Patents by Inventor Nadine Garcel
Nadine Garcel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20060257321Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.Type: ApplicationFiled: June 1, 2006Publication date: November 16, 2006Applicant: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Nadine Garcel, Pascal Grenier, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
-
Patent number: 7083778Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.Type: GrantFiled: March 12, 2003Date of Patent: August 1, 2006Assignee: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Nadine Garcel, legal representative, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Pascal Grenier, deceased
-
Publication number: 20060034771Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.Type: ApplicationFiled: September 22, 2005Publication date: February 16, 2006Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Maria Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
-
Publication number: 20050207980Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.Type: ApplicationFiled: March 22, 2005Publication date: September 22, 2005Applicant: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
-
Patent number: 6896875Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.Type: GrantFiled: August 23, 2002Date of Patent: May 24, 2005Assignee: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Pascal Grenier
-
Patent number: 6881397Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.Type: GrantFiled: February 4, 2002Date of Patent: April 19, 2005Assignee: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Nadine Garcel, Jèróme Puginier, Marie-Bernadette Barrau, Pascal Grenier
-
Publication number: 20050058605Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.Type: ApplicationFiled: October 13, 2004Publication date: March 17, 2005Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau
-
Publication number: 20030194376Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.Type: ApplicationFiled: January 6, 2003Publication date: October 16, 2003Applicant: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
-
Publication number: 20030185759Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.Type: ApplicationFiled: January 6, 2003Publication date: October 2, 2003Applicant: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
-
Publication number: 20030175211Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.Type: ApplicationFiled: March 12, 2003Publication date: September 18, 2003Applicant: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Nadine Garcel
-
Publication number: 20030064030Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.Type: ApplicationFiled: March 22, 2002Publication date: April 3, 2003Inventors: Michel Schneider, Feng Yan, Nadine Garcel, Pascal Grenier, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva hybl, Daniel Bichon
-
Publication number: 20030017109Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.Type: ApplicationFiled: August 23, 2002Publication date: January 23, 2003Inventors: Michel Schneider, Feng Yan, Pascal Greiner, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon
-
Publication number: 20020150538Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.Type: ApplicationFiled: February 4, 2002Publication date: October 17, 2002Applicant: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Pascal Grenier, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau
-
Publication number: 20010024640Abstract: Gas filled microbubble and microballoon suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles and microballoons used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are disclosed that have advantageous properties. Dry formulations useful in making the contrast agents are also disclosed.Type: ApplicationFiled: December 27, 2000Publication date: September 27, 2001Inventors: Michel Schneider, Daniel Bichon, Philippe Bussat, Jerome Puginier, Eva Hybl, Feng Yan, Pascal Grenier, Nadine Garcel, Marie-Bernadette Barrau
-
Publication number: 20010012507Abstract: Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain surfactants and, optionally, hydrophilic stabilizers. The surfactants can be in the form of liposomes. The suspensions are obtained by exposing the surfactants to air or a gas before or after admixing with an aqueous phase. One can impart outstanding resistance against collapse under pressure to these gas-filled microbubbles used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003. Contrast agents with particular mixtures of gases are also disclosed that have advantageous properties.Type: ApplicationFiled: September 22, 1999Publication date: August 9, 2001Inventors: MICHEL SCHNEIDER, FENG YAN, PASCAL GRENIER, NADINE GARCEL, JEROME PUGINIER, MARIE-BERNADETTE BARRAU, PHILIPPE BUSSAT, EVA HYBL, DANIEL BICHON
-
Publication number: 20010001657Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.Type: ApplicationFiled: April 4, 1997Publication date: May 24, 2001Inventors: MICHEL SCHNEIDER, FENG YAN, PASCAL GRENIER, NADINE GARCEL, JEROME PUGINIER, MARIE-BERNADETTE BARRAU
-
Patent number: RE39146Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.Type: GrantFiled: July 15, 1998Date of Patent: June 27, 2006Assignee: Bracco International B.V.Inventors: Michel Schneider, Feng Yan, Nadine Garcel, Jerome Puginier, Marie-Bernadette Barrau, Philippe Bussat, Eva Hybl, Daniel Bichon, Pascal Grenier