Patents by Inventor Motohiro Yamazaki

Motohiro Yamazaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11782022
    Abstract: The capillary electrophoresis apparatus according to the present invention can maintain the temperature in the longitudinal direction of each of a plurality of capillaries uniformly, such that the separation performance of the capillary electrophoresis apparatus can be stabilized, and the analysis performance can be improved.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: October 10, 2023
    Assignee: Hitachi High-Tech Corporation
    Inventors: Wataru Sato, Motohiro Yamazaki
  • Publication number: 20230152273
    Abstract: An electrophoresis device of the present disclosure includes an electrophoresis path of a sample, a dispersion element for dispersing light from the sample within the electrophoresis path, a photodetector for detecting the light dispersed by the dispersion element, and a computation unit for determining a spectrum of the light on the basis of a signal from the photodetector, and is characterized in that the computation unit corrects the spectrum using correction factors determined for each migration condition or fluorescent dye.
    Type: Application
    Filed: May 12, 2020
    Publication date: May 18, 2023
    Inventors: Noriyuki SUMIDA, Michiru FUJIOKA, Motohiro YAMAZAKI, Isao HARAURA, Yoshimasa MOMOSE, Masateru KUMAGAI
  • Patent number: 11644438
    Abstract: A capillary cartridge achieves both improvement of attachability and improvement of heat dissipation performance for realizing short-time analysis. A heat dissipation body is provided between a capillary having a detection unit provided in a part thereof and a plate-like support body that supports the capillary, and temperature increase inside the capillary is suppressed by the heat dissipation body, and thereby, electrophoresis can be performed under a high voltage application condition where the amount of heat increases and analysis time is reduced. In addition, it is possible to redress complexity of an operation by reducing a fixing place at the time of attachment to only a detection unit and an electrode holder by using an integration structure in which the capillary, the supporting body, and the heat radiating body are integrated.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: May 9, 2023
    Assignee: Hitachi High-Tech Corporation
    Inventors: Ayaka Okuno, Motohiro Yamazaki, Taro Nakazawa, Mitsuhiro Miyazaki, Ryusuke Kimura
  • Publication number: 20230046895
    Abstract: Provided is the technique for efficiently using the phoresis medium contained in the phoresis medium container by minimizing the remaining phoresis medium as small as possible, and further lowering the running cost. The disclosure proposes the measurement system as an example, which includes an electrophoresis device and a computer. The electrophoresis device includes a phoresis medium container for storing a phoresis medium, a capillary having its inside filled with the phoresis medium, a delivery mechanism for delivering the phoresis medium in the phoresis medium container to the capillary, and a device control section for controlling an operation of the delivery mechanism. The computer calculates a deliverable number of times from an amount of the phoresis medium in the phoresis medium container and an estimated delivery amount of the phoresis medium delivered by the delivery mechanism (see FIG 16).
    Type: Application
    Filed: March 6, 2020
    Publication date: February 16, 2023
    Inventors: Ryusuke Kimura, Motohiro Yamazaki
  • Patent number: 11543355
    Abstract: A light-emission detection apparatus is provided for individually condensing light emitted from each emission point of an emission-point array using each condensing lens of a condensing-lens array to forma light beam and detecting each light beam incident on a sensor in parallel. The light-emission detection apparatus can be downsized and high sensitivity and low crosstalk can be simultaneously accomplished when a certain relation between the diameter of each emission point, a focal length of each condensing lens, an interval of condensing lenses, and an optical path length between each condensing lens and a sensor is satisfied.
    Type: Grant
    Filed: August 3, 2022
    Date of Patent: January 3, 2023
    Assignee: Hitachi High-Tech Corporation
    Inventors: Takashi Anazawa, Motohiro Yamazaki
  • Publication number: 20220381694
    Abstract: A light-emission detection apparatus is provided for individually condensing light emitted from each emission point of an emission-point array using each condensing lens of a condensing-lens array to forma light beam and detecting each light beam incident on a sensor in parallel. The light-emission detection apparatus can be downsized and high sensitivity and low crosstalk can be simultaneously accomplished when a certain relation between the diameter of each emission point, a focal length of each condensing lens, an interval of condensing lenses, and an optical path length between each condensing lens and a sensor is satisfied.
    Type: Application
    Filed: August 3, 2022
    Publication date: December 1, 2022
    Inventors: Takashi Anazawa, Motohiro Yamazaki
  • Publication number: 20220365025
    Abstract: The present invention aims to provide an electrophoresis device which detects the presence or absence of foreign matter in a flow path 111. In order to solve the above problems, the electrophoresis device of the present invention is characterized by including a flow path 111 filled thereinside with a migration medium, a migration medium container which stores a migration medium, a liquid feeding mechanism which feeds the migration medium to the flow path 111, a photographing device 115 which photographs the flow path 111, and a control unit which analyzes an image of the flow path 111 photographed by the photographing device 115 and in that the control unit determines the presence or absence of the foreign matter in the flow path 111 on the basis of the image of the flow path 111.
    Type: Application
    Filed: November 11, 2019
    Publication date: November 17, 2022
    Applicant: HITACHI HIGH-TECH CORPORATION
    Inventors: Masashi TOMIYOSHI, Masashi WATANABE, Takeshi OOURA, Motohiro YAMAZAKI
  • Patent number: 11442016
    Abstract: The invention is directed to a light-emission detection apparatus for individually condensing light emitted from each emission point of a emission-point array using each condensing lens of a condensing-lens array to form a light beam and detecting each light beam incident on a sensor in parallel, and the light-emission detection apparatus can be downsized and high sensitivity and low crosstalk can be simultaneously accomplished when a certain relation between the diameter of each emission point, a focal length of each condensing lens, an interval of condensing lenses, and an optical path length between each condensing lens and a sensor is satisfied.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: September 13, 2022
    Assignee: Hitachi High-Tech Corporation
    Inventors: Takashi Anazawa, Motohiro Yamazaki
  • Patent number: 11426721
    Abstract: Provided are a bubble eliminating structure and a bubble eliminating method which eliminate bubbles in a liquid by agitating the liquid, and an agitating method using the same. A first groove 114, which is an upstream bubble eliminating groove, and a second groove 131, which is a downstream bubble eliminating groove, are branched from a mixing well 13. After starting suction of the liquid from mixing well 13 into the first groove 114, suction of the liquid from the mixing well 13 into the second groove 131 is started, and after completion of discharge of the liquid from the first groove 114 into the mixing well 13, discharge of the liquid from the second groove 131 into the mixing well 13 is completed. This operation is repeated to eliminate bubbles.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: August 30, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Yoshihiro Nagaoka, Taro Nakazawa, Mitsuhiro Miyazaki, Ryusuke Kimura, Motohiro Yamazaki
  • Publication number: 20220236183
    Abstract: In an analysis method and an analysis system for detecting fluorescences from each of a plurality of light-emitting points in a plurality of wavelength bands in order to identify fluorescence emissions of a plurality of types of fluorophores from the plurality of light-emitting points, spatial crosstalk and spectral crosstalk are present between the plurality of light-emitting points and between the plurality of wavelength bands, and then performance of the identification is reduced. The spatial crosstalk and the spectral crosstalk are eliminated and concentrations of each of the plurality of types of fluorophores at each of the plurality of light-emitting points are derived by inputting all detection signals in the plurality of wavelength bands for the plurality of light-emitting points to a predetermined arithmetic operation expression.
    Type: Application
    Filed: April 21, 2020
    Publication date: July 28, 2022
    Applicant: Hitachi High-Tech Corporation
    Inventors: Takashi ANAZAWA, Ryoji INABA, Shuhei YAMAMOTO, Taro NAKAZAWA, Michiru FUJIOKA, Motohiro YAMAZAKI
  • Publication number: 20220229013
    Abstract: A multicapillary electrophoresis device includes: a capillary array formed by arranging a plurality of capillaries; a light source irradiating the capillaries with excitation light; a photodetector detecting fluorescence from a sample in the capillaries; and an arithmetic control unit calculating a signal intensity of the fluorescence according to a signal from the photodetector. The arithmetic control unit is configured so as to correct the signal intensity according to a correction index determined for each of the combinations of any of the capillaries and a fluorophore labeled to the sample.
    Type: Application
    Filed: June 6, 2019
    Publication date: July 21, 2022
    Inventors: Noriyuki SUMIDA, Takashi ANAZAWA, Michiru FUJIOKA, Motohiro YAMAZAKI, Taro NAKAZAWA
  • Patent number: 11391694
    Abstract: In order to provide a piston and a syringe with good sliding performance and pressure resistance performance, the piston contained in the syringe that pressurizes or decompresses an internal medium is configured such that a soft portion made of a soft material and a rigid portion made of a material having rigidity higher than rigidity of the soft portion, are connected in series, and arranged such that the soft portion is in contact with the medium and the rigid portion is not in contact with the medium. The soft portion includes a hollow on a surface in contact with the medium. The rigid portion has an end surface facing the soft portion, the end surface including at least an outer peripheral portion in contact with the soft portion. The outer diameter of the soft portion is larger than the outer diameter of the rigid portion, and the outer diameter of the rigid portion is slightly smaller than the inner diameter of an outer cylinder of the syringe.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: July 19, 2022
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Takashi Anazawa, Kunio Harada, Motohiro Yamazaki
  • Patent number: 11360047
    Abstract: An electrophoresis device has: a sample tray (112) on which there are placed a positive-electrode-side buffer solution container (103) containing a buffer solution and a phoresis medium container (102) containing a phoresis medium, and which is driven in a vertical direction and a horizontal direction; a thermostat oven unit (113) that holds a capillary array having a capillary head in which a plurality of capillaries are bundled in a single unit at one end thereof in a state where the capillary array being held in a state in which the capillary head protrudes downward, and that keeps the interior temperature constant; a solution-delivering mechanism (106) for delivering the phoresis medium in the phoresis medium container to the capillary array from the capillary head; and a power source for applying a voltage to both ends of the capillary array. Holes for insertion of the capillary head are provided in upper sections of the positive-electrode-side buffer solution container and the phoresis medium container.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: June 14, 2022
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Katsuhiro Aritome, Ryusuke Kimura, Motohiro Yamazaki
  • Publication number: 20220082524
    Abstract: Provided is an electrophoresis device that, by electrophoresis, feeds a sample into capillaries and optically detects the sample, the electrophoresis device being provided with capillaries, a capillary head provided at the distal end of the capillaries, a phoretic medium-filled container used for electrophoresis and filled with a phoretic medium, a guide member that covers the side surface of the phoretic medium-filled container, a seal member that seals from below the phoretic medium filled in the phoretic medium-filled container, and a plunger that presses the seal member.
    Type: Application
    Filed: November 23, 2021
    Publication date: March 17, 2022
    Inventors: Ryusuke KIMURA, Motohiro YAMAZAKI, Hitoshi MIYATA, Hiroyuki HIGASHINO
  • Patent number: 11243187
    Abstract: The present invention addresses the problem of providing an electrophoretic medium container capable of stabilizing a liquid delivery pressure while ensuring sealing of an electrophoretic medium. In order to resolve this problem, this electrophoretic medium container is provided with a syringe part for holding an electrophoretic medium, and a sealing component for sealing one end of the syringe part, the electrophoretic medium container being characterized in that the sealing component has a sealing surface, a body part, and a groove provided between the sealing surface and the body part, wherein the sealing surface is in contact with the inner wall of the syringe part.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: February 8, 2022
    Assignee: Hitachi High-Tech Corporation
    Inventors: Naomichi Kawasaki, Ryusuke Kimura, Katsuhiro Aritome, Go Nakajima, Takashi Gomi, Motohiro Yamazaki
  • Patent number: 11226307
    Abstract: Provided is an electrophoresis device that, by electrophoresis, feeds a sample into capillaries and optically detects the sample, the electrophoresis device being provided with capillaries, a capillary head provided at the distal end of the capillaries, a phoretic medium-filled container used for electrophoresis and filled with a phoretic medium, a guide member that covers the side surface of the phoretic medium-filled container, a seal member that seals from below the phoretic medium filled in the phoretic medium-filled container, and a plunger that presses the seal member.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: January 18, 2022
    Assignee: Hitachi High-Tech Corporation
    Inventors: Ryusuke Kimura, Motohiro Yamazaki, Hitoshi Miyata, Hiroyuki Higashino
  • Publication number: 20210404987
    Abstract: The capillary electrophoresis apparatus according to the present invention can maintain the temperature in the longitudinal direction of each of a plurality of capillaries uniformly, such that the separation performance of the capillary electrophoresis apparatus can be stabilized, and the analysis performance can be improved.
    Type: Application
    Filed: September 8, 2021
    Publication date: December 30, 2021
    Inventors: Wataru Sato, Motohiro Yamazaki
  • Publication number: 20210382004
    Abstract: A capillary electrophoresis apparatus is disclosed that does not discharge and achieves both compactness and performance even with a part configuration having insufficient spatial distance or creeping distance. This capillary electrophoresis apparatus is provided with a resistance heater for heating capillaries, an electrode holder that holds capillary electrodes and is connected to a high-voltage unit, and a conductive member that at least partially comprises metal and has been grounded to a low potential. The electrode holder and conductive member are in contact with heat-dissipating rubber disposed there between that composes a structure comprising an insulation member. As a result of this configuration, discharge risk is reduced through the reduction of the potential of parts near the high-voltage unit and the slow reduction of the high potential of the high-voltage unit.
    Type: Application
    Filed: August 19, 2021
    Publication date: December 9, 2021
    Inventors: Taro NAKAZAWA, Motohiro YAMAZAKI, Kenko UCHIDA, Akira FUJII
  • Publication number: 20210356426
    Abstract: Provided is an electrophoresis device for enhancing its analysis performance. In order to achieve the task, the electrophoresis device includes a capillary array constituted by a capillary, a capillary head for bundling an end of the capillary, an electrode holder for holding an electrode provided at the other end of the capillary and a detector provided for the capillary, a first heater for heating the capillary, and an irradiation detection unit for irradiating a light to the detector to detect a fluorescence generated from a fluorescence labelled sample in the capillary. The electrophoresis device further includes a second heater for heating the detector.
    Type: Application
    Filed: October 29, 2018
    Publication date: November 18, 2021
    Inventors: Jin MATSUMURA, Ayaka OKUNO, Ryusuke KIMURA, Takashi ANAZAWA, Michiru FUJIOKA, Wataru SATO, Taro NAKAZAWA, Motohiro YAMAZAKI
  • Patent number: 11150214
    Abstract: The capillary electrophoresis apparatus according to the present invention can maintain the temperature in the longitudinal direction of each of a plurality of capillaries uniformly, such that the separation performance of the capillary electrophoresis apparatus can be stabilized, and the analysis performance can be improved.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: October 19, 2021
    Assignee: Hitachi High-Tech Corporation
    Inventors: Wataru Sato, Motohiro Yamazaki