Abstract: The present application discloses a gate drive circuit and a display device. The gate drive circuit includes a plurality of cascaded gate drive units, in which one of the gate drive units includes a first layout, an input module and a pull-up module. By receiving a potential changeable signal by the gate of a first transistor or the gate of a second thin-film transistor, it can alleviate or avoid current leakage caused when a first node keeps at a same voltage level for a long time, thereby improving the stability of the potential of the first node.

Abstract: A method for constructing a library of cell-free DNAs in body fluids, comprising directly acting a transposase or an endonuclease on a body fluid sample, fragmenting the cell-free DNAs within, and performing amplification to obtain a library. Also provided is a test kit using the present method for prenatal diagnosis or early detection of cancer.

Abstract: The present application discloses a gate drive circuit and a display device. The gate drive circuit includes a plurality of cascaded gate drive units, in which one of the gate drive units includes a first layout, an input module and a pull-up module. By receiving a potential changeable signal by the gate of a first transistor or the gate of a second thin-film transistor, it can alleviate or avoid current leakage caused when a first node keeps at a same voltage level for a long time, thereby improving the stability of the potential of the first node.

Abstract: The disclosure relates to anti-Siglec-10 antibodies and the use of such antibodies in cancer therapy.

Abstract: The present invention relates to a CD24 protein for treating immune-related adverse events (irAEs) associated with cancer immunotherapy. Provided herein is a method of treating, mitigating, minimizing, or preventing immunerelated adverse events (irAEs) associated with a cancer immunotherapy by administering a CD24 protein to a subject in need thereof. The irAE may be diarrhea or another gastrointestinal disorder, pure red cell aplasia, microcytic anemia, lupus, autoimmune nephritism, autoimmune hepatitis, pneumonitis, myocarditis, pericarditis, endocrinopathy, Addison's disease, hypogonadism, Sjogren's syndrome, or type I diabetes. The CCD24 protein may comprise a mature human CD24 or a variant thereof.

Abstract: An apparatus and a method for preparing a multi-directional continuous fiber-reinforced composite material. The apparatus includes an electrostatic fiber-splitting device configured to controllably split a fiber bundle, a powder spreading device configured to spread a powder, and a pre-press molding device configured to cut the fiber and compact the powder. The electrostatic fiber-splitting device includes a rotatable fiber-splitting table. The pressing plate is controlled by an electromagnet, and the pressing plate is energized to generate a high-voltage electrostatic field to disperse the continuous fiber bundle into monofilament fibers.

Abstract: A special suspension-type tracked underwater robot adaptable to ultra-soft geological conditions comprises traveling mechanisms, wherein the traveling mechanisms are track-mud sled structures, the mud sled structures are fixedly arranged on two sides of each track, and the bottoms of the mud sled structures are higher than the bottoms of the tracks and are provided with arched plate heads; the arched plate heads are provided with plate water-jet devices capable of spraying water forwards; and in the traveling process of the traveling mechanisms, and the arched plate heads press water downwards to form a water film at the bottoms of the mud sled structures together with the water sprayed by the plate water-jet devices, so that the traveling mud resistance is reduced, and the robot can stably advance under ultra-soft geological conditions.

Abstract: This invention relates to CTLA-4 protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy.

Abstract: This invention relates to CTLA-4 protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy.

Abstract: This invention relates to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy. Specifically, the disclosure provides a CTLA-4 protein comprising a mutant extracellular domain of CTLA-4, wherein the CTLA-4 protein exhibits reduced binding to an anti-CTLA-4 antibody as compared to a wild-type extracellular domain of CTLA-4, wherein the anti-CTLA-4 antibody has anti-cancer immunotherapeutic activity.

Abstract: A porous-structure device includes a semi-submersible platform consisting of four columns, two pontoons, two horizontal supports and a deck. Fillets on middle portions of the columns have a square section, a radius of the fillets, close to the deck and the pontoons, of the columns is gradually decreased to 0, a porous device is disposed outside each column and is formed by combining and connecting four single components, and each single component is formed by combining and connecting a plurality of porous laminated plates and a plurality of connecting pieces. The parameters, such as the pore type, porosity, number of layers, interlayer spacing and installation height, of the porous laminated plates are set according to the wave characteristics in different sea areas.

Abstract: Provided herein are methods and compositions for the prevention and treatment of nonalcoholic steatohepatitis (NASH) by targeting the CD24-Siglec axis.

Abstract: An apparatus and a method for preparing a multi-directional continuous fiber-reinforced composite material. The apparatus includes an electrostatic fiber-splitting device configured to controllably split a fiber bundle, a powder spreading device configured to spread a powder, and a pre-press molding device configured to cut the fiber and compact the powder. The electrostatic fiber-splitting device includes a rotatable fiber-splitting table. The pressing plate is controlled by an electromagnet, and the pressing plate is energized to generate a high-voltage electrostatic field to disperse the continuous fiber bundle into monofilament fibers.

Abstract: The present invention relates to compositions of anti-CTLA-4 antibodies that bind to the human CTLA4 molecule and their use in cancer immunotherapy and for the reduction of autoimmune side effects compared to other immunotherapeutic agents.

Abstract: This invention relates to anti-CTLA-4 antibody compositions that bind to the human CTLA-4 molecule, and the use of the compositions in cancer immunotherapy and for reducing autoimmune side effects compared to other immunotherapeutic agents.

Abstract: A porous-structure device includes a semi-submersible platform consisting of four columns, two pontoons, two horizontal supports and a deck. Fillets on middle portions of the columns have a square section, a radius of the fillets, close to the deck and the pontoons, of the columns is gradually decreased to 0, a porous device is disposed outside each column and is formed by combining and connecting four single components, and each single component is formed by combining and connecting a plurality of porous laminated plates and a plurality of connecting pieces. The parameters, such as the pore type, porosity, number of layers, interlayer spacing and installation height, of the porous laminated plates are set according to the wave characteristics in different sea areas.

Abstract: A special suspension-type tracked underwater robot adaptable to ultra-soft geological conditions comprises traveling mechanisms, wherein the traveling mechanisms are track-mud sled structures, the mud sled structures are fixedly arranged on two sides of each track, and the bottoms of the mud sled structures are higher than the bottoms of the tracks and are provided with arched plate heads; the arched plate heads are provided with plate water-jet devices capable of spraying water forwards; and in the traveling process of the traveling mechanisms, and the arched plate heads press water downwards to form a water film at the bottoms of the mud sled structures together with the water sprayed by the plate water-jet devices, so that the traveling mud resistance is reduced, and the robot can stably advance under ultra-soft geological conditions.

Abstract: This invention relates to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) protein compositions and their use in the mitigation of autoimmune adverse events associated with cancer immunotherapy. Specifically, the disclosure provides a CTLA-4 protein comprising a mutant extracellular domain of CTLA-4, wherein the CTLA-4 protein exhibits reduced binding to an anti-CTLA-4 antibody as compared to a wild-type extracellular domain of CTLA-4, wherein the anti-CTLA-4 antibody has anti-cancer immunotherapeutic activity.