Patents by Inventor Munira F. FOUZ

Munira F. FOUZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced biomolecule detection assays based on tyramide signal amplification and gammaPNA probes
    Patent number: 11124822
    Abstract: Provided herein are methods of detecting target analytes, such as nucleic acids, for example microRNAs using an enhanced Tyramide Signal Amplification (TSA) method that employs probes tagged with tyramide-binding groups to amplify the effects of the TSA. The accessibility of the tyramide-binding groups, such as hydroxyphenyl groups, provides for large improvements in signal due to faster reaction with the radicals. The present invention further includes the application of the assay for detecting specific microRNAs.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: September 21, 2021
    Assignee: Carnegie Mellon University
    Inventors: Bruce Alan Armitage, Veronica Hinman, Munira F. Fouz
  • Nucleic acid-polymer conjugates for bright fluorescent tags
    Patent number: 10982266
    Abstract: A composition includes a polymer including extending chains, side chains, or branches. One (or more) of a plurality of a first strand of nucleic acid is attached to each of a plurality of the side chains. One (or more) of a plurality of a second strand of nucleic acid, which is complementary to the first strand of nucleic acid, is complexed to each of the plurality of the first strand of nucleic acid to form a double strand of nucleic acid on each of the plurality of the side chains. At least one fluorescent compound is associated with the double strand of nucleic acid on each of the plurality of the side chains.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: April 20, 2021
    Assignee: CARNEGIE MELLON UNIVERSITY
    Inventors: Munira F. Fouz, Krzysztof Matyjaszewski, Bruce A. Armitage, Subha Ranjan Das, Saadyah Averick
  • NUCLEIC ACID-POLYMER CONJUGATES FOR BRIGHT FLUORESCENT TAGS
    Publication number: 20180142288
    Abstract: A composition includes a polymer including extending chains, side chains, or branches. One (or more) of a plurality of a first strand of nucleic acid is attached to each of a plurality of the side chains. One (or more) of a plurality of a second strand of nucleic acid, which is complementary to the first strand of nucleic acid, is complexed to each of the plurality of the first strand of nucleic acid to form a double strand of nucleic acid on each of the plurality of the side chains. At least one fluorescent compound is associated with the double strand of nucleic acid on each of the plurality of the side chains.
    Type: Application
    Filed: November 2, 2017
    Publication date: May 24, 2018
    Inventors: Munira F. Fouz, Krzysztof Matyjaszewski, Bruce A. Armitage, Subha Ranjan Das, Saadyah Averick
  • Enhanced Biomolecule Detection Assays Based on Tyramide Signal Amplification and gammaPNA Probes
    Publication number: 20170226572
    Abstract: Provided herein are methods of detecting target analytes, such as nucleic acids, for example microRNAs using an enhanced Tyramide Signal Amplification (TSA) method that employs probes tagged with tyramide-binding groups to amplify the effects of the TSA. The accessibility of the tyramide-binding groups, such as hydroxyphenyl groups, provides for large improvements in signal due to faster reaction with the radicals. The present invention further includes the application of the assay for detecting specific microRNAs.
    Type: Application
    Filed: October 16, 2015
    Publication date: August 10, 2017
    Inventors: Bruce Alan ARMITAGE, Veronica HINMAN, Munira F. FOUZ