Patents by Inventor Muneaki Takase
Muneaki Takase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5393889Abstract: A pharmaceutically-acceptable acid addition salt of a bis-dioxopiperazine derivative of the formula (I): ##STR1## which derivative exhibits anti-tumor potency and is water-soluble, wherein R.sup.1 is a C.sub.1-6 alkyl group,R.sup.2 represents a hydrogen atom or: ##STR2## R.sup.3 represents a hydrogen atom, a C.sub.1-6 alkyl group or (CH.sub.2).sub.n A, wherein A respresents carboxyl, benzyloxycarbonyl, mercapto, amino, benzyloxycarbonylamino or: ##STR3## and n is an integer of 1, 2, 3 or 4, and R.sup.4 represents a hydrogen atom or is coupled with R.sup.3 into a 5-membered ring, which may contain one sulfur atom as an additional ring heteroatom.Type: GrantFiled: March 2, 1992Date of Patent: February 28, 1995Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Muneaki Takase, Toshiharu Narita, Toshihiko Komatsu
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Patent number: 5112833Abstract: Novel 1-azaindolizine derivatives having excellent antiallergic action, synthetic intermediates thereof and antiallergic agents containing 1-azaindolizine derivatives.Type: GrantFiled: June 26, 1991Date of Patent: May 12, 1992Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Muneaki Takase, Toshihiko Komatsu, Toshiyuki Matsuno, Akihisa Miyakawa, Kenichi Saito
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Patent number: 4877803Abstract: Novel bis-dioxopiperazine derivatives represented by the following formula (I) and having a broader antitumor spectrum as well as pharmaceutical compositions containing the compounds as antitumor active components: ##STR1## wherein R.sup.1 represents a lower alkyl group; A represents an oxygen atom, a sulfur atom or a group of ##STR2## wherein R.sup.2 represents a hydrogen atom, a lower alkyl group or phenyl; R.sup.3 represents a lower alkyl group, phenyl or benzyl; and X and Y, which are respectively independent and are the same or different, represent a hydrogen atom or a lower alkyl group.Type: GrantFiled: February 24, 1987Date of Patent: October 31, 1989Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Jun-Chao Cai, Muneaki Takase
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Patent number: 4868303Abstract: Novel bis-dioxopiperazine derivatives or pharmaceutically acceptable salts thereof having broader antitumor spectra and represented by the following formula (I): ##STR1## wherein R.sup.1 represents a lower alkyl group;R.sup.2 represents a hydrogen atom or a group of ##STR2## and R.sup.3 represents a lower alkyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted furyl group, a substituted or unsubstituted styryl group or a group of --(CH.sub.2).sub.n --R.sup.4, ##STR3## or --OR.sup.7 in whichR.sup.4 represents a carboxyl group, a substituted or unsubstituted phenyl group or a substituted or unsubstituted phenoxy group,R.sup.5 and R.sup.6 respectively represent a hydrogen atom or a protective group for amino group,R.sup.7 represents a lower alkyl group or a substituted or unsubstituted benzyl group, andn is an integer and 1 or 2.Type: GrantFiled: September 25, 1987Date of Patent: September 19, 1989Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Muneaki Takase, Jun-Chao Cai
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Patent number: 4804668Abstract: A thiazole derivative represented by the formula I, pharmaceutically acceptable acid addition salt thereof, and a process for preparation thereof ##STR1## wherein R.sub.1 represents --COOR.sub.4, ##STR2## or cyano wherein R.sub.4 represents hydrogen or lower alkyl, andR.sub.5 and R.sub.6 may be the same or different and represent hydrogen, lower alkyl, aryl, amino-lower alkyl, N-lower alkylamino-lower alkyl, N,N-di-lower alkylamino-lower alkyl or R.sub.5 and R.sub.6 are joined to form a N-containing heterocyclic group;R.sub.2 represents hydrogen or lower alkyl; andR.sub.3 represents N-containing heterocyclic group.These compounds are useful as cardiotonic agents.Type: GrantFiled: March 27, 1986Date of Patent: February 14, 1989Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Muneaki Takase, Kimitomo Yoshioka, Hiroaki Yamazaki
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Patent number: 4800201Abstract: A novel 1,4-thiazine derivative represented by the formula I, a pharmaceutically acceptable acid addition salt thereof, a process for preparation thereof and a cardiotonic agent comprising it as an effective component; ##STR1## wherein R.sub.1 and R.sub.2 represent respectively hydrogen atom, lower alkyl group, lower alkoxy group, amino group, lower alkyl-amino group, aryl-amino group, hydroxy group, aryl group or 5- or 6-membered heterocyclic residue;R.sub.3 and R.sub.4 represent hydrogen atom or lower alkyl group; andR.sub.5 represents N-containing heterocyclic residue and is not pyridinyl group when R.sub.1 and R.sub.2 represent hydrogen atom and R.sub.3 and R.sub.4 represent hydrogen atom or lower alkyl group.Type: GrantFiled: June 3, 1986Date of Patent: January 24, 1989Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Muneaki Takase, Kimitomo Yoshioka, Hiroaki Yamazaki
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Patent number: 4650799Abstract: Disclosed are novel bis-dioxopiperazine derivatives and non-toxic salts thereof, process for their preparation, antitumor agents comprising them and compositions containing them.Type: GrantFiled: October 25, 1984Date of Patent: March 17, 1987Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Jun-Chao Cai, Muneaki Takase
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Patent number: 4565813Abstract: Disclosed is a novel 1,4-thiazine derivatives represented by the following general formula I and a pharmaceutically acceptable acid addition salt thereof: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 respectively represent a hydrogen atom or a lower alkyl group. Also disclosed are processes for preparation of a novel thiazine derivative represented by the general formula I, which comprise reacting a compound of the general formula III with a compound of the general formula A-X' in a compound containing a pyridinyl group as a solvent to obtain a compound of the general formula II: ##STR2## wherein R.sub.1, R.sub.2 and R.sub.Type: GrantFiled: September 14, 1984Date of Patent: January 21, 1986Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Muneaki Takase, Kimitomo Yoshioka, Hiroaki Yamazaki
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Patent number: 4528188Abstract: A polysaccharide PS-A obtained from plants belonging to the genus Epimedium and having the following physicochemical properties, a process for preparation thereof and use as phylactic and immunostimulating agents comprising the polysaccharide PS-A as an effective component:1. Elementary analysis: C=40.92; H=6.17; Ash=very small;2. Molecular weight: 75,000.+-.25,000 (average molecular weight);3. Decomposition point: 205.degree. C.;4. pH: 7.0 (solution of 100 mg of PS-A in 50 ml of water);5. Specific rotatory power: [.alpha.].sub.D.sup.19 =-23.6.degree. (in H.sub.2 O, c=0.527);6. Infrared absorption spectrum: .nu..sub.max.sup.KBr (cm.sup.-1)/3400, 2900, 1620, 1400, 1230, 1060;7. Ultraviolet absorption spectrum: Maximum absorption is not recognized in the range of 240-400 nm.;8. Outward form: White or faint brown, amorphous powder;9. Solubility:(a) Soluble in water;(b) Insoluble in methanol, ethanol, acetone, ethyl acetate, diethyl ether, hexane and chloroform;10.Type: GrantFiled: December 30, 1982Date of Patent: July 9, 1985Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Susumu Mitsuhashi, Muneaki Takase, Sosuke Yasui, Ichiro Washizawa, Kimitomo Yoshioka
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Patent number: 4501736Abstract: The present invention provides an extract obtained by extracting a plant belonging to the genus Epimedium sp. with a mixed solvent of water and a water-miscible organic solvent or with water, defatting the obtained aqueous extract and collecting a high-molecular compounds-containing fraction from the defatted aqueous extract, a process for preparation of this extract, an antibacterial agent comprising this extract as an effective component and an antibacterial therapy by using this extract.Type: GrantFiled: August 8, 1983Date of Patent: February 26, 1985Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Susumu Mitsuhashi, Muneaki Takase, Sosuke Yasui, Ichiro Washizawa, Kimitomo Yoshioka
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Patent number: 4452786Abstract: Novel condurango glycoside compounds, antitumor agents comprising them and processes for their preparation, compositions containing them and methods of treating tumor with them are disclosed herein in which the novel condurango glycoside compounds are represented by the following formula (I): ##STR1## where X together with the 13 and 14 position carbon atoms is a group selected from the group consisting of ##STR2##Type: GrantFiled: November 2, 1981Date of Patent: June 5, 1984Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Hiroshi Mitsuhashi, Den-ichi Mizuno, Koji Hayashi, Shigeru Abe, Muneaki Takase, Toshiharu Narita
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Patent number: 4410724Abstract: There is provided a process for production of o-(2,6-dichloroanilino)phenylacetic acid or a salt thereof by reacting o-chlorophenylacetic acid or an alkali metal salt thereof with 2,6-dichloroaniline in the presence of a base and at least 0.5 mol of a copper catalyst per mol of o-chlorophenylacetic acid in a polar solvent.Type: GrantFiled: October 16, 1981Date of Patent: October 18, 1983Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Muneaki Takase, Tadahiro Nakamura, Kazuo Kamiya, Toshiyuki Takezawa, Hiroaki Yamazaki, Takashi Iwaki
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Patent number: 4320120Abstract: New extracts of Marsdenia cundurango Reichenbach fil., processes for preparing them, antitumor agents comprising them, compositions containing them and methods of treating tumor with them are described herein in which the extracts consist essentially of the portion of Marsdenia cundurango Reichenbach fil. which is soluble in lower alcohols and in chlorinated hydrocarbons other than carbon tetrachloride and insoluble in carbon tetrachloride or aromatic hydrocarbons.Type: GrantFiled: August 18, 1980Date of Patent: March 16, 1982Assignee: Zenyaku Kogyo Kabushiki KaishaInventors: Hiroshi Mitsuhashi, Den-ichi Mizuno, Koji Hayashi, Shigeru Abe, Muneaki Takase, Toshiharu Narita
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Patent number: 4044713Abstract: A coating apparatus for manufacturing of solid particles with digestive tracts-soluble film by rolling water-containing solid particles at high speed, adding a coating liquid and drying them simultaneously. Particles are disposed in a generally annular volume and supported on a generally rotary disk which is closely confined within a fixed cylinder and closely spaced from an inner fixed cylinder; said cylinder forming said annular volume. Partition means adjustably spaced from said plate, divide said volume into separate coating, water feed and drying chambers. The partitions form a sealing relationship with the particles.Type: GrantFiled: August 29, 1975Date of Patent: August 30, 1977Assignee: Zenyaku Kogyo Kabushiki KaishaInventor: Muneaki Takase
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Patent number: 3968277Abstract: A coating process and apparatus for manufacturing of solid particles with digestive tracts-soluble film by rolling water-containing solid particles at high speed, adding a coating liquid and drying them simultaneously.Type: GrantFiled: February 20, 1974Date of Patent: July 6, 1976Assignee: Zenyaku Kogyo Kabushiki KaishaInventor: Muneaki Takase