Patents by Inventor Munehisa Shimamura

Munehisa Shimamura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200023045
    Abstract: Provided is an immunogenic composition comprising an antigenic peptide capable of inducing production of a neutralizing antibody against S100A9 and a carrier protein. The immunogenic composition can be used as a highly safe antithrombotic vaccine having antithrombotic effect without a long-term bleeding risk and is useful for the prevention of a disease associated with thrombus formation in which platelet aggregation is involved, particularly for the prevention of recurrent ischemic stroke.
    Type: Application
    Filed: February 20, 2018
    Publication date: January 23, 2020
    Applicants: OSAKA UNIVERSITY, FUNPEP CO., LTD.
    Inventors: Munehisa SHIMAMURA, Tomohiro KAWANO, Hironori NAKAGAMI, Ryuichi MORISHITA, Hideki MOCHIZUKI, Akiko TENMA, Takako EHARA
  • Patent number: 10517926
    Abstract: Provided is an oligopeptide having preventive and therapeutic effects on infarction diseases. The oligopeptide contains a DE loop sequence of RANKL protein, and has inhibitory activity on proinflammatory cytokine secretion from cells.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: December 31, 2019
    Assignee: Osaka University
    Inventors: Munehisa Shimamura, Hironori Nakagami, Hitomi Kurinami, Ryuichi Morishita
  • Publication number: 20190365859
    Abstract: The present invention provides a preventive or therapeutic agent for an inflammatory skin disease, such as psoriasis, the agent comprising an oligopeptide as an active ingredient. More specifically, the invention provides a preventive or therapeutic agent for an inflammatory skin disease, the agent comprising an oligopeptide consisting of an amino acid sequence containing a DE loop sequence of RANKL protein and a ?-strand D sequence of RANKL protein placed adjacent to the N-terminal side of the DE loop sequence.
    Type: Application
    Filed: November 7, 2017
    Publication date: December 5, 2019
    Inventors: Munehisa Shimamura, Hironori Nakagami, Yuka Ikeda, Ryuichi Morishita, Hiroshi Koriyama
  • Publication number: 20180147259
    Abstract: Provided is an oligopeptide having preventive and therapeutic effects on infarction diseases. The oligopeptide contains a DE loop sequence of RANKL protein, and has inhibitory activity on proinflammatory cytokine secretion from cells.
    Type: Application
    Filed: May 16, 2016
    Publication date: May 31, 2018
    Inventors: Munehisa Shimamura, Hironori Nakagami, Hitomi Kurinami, Ryuichi Morishita
  • Publication number: 20090082263
    Abstract: It is intended to provide a novel remedy for improving the brain function or preventing the same from worsening and a novel administration method for the remedy. Namely, a composition for preventing the brain function from worsening or improving the brain function which contains a cell growth factor. It is preferred that this cell growth factor is one selected from the group consisting of vascular endothelial growth factors (VEGFs), fibroblast growth factors (FGFs) and hepatocyte growth factors (HGFs). A method for preventing the brain function from worsening or improving the brain function which comprises the step of administering a cell growth factor to a patient.
    Type: Application
    Filed: July 29, 2005
    Publication date: March 26, 2009
    Applicant: AnGes, MG, Inc.
    Inventors: Yasufumi Kaneda, Ryuichi Morishita, Munehisa Shimamura
  • Patent number: 7504098
    Abstract: The object of the present invention is to provide a method of efficient delivery into a brain and central nervous system, and to provide a method of efficient delivery with a viral envelope. The present invention provides a system for introducing a biomolecule into a cell comprising A) a biomolecule; B) a viral envelope; and C) glycosaminoglycan. Further, the present invention provides a method for delivering a biomolecule into a brain, comprising the steps of: A) transiently closing an artery of the head portion or cervical portion; and B) introducing a biomolecule into the brain during the closing of the artery of the head portion or the cervical portion.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: March 17, 2009
    Assignee: AnGes MG, Inc.
    Inventors: Yasufumi Kaneda, Ryuichi Morishita, Munehisa Shimamura
  • Publication number: 20080213348
    Abstract: The present invention provides novel methods for treating cerebrovascular disorders, in which HGF is overexpressed by introducing an HGF gene. The methods of this invention using an HGF gene enable active treatment of cerebrovascular disorders, such as cerebral infarction, by gene transfer, and enable the maintenance of neuronal function and the suppression of infarcted areas in patients for whom appropriate treatment methods were unavailable until now.
    Type: Application
    Filed: January 24, 2008
    Publication date: September 4, 2008
    Inventors: Ryuichi Morishita, Munehisa Shimamura
  • Publication number: 20060074036
    Abstract: The present invention provides novel methods for treating cerebrovascular disorders, in which HGF is overexpressed by introducing an HGF gene. The methods of this invention using an HGF gene enable active treatment of cerebrovascular disorders, such as cerebral infarction, by gene transfer, and enable the maintenance of neuronal function and the suppression of infarcted areas in patients for whom appropriate treatment methods were unavailable until now.
    Type: Application
    Filed: June 3, 2003
    Publication date: April 6, 2006
    Inventors: Ryuichi Morishita, Munehisa Shimamura
  • Publication number: 20060002894
    Abstract: The object of the present invention is to provide a method of efficient delivery into a brain and central nervous system, and to provide a method of efficient delivery with a viral envelope. The present invention provides a system for introducing a biomolecule into a cell comprising A) a biomolecule; B) a viral envelope; and C) glycosaminoglycan. Further, the present invention provides a method for delivering a biomolecule into a brain, comprising the steps of: A) transiently closing an artery of the head portion or cervical portion; and B) introducing a biomolecule into the brain during the closing of the artery of the head portion or the cervical portion.
    Type: Application
    Filed: February 25, 2005
    Publication date: January 5, 2006
    Inventors: Yasufumi Kaneda, Ryuichi Morishita, Munehisa Shimamura