    Inventors: MING-HSIN LI, WUU-JYH LIN, TAIN-SHI ZEN
  • Publication number: 20080097370
    Abstract: An improved medication dispensing device includes an apyrexia receptacle, a transport pipeline, a perfusion device, a filter, and a dispensing needle, which operates in an environment in compliance with Class 100 laminar air ventilation. The perfusion device erected at the middle of the transport pipeline which has two ends linking to the apyrexia receptacle and the filter, respectively. In operation, the perfusion device pumps the prepared medication solution from the apyrexia receptacle to get through the filter to remove particles and bacterium, and a thin tubular dispensing needle which punctures the rubber plug of an aseptic bottle. An axial groove rendered in middle section of the dispensing needle forms a pressurized seal part with the rubber plug resiliently wrapped around at the middle of the dispensing needle to discharge redundant air pressure accumulating in the aseptic bottle while keeps outside air from entering.
    Type: Application
    Filed: July 20, 2006
    Publication date: April 24, 2008
    Inventors: Ming-Hsin Li, Wuu-Jyh Lin, Cheng-Hung Chien, Jun-Chieh Tsai, Wun-Shen Lan
  • Publication number: 20070062865
    Abstract: The present invention relates to a novel flocculant comprising bacteria of the Bacillus genus cultivated in a culture medium comprising soybean protein, glucose, molasses, and yeast. Alternatively, the flocculant comprises soybean protein. The present invention also relates to methods of making the flocculant, including fermentation method for mass production, and methods of using the flocculant in water treatment.
    Type: Application
    Filed: November 20, 2006
    Publication date: March 22, 2007
    Inventors: Heng-Chuan Wang, Ming-Hsin Li, Hsu-Wen Tsang, Mei-Mao Wu, Hsui-Ping Lin
  • Patent number: 6867441
    Abstract: A fuse structure for a semiconductor device on a substrate includes a fuse having an electrically conductive fuse line of a standard fuse length formed in an electrically conductive layer disposed over the substrate, and a pair of electrically conductive, inwardly bent interconnects formed in a first plurality of electrically conductive layers disposed over the substrate, below the electrically conductive layer in which the fuse line is formed. The inwardly bent interconnects couple the fuse line to a circuit area of the substrate disposed under the fuse line. The fuse structure may further include a protective guard ring formed around the fuse. The guard ring includes a second plurality of electrically conductive interconnects.
    Type: Grant
    Filed: October 8, 2003
    Date of Patent: March 15, 2005
    Assignee: Taiwan Semiconductor Manufacturing Co., Ltd.
    Inventors: Chao-Hsiang Yang, Charles Chen, Wesley Lin, Harry Chuang, Ming-Hsin Li, Jeng-Long Huang
  • Publication number: 20040219651
    Abstract: The present invention relates to a novel flocculant comprising bacteria of the Bacillus genus cultivated in a culture medium comprising soybean protein, glucose, molasses, and yeast. Alternatively, the flocculant comprises soybean protein. The present invention also relates to methods of making the flocculant, including fermentation method for mass production, and methods of using the flocculant in water treatment.
    Type: Application
    Filed: January 21, 2004
    Publication date: November 4, 2004
    Inventors: Heng-Chuan Wang, Ming-Hsin Li, Hsu-Wen Tsang, Mei-Mao Wu, Hsui-Ping Pearl Lin
  • Patent number: 6162686
    Abstract: A method of forming a grooved fuse (plug fuse) in the same step that via plugs are formed in the guard ring area 14 and in product device areas. A key point of the invention is to form fuses from the via plug layer, not from the metal layers. Also, key guard rings are formed around the plug guise. The invention can include the following: a semiconductor structure is provided having a fuse area, a guard ring area surrounding the fuse area; and a device area. First and second conductive strips are formed. First and second insulating layers are formed over the first and second conductive strips. Plug contacts and fuse plugs are formed through the first and second insulating layers to the first and second conductive strips. A third insulating layer is formed over the second insulating layer. Metal lines are formed over the third insulating layer in the device area. A fuse via opening is formed in the third insulating layer. A plug fuse is formed in the fuse via opening.
    Type: Grant
    Filed: September 18, 1998
    Date of Patent: December 19, 2000
    Assignee: Taiwan Semiconductor Manufacturing Company
    Inventors: Kuo Ching Huang, Tse-Liang Ying, Yu-Hua Lee, Ming-Hsin Li