Abstract: Disclosed herein are methods and compositions for treatment and prevention of neuropathic pain conditions. Aspects of the present disclosure are directed to methods for treatment of neuropathic pain conditions using STAT3 inhibitors. Certain aspects pertain to TTI-101 and methods for use in treatment of chemotherapy-induced peripheral neuropathy, mechanical nerve injury, and other neuropathic pain conditions. Also disclosed are methods for treatment of chemotherapy-induced peripheral neuropathy comprising administering TTI-101 and one or more chemotherapeutic agents to a subject with cancer.

Abstract: In one aspect, the present disclosure provides methods of inhibiting STAT3 in a cell comprising contacting the cell with a compound of the formula: (I) wherein the variables are as defined herein. In another aspect, the present disclosure provides methods of using of the compounds disclosed herein for the treatment of cancer.