Patents by Inventor Mordechai Chevion

Mordechai Chevion has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11033630
    Abstract: The present invention provides pharmaceutical compositions comprising a metal-desferrioxamine B complex or a combination thereof, for preventing, inhibiting, reducing or ameliorating neurodegeneration, thereby treating diseases, disorders, or conditions characterized by or associated with neurodegeneration; as well as methods of use.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: June 15, 2021
    Inventors: Mordechai Chevion, Vladimir Vinokur, Eduard Berenshtein
  • Publication number: 20210161840
    Abstract: The present invention relates to an iron chelator combination, more specifically a combination of a non-iron metal-desferrioxamine B complex and an additional iron chelator, for preventing, inhibiting, reducing or ameliorating iron overload or elevated levels of labile iron.
    Type: Application
    Filed: April 11, 2019
    Publication date: June 3, 2021
    Inventor: Mordechai CHEVION
  • Publication number: 20190358334
    Abstract: The present invention provides pharmaceutical compositions comprising a metal-desferrioxamine B complex or a combination thereof, for preventing, inhibiting, reducing or ameliorating neurodegeneration, thereby treating diseases, disorders, or conditions characterized by or associated with neurodegeneration; as well as methods of use.
    Type: Application
    Filed: February 8, 2017
    Publication date: November 28, 2019
    Inventors: Mordechai CHEVION, Vladimir VINOKUR, Eduard BERENSHTEIN
  • Publication number: 20190022103
    Abstract: The present invention relates to complexes of nocardamine (desferrioxamine E) with at least one metal, specifically with Zn2+ or Ga3+ or silver or gold or any combinations thereof. The invention further provides procedures for the preparation of the complexes and pharmaceutical compositions comprising said complexes or any combinations of said complexes, as well as methods using the compositions and complexes of the invention in modulating cytokine levels in a subject and thereby treating inflammation-associated disorders.
    Type: Application
    Filed: December 22, 2015
    Publication date: January 24, 2019
    Inventors: Mordechai CHEVION, Vladimir VINOKUR, Ron ELIASHAR, Eduard BERENSHTEIN
  • Patent number: 9770430
    Abstract: The present invention relates to methods kits and combined compositions using DFO-metal complexes, specifically, Zinc-desferrioxamine (Zn-DFO), gallium-desferrioxamine (Ga-DFO) complexes and any combinations thereof for preventing, treating, ameliorating or inhibiting an immune-related disorder, specifically, a skin-related inflammatory disorder such as psoriasis, an inflammatory respiratory condition such as asthma, and an autoimmune disease such as diabetes and any immune-related disorder.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: September 26, 2017
    Inventor: Mordechai Chevion
  • Publication number: 20150148413
    Abstract: The present invention relates to methods kits and combined compositions using DFO-metal complexes, specifically, Zinc-desferrioxamine (Zn-DFO), gallium-desferrioxamine (Ga-DFO) complexes and any combinations thereof for preventing, treating, ameliorating or inhibiting an immune-related disorder, specifically, a skin-related inflammatory disorder such as psoriasis, an inflammatory respiratory condition such as asthma, and an autoimmune disease such as diabetes and any immune-related disorder.
    Type: Application
    Filed: January 27, 2015
    Publication date: May 28, 2015
    Inventors: Mordechai Chevion, Vladimir Vinokur, Eduard Berenshtein, Ron Eliashar, Baruch Bulvik
  • Patent number: 8975294
    Abstract: The present invention relates to methods kits and combined compositions using DFO-metal complexes, specifically, Zinc-desferrioxamine (Zn-DFO), gallium-desferrioxamine (Ga-DFO) complexes and any combinations thereof for preventing, treating, ameliorating or inhibiting an immune-related disorder, specifically, a skin-related inflammatory disorder such as psoriasis, an inflammatory respiratory condition such as asthma, and an autoimmune disease such as diabetes and any immune-related disorder.
    Type: Grant
    Filed: August 19, 2010
    Date of Patent: March 10, 2015
    Assignees: Hadasit Medical Research Services and Development Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Mordechai Chevion, Vladimir Vinokur, Eduard Berenshtein, Ron Eliashar, Baruch Bulvik
  • Patent number: 8680148
    Abstract: Methods for treating a bacterial infection by using a metallo-desferrioxamine complex.
    Type: Grant
    Filed: August 13, 2007
    Date of Patent: March 25, 2014
    Assignees: University of Washington, Hadasit Medical Research Services and Development Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: E. Peter Greenberg, Ehud Banin, Eyal Banin, Eduard Berenshtein, Mordechai Chevion
  • Publication number: 20120220651
    Abstract: The present invention relates to methods kits and combined compositions using DFO-metal complexes, specifically, Zinc-desferrioxamine (Zn-DFO), gallium-desferrioxamine (Ga-DFO) complexes and any combinations thereof for preventing, treating, ameliorating or inhibiting an immune-related disorder, specifically, a skin-related inflammatory disorder such as psoriasis, an inflammatory respiratory condition such as asthma, and an autoimmune disease such as diabetes and any immune-related disorder.
    Type: Application
    Filed: August 19, 2010
    Publication date: August 30, 2012
    Applicants: Hadasit Medical Research Services & Development Lt, Yissum Research Development Company of the Hebrew
    Inventors: Mordechai Chevion, Vladimir Vinokur, Eduard Berenshtein, Ron Eliashar, Baruch Bulvik
  • Publication number: 20080085866
    Abstract: Methods for treating a bacterial infection by using a metallo-desferrioxamine complex.
    Type: Application
    Filed: August 13, 2007
    Publication date: April 10, 2008
    Applicants: WASHINGTON, UNIVERSITY OF, HADASSAH MEDICAL ORGANIZATION - HADASIT
    Inventors: E. Greenberg, Ehud Banin, Eyal Banin, Eduard Berenshtein, Mordechai Chevion
  • Patent number: 6426093
    Abstract: A biocidal composition composed of a ternary complex of a negatively-charged biocide, a transition metal ion and chelator has synergistic biocidal effects as compared with a composition of each of the components alone. The chelator is preferably a neutral or positively-charged chelator. The ternary complex may be used for killing or inhibiting the growth of living cells.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: July 30, 2002
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Mordechai Chevion, Benzhan Zhu, Svetlana Schechtman
  • Patent number: 5618838
    Abstract: A pharmaceutical composition comprises a gallium complex of desferrioxamine r penicillamine as active ingredients therein, in combination with a pharmacologically acceptable carrier. The gallium desferrioxamine or gallium penicillamine complex are useful in the treatment of free radical-induced pathological conditions; the treatment of injury resulting from ischemic insult to the heart, brain or kidney; the treatment of thalassemia; the treatment of hemochromatosis; the treatment of Wilson's disease; the treatment of paraquat toxicity; or for exchanging gallium for iron.
    Type: Grant
    Filed: February 29, 1996
    Date of Patent: April 8, 1997
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Mordechai Chevion, Edward Berenshtein
  • Patent number: 5082851
    Abstract: The invention provides a composition for protecting the heart from myocardial ischemia and reperfusion injury as well as for reducing post-ischemic damage, improving cardiac function and serving as a hypothermic cardiac preservative solution comprising N,N,N'N'-tetrakis-(2-pyridylmethyl)-ethylenediamine (TPEN) as active ingredient therein.
    Type: Grant
    Filed: February 7, 1990
    Date of Patent: January 21, 1992
    Assignees: Hadassah Medical Organization, Yissum Research and Development Corporation of the Hebrew University of Jerusalem
    Inventors: Jerachmiel Y. Appelbaum, Mordechai Chevion, Gideon Uretzky
  • Patent number: 5075469
    Abstract: The invention provides a pharmaceutical composition comprising a zinc complex of desferrioxamine or penicillamine as active ingredient therein in combination with a pharmacologically acceptable carrier.
    Type: Grant
    Filed: July 10, 1990
    Date of Patent: December 24, 1991
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventor: Mordechai Chevion