Patents by Inventor Motohisa Shimizu

Motohisa Shimizu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell cultivation module
    Patent number: 11932841
    Abstract: The present invention provides a cell cultivation module comprising a polymer porous film and a casing that has two or more culture medium inflow/outflow ports and accommodates the polymer porous film, wherein the polymer porous film is a polymer porous film with a three-layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, the average hole diameter of the holes present in the surface layer A is smaller than the average hole diameter of the holes present in the surface layer B, the macrovoid layer has dividing walls that are connected to the surface layers A and B, and a plurality of macrovoids that are surrounded by the dividing walls and the surface layers A and B, the holes in the surface layers A and B are in communication with the macrovoids, and the polymer porous film is accommodated within the casing.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: March 19, 2024
    Assignee: UBE CORPORATION
    Inventors: Masahiko Hagihara, Shinsaku Fuse, Motohisa Shimizu, Yukinori Wada
  • Cell culturing method and kit
    Patent number: 10982186
    Abstract: The present invention relates to a cell culturing method and kit. More specifically, it relates to a cell culturing method and kit using a support that is exposed to the air. It further relates to a method of culturing cells by allowing them to migrate onto a porous polyimide film.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: April 20, 2021
    Assignee: UBE INDUSTRIES, LTD.
    Inventors: Masahiko Hagihara, Motohisa Shimizu, Yukinori Wada
  • Compounds for the treatment of mycobacterial infections
    Patent number: 10766872
    Abstract: The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof:
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: September 8, 2020
    Assignee: The Board Institute, Inc.
    Inventors: Deborah Hung, Sarah Stanley, Tomohiko Kawate, Noriakie Iwase, Motohisa Shimizu
  • Cell culturing method and kit
    Patent number: 10738277
    Abstract: The present invention relates to a cell culturing method and kit. More specifically, it relates to a cell culturing method and kit using a support that is exposed to the air. It further relates to a method of culturing cells by allowing them to migrate onto a porous polyimide film.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: August 11, 2020
    Assignee: UBE INDUSTRIES, LTD.
    Inventors: Masahiko Hagihara, Motohisa Shimizu, Yukinori Wada
  • Method, device and kit for mass cultivation of cells using polyimide porous membrane
    Patent number: 10696943
    Abstract: The present invention pertains to a method for the mass cultivation of cells, and a cell cultivation device and kit. The present invention further pertains to a continuous cell cultivation method and a continuous cell cultivation device in which a carrier is used.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: June 30, 2020
    Assignee: UBE INDUSTRIES, LTD.
    Inventors: Masahiko Hagihara, Motohisa Shimizu, Yukinori Wada
  • Long-term cell-cultivation using polyimide porous membrane and cell-cryopreservation method using polyimide porous membrane
    Patent number: 10626365
    Abstract: The invention relates to a long term cell culturing method and a cell culturing apparatus and kit that employ a porous polyimide film. The invention further relates to a cell cryopreservation method and kit employing the porous polyimide film.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: April 21, 2020
    Assignee: UBE INDUSTRIES, LTD.
    Inventors: Masahiko Hagihara, Motohisa Shimizu, Yukinori Wada
  • Cell culture method using bone marrow-like structure, and porous polyimide film for healing bone injury site
    Patent number: 10590388
    Abstract: The present invention relates to a method for culturing bone marrow cells, in which bone marrow cells are applied to a porous polyimide film and cultured. Moreover, the present invention relates to a porous polyimide film for healing a bone injury site.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: March 17, 2020
    Assignees: UBE INDUSTRIES, LTD., KURUME UNIVERSITY
    Inventors: Keisuke Ohta, Shingo Hirashima, Masahiko Hagihara, Motohisa Shimizu
  • Method of producing substance
    Patent number: 10519478
    Abstract: The present invention relates to a method of using cells to produce a substance, and involves applying the cells to a polyimide porous film, culturing the cells and producing the substance by means of the cells.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: December 31, 2019
    Assignee: UBE INDUSTRIES, LTD.
    Inventors: Masahiko Hagihara, Motohisa Shimizu, Yukinori Wada
  • Cell culture method using bone marrow-like structure, and porous polyimide film for healing bone injury site
    Patent number: 10508264
    Abstract: The present invention relates to a method for culturing bone marrow cells, in which bone marrow cells are applied to a porous polyimide film and cultured. Moreover, the present invention relates to a porous polyimide film for healing a bone injury site.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: December 17, 2019
    Assignees: UBE INDUSTRIES, LTD., KURUME UNIVERSITY
    Inventors: Keisuke Ohta, Shingo Hirashima, Masahiko Hagihara, Motohisa Shimizu
  • Method, device and kit for mass cultivation of cells using polyimide porous membrane
    Patent number: 10479974
    Abstract: The present invention pertains to a method for the mass cultivation of cells, and a cell cultivation device and kit. The present invention further pertains to a continuous cell cultivation method and a continuous cell cultivation device in which a carrier is used.
    Type: Grant
    Filed: January 26, 2016
    Date of Patent: November 19, 2019
    Assignee: UBE INDUSTRIES, LTD.
    Inventors: Masahiko Hagihara, Motohisa Shimizu, Yukinori Wada
  • CELL CULTIVATION MODULE
    Publication number: 20190330581
    Abstract: The present invention provides a cell cultivation module comprising a polymer porous film and a casing that has two or more culture medium inflow/outflow ports and accommodates the polymer porous film, wherein the polymer porous film is a polymer porous film with a three-layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, the average hole diameter of the holes present in the surface layer A is smaller than the average hole diameter of the holes present in the surface layer B, the macrovoid layer has dividing walls that are connected to the surface layers A and B, and a plurality of macrovoids that are surrounded by the dividing walls and the surface layers A and B, the holes in the surface layers A and B are in communication with the macrovoids, and the polymer porous film is accommodated within the casing.
    Type: Application
    Filed: July 25, 2017
    Publication date: October 31, 2019
    Inventors: Masahiko HAGIHARA, Shinsaku FUSE, Motohisa SHIMIZU, Yukinori WADA
  • Long-term cell-cultivation using polyimide porous membrane and cell-cryopreservation method using polyimide porous membrane
    Patent number: 10443037
    Abstract: The invention relates to a long term cell culturing method and a cell culturing apparatus and kit that employ a porous polyimide film. The invention further relates to a cell cryopreservation method and kit employing the porous polyimide film.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: October 15, 2019
    Assignee: UBE INDUSTRIES, LTD.
    Inventors: Masahiko Hagihara, Motohisa Shimizu, Yukinori Wada
  • CELL CULTIVATION DEVICE AND CELL CULTIVATION METHOD USING SAME
    Publication number: 20190276788
    Abstract: The present invention provides a cell cultivation device that is characterized by comprising: a polymer porous film; a cell cultivation part that has the polymer porous film; a shaft that passes through the cell cultivation part; and a cultivation tank in which at least one portion of the cell cultivation part is immersed, wherein the polymer porous film is a polymer porous film with a three-layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, the average hole diameter of the holes present in the surface layer A is smaller than the average hole diameter of the holes present in the surface layer B, the macrovoid layer has dividing walls that are connected to the surface layers A and B, and a plurality of macrovoids that are surrounded by the dividing walls and the surface layers A and B, the holes in the surface layers A and B are in communication with the macrovoids, the cel
    Type: Application
    Filed: July 25, 2017
    Publication date: September 12, 2019
    Inventors: Masahiko HAGIHARA, Shinsaku FUSE, Motohisa SHIMIZU, Yukinori WADA
  • MULTIPLE FLOW PATH CELL CULTIVATION METHOD
    Publication number: 20190270956
    Abstract: Provided are a cell cultivation device comprising a polymer porous film, and a cell cultivation method using said cell cultivation device. The cell cultivation device comprises: two or more levels of parallel or antiparallel flat flow paths; a polymer porous film that is positioned in the flat flow paths; a culture medium supply means that is positioned at one end of the flat flow paths; a culture medium discharge means that is positioned at the other end of the flat flow paths; a head tank that is positioned at an upper section of the flat flow path of the uppermost level; a culture medium distribution means that distributes a culture broth from the head tank to the flat flow paths; and a culture medium recovery means that recovers the culture broth that is discharged from the culture medium discharge means.
    Type: Application
    Filed: July 25, 2017
    Publication date: September 5, 2019
    Inventors: Masahiko HAGIHARA, Shinsaku FUSE, Motohisa SHIMIZU, Yukinori WADA
  • CELL CULTIVATION METHOD, SUSPENDED CELL ELIMINATION METHOD, AND METHOD TO KILL SUSPENDED CELLS
    Publication number: 20190264150
    Abstract: The present invention provides a cell cultivation method that includes: (1) a step in which a first culture medium including suspended cells is applied to a cell cultivation module; (2) a step in which a temperature at which cell cultivation is possible is maintained, and the cells are made to adsorb to the cell cultivation module; and (3) a step in which the cell cultivation module to which the cells are adsorbed is cultivated within a culture vessel with a second culture medium, wherein a polymer porous film is a polymer porous film with a three-layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, the average hole diameter of the holes present in the surface layer A is smaller than the average hole diameter of the holes present in the surface layer B, the macrovoid layer has dividing walls that are connected to the surface layers A and B, and a plurality of macrovoids that
    Type: Application
    Filed: July 25, 2017
    Publication date: August 29, 2019
    Inventors: Masahiko HAGIHARA, Shinsaku FUSE, Motohisa SHIMIZU, Yukinori WADA
  • CELL CULTIVATION DEVICE AND CELL CULTIVATION METHOD USING SAME
    Publication number: 20190241854
    Abstract: The present invention provides a cell cultivation device comprising: a polymer porous film; a cell cultivation part that accommodates the polymer porous film; a culture medium supply means that is positioned at an upper section of the cell cultivation part; and a culture medium recovery means that is positioned at a lower section of the cell cultivation part, wherein the polymer porous film is a polymer porous film with a three-layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, the average hole diameter of the holes present in the surface layer A is smaller than the average hole diameter of the holes present in the surface layer B, the macrovoid layer has dividing walls that are connected to the surface layers A and B, and a plurality of macrovoids that are surrounded by the dividing walls and the surface layers A and B, the holes in the surface layers A and B are in commu
    Type: Application
    Filed: July 25, 2017
    Publication date: August 8, 2019
    Inventors: Masahiko HAGIHARA, Shinsaku FUSE, Motohisa SHIMIZU, Yukinori WADA
  • CELL CULTURE METHOD USING BONE MARROW-LIKE STRUCTURE, AND POROUS POLYIMIDE FILM FOR HEALING BONE INJURY SITE
    Publication number: 20180237750
    Abstract: The present invention relates to a method for culturing bone marrow cells, in which bone marrow cells are applied to a porous polyimide film and cultured. Moreover, the present invention relates to a porous polyimide film for healing a bone injury site.
    Type: Application
    Filed: April 20, 2018
    Publication date: August 23, 2018
    Inventors: Keisuke OHTA, Shingo HIRASHIMA, Masahiko HAGIHARA, Motohisa SHIMIZU
  • LONG-TERM CELL-CULTIVATION USING POLYIMIDE POROUS MEMBRANE AND CELL-CRYOPRESERVATION METHOD USING POLYIMIDE POROUS MEMBRANE
    Publication number: 20180208887
    Abstract: The invention relates to a long term cell culturing method and a cell culturing apparatus and kit that employ a porous polyimide film. The invention further relates to a cell cryopreservation method and kit employing the porous polyimide film.
    Type: Application
    Filed: January 25, 2018
    Publication date: July 26, 2018
    Inventors: Masahiko HAGIHARA, Motohisa SHIMIZU, Yukinori WADA
  • METHOD, DEVICE AND KIT FOR MASS CULTIVATION OF CELLS USING POLYIMIDE POROUS MEMBRANE
    Publication number: 20180163174
    Abstract: The present invention pertains to a method for the mass cultivation of cells, and a cell cultivation device and kit. The present invention further pertains to a continuous cell cultivation method and a continuous cell cultivation device in which a carrier is used.
    Type: Application
    Filed: January 26, 2018
    Publication date: June 14, 2018
    Inventors: Masahiko HAGIHARA, Motohisa SHIMIZU, Yukinori WADA
  • Compounds for the treatment of mycobacterial infections
    Patent number: RE48105
    Abstract: The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof:
    Type: Grant
    Filed: August 14, 2018
    Date of Patent: July 21, 2020
    Assignees: The Broad Institute, Inc., The General Hospital Corporation
    Inventors: Deborah Hung, Sarah Stanley, Tomohiko Kawate, Noriaki Iwase, Motohisa Shimizu