Patents by Inventor Miyako Masubuchi
Miyako Masubuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110098477Abstract: There is provided a convenient and inexpensive method of producing a compound which has a high activity of inhibiting replication of hepatitis C virus (HCV) and is useful for preventing and treating a liver disease caused by HCV infection.Type: ApplicationFiled: June 27, 2006Publication date: April 28, 2011Inventors: Masahiro Aoki, Yoshie Nagahashi, Hideyuki Kato, Tatsuya Ito, Miyako Masubuchi, Toru Okuda
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Publication number: 20100274026Abstract: The object of the present invention is to provide a pharmaceutical composition for preventing or treating viral infectious diseases. The compounds of the present invention have extremely potent anti-HCV activity and HCV growth inhibitory effects, and since they also only demonstrate mild cytotoxicity in vivo, a pharmaceutical composition containing the compound of the present invention is extremely useful as an anti-HCV preventive/therapeutic agent.Type: ApplicationFiled: July 6, 2010Publication date: October 28, 2010Inventors: Masahiro Aoki, Hideyuki Kato, Masayuki Sudoh, Takuo Tsukuda, Miyako Masubuchi, Kenichi Kawasaki
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Patent number: 7820693Abstract: The present invention provides a compound having high antitumor activity, which is useful for therapeutic and preventive agents effective for proliferative diseases such as cancer; a production method thereof; an intermediate compound useful for such production; and a pharmaceutical composition comprising such a compound. The present invention provides a compound represented by the formula (1): wherein X represents an aryl group or heteroaryl group which may be substituted, Cy represents a 4- to 7-membered monocyclic heterocyclic ring or a 8- to 10-membered condensed heterocyclic ring which may be substituted, and Z represents O, S, or NRa; or a prodrug thereof; or a pharmaceutically acceptable salt thereof; and a pharmaceutical and a pharmaceutical composition which comprise the compound.Type: GrantFiled: February 22, 2006Date of Patent: October 26, 2010Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Kazuo Hattori, Satoshi Niizuma, Miyako Masubuchi, Kohei Koyama, Osamu Kondoh, Toshiyuki Tsukaguchi, Takehiro Okada
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Patent number: 7776918Abstract: The object of the present invention is to provide a pharmaceutical composition for preventing or treating viral infectious diseases. The compounds of the present invention have extremely potent anti-HCV activity and HCV growth inhibitory effects, and since they also only demonstrate mild cytotoxicity in vivo, a pharmaceutical composition containing the compound of the present invention is extremely useful as an anti-HCV preventive/therapeutic agent.Type: GrantFiled: February 12, 2004Date of Patent: August 17, 2010Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Masahiro Aoki, Hideyuki Kato, Masayuki Sudoh, Takuo Tsukuda, Miyako Masubuchi, Kenichi Kawasaki
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Publication number: 20090030195Abstract: The present invention provides a compound having high antitumor activity, which is useful for therapeutic and preventive agents effective for proliferative diseases such as cancer; a production method thereof; an intermediate compound useful for such production; and a pharmaceutical composition comprising such a compound. The present invention provides a compound represented by the formula (1): wherein X represents an aryl group or heteroaryl group which may be substituted, Cy represents a 4- to 7-membered monocyclic heterocyclic ring or a 8- to 10-membered condensed heterocyclic ring which may be substituted, and Z represents O, S, or NRa; or a prodrug thereof; or a pharmaceutically acceptable salt thereof; and a pharmaceutical and a pharmaceutical composition which comprise the compound.Type: ApplicationFiled: February 22, 2006Publication date: January 29, 2009Applicant: Chugai Seiyaku Kabushiki KaishaInventors: Kazuo Hattori, Satoshi Niizuma, Miyako Masubuchi, Kohei Koyama, Osamu Kondoh, Toshiyuki Tsukaguchi, Takehiro Okada
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Patent number: 7378446Abstract: The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its having a high degree of replication inhibitory activity against HCV, its production method, an intermediate compound useful for its production and a pharmaceutical composition containing these compounds, and the present invention relates to a compound represented by the formula (I): (wherein A represents —(CH2)n—, etc.; B represents —(C?O)—, etc.; D represents —(CH2)m—R?, etc.; E represents a hydrogen atom, etc.; G represents —(CH2)p-J, etc.; bond Q represents a single bond or double bond; and R1, R2 and R3 may be the same or different and each represent a hydrogen atom, etc.), a prodrug thereof or a pharmaceutically acceptable salt thereof.Type: GrantFiled: July 9, 2004Date of Patent: May 27, 2008Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Masayuki Sudoh, Takuo Tsukuda, Miyako Masubuchi, Kenichi Kawasaki, Takeshi Murata, Fumio Watanabe, Hiroshi Fukuda, Susumu Komiyama, Tadakatsu Hayase
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Publication number: 20060217434Abstract: The object of the present invention is to provide a pharmaceutical composition for preventing or treating viral infectious diseases. The compounds of the present invention have extremely potent anti-HCV activity and HCV growth inhibitory effects, and since they also only demonstrate mild cytotoxicity in vivo, a pharmaceutical composition containing the compound of the present invention is extremely useful as an anti-HCV preventive/therapeutic agent.Type: ApplicationFiled: February 12, 2004Publication date: September 28, 2006Inventors: Masahiro Aoki, Hideyuki Kato, Masayuki Sudoh, Takuo Tsukuda, Miyako Masubuchi, Kenichi Kawasaki
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Publication number: 20060194870Abstract: The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its having a high degree of replication inhibitory activity against HCV, its production method, an intermediate compound useful for its production and a pharmaceutical composition containing these compounds, and the present invention relates to a compound represented by the formula (I): (wherein A represents —(CH2)n—, etc.; B represents —(C?O)—, etc.; D represents —(CH2)m—R?, etc.; E represents a hydrogen atom, etc.; G represents —(CH2)p-J, etc.; bond Q represents a single bond or double bond; and R1, R2 and R3 may be the same or different and each represent a hydrogen atom, etc.), a prodrug thereof or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: July 9, 2004Publication date: August 31, 2006Inventors: Masayuki Sudoh, Takuo Tsukuda, Miyako Masubuchi, Kenichi Kawasaki, Takeshi Murata, Fumio Watanabe, Hiroshi Fukuda, Susumu Komiyama, Tadakatsu Hayase
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Patent number: 6680326Abstract: Novel polycyclic compounds of the formula [I], wherein R1, R2, R3, R4, R5, R6, R7, ring A, ring B, X, Y and Z are as defined herein and the pharmaceutically acceptable salts thereof. These compounds have antitumor activity and useful for the treatment of cancer.Type: GrantFiled: September 25, 2002Date of Patent: January 20, 2004Assignee: Hoffmann-La Roche Inc.Inventors: Tsunehisa Aoyama, Kenichi Kawasaki, Miyako Masubuchi, Tatsuo Ohtsuka, Kiyoaki Sakata
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Publication number: 20030073691Abstract: Novel polycyclic compounds of the formula [I], 1Type: ApplicationFiled: September 25, 2002Publication date: April 17, 2003Inventors: Tsunehisa Aoyama, Kenichi Kawasaki, Miyako Masubuchi, Tatsuo Ohtsuka, Kiyoaki Sakata
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Patent number: 6376491Abstract: The present invention is directed to new bicyclic compounds of the formula [I], and pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4, R5, R6, R7, Q1 Q2 and Q3 are as defined in the claims. The compounds have N-myristoyltransferase inhibitory and antifungal activity.Type: GrantFiled: December 15, 1999Date of Patent: April 23, 2002Assignee: Basilea Pharmaceutica AGInventors: Yuhko Aoki, Hirosato Ebiike, Toshihiko Fujii, Kenichi Kawasaki, Pingli Liu, Miyako Masubuchi, Tatsuo Ohtsuka, Shinji Tsujii
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Patent number: 5292648Abstract: The compound of the formula ##STR1## and its tautomer are obtained from cultures of Eupenicillium sp. The compound has antifungal activity.Type: GrantFiled: February 18, 1993Date of Patent: March 8, 1994Assignee: Hoffmann-La Roche Inc.Inventors: Miyako Masubuchi, Toru Okuda, Hisao Shimada
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Patent number: 5229123Abstract: The compound of the formula ##STR1## and its tautomer are obtained from cultures of Eupenicillium sp. The compound has antifungal activity.Type: GrantFiled: September 18, 1992Date of Patent: July 20, 1993Assignee: Hoffmann-La Roche Inc.Inventors: Miyako Masubuchi, Toru Okuda, Hisao Shimada