Patents by Inventor Mohammad A. Heidaran

Mohammad A. Heidaran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050153429
    Abstract: A coated surface that resists cell adhesion comprises hyaluronic acid directly bound to a plasma-treated polymer surface. A process for producing the coated surface is disclosed as are further modifications of the hyaluronic acid by attaching ligand-binding polypeptides (antibodies or antibody binding proteins).
    Type: Application
    Filed: November 22, 2004
    Publication date: July 14, 2005
    Inventors: Andrea Liebmann-Vinson, Richard Clarke, Ruiling Xu, Mohammad Heidaran
  • Publication number: 20050106727
    Abstract: The present invention relates to cell adhesion promoting (“CAP”) peptide combinations that promote cell attachment or cell adhesion to culture surfaces that are otherwise cell adhesion resistant “CAR”. The invention provides combination of peptides that, when covalently coupled to a CAR layer such as hyaluronic acid that has been created on a polystyrene surface, promote cell attachment, growth differentiation, and execution of other desired cellular functions in culture.
    Type: Application
    Filed: September 26, 2003
    Publication date: May 19, 2005
    Applicant: Becton, Dickinson and Company
    Inventors: Richard Guarino, Bryce Chaney, Andrea Liebmann-Vinson, Perry Haaland, Mohammad Heidaran
  • Publication number: 20050095234
    Abstract: A method and composition are provided for inducing or enhancing chondrogenesis in vivo or in vitro. The method is performed by exposing the cells in vitro or in vivo to an extracellular matrix comprising of type I collagen, type II collagen or a mixture of type I collagen or type II collagen and hyaluronate and further containing GDF-5.
    Type: Application
    Filed: November 5, 2004
    Publication date: May 5, 2005
    Inventors: Mohammad Heidaran, Robert Spiro, Robin Daverman, LinShu Liu
  • Publication number: 20050059150
    Abstract: Surfaces useful for cell culture comprise a support to which is bound a CAR material, and, bound to the CAR material, an ECM protein, or a biologically active fragment or variant thereof such as elastin, fibronectin, vitronectin, laminin, collagen I, collagen III, collagen IV, and collagen VI. Also, optionally present on the surface is an active factor, preferably a polycationic polymer or a biologically active fragment or variant thereof, such as polyethyleneimine (PEI), poly-D-lysine (PDL), poly-L-lysine (PLL), poly-D-ornithine (PDO) or poly-L-ornithine (PLO). This surface is used in cell culture to promote cell attachment, survival, and/or proliferation of primary liver cells. The invention also relates to methods utilizing this surface, such as methods for attachment, survival, and/or proliferation of cells. Further disclosed is the use of the surface in cell culture with serum-free medium. Methods of screening using the surface of the invention are also disclosed.
    Type: Application
    Filed: September 17, 2003
    Publication date: March 17, 2005
    Applicant: Becton, Dickinson and Company
    Inventors: Richard Guarino, Sharon Presnell, Andrea Liebmann-Vinson, Mohammad Heidaran
  • Publication number: 20050060100
    Abstract: An automated method and system for identifying agents capable of eliciting a phenotypic change in a cell-type is provided. The method includes the steps of: providing receptacles in an array; and providing a statistical design including generic factor names, factor levels and experimental runs. The method further includes the steps of utilizing a software program to generate a computer representation of the statistical design by automatically mapping the identities of the agents to the generic factor names, by mapping the concentration or amounts of the agents to the factor levels and by mapping the locations of the receptacles within the array to the experimental runs.
    Type: Application
    Filed: September 15, 2003
    Publication date: March 17, 2005
    Inventors: Perry Haaland, Mohammad Heidaran
  • Publication number: 20050058687
    Abstract: Surfaces useful for cell culture comprise a support to which is bound a CAR material, and, bound to the CAR material, collagen VI or a biologically active fragment or variant thereof and, optionally, one or more other ECM proteins (or fragments or variants thereof) such as elastin, fibronectin, vitronectin, tenascin, laminin, entactin, aggrecan, decorin, collagen I, collagen III, and collagen IV. Also, optionally present on the surface is one or more polycationic polymers, such as poly-D-lysine or poly-D-ornithine. This surface is used in cell culture to promote cell attachment, survival, and/or proliferation of a number of different cell types such as (a) liver cells (e.g., HepG2 tumor cells, and a newly discovered line of rat liver epithelial stem cells) (b) osteoblasts, such as the murine cell line MC3T3 cell line and (c) primary bone marrow cells. Kits comprising the surfaces and additional reagents are also disclosed.
    Type: Application
    Filed: September 12, 2003
    Publication date: March 17, 2005
    Applicant: Becton, Dickinson and Company
    Inventors: Richard Guarino, Jonathan Rowley, Andrea Liebmann-Vinson, John Hemperly, Mohammad Heidaran, Sharon Presnell
  • Publication number: 20050059083
    Abstract: A high throughput method is provided for identifying agents capable of producing a desired biological response in whole cells. The method includes the steps of providing receptacles having a culture surface; placing different mixtures of single agents into selective ones of the receptacles according to a statistical design; and immobilizing the mixtures of single agents to the culture surface. The method further includes contacting the immobilized agents with the whole cells; and acquiring data which is indicative of a desired biological response in the contacted cells. The method also includes using statistical modeling of the acquired data to determine which mixtures of single agents and/or which single agents in these mixtures are effective in producing the desired biological response in the contacted cells.
    Type: Application
    Filed: September 15, 2003
    Publication date: March 17, 2005
    Inventors: Andrea Liebmann-Vinson, Jonathan Rowley, Chris Bodily, Mohammad Heidaran
  • Publication number: 20050036980
    Abstract: The present invention relates to cell adhesion promoting (“CAP”) peptide combinations that promote cell attachment or cell adhesion to culture surfaces that are otherwise cell adhesion resistant “CAR”. The invention provides combination of peptides that, when covalently coupled to a CAR layer such as hyaluronic acid that has been created on a polystyrene surface, promote cell attachment, growth differentiation, and execution of other desired cellular functions in culture.
    Type: Application
    Filed: August 15, 2003
    Publication date: February 17, 2005
    Applicant: Becton, Dickinson and Company
    Inventors: Bryce Chaney, Mohammad Heidaran, Andrea Liebmann-Vinson
  • Publication number: 20050037512
    Abstract: The present invention relates to compositions comprising a core and a hydrophobic coating material surrounding the core. The core comprises at least one oxygen-sensing particle. The present invention also relates to methods of detecting and monitoring oxygen in a sample using the microencapsulated oxygen-sensing particles.
    Type: Application
    Filed: August 12, 2003
    Publication date: February 17, 2005
    Inventors: Ming-Hsiung Yeh, Jon Rowley, John Hemperly, Steven Keith, Mohammad Heidaran
  • Patent number: 6849606
    Abstract: A method and composition are provided for inducing or enhancing chondrogenesis in vivo or in vitro. The method is performed by exposing the cells in vitro or in vivo to an extracellular matrix comprising of type I collagen, type II collagen or a mixture of type I collagen or type II collagen and hyaluronate and further containing GDF-5.
    Type: Grant
    Filed: May 22, 2003
    Date of Patent: February 1, 2005
    Assignee: Depuy Spine, Inc.
    Inventors: Mohammad A. Heidaran, Robert C. Spiro, Robin Daverman, LinShu Liu
  • Publication number: 20040259244
    Abstract: A method of converting differentiated non-hormone producing pancreatic cells into differentiated hormone producing cells is disclosed. The method comprises two steps: first, culturing cells under conditions which convert differentiated non-hormone producing cells into stem cells; and second, culturing stem cells under conditions which provide for differentiating stem cells into hormone-producing cells. The invention defines growth and differentiation factors that are presented to the stem cells to result in their differentiation into hormone-producing cells, especially insulin-producing cells. The invention provides a new source of large quantities of hormone producing cells such as insulin-producing cells that are riot currently available for therapeutic uses such as the treatment of diabetes.
    Type: Application
    Filed: March 15, 2004
    Publication date: December 23, 2004
    Inventors: David William Scharp, Paul Presley Latta, Margaret Coutts, Catherine Anne McIntyre, Sharon C. Presnell, Mohammad A. Heidaran, Perry D. Haaland
  • Publication number: 20040209361
    Abstract: Solid substrates for cell culture are UV-cross-linked PVA-based hydrogel polymer particles. The particles are biocompatible with living cells and support cell adherence. Bioaffecting molecules may be reversibly entrapped within the particles. The particles are capable of forming self-assembled aggregates with cultured cells in aqueous suspension. Preferably, the PVA-based polymer is PVA-SbQ.
    Type: Application
    Filed: April 18, 2003
    Publication date: October 21, 2004
    Inventors: John J. Hemperly, Chorng-Fure Robin Hwang, Steven C. Keith, Mohammad A. Heidaran
  • Publication number: 20040209360
    Abstract: A UV-cross-linkable PVA-based polymer coating for cell culture that provides support for cell adhesion. The polymer coating may also contain bioaffecting molecules reversibly entrapped within the polymer coating that provides necessary nutrients to cell culture. Preferably, the UV-cross-linkable PVA-based polymer is PVA-SbQ.
    Type: Application
    Filed: April 18, 2003
    Publication date: October 21, 2004
    Inventors: Steven C. Keith, Mohammad A. Heidaran, John J. Hemperly, Christopher J. Knors
  • Publication number: 20040147016
    Abstract: The present invention relates to a programmable scaffold, which is a three-dimensional scaffold having interconnected pores and biologically active molecules physically entrapped therein. The scaffold is a lyophilized hydrogel of a polymer. The scaffold can be used in an array on a platform and loaded with various combinations of biologically active molecules for high throughput and parallel screening, as well as tissue engineering. The present invention also relates to methods for making and modifying the scaffolds.
    Type: Application
    Filed: September 30, 2003
    Publication date: July 29, 2004
    Inventors: Jonathan A. Rowley, Mohammad A. Heidaran
  • Publication number: 20040127406
    Abstract: This invention relates, e.g., to a method for expanding mammalian acinar cells, comprising culturing the cells in a cell culture system comprising a cell culture medium and a cell attachment surface, under conditions wherein the acinar cells undergo a 3-4 fold expansion together with transdifferentiation into a modified cell phenotype (IP cells) showing characteristics of acinar cells and liver cells. The invention also relates to a method for transforming these IP cells to insulin-producing cells in vitro, comprising culturing the cells in a novel, defined medium. Also disclosed are suitable culture media for performing these methods, isolated cells having the phenotype of IP cells and/or produced by these methods, and kits for performing the methods.
    Type: Application
    Filed: May 22, 2003
    Publication date: July 1, 2004
    Inventors: Sharon C. Presnell, Mohammad Heidaran, Perry Haaland
  • Publication number: 20040062882
    Abstract: A coated surface that resists cell adhesion comprisesg hyaluronic acid directly bound to a plasma-treated polymer surface. A process for producing the coated surface is disclosed as are further modifications of the hyaluronic acid by attaching ligand-binding polypeptides (antibodies or antibody binding proteins).
    Type: Application
    Filed: September 30, 2002
    Publication date: April 1, 2004
    Inventors: Andrea Liebmann-Vinson, Richard P. Clarke, Ruiling Xu, Mohammad A. Heidaran
  • Publication number: 20040063206
    Abstract: A programmable scaffold which is a three-dimensional scaffold having interconnected pore structures and biologically active molecules physically entrapped therein. Preferably, the scaffold is a lyophilized hydrogel of crosslinked alginate or hyaluronic acid. The scaffold can be arrayed on a platform and loaded with various combinations of biologically active molecules for high throughput and high parallel screening and tissue engineering. A method for making and modifying the scaffold having steps of impregnating the scaffold with solutions of biologically active molecule and lyophilizing the impregnated scaffold.
    Type: Application
    Filed: September 30, 2002
    Publication date: April 1, 2004
    Inventors: Jon A. Rowley, Mohammad A. Heidaran
  • Patent number: 6645945
    Abstract: A composition is provided for treating diseased, injured or diseased cartilage comprising hyaluronic acid and a growth factor. The composition has a viscosity and biodegradability sufficient to persist at the site for a period of time sufficient to alleviate the symptoms of the disease, injury or abnormality. Preferably hyaluronic acid is used in a composition range of 0.01-4% by weight and the preferred growth factor is IGF-I, present in a concentration range of about 10−6 to 100 mg/ml.
    Type: Grant
    Filed: April 22, 1999
    Date of Patent: November 11, 2003
    Assignee: DePuy Acromed, Inc.
    Inventors: Michael Radomsky, Mohammad A. Heidaran
  • Publication number: 20030207816
    Abstract: A method and composition are provided for inducing or enhancing chondrogenesis in vivo or in vitro. The method is performed by exposing the cells in vitro or in vivo to an extracellular matrix comprising of type I collagen, type II collagen or a mixture of type I collagen or type II collagen and hyaluronate and further containing GDF-5.
    Type: Application
    Filed: May 22, 2003
    Publication date: November 6, 2003
    Inventors: Mohammad A. Heidaran, Robert C. Spiro, Robin Daverman, LinShu Liu
  • Publication number: 20030175745
    Abstract: Peptides and peptide compositions are identified which inhibit the growth of abnormal cells. In one embodiment, the peptides are useful for inhibiting the growth of cells dependent on autocrine activation of the PDGF receptor. Such peptides may be used in the treatment of cell proliferative disorders including cancer, fibrotic disorders, myeloproliferative diseases and blood vessel proliferative (angiogenic) disorders characterized by inappropriate PDGF receptor activity. A biomedical device is further disclosed which has associated with it a peptide or peptide composition according to the present invention.
    Type: Application
    Filed: September 30, 2002
    Publication date: September 18, 2003
    Inventors: Cheryl H. Dean, Mohammad A. Heidaran, Catherine A. Spargo, Perry D. Haaland