Patents by Inventor Mitsuo Nagano
Mitsuo Nagano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5643923Abstract: Compounds of formula (I): ##STR1## wherein R.sup.1 is hydrogen, halogen or alkyl; R.sup.2 is hydrogen, alkyl, optionally substituted phenyl or a heterocycle; or R.sup.1 and R.sup.2 together form a group of formula --CR.sup.4 .dbd.CR.sup.5 --CR.sup.6 .dbd.CR.sup.7 --, where R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are hydrogen, halogen, alkyl group, alkoxy, halomethyl, alkylamino, dialkylamino, hydroxy, nitro, aliphatic carboxylic acylamino or amino; and R.sup.3 is piperidyl, substituted piperidyl or quinuclidinyl. The compounds are useful in the treatment and prophylaxis of cognitive disorders, notably senile dementia, including Alzheimer's disease. Processes for preparing the compounds are also provided.Type: GrantFiled: August 27, 1992Date of Patent: July 1, 1997Assignee: Sankyo Company, LimitedInventors: Mitsuo Nagano, Takeo Kobayashi, Junichi Sakai, Masao Kozuka, Nobuyoshi Iwata, Yoshiko Kubo
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Patent number: 5321037Abstract: Compounds of formula (I): ##STR1## [in which: either (a) the dotted line ( ) is a single bond; A=is oxygen; and B is a group of formula (II): ##STR2## (in which m is 0 and n is 0 or 1) or (b) the dotted line ( ) is a double bond; A=is said group of formula (II) in which m is 1 and n is 0 or 1; and B is absent; and R.sup.1 is hydrogen, halogen, alkyl, alkenyl, alkynyl, optionally substituted benzyl or optionally substituted phenyl; R.sup.2 is hydrogen, halogen, alkyl, optionally substituted phenyl or heterocyclic; or R.sup.1 and R.sup.2, together with the carbon atoms to which they are attached, are a hydrocarbon ring fused to the isoxazole ring; R.sup.3 and R.sup.4 are each hydrogen, alkyl, optionally substituted benzyl or optionally substituted phenyl; or R.sup.3, R.sup.4 and the nitrogen atom to which they are attached together represent an alicyclic amino group]; and salts thereof may be used for the treatment of cerebral circulatory problems and for use as centrally acting muscle relaxants.Type: GrantFiled: March 4, 1993Date of Patent: June 14, 1994Assignee: Sankyo Company, LimitedInventors: Mitsuo Nagano, Junichi Sakai, Nobuyoshi Iwata, Kazuo Kobayashi, Masao Kozuka, Kenji Yoshimi, Katsunori Kato, Yoshiko Kubo, Toshiyuki Tonohiro, Takao Hara
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Patent number: 5262413Abstract: A method of treating depression comprising administering to a patient an effective amount of a compound of the formula (Ib): ##STR1## wherein R.sup.1b is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, C.sub.2 -C.sub.4 alkynyl, an unsubstituted benzyl group, a substituted benzyl having at least one substitutent (b) selected from the group consisting of C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, hydroxy, halogen, nitro, amino and C.sub.2 -C.sub.4 aliphatic carboxylic acylamino; unsubstituted phenyl or a substituted phenyl having at least one substitutent (b); R.sup.2b is hydrogen, C.sub.1 -C.sub.4 alkyl, unsubstituted phenyl, substituted phenyl having at least one substitutent (b), unsubstituted 5- or 6- membered heterocyclic having an oxygen, sulfur or nitrogen as a heteroatom, or substituted 5- or 6- membered heterocyclic having an oxygen, sulfur or nitrogen as a heteroatom and having at least one substitutent (b); and R.sup.3b and R.sup.Type: GrantFiled: January 29, 1993Date of Patent: November 16, 1993Assignee: Sankyo Company, LimitedInventors: Nobuyoshi Iwata, Kenji Yoshimi, Mitsuo Nagano
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Patent number: 5217970Abstract: A method of treating depression comprising administering to a patient an effective antidepressive amount of a compound of the formula ##STR1## wherein either (i) the endocyclic dotted line ( ) is a double bond; the exoxyclic dotted line ( ) is a single bond;A is ##STR2## m is 1; n is 0; R.sup.3 and R.sup.4 are hydrogen, C.sub.1 -C.sub.4 alkyl, benzyl or phenyl or R.sup.3, R.sup.4 and the nitrogen to which they are attached represent an alicyclic amino having 5 or 6 ring atoms, of which one ring atom is nitrogen and one ring atom is optionally an additional nitrogen, oxygen or sulfur heteroatom; R.sup.1 is hydrogen, halogen C.sub.1 -C.sub.4 alkyl C.sub.2 -C.sub.4 alkenyl, C.sub.2 -C.sub.4 alkynyl, benzyl or phenyl; and R.sup.2 is hydrogen, C.sub.1 -C.sub.4 alkyl phenyl or a 5- or 6- membered heterocyclic; or(ii) the endocyclic dotted line ( ) is a single bond; the exocyclic dotted line ( ) is a double bond;A is oxygen;B is ##STR3## m is 0; n is 1; R.sup.3, R.sup.Type: GrantFiled: March 24, 1992Date of Patent: June 8, 1993Assignee: Sankyo Company, LimitedInventors: Nobuyoshi Iwata, Kenji Yoshimi, Mitsuo Nagano
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Patent number: 5116839Abstract: A method of treating depression comprising administering to a patient an effective antidepressive amount of a compound of the formula (I) ##STR1## wherein the endocyclic dotted line ##STR2## is a single bond; the exocyclic dotted line ##STR3## is a double bond; A is oxygen; B is a group of the formula (II) ##STR4## wherein m is 0 and n is 0 or 1; R.sup.3, R.sup.4 and the nitrogen to which they are attached together represent an alicyclic amino having a total of 5 or 6 ring atoms, of which one ring atom is the nitrogen and one ring atom is optionally an additional heteroatom selected from the group consisting of nitrogen, oxygen and sulfur, the alicyclic amino being unsubstituted or, where there is an additional nitrogen heteroatom, the alicyclic amino having as a substituent a C.sub.1 -C.sub.3 alkyl on the additional nitrogen heteroatom; R.sup.1 is hydrogen or halogen; and R.sup.2 is an unsubstituted phenyl, a substituted phenyl having a substituent selected from the group consisting of C.sub.1-3 alkyl, C.Type: GrantFiled: June 13, 1990Date of Patent: May 26, 1992Assignee: Sankyo Company, LimitedInventors: Nobuyoshi Iwata, Kenji Yoshimi, Mitsuo Nagano
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Patent number: 4904680Abstract: Amino acid amides of formula (I): ##STR1## wherein R.sup.1 -R.sup.5 and Y represent a variety of organic groups and atoms (including where R.sup.2, Y and the adjacent nitrogen atom together represent a thiazolidine or pyrrolidine group) and X represents carbonyl or sulfonyl are mostly new compounds and have valuable anti-tumor and immuno-regulatory activities. They may be formulated in compositions for pharmaceutical use.Type: GrantFiled: January 22, 1988Date of Patent: February 27, 1990Assignee: Sankyo Company, LimitedInventors: Takashi Matsui, Mitsuo Nagano, Koichi Kitamura, Fusaaki Shimizu
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Patent number: 4662942Abstract: A cement additive comprising at least two fluidizing agents wherein one of the fluidizing agents is a saponified product of a sulfonated styrene-maleic acid copolymer and the other is one or more of a formalin condensate of naphthalenesulfonic acid and a polyoxyethylene-based compound.The cement additive of this invention is added to a cement composition (cement paste, mortar or concrete) and especially prevents a reduction in the fluidity with a lapse of time.Type: GrantFiled: September 20, 1985Date of Patent: May 5, 1987Assignee: Idemitsu Petrochemical Co., Ltd.Inventors: Yasuharu Koga, Jiro Yasumura, Mitsuo Nagano
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Patent number: 4545942Abstract: New compounds useful as immunoregulatory and antineoplastic agents are amino-acid derivatives of formula: ##STR1## wherein: n is an integer from 1 to 5;R.sup.1 is a hydrogen atom, an alkyl group, a haloalkyl group, a halogen atom, a mercapto group, an alkylmercapto group, a hydroxy group, an alkoxy group, an acyloxy group, a carboxyl group, an alkoxycarbonyl group, an amino group, an alkyl-substituted amino group, an aryl-substituted amino group, an acylamino group, a haloalkoxycarbonylamino group, an alkanesulphonyl group, a nitro group or a cyano group (and, when n is an integer from 2 to 5, the radicals R.sup.1 may be the same or different);R.sup.2 and R.sup.3 may be the same or different and each is a hydrogen atom or an alkyl group;R.sup.Type: GrantFiled: April 9, 1984Date of Patent: October 8, 1985Assignee: Sankyo Company, LimitedInventors: Mitsuo Nagano, Koichi Hirai, Kouichi Kitamura, Kenkichi Shinkai, Hiroshi Yasuda
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Patent number: 4403718Abstract: This invention provides an improved method and apparatus for automatically controlling travel of two transversely spaced parallel plastics film strips in a bag-making machine or the like that can correct rapidly the relative positional gaps produced between the register marks on the strips by means of a new retarding device for the strips as incorporated in the apparatus.Type: GrantFiled: October 16, 1981Date of Patent: September 13, 1983Assignee: Taiyo Shokai Co., Ltd.Inventor: Mitsuo Nagano
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Patent number: 4147863Abstract: Novel cephalosporin derivatives having a (1-alkyl-1H-tetrazol-5-yl)vinyl group at the 3-position of the cephem nucleus and showing an excellent antibacterial activity are disclosed. A process for preparing the cephalosporin derivatives is also disclosed.Type: GrantFiled: August 25, 1975Date of Patent: April 3, 1979Assignee: Sankyo Company LimitedInventors: Tetsuo Miyadera, Mitsuo Nagano, Shinichi Sugawara
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Patent number: 4126745Abstract: A compound having the formula ##STR1## wherein Y represents a 2-carboxyethylthio group or a trifluoromethylthio group and a nontoxic pharmaceutically acceptable salt thereof are useful as antibacterial agents. They may be prepared by (a) reacting a compound having the formula ##STR2## wherein X.sub.1 represents a halogen atom with a compound having the formulaY -- Hwherein Y has the same meaning as defined above, or (b) reacting a compound having the formula ##STR3## wherein R represents a protective group for the carboxyl group with a compound having the formulaY -- CH.sub.2 COX.sub.2wherein X.sub.2 represents a halogen atom and Y has the same meaning as defined above and removing the protective group for the carboxyl group from the resulting product, or (c) reacting a compound having the formula ##STR4## wherein A represents an acetoxy group or a carbamoyloxy group and Y has the same meaning as defined above with 5-mercapto-1-methyl-1H-tetrazole or its alkali metal salt.Type: GrantFiled: April 13, 1976Date of Patent: November 21, 1978Assignee: Sankyo Company LimitedInventors: Hideo Nakao, Hiroaki Yanagisawa, Bunji Shimizu, Masakatsu Kaneko, Mitsuo Nagano, Shinichi Sugawara
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Patent number: 4007177Abstract: A compound of the formula ##STR1## wherein A represents acetoxy group, carbamoyloxy group or (1-metyl-1H-tetrazol-5-yl)thio group and Y represents propargylthio group, azidomethylthio group, 2-hydroxyethylthio group, 3-isoxazolyloxy group, 3-isoxazolylthio group, methylsulfonyl group, ethylsulfonyl group, 2-cyanoethyl-sulfonyl group or sydnon-3-yl group and nontoxic pharmaceutically acceptable salts thereof are prepared by a process which comprises reacting a compound of the formula ##STR2## wherein R represents a protective group for a carboxyl group and A has the same meaning as defined above with a carboxylic acid of the formulaY - CH.sub.2 COOHwherein Y has the same meaning as defined above or a reactive derivative thereof to give a compound having the formula ##STR3## wherein A, R and Y have the same meanings as defined above and removing the protective group for the carboxyl group from said compound.The compounds are antibacterial agents.Type: GrantFiled: November 14, 1974Date of Patent: February 8, 1977Assignee: Sankyo Company LimitedInventors: Hideo Nakao, Hiroaki Yanagisawa, Mitsuo Nagano, Bunji Shimizu, Masakatsu Kaneko, Shinichi Sugawara