Patents by Inventor Molly B. Schmid
Molly B. Schmid has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120010127Abstract: In part, the present invention is directed to compositions comprising a FabI inhibitor and at least one other bioactive agent. In another part, the present invention is directed to antibacterial compositions comprising a compound of formulas I-III and at least one other antibacterial agent.Type: ApplicationFiled: December 8, 2010Publication date: January 12, 2012Inventors: JUDD M. BERMAN, MOLLY B. SCHMID, JOHN D. MENDLEIN, NACHUM KAPLAN
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Patent number: 7879872Abstract: In part, the present invention is directed to compositions having a FabI inhibitor and at least one other bioactive agent. In another part, the present invention is directed to antibacterial compositions having a compound of formulas I-III and at least one other antibacterial agent.Type: GrantFiled: September 19, 2005Date of Patent: February 1, 2011Assignee: Affinium Pharmaceuticals, Inc.Inventors: Judd M. Berman, Molly B. Schmid, John D. Mendlein, Nachum Kaplan
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Patent number: 7601526Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein derived from Fransicella tularensis comprising the amino acid sequence set forth in SEQ ID NO: 2. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.Type: GrantFiled: December 28, 2006Date of Patent: October 13, 2009Assignee: Affinium Pharmaceuticals, Inc.Inventors: Judd M. Berman, Molly B. Schmid, Donald E. Awrey, Teresa Clarke, Bryan Beattie, Mandy Dorsey
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Publication number: 20080108793Abstract: The present invention relates to novel drug targets for pathogenic bacteria. Accordingly, the invention provides purified protein comprising the amino acid sequence set forth in SEQ ID NO: 2. The invention also provides biochemical and biophysical characteristics of the polypeptides of the invention.Type: ApplicationFiled: December 28, 2006Publication date: May 8, 2008Inventors: Judd M. Berman, Molly B. Schmid, Donald E. Awrey, Teresa Clarke McGrath, Bryan Beattie, Mandy Dorsey
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Patent number: 6638718Abstract: This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.Type: GrantFiled: March 17, 2000Date of Patent: October 28, 2003Assignee: Essential Therapeutics, Inc.Inventors: Bret Benton, Ving J. Lee, Francois Malouin, Patrick K. Martin, Molly B. Schmid, Dongxu Sun
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Patent number: 6630303Abstract: This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.Type: GrantFiled: March 17, 2000Date of Patent: October 7, 2003Assignee: Essential Therapeutics, Inc.Inventors: Bret Benton, Ving J. Lee, Francois Malouin, Patrick K. Martin, Molly B. Schmid, Dongxu Sun
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Patent number: 6514746Abstract: This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial genes which encode the components of a two-component regulatory pair. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.Type: GrantFiled: May 20, 1998Date of Patent: February 4, 2003Assignee: Essential Therapeutics, Inc.Inventors: Bret Benton, Francois Malouin, Patrick K. Martin, Molly B. Schmid, Dongxu Sun
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Patent number: 6228588Abstract: This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.Type: GrantFiled: March 9, 1999Date of Patent: May 8, 2001Assignee: Microcide Pharmaceuticals, Inc.Inventors: Bret Benton, Ving J. Lee, Francois Malouin, Patrick K. Martin, Molly B. Schmid, Dongxu Sun
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Patent number: 6187541Abstract: This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.Type: GrantFiled: March 9, 1999Date of Patent: February 13, 2001Assignee: Microcide Pharmaceuticals, Inc.Inventors: Bret Benton, Ving J. Lee, Francois Malouin, Patrick K. Martin, Molly B. Schmid, Dongxu Sun
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Patent number: 6037123Abstract: This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.Type: GrantFiled: September 13, 1996Date of Patent: March 14, 2000Assignee: Microcide Pharmaceuticals, Inc.Inventors: Bret Benton, Ving J. Lee, Francois Malouin, Patrick K. Martin, Molly B. Schmid, Dongxu Sun
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Patent number: 5962249Abstract: A method for identifying a cell or strain of cells containing a mutation in a gene involved in growth, comprising the steps of forming a labeled set of strains comprising a plurality of members, each member of the set containing an exogenous DNA fragment of a defined length stably integrated into the chromosome of a member, the defined length in each member differing from the defined length in other members, subjecting the labeled set of strains to mutagenesis so as to obtain mutants from each member of the set of strains, and introducing the mutant strains into a growth environment for a period of time sufficient for growth of a non-mutated strain and determining which strains have reduced growth compared to a non-mutated strain, by determining the presence and size of exogenous DNA fragments relative to each other using PCR and agarose/polyacrylamide gel electrophoresis.Type: GrantFiled: December 20, 1996Date of Patent: October 5, 1999Assignee: Microcide Pharmaceuticals, Inc.Inventors: Bret Benton, Keith Bostian, Molly B. Schmid, Dongxu Sun, Jerry M. Buysse