Patents by Inventor Morten Meldal
Morten Meldal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10562872Abstract: The invention relates to a method for synthesis of 1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]piperazine in the presence of a strong base.Type: GrantFiled: February 6, 2017Date of Patent: February 18, 2020Assignee: H. Lundbeck A/SInventors: Frederik Diness, Morten Meldal, Christian Borch Jacobsen
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Publication number: 20190284243Abstract: The present invention relates to peptides binding target compounds including other peptides with high specificity and affinity.Type: ApplicationFiled: November 9, 2017Publication date: September 19, 2019Inventors: Morten MELDAL, Hongxia HU, Ming LI, Niklas Henrik FISCHER, Sanne SCHOFFELEN, Frederik DINESS
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Publication number: 20190040027Abstract: The invention relates to a method for synthesis of 1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]piperazine in the presence of a strong base.Type: ApplicationFiled: February 6, 2017Publication date: February 7, 2019Inventors: Frederik Diness, Morten Meldal, Christian Borch Jacobsen
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Publication number: 20190040028Abstract: The invention relates to a method for arylation of amines, such as aliphatic amines by reaction of aryl-halogens, e.g. chloro- or fluorobenzene derivatives without strongly electron withdrawing substituents in the presence of a strong base.Type: ApplicationFiled: February 6, 2017Publication date: February 7, 2019Inventors: Frederik Diness, Morten Meldal, Christian Borch Jacobsen
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Patent number: 9428635Abstract: A method of coating hydroxylated surfaces by gas phase grafting is described. Especially acyl groups, silyl groups and/or alkyl groups are located on the surface of materials by gas phase grafting. The grafting method is a dry process. The material to coat can be organic or inorganic materials. The produced surface coated material are strong and durable and material normally not water-proof can be water-proof due to the surface treating. Examples of items produced from surface treated material may be water-proof cardboard boxes, other containers, furniture, interior for cars and boats. Items produced from organic materials such as from plant parts are biodegradable.Type: GrantFiled: December 16, 2009Date of Patent: August 30, 2016Assignee: CARLSBERG A/SInventors: Morten Meldal, Manat Renil, Steen Vesborg
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Patent number: 9150899Abstract: The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. The test compounds are linked to the solid support via cleavable linkers and may thus be released from the solid supports. Solid supports comprising cells, wherein the cellular response of interest has been modulated are selected and the test compound of the solid support can then be identified. The cellular response may for example be changes in complex formation between proteins.Type: GrantFiled: April 6, 2012Date of Patent: October 6, 2015Assignee: 2cureXInventors: Ole Thastrup, Morten Meldal, Grith Hagel, Jens Chr. Norrild, Morten Hentzer
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Patent number: 8796362Abstract: The invention relates to a polymer material with several advantageous properties. The polymer material has a low degree of swelling in water, it is biodegradable, it has extremely low permeability to gasses such as CO2 and it has a high strength. The polymer material is useful for a number of purposes, such as for preparing containers for food or beverages. The polymer material is prepared from a prepolymerization mixture comprising grafted plant derived material and monomers and/or cross-linkers.Type: GrantFiled: December 16, 2009Date of Patent: August 5, 2014Assignee: Carlsberg A/SInventors: Morten Meldal, Renil Manat
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Patent number: 8791053Abstract: The invention relates to a spatially encoded polymer matrix in the form of a bead or a granule for combinatorial solid phase synthesis, assaying, functional proteomics and diagnostic use. Compositions of such beads or granules are also provided. Each beaded polymer matrix of the composition comprises a plurality of spatially immobilized particles. The spatial immobilization of the particles confers on each beaded polymer matrix a “fingerprint” which enables identification of unique beads in a population of beads. The unique identification of individual beads makes it possible to perform combinatorial chemistry strategies while logging individual chemical transformation. Also provided are methods for detection of relative positions in space of particles, methods for generating matrices, methods for distance matrix determination, methods for identifying individual matrices and devices for recording and storing images of matrices.Type: GrantFiled: September 26, 2003Date of Patent: July 29, 2014Assignee: MPM-Holding APSInventors: Soren Flygenring Christensen, Jens Hog Truelsen, Morten Meldal, Roice Michael, Ib Johannsen
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Publication number: 20130123140Abstract: The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. The test compounds are linked to the solid support via cleavable linkers and may thus be released from the solid supports. Solid supports comprising cells, wherein the cellular response of interest has been modulated are selected and the test compound of the solid support can then be identified. The cellular response may for example be changes in complex formation between proteins.Type: ApplicationFiled: April 6, 2012Publication date: May 16, 2013Applicant: 2cureXInventors: Ole Thastrup, Morten Meldal, Grith Hagel, Jens Chr. Norrild, Morten Hentzer
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Publication number: 20120135170Abstract: The invention relates to a polymer material with several advantageous properties. The polymer material has a low degree of swelling in water, it is biodegradable, it has extremely low permeability to gasses such as CO2 and it has a high strength. The polymer material is useful for a number of purposes, such as for preparing containers for food or beverages. The polymer material is prepared from a prepolymerisation mixture comprising grafted plant derived material and monomers and/or cross-linkers.Type: ApplicationFiled: December 16, 2009Publication date: May 31, 2012Inventors: Morten Meldal, Renil Manat
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Publication number: 20110319274Abstract: The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. Test compounds modulating a cellular response, for example via a cell surface molecule may be identified by selecting solid supports comprising cells, wherein the cellular response of interest has been modulated. The cellular response may for example be changes in signal transduction pathways modulated by a cell surface molecule.Type: ApplicationFiled: May 25, 2005Publication date: December 29, 2011Applicant: Carlsberg A/SInventors: Grith Hagel, Morten Meldal, Dorte W. Kaznelson, Ole Thastrup, Thomas E. Nielsen, Frederik Diness
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Publication number: 20090239755Abstract: The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. The test compounds are linked to the solid support via cleavable linkers and may thus be released from the solid supports. Solid supports comprising cells, wherein the cellular response of interest has been modulated are selected and the test compound of the solid support can then be identified. The cellular response may for example be changes in complex formation between proteins.Type: ApplicationFiled: May 25, 2005Publication date: September 24, 2009Applicant: 2cureXInventors: Ole Thastrup, Morten Meldal, Grith Hagel, Jens Chr. Norrild, Morten Hentzer
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Publication number: 20090210165Abstract: The present invention is related to methods for the identification of spatially encoded beaded or granulated matrices comprising a plurality of immobilised particles. The identification is based on a distance matrix determination or based on a set of geometrical figures, such a triangles, on the basis of which individual matrices can be determined.Type: ApplicationFiled: December 22, 2004Publication date: August 20, 2009Applicant: Carlsberg A/SInventors: Soeren Flygenring Christensen, Ib Johannsen, Jens Michael Carstensen, Lionel Kuhlmann, Morten Meldal
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Publication number: 20060252093Abstract: The present invention relates to a method of preparing heterocyclic organic com-pounds involving intramolecular formation of an N-acyliminium ion and an in-tramolecular Pictet-Spengler reaction. The invention furthermore discloses precursor molecules useful for the method and methods of preparing these precursor mole-cules. The invention also relates to heterocyclic organic compounds prepared by the methods, libraries of such heterocyclic organic compound and methods of preparing them, as well as to various uses of the heterocyclic organic compounds.Type: ApplicationFiled: June 25, 2004Publication date: November 9, 2006Inventors: Morten Meldal, Thomas Nielsen
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Patent number: 7064179Abstract: The present invention relates to macromonomers containing ethylene glycol repeat units, to chemically inert polymers prepared therefrom and to the use of such polymers in solid phase biochemical assays.Type: GrantFiled: September 28, 1999Date of Patent: June 20, 2006Assignee: Carlsberg A/SInventors: Morten Meldal, Jens Buchardt, Joerg Rademann
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Publication number: 20060127369Abstract: The invention relates to a spatially encoded polymer matrix in the form of a bead or a granule for combinatorial solid phase synthesis, assaying, functional proteomics and diagnostic use. Compositions of such beads or granules are also provided. Each beaded polymer matrix of the composition comprises a plurality of spatially immobilised particles. The spatial immobilisation of the particles confers on each beaded polymer matrix a “fingerprint” which enables identification of unique beads in a population of beads. The unique identification of individual beads makes it possible to perform combinatorial chemistry strategies while logging individual chemical transformation. Also provided are methods for detection of relative positions in space of particles, methods for generating matrices, methods for distance matrix determination, methods for identifying individual matrices and devices for recording and storing images of matrices.Type: ApplicationFiled: September 26, 2003Publication date: June 15, 2006Applicant: Carlsberg A/SInventors: Soren Christensen, Jens Truelsen, Morten Meldal, Roice Michael, Ib Johanssen
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Publication number: 20030144467Abstract: The present invention relates to a polymer matrix comprising a backbone of linked macromonomers, wherein said macromonomers are selected from the group consisting of triethylene glycols, tetraethylene glycols, and pentaethylene glycols, including any derivative and/or combination thereof. The polymer matrix of the present invention has a high-loading capacity while still being able to swell in small volumes of organic and aqueous solvents; it forms beads effectively so as to provide a resin of homogeneous size and shape; and it is more stable both chemically and physically than state of the art resins. One preferred type of SPOCC resin according to the present invention comprises short chained ethylene glycol macromonomers, including tetraethylene glycol (TEG194), or derivatives thereof.Type: ApplicationFiled: October 15, 2002Publication date: July 31, 2003Inventors: Morten Meldal, Leslie P. Miranda
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Patent number: 5795958Abstract: Glycopeptides having the following structure are described: ##STR1## wherein: X.sub.1 is hydrogen, an acetyl group, an acyl group or amino acid; R is .alpha.-L-fucose, .alpha.-D-fucose, .beta.-L-fucose or .beta.-D-fucose, wherein R is O-glucosidically linked to A.sub.1 ; A.sub.1 is serine, threonine, tyrosine, hydroxyproline, asparagine, glutamine, homeoserine and hydroxylysine; A.sub.2 is a glycine, an L-amino acid, a D-amino acid or a modified amino acid; A.sub.3 is L or D aspartic acid, glycine or glutamic acid; and X.sub.2 is a hydroxyl, an amine or an amino acid.Type: GrantFiled: June 10, 1996Date of Patent: August 18, 1998Assignee: Glycomed CorporationInventors: Narasinga Rao, Morten Meldal, Klaus Bock, Ole Hindsgaul