Patents by Inventor Mohammed A. Maraheil

Mohammed A. Maraheil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby
    Patent number: 7279304
    Abstract: The preparation of macrocyclic molecules from linear, synthetic thioester precursors is disclosed. An excised thioesterase domain isolated from either a polyketide synthases (PKS) or non-ribosomal peptide synthetases (NRPS) multido system catalyzes the cyclization reaction. Thioester substrates also are described that are efficiently cyclized by the method of the present invention. Additionally, macrocyclic molecules, including macrolactones and macrolactams, that are prepared by the macrocyclization methods of the invention are described.
    Type: Grant
    Filed: December 15, 2001
    Date of Patent: October 9, 2007
    Assignee: President and Fellows of Harvard College
    Inventors: Christopher Thomas Walsh, John W. Trauger, Rahul Manu Kohli, Michael D. Burkart, Mohammed A. Maraheil, Henning Dieter Mootz, Dirk Schwarzer
  • Methods for preparation of macrocyclic molecules and macrocyclic molecules prepared thereby
    Publication number: 20020192773
    Abstract: The preparation of macrocyclic molecules from linear, synthetic thioester precursors is disclosed. An excised thioesterase domain isolated from either a PKS or NRPS multidomain system catalyzes the cyclization reaction. Thioester substrates also are described that are efficiently cyclized by the method of the present invention. Additionally, macrocyclic molecules, including macrolactones and macrolactams, that are prepared by the macrocyclization methods of the invention are described.
    Type: Application
    Filed: December 15, 2001
    Publication date: December 19, 2002
    Applicant: The President and Fellows of Harvard College
    Inventors: Christopher Thomas Walsh, John W. Trauger, Rahul Manu Kohli, Michael D. Burkart, Mohammed A. Maraheil, Henning Dieter Mootz, Dirk Schwarzer