Patents by Inventor Monika Lavan

Monika Lavan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BLOOD BRAIN BARRIER MODELS AND METHODS TO GENERATE AND USE THE SAME
    Publication number: 20210140947
    Abstract: The present disclosure generally relates to a process to prepare a cell culture system that mimics the structure of blood brain barrier (BBB) and are useful to study the functions thereof. In particular, the present invention relates to a direct-contact coculture and triculture systems prepared by plating BMECs on a pre-formed lawn of coculture of astrocytes and pericytes on the apical surface of a culture-chamber to achieve a truly direct contact triculture model for BBB. The cell culture systems disclosed herein are also useful for studying the functions of the blood brain barrier and predicting the efficacy and potential toxicity of a drug candidate.
    Type: Application
    Filed: December 18, 2020
    Publication date: May 13, 2021
    Applicant: Purdue Research Foundation
    Inventors: Gregory T. Knipp, Aimable Ngendahimana, Christopher D. Kulczar, Kelsey E. Lubin, Monika Lavan
  • Blood brain barrier models and methods to generate and use the same
    Patent number: 10877026
    Abstract: The present disclosure generally relates to a process to prepare a cell culture system that mimics the structure of blood brain barrier (BBB) and are useful to study the functions thereof. In particular, the present invention relates to a direct-contact coculture and triculture systems prepared by plating BMECs on a pre-formed lawn of coculture of astrocytes and pericytes on the apical surface of a culture-chamber to achieve a truly direct contact triculture model for BBB. The cell culture systems disclosed herein are also useful for studying the functions of the blood brain barrier and predicting the efficacy and potential toxicity of a drug candidate.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: December 29, 2020
    Assignee: Purdue Research Foundation
    Inventors: Gregory T. Knipp, Aimable Ngendahimana, Christopher D. Kulczar, Kelsey E. Lubin, Monika Lavan
  • BLOOD BRAIN BARRIER MODELS AND METHODS TO GENERATE AND USE THE SAME
    Publication number: 20180067103
    Abstract: The present disclosure generally relates to a process to prepare a cell culture system that mimics the structure of blood brain barrier (BBB) and are useful to study the functions thereof. In particular, the present invention relates to a direct-contact coculture and triculture systems prepared by plating BMECs on a pre-formed lawn of coculture of astrocytes and pericytes on the apical surface of a culture-chamber to achieve a truly direct contact triculture model for BBB. The cell culture systems disclosed herein are also useful for studying the functions of the blood brain barrier and predicting the efficacy and potential toxicity of a drug candidate.
    Type: Application
    Filed: September 7, 2017
    Publication date: March 8, 2018
    Applicant: Purdue Research Foundation
    Inventors: Gregory T. Knipp, Aimable Ngendahimana, Christopher D. Kulczar, Kelsey E. Lubin, Monika Lavan