Patents by Inventor Nam-Hai Chua
Nam-Hai Chua has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230184684Abstract: The present invention relates to the use of a Raman spectral signature of nitrate, as a biomarker for an early, real-time diagnosis of nitrogen status in growing plants in a non-invasive or non-destructive way in order to detect nitrogen deficiency before the onset of any visible symptoms. The early, real-time diagnosis of nitrogen deficiency in plants makes it possible to correct nitrogen deficiency for the avoidance of negative effects on the yield and biomass of growing plants or leafy vegetables.Type: ApplicationFiled: May 20, 2021Publication date: June 15, 2023Applicants: TEMASEK LIFE SCIENCES LABORATORY LIMITED, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Bong Soo PARK, Rajeev J. RAM, Chung Hao HUANG, Gajendra Pratap SINGH, Nam-Hai CHUA
-
Patent number: 10100321Abstract: The present invention relates to the field of plant molecular biology, more particularly cotton WRINKLED 1-like (WREL) genes. More specifically, the present invention relates to cotton WRIL genes whose products act as transcription factors of genes involved in fatty acid biosynthesis. The present invention also relates to methods of increasing cotton fiber length in cotton. In one embodiment, the methods involve modulating the level of activity of an enzyme involved in a fatty acid biosynthesis in the host cotton cell and/or culturing the host cotton cell. In another embodiment, the methods involve the manipulation of transcription factors which can regulate an enzyme involved in fatty acid biosynthesis.Type: GrantFiled: April 19, 2012Date of Patent: October 16, 2018Assignee: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: Nam-Hai Chua, Jian Ye, Jing Qu
-
Patent number: 10017774Abstract: The present invention relates to the field of controlling pests, such as insects, using a virus to express pest genes in hosts. More specifically, the present invention relates to a method for rapidly screening for pest genes which can lead to mortality of the pest when the pest has ingested host tissues expressing virus-linked pest gene sequences. The present invention also relates to a method for controlling pests by viral expression of target pest sequences to modify endogenous expression of pest genes in cells or tissues of the pest.Type: GrantFiled: September 15, 2010Date of Patent: July 10, 2018Assignee: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: Jian Ye, Nam-Hai Chua, Jing Qu, Shi-Qiang Gao
-
Publication number: 20170306346Abstract: The present invention provides methods and compositions for modulating drought tolerance and/or other agronomic traits in plants. This invention relates to compositions and methods for down-regulating the level and/or activity of PUB10 in plants for creation of plants with improved abiotic stress tolerance, preferably improved drought tolerance. Thus, in one aspect, the present invention provides an isolated nucleic acid comprising a polynucleotide sequence for use in a recombinant DNA construct or a suppression DNA construct for modulating PUB10 expression.Type: ApplicationFiled: November 10, 2015Publication date: October 26, 2017Applicant: THE ROCKEFELLER UNIVERSITYInventors: Nam-Hai CHUA, Choonkyun JUNG, Pingzhi ZHAO
-
Publication number: 20170183672Abstract: The present invention relates to processes for the transformation of plant tissues with a genetic construct which comprises a transgene and a selection gene. The selection gene preferably encodes an auxin biosynthetic polypeptide, thus allowing for selection of transformed plants on media lacking plant auxins. The invention particularly relates to processes wherein the selection step is carried out under a light/dark cycle.Type: ApplicationFiled: April 17, 2015Publication date: June 29, 2017Inventors: Simon Geir Møller, Aisling Dunne, Nam-Hai Chua
-
Patent number: 9650644Abstract: The present invention relates to the field of plant molecular biology and gene silencing. More particularly, the present invention relates to gene silencing of Sugar-dependent 1 (JcSDP1) in Jatropha curcas. JcSDP1 encodes a patatin-domain triacylglyerol lipase. Silencing of JcSDP1 enhances seed oil accumulation in J. curcas.Type: GrantFiled: February 25, 2014Date of Patent: May 16, 2017Assignee: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: Nam-Hai Chua, Mi Jung Kim, Seong Wook Yang
-
Publication number: 20160115494Abstract: The present invention relates to transcriptional gene activation. More specifically, the present invention relates to the methylation of the gene body using inverted repeat RNAs which results in the activation of gene expression without changing the tempo-spatial regulatory patterns of the gene expression.Type: ApplicationFiled: October 27, 2014Publication date: April 28, 2016Applicant: THE ROCKEFELLER UNIVERSITYInventors: Nam-Hai CHUA, Shulin DENG
-
Publication number: 20160010097Abstract: The present invention relates to the field of plant molecular biology and gene silencing. More particularly, the present invention relates to gene silencing of Sugar-dependent 1 (JcSDP1) in Jatropha curcas. JcSDP1 encodes a patatin-domain triacylglyerol lipase. Silencing of JcSDP1 enhances seed oil accumulation in J. curcas.Type: ApplicationFiled: February 25, 2014Publication date: January 14, 2016Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: Nam-Hai CHUA, Mi Jung KIM, Seong Wook YANG
-
Publication number: 20150329860Abstract: The present invention relates to transcriptional gene silencing (TGS) of endogenes in plants, plant tissue and plant cells. More specifically, the present invention relates to nucleic acid constructs that are capable of more effectively silencing genes of interest, such as endogenes, in plants, plant tissue and plant cells by TGS. The present invention further relates to methods of more effectively reducing endogenous gene expression in plants, plant tissues or plant cells by TGS using the nucleic acid constructs of the invention.Type: ApplicationFiled: December 17, 2013Publication date: November 19, 2015Applicant: THE ROCKEFELLER UNIVERSITYInventors: Nam-Hai CHUA, Qiwen NIU, Shulin DENG
-
Publication number: 20150252375Abstract: The present invention relates to transcriptional gene silencing (TGS) of endogenes in plants, plant tissue and plant cells. More specifically, the present invention relates to nucleic acid constructs that are capable of TGS of endogenes in plants, plant tissue and plant cells. The present invention further relates to methods of reducing endogenous gene expression in plants, plant tissues or plant cells by TGS using the nucleic acid constructs of the invention.Type: ApplicationFiled: August 27, 2013Publication date: September 10, 2015Applicant: THE ROCKEFELLER UNIVERSITYInventors: Nam-Hai Chua, Shulin Deng, Hongzheng Dai, Qi-Wen Niu, Huan Wang, Catalina Arenas Huertero
-
Publication number: 20150159157Abstract: The invention provides methods and compositions useful in target sequence suppression, target sequence validation and target sequence down regulation. The invention provides polynucleotide constructs useful for gene silencing or RNA down regulation, as well as cells, plants and seeds comprising the polynucleotides. The invention also provides a method for using microRNA to silence a target sequence or to down regulate RNA.Type: ApplicationFiled: February 20, 2015Publication date: June 11, 2015Applicant: THE ROCKEFELLER UNIVERSITYInventors: Jose L. REYES-TABOADA, Xiuren ZHANG, Takashi SOYANO, Nam-Hai CHUA, Qi-Wen NIU, Shih-Shun LIN
-
Publication number: 20150074847Abstract: The present invention provides compositions and methods for enhancing protein stability in transgenic plants. The compositions are nucleic acid constructs which encode fusion proteins, fusion proteins, transgenic plant cells and transgenic plants. A fusion protein in accordance with the present invention comprises a protein of interest and a UBA1 or UBA2 domain of an Arabidopsis RAD23 protein. The methods use the nucleic acid constructs to produce fusion proteins in transgenic plant cells or transgenic plants. The fusion proteins have greater stability than the protein of interest and have the same function as the proteins of interest.Type: ApplicationFiled: March 13, 2013Publication date: March 12, 2015Applicant: THE ROCKEFELLER UNIVERSITYInventors: Nam-Hai Chua, In Cheol Jang, Qiwen Niu, Shulin Deng
-
Publication number: 20150074853Abstract: The present invention relates to the field of plant molecular biology, more particularly cotton WRINKLED 1-like (WREL) genes. More specifically, the present invention relates to cotton WRIL genes whose products act as transcription factors of genes involved in fatty acid biosynthesis. The present invention also relates to methods of increasing cotton fiber length in cotton. In one embodiment, the methods involve modulating the level of activity of an enzyme involved in a fatty acid biosynthesis in the host cotton cell and/or culturing the host cotton cell. In another embodiment, the methods involve the manipulation of transcription factors which can regulate an enzyme involved in fatty acid biosynthesis.Type: ApplicationFiled: April 19, 2012Publication date: March 12, 2015Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: Nam-Hai Chua, Jian Ye, Jing Qu
-
Patent number: 8975471Abstract: The invention provides methods and compositions useful in target sequence suppression, target sequence validation and target sequence down regulation. The invention provides polynucleotide constructs useful for gene silencing or RNA down regulation, as well as cells, plants and seeds comprising the polynucleotides. The invention also provides a method for using microRNA to silence a target sequence or to down regulate RNA.Type: GrantFiled: October 12, 2005Date of Patent: March 10, 2015Assignee: The Rockefeller UniversityInventors: Jose L. Reyes Taboada, Xiuren Zhang, Takashi Soyano, Nam-Hai Chua, Qi-Wen Niu, Shih-Shun Lin
-
Publication number: 20150033414Abstract: The present invention relates to the field of modifying Jatropha branching, flowering time, fruiting and seed setting. More specifically, the present invention relates to a method for control and optimization of Jatropha curcas flowering time, fruiting and seed production by manipulating one gene from Jatropha. The present invention can be used in various Jatropha breeding efforts.Type: ApplicationFiled: February 27, 2013Publication date: January 29, 2015Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITEDInventors: Nam-Hai Chua, Jian Ye, Yun-Feng Geng, Bipei Zhang
-
Patent number: 8921655Abstract: The present invention relates to the field of functional analysis of Jatropha genes on a genomic scale. More specifically, the present invention relates to a method for high-throughtput functional analysis of Jatropha curcas genes on a genomic scale using virus-induced gene silencing. The method involves use of the tobacco rattle virus (TRV).Type: GrantFiled: December 16, 2009Date of Patent: December 30, 2014Assignee: Joil (S) Pte Ltd.Inventors: Jian Ye, Nam Hai Chua, Jing Qu
-
Patent number: 8853493Abstract: The invention relates to the functional analysis of genes in cotton by employing the Virus Induced Gene Silencing (VIGS) method. More specifically this method induces gene silencing in cotton with the help of the Tobacco Rattle Virus (TRV) vectors RNA1 and RNA2 and phenotypic effects on the cotton plant can be analysed Moreover this invention also provides transient expression vector TRV RNA2 in order to transiently express genes in cotton plants and plant tissue under the influence of a strong subgenomic promoter.Type: GrantFiled: June 10, 2010Date of Patent: October 7, 2014Assignee: Temasek Life Sciences Laboratory LimitedInventors: Jian Ye, Nam Hai Chua, Jing Qu, Yun Feng Geng, Yun Ping Bu
-
Patent number: 8852928Abstract: The present invention relates generally to chemical-inducible system and to methods of use in transgenic animals. More specifically, the present invention relates to a chimeric transcription factor that binds to a ligand and functions in ligand-dependent manner to induce expression of genes of interest under the control of a synthetic operator-promoter sequence. The expression of genes of interest can be tightly controlled by adding or removing the ligand.Type: GrantFiled: July 2, 2008Date of Patent: October 7, 2014Assignee: Temasek Life Sciences Laboratory LimitedInventors: Alexander Emelyanov, Sergey Parinov, Nam-Hai Chua
-
Patent number: 8686223Abstract: The present invention relates to methods for the regeneration and Agrobacterium-mediated transformation of plants in the genera of Jatropha, more specifically, in Jatropha curcas.Type: GrantFiled: July 3, 2012Date of Patent: April 1, 2014Assignee: Joil (S) Pte Ltd.Inventors: Hui Zhu Mao, Jian Ye, Nam Hai Chua
-
Patent number: 8609418Abstract: The present invention relates to methods for the regeneration and Agrobacterium-mediated transformation of plants in the genera of Jatropha, more specifically, in Jatropha curcas.Type: GrantFiled: December 15, 2009Date of Patent: December 17, 2013Assignee: Joil (S) Pte Ltd.Inventors: Hui Zhu Mao, Jian Ye, Nam Hai Chua