Patents by Inventor Motoo Watanabe

Motoo Watanabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220298479
    Abstract: The present invention discloses a composition of an albumin-free, serum-free medium suited for culturing human hematopoietic stem cells and an albumin-free culturing method. According to the present invention, a method of culturing human hematopoietic stem cells is provided which comprises bringing human hematopoietic stem cells into contact with PVA and a PI3K activator.
    Type: Application
    Filed: September 11, 2020
    Publication date: September 22, 2022
    Applicant: The University of Tokyo
    Inventors: Satoshi YAMAZAKI, Motoo WATANABE, Masatoshi SAKURAI, Hiromitsu NAKAUCHI
  • Patent number: 11432537
    Abstract: The present invention discloses a novel means capable of producing a blood chimeric animal in which a state of retaining blood cells originating in a heterologous animal at a high percentage is sustained for a long period of time. The method for producing a non-human animal that retains blood cells originating in a heterologous animal, according to the present invention, comprises transplanting hematopoietic cells of a heterologous animal into a non-human animal, in which hematopoietic cells the function of a gene that acts on the hematopoietic system is modified, The gene that acts on the hematopoietic system is, for example, Lnk gene, When a medium to large mammal is used as a recipient, the survival rate of hematopoietic cells originating in a heterologous animal is dramatically increased such that blood chimerism of 10% or more can be maintained even in a 16 month old animal.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: September 6, 2022
    Assignees: THE UNIVERSITY OF TOKYO, NATIONAL FEDERATION OF AGRICULTURAL COOPERTIVE ASSOCIATIONS
    Inventors: Kazuo Fukawa, Tetsuya Ito, Mai Kamikawa, Yutaka Sendai, Hiromitsu Nakauchi, Satoshi Yamazaki, Motoo Watanabe
  • Publication number: 20220160789
    Abstract: Provided is an immune cell therapy which uses an iPS technology allowing long-term survival in a living body and which exhibits an excellent antitumor effect by recognition of two antigens. An iPS cell derived from an antigen-specific cytotoxic T cell having a chimeric antigen receptor introduced therein.
    Type: Application
    Filed: April 1, 2020
    Publication date: May 26, 2022
    Applicants: JUNTENDO EDUCATIONAL FOUNDATION, THE UNIVERSITY OF TOKYO
    Inventors: Miki ANDO, Norio KOMATSU, Jun ANDO, Sakiko HARADA, Hiromitsu NAKAUCHI, Tomoyuki YAMAGUCHI, Motoo WATANABE
  • Patent number: 10900092
    Abstract: The invention provides a primer set for detecting Chlamydia trachomatis containing (a) a first primer pair composed of a forward primer consisting of a base sequence represented by SEQ ID NO: 5 and (b) a reverse primer consisting of a base sequence represented by SEQ ID NO: 6, as well as a method for detecting Chlamydia trachomatis using the primer set, and a reagent kit therefor.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: January 26, 2021
    Assignee: FUJIFILM WAKO PURE CHEMICAL CORPORATION
    Inventors: Tatsuya Nakamura, Motoo Watanabe
  • Publication number: 20200315146
    Abstract: The present invention provides a method for preparing a somatic chimera by using a pluripotent cell genetically engineered not to differentiate into a predetermined type of cell. The present invention particularly provides a method for preventing a pluripotent cell from contributing to the brain and gonad in a somatic chimera animal.
    Type: Application
    Filed: October 9, 2018
    Publication date: October 8, 2020
    Applicant: The University of Tokyo
    Inventors: Hiromitsu NAKAUCHI, Hideyuki SATO, Hideki MASAKI, Motoo WATANABE
  • Publication number: 20200315148
    Abstract: The present invention provides a method for producing a chimeric animal using a primed pluripotent stem cell, a tissue stem cell, a progenitor cell, a somatic cell, or a germ cell. The method for producing a chimeric animal according to the present invention comprises introducing a mammal-derived cell into the embryo of a mammal, the cell being primed pluripotent stem cell, tissue stem cell, progenitor cell, somatic cell, or germ cell.
    Type: Application
    Filed: April 24, 2020
    Publication date: October 8, 2020
    Applicants: THE UNIVERSITY OF TOKYO, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Hiromitsu NAKAUCHI, Hideki MASAKI, Motoo WATANABE, Irving WEISSMAN
  • Patent number: 10645912
    Abstract: [Problem to be Solved] The present invention provides a method for producing a chimeric animal using a primed pluripotent stem cell, a tissue stem cell, a progenitor cell, a somatic cell, or a germ cell. [Solution] The method for producing a chimeric animal according to the present invention comprises introducing a mammal-derived cell into the embryo of a mammal, the cell being primed pluripotent stem cell, tissue stem cell, progenitor cell, somatic cell, or germ cell.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: May 12, 2020
    Assignees: THE UNIVERSITY OF TOKYO, THE BOARD OF REGENTS OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Hiromitsu Nakauchi, Hideki Masaki, Motoo Watanabe, Irving Weissman
  • Publication number: 20200137991
    Abstract: The present invention has found that chimeric animals suffer from noticeable inflammation after birth, though neither immune response nor inflammation in the fetal period of these animals has been reported hitherto. This is an unexpected finding since chimeric animals in the fetal period were exclusively analyzed in prior studies and thus it is deemed that immunotolerance has been theoretically established therein. The present invention provides a composition for suppressing immune response or inflammation in the fetal period of a born chimeric animal.
    Type: Application
    Filed: January 25, 2018
    Publication date: May 7, 2020
    Inventors: Hiromitsu NAKAUCHI, Tomoyuki YAMAGUCHI, Sanae HAMANAKA, Hideyuki SATO, Hideki MASAKI, Naoaki MIZUNO, Motoo WATANABE
  • Publication number: 20190112638
    Abstract: The invention provides a primer set for detecting Chlamydia trachomatis containing (a) a first primer pair composed of a forward primer consisting of a base sequence represented by SEQ ID NO: 5 and (b) a reverse primer consisting of a base sequence represented by SEQ ID NO: 6, as well as a method for detecting Chlamydia trachomatis using the primer set, and a reagent kit therefor.
    Type: Application
    Filed: March 27, 2017
    Publication date: April 18, 2019
    Applicant: FUJIFILM WAKO PURE CHEMICAL CORPORATION
    Inventors: Tatsuya NAKAMURA, Motoo WATANABE
  • Publication number: 20180360004
    Abstract: [Problem to be Solved] The present invention provides a method for producing a chimeric animal using a primed pluripotent stem cell, a tissue stem cell, a progenitor cell, a somatic cell, or a germ cell. [Solution] The method for producing a chimeric animal according to the present invention comprises introducing a mammal-derived cell into the embryo of a mammal, the cell being primed pluripotent stem cell, tissue stem cell, progenitor cell, somatic cell, or germ cell.
    Type: Application
    Filed: January 17, 2018
    Publication date: December 20, 2018
    Applicants: THE UNIVERSITY OF TOKYO, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Hiromitsu Nakauchi, Hideki Masaki, Motoo Watanabe, Irving Weissman
  • Publication number: 20180177164
    Abstract: The present invention discloses a novel means capable of producing a blood chimeric animal in which a state of retaining blood cells originating in a heterologous animal, such as a human, at a high percentage is sustained for a long period of time, even in cases where a medium to large domestic animal is used as a recipient. The method for producing a non-human animal that retains blood cells originating in a heterologous animal, according to the present invention, comprises transplanting hematopoietic cells of a heterologous animal into a non-human animal, in which hematopoietic cells the function of a gene that acts on the hematopoietic system is modified. The gene that acts on the hematopoietic system is, for example, Lnk gene.
    Type: Application
    Filed: June 20, 2016
    Publication date: June 28, 2018
    Applicants: National Federation of Agricultural Cooperative Associations, The University of Tokyo
    Inventors: Kazuo FUKAWA, Tetsuya ITO, Mai KAMIKAWA, Yutaka SENDAI, Hiromitsu NAKAUCHI, Satoshi YAMAZAKI, Motoo WATANABE
  • Publication number: 20160073616
    Abstract: [Problem to be Solved] The present invention provides a method for producing a chimeric animal using a primed pluripotent stem cell, a tissue stem cell, a progenitor cell, a somatic cell, or a germ cell. [Solution] The method for producing a chimeric animal according to the present invention comprises introducing a mammal-derived cell into the embryo of a mammal, the cell being primed pluripotent stem cell, tissue stem cell, progenitor cell, somatic cell, or germ cell.
    Type: Application
    Filed: January 29, 2014
    Publication date: March 17, 2016
    Applicants: THE UNIVERSITY OF TOKYO, THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Hiromitsu NAKAUCHI, Hideki MASAKI, Motoo WATANABE, Irving WEISSMAN
  • Patent number: 6587647
    Abstract: A method and system for monitoring and controlling machines, such as printers, copiers, facsimile machine and other image forming machines. A server is used for transmitting and communicating information among machines and computers. The server acquires, after machine installation, reference values and during operation, current condition information. The server evaluates this information with the reference values such that a response to the machine may be executed remotely. The server also may update the reference values which change during operation.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: July 1, 2003
    Assignee: Ricoh Co., Ltd.
    Inventors: Motoo Watanabe, Gregory Wright
  • Patent number: RE43227
    Abstract: A method and system for monitoring and controlling machines, such as printers, copiers, facsimile machine and other image forming machines. A server is used for transmitting and communicating information among machines and computers. The server acquires, after machine installation, reference values and during operation, current condition information. The server evaluates this information with the reference values such that a response to the machine may be executed remotely. The server also may update the reference values which change during operation.
    Type: Grant
    Filed: April 2, 2007
    Date of Patent: March 6, 2012
    Assignee: Ricoh Company, Limited
    Inventors: Motoo Watanabe, Gregory Wright
  • Patent number: RE43257
    Abstract: A method and system for monitoring and controlling machines, such as printers, copiers, facsimile machine and other image forming machines. A server is used for transmitting and communicating information among machines and computers. The server acquires, after machine installation, reference values and during operation, current condition information. The server evaluates this information with the reference values such that a response to the machine may be executed remotely. The server also may update the reference values which change during operation.
    Type: Grant
    Filed: July 1, 2005
    Date of Patent: March 20, 2012
    Assignee: Ricoh Company, Limited
    Inventors: Motoo Watanabe, Gregory Wright