Patents by Inventor Nadine Garcel

Nadine Garcel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060257321
    Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.
    Type: Application
    Filed: June 1, 2006
    Publication date: November 16, 2006
    Applicant: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, Nadine Garcel, Pascal Grenier, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
  • Patent number: 7083778
    Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.
    Type: Grant
    Filed: March 12, 2003
    Date of Patent: August 1, 2006
    Assignee: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, Nadine Garcel, legal representative, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Pascal Grenier, deceased
  • Publication number: 20060034771
    Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.
    Type: Application
    Filed: September 22, 2005
    Publication date: February 16, 2006
    Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Maria Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
  • Publication number: 20050207980
    Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.
    Type: Application
    Filed: March 22, 2005
    Publication date: September 22, 2005
    Applicant: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
  • Patent number: 6896875
    Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: May 24, 2005
    Assignee: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Pascal Grenier
  • Patent number: 6881397
    Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.
    Type: Grant
    Filed: February 4, 2002
    Date of Patent: April 19, 2005
    Assignee: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, Nadine Garcel, Jèróme Puginier, Marie-Bernadette Barrau, Pascal Grenier
  • Publication number: 20050058605
    Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.
    Type: Application
    Filed: October 13, 2004
    Publication date: March 17, 2005
    Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau
  • Publication number: 20030194376
    Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.
    Type: Application
    Filed: January 6, 2003
    Publication date: October 16, 2003
    Applicant: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
  • Publication number: 20030185759
    Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.
    Type: Application
    Filed: January 6, 2003
    Publication date: October 2, 2003
    Applicant: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
  • Publication number: 20030175211
    Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.
    Type: Application
    Filed: March 12, 2003
    Publication date: September 18, 2003
    Applicant: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Nadine Garcel
  • Publication number: 20030064030
    Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.
    Type: Application
    Filed: March 22, 2002
    Publication date: April 3, 2003
    Inventors: Michel Schneider, Feng Yan, Nadine Garcel, Pascal Grenier, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva hybl, Daniel Bichon
  • Publication number: 20030017109
    Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.
    Type: Application
    Filed: August 23, 2002
    Publication date: January 23, 2003
    Inventors: Michel Schneider, Feng Yan, Pascal Greiner, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
  • Publication number: 20020150538
    Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.
    Type: Application
    Filed: February 4, 2002
    Publication date: October 17, 2002
    Applicant: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau
  • Publication number: 20010024640
    Abstract: Gas filled microbubble and microballoon suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles and microballoons used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are disclosed that have advantageous properties. Dry formulations useful in making the contrast agents are also disclosed.
    Type: Application
    Filed: December 27, 2000
    Publication date: September 27, 2001
    Inventors: Michel Schneider, Daniel Bichon, Philippe Bussat, Jerome Puginier, Eva Hybl, Feng Yan, Pascal Grenier, Nadine Garcel, Marie-Bernadette Barrau
  • Publication number: 20010012507
    Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.
    Type: Application
    Filed: September 22, 1999
    Publication date: August 9, 2001
    Inventors: MICHEL SCHNEIDER, FENG YAN, PASCAL GRENIER, NADINE GARCEL, JEROME PUGINIER, MARIE-BERNADETTE BARRAU, PHILIPPE BUSSAT, EVA HYBL, DANIEL BICHON
  • Publication number: 20010001657
    Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.
    Type: Application
    Filed: April 4, 1997
    Publication date: May 24, 2001
    Inventors: MICHEL SCHNEIDER, FENG YAN, PASCAL GRENIER, NADINE GARCEL, JEROME PUGINIER, MARIE-BERNADETTE BARRAU
  • Patent number: RE39146
    Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.
    Type: Grant
    Filed: July 15, 1998
    Date of Patent: June 27, 2006
    Assignee: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Pascal Grenier