Patents by Inventor Mukesh Kumar Madhra

Mukesh Kumar Madhra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the preparation of eluxadoline
    Patent number: 10822308
    Abstract: The present invention relates to processes for the preparation of eluxadoline and its intermediates.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: November 3, 2020
    Assignee: Sun Pharmaceutical Industries Limited
    Inventors: Kdv Jesunadh, Murad Ismail Inamdar, Mukesh Kumar Madhra
  • PROCESSES FOR THE PREPARATION OF ELUXADOLINE
    Publication number: 20190202793
    Abstract: The present invention relates to processes for the preparation of eluxadoline and its intermediates.
    Type: Application
    Filed: June 23, 2017
    Publication date: July 4, 2019
    Inventors: Kdv JESUNADH, Murad Ismail INAMDAR, Mukesh Kumar MADHRA
  • A PROCESS FOR THE PREPARATION OF ELUXADOLINE
    Publication number: 20190177282
    Abstract: The present invention relates to an improved process for the preparation of eluxadoline and its intermediates and that includes the use of an aqueous surfactant solution in the preparation of N2-[(benzyloxy)carbonyl]-N-(2-oxo-2-phenylethyl)-L-alaninamide, an intermediate in the preparation of eluxadoline.
    Type: Application
    Filed: May 30, 2017
    Publication date: June 13, 2019
    Inventors: Pankaj Kumar SINGH, Mukesh Kumar MADHRA, Mohan PRASAD
  • A PROCESS FOR THE PREPARATION OF TOFACITINIB CITRATE
    Publication number: 20180010158
    Abstract: The present invention provides a process for the preparation of tofacitinib citrate of Formula I. Specifically, the present invention provides an enzymatic route for the preparation of tofacitinib of Formula II, which is converted to tofacitinib citrate of Formula I.
    Type: Application
    Filed: February 22, 2016
    Publication date: January 11, 2018
    Inventors: Somashekar Rudrappa BHANDYA, Mukesh Kumar MADHRA
  • Processes for reducing impurities in lacosamide
    Patent number: 8853453
    Abstract: The present invention relates to processes for reducing impurities in lacosamide during the preparation of lacosamide. The invention provides processes for minimizing or removing impurities such as (2R)-2-(acetylamino)-3-(benzylamino)-3-oxopropyl acetate of Formula II or (2R)-2-propanoylamino-N-benzyl-3-methoxypropionamide of Formula III in lacosamide.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: October 7, 2014
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Hari Mohan Sriram, Mukesh Kumar Madhra, Mukesh Kumar Sharma
  • PROCESSES FOR REDUCING IMPURITIES IN LACOSAMIDE
    Publication number: 20130204042
    Abstract: The present invention relates to processes for reducing impurities in lacosamide during the preparation of lacosamide. The invention provides processes for minimizing or removing impurities such as (2R)-2-(acetylamino)-3-(benzylamino)-3-oxopropyl acetate of Formula II or (2R)-2-propanoylamino-N-benzyl-3-methoxypropionamide of Formula III in lacosamide.
    Type: Application
    Filed: January 31, 2011
    Publication date: August 8, 2013
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Hari Mohan Sriram, Mukesh Kumar Madhra, Mukesh Kumar Sharma
  • PROCESSES FOR PREPARATION OF POLYMORPHIC FORMS OF LACOSAMIDE
    Publication number: 20130085304
    Abstract: The present invention relates to processes for the preparation of crystalline polymorphic forms of lacosamide (Formula I), including processes for inter-conversion among such polymorphic forms.
    Type: Application
    Filed: November 19, 2010
    Publication date: April 4, 2013
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Mukesh Kumar Madhra, Hari Mohan Sriram, Mukesh Kumar Sharma, Satish Chandra Jha
  • Intermediate compounds and their use in preparation of lacosamide
    Patent number: 8378142
    Abstract: The present invention is concerned with novel compounds and their use for the preparation of lacosamide. The present invention also contemplates processes for the preparation of lacosamide employing the novel compound of general Formula II, Formula IIa or Formula IIb as intermediate. Wherein R1 is —OH or —OMe; R2 is —OH or —NH—CH2—C6H5.
    Type: Grant
    Filed: June 7, 2011
    Date of Patent: February 19, 2013
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Mukesh Kumar Madhra, Pankaj Kumar Singh, Chandra Has Khanduri
  • Intermediate compounds and their use in preparation of lacosamide
    Patent number: 8093426
    Abstract: The present invention is concerned with novel compounds and their use for the preparation of lacosamide. The present invention also contemplates processes for the preparation of lacosamide employing the novel compound of general Formula II, Formula IIa or Formula IIb as intermediate. Wherein R1 is —OH or —OMe; R2 is —OH or —NH—CH2—C6H5.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: January 10, 2012
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Mukesh Kumar Madhra, Pankaj Kumar Singh, Chandra Has Khanduri
  • INTERMEDIATE COMPOUNDS AND THEIR USE IN PREPARATION OF LACOSAMIDE
    Publication number: 20120004452
    Abstract: The present invention is concerned with novel compounds and their use for the preparation of lacosamide. The present invention also contemplates processes for the preparation of lacosamide employing the novel compound of general Formula II, Formula IIa or Formula IIb as intermediate. Wherein R1 is —OH or —OMe; R2 is —OH or —NH—CH2—C6H5.
    Type: Application
    Filed: June 7, 2011
    Publication date: January 5, 2012
    Inventors: Mukesh Kumar MADHRA, Pankaj Kumar Singh, Chandra Has Khanduri
  • INTERMEDIATE COMPOUNDS AND THEIR USE IN PREPARATION OF LACOSAMIDE
    Publication number: 20120004462
    Abstract: The present invention is concerned with novel compounds and their use for the preparation of lacosamide. The present invention also contemplates processes for the preparation of lacosamide employing the novel compound of general Formula II, Formula IIa or Formula IIb as intermediate. Wherein R1 is —OH or —OMe; R2 is —OH or —NH—CH2—C6H5.
    Type: Application
    Filed: June 7, 2011
    Publication date: January 5, 2012
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Mukesh Kumar MADHRA, Pankaj Kumar Singh, Chandra Has Khanduri
  • PROCESS FOR THE PREPARATION OF EFAVIRENZ
    Publication number: 20110071287
    Abstract: The present invention relates to a process for the preparation of Efavirenz (Formula I), wherein triphosgene is used as a cyclizing agent.
    Type: Application
    Filed: May 1, 2009
    Publication date: March 24, 2011
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Mukesh Kumar Madhra, Pankaj Kumar Singh, Mukesh Sharma, Chandra Has Khanduri
  • INTERMEDIATE COMPOUNDS AND THEIR USE IN PREPARATION OF LACOSAMIDE
    Publication number: 20090143472
    Abstract: The present invention is concerned with novel compounds and their use for the preparation of lacosamide. The present invention also contemplates processes for the preparation of lacosamide employing the novel compound of general Formula II, Formula IIa or Formula IIb as intermediate. Wherein R1 is —OH or —OMe; R2 is —OH or —NH—CH2—C6H5.
    Type: Application
    Filed: December 3, 2008
    Publication date: June 4, 2009
    Inventors: Mukesh Kumar Madhra, Pankaj Kumar Singh, Chandra Has Khanduri