Patents by Inventor Nam-Hai Chua

Nam-Hai Chua has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10100321
    Abstract: The present invention relates to the field of plant molecular biology, more particularly cotton WRINKLED 1-like (WREL) genes. More specifically, the present invention relates to cotton WRIL genes whose products act as transcription factors of genes involved in fatty acid biosynthesis. The present invention also relates to methods of increasing cotton fiber length in cotton. In one embodiment, the methods involve modulating the level of activity of an enzyme involved in a fatty acid biosynthesis in the host cotton cell and/or culturing the host cotton cell. In another embodiment, the methods involve the manipulation of transcription factors which can regulate an enzyme involved in fatty acid biosynthesis.
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: October 16, 2018
    Assignee: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Nam-Hai Chua, Jian Ye, Jing Qu
  • Patent number: 10017774
    Abstract: The present invention relates to the field of controlling pests, such as insects, using a virus to express pest genes in hosts. More specifically, the present invention relates to a method for rapidly screening for pest genes which can lead to mortality of the pest when the pest has ingested host tissues expressing virus-linked pest gene sequences. The present invention also relates to a method for controlling pests by viral expression of target pest sequences to modify endogenous expression of pest genes in cells or tissues of the pest.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: July 10, 2018
    Assignee: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Jian Ye, Nam-Hai Chua, Jing Qu, Shi-Qiang Gao
  • Publication number: 20170306346
    Abstract: The present invention provides methods and compositions for modulating drought tolerance and/or other agronomic traits in plants. This invention relates to compositions and methods for down-regulating the level and/or activity of PUB10 in plants for creation of plants with improved abiotic stress tolerance, preferably improved drought tolerance. Thus, in one aspect, the present invention provides an isolated nucleic acid comprising a polynucleotide sequence for use in a recombinant DNA construct or a suppression DNA construct for modulating PUB10 expression.
    Type: Application
    Filed: November 10, 2015
    Publication date: October 26, 2017
    Applicant: THE ROCKEFELLER UNIVERSITY
    Inventors: Nam-Hai CHUA, Choonkyun JUNG, Pingzhi ZHAO
  • Publication number: 20170183672
    Abstract: The present invention relates to processes for the transformation of plant tissues with a genetic construct which comprises a transgene and a selection gene. The selection gene preferably encodes an auxin biosynthetic polypeptide, thus allowing for selection of transformed plants on media lacking plant auxins. The invention particularly relates to processes wherein the selection step is carried out under a light/dark cycle.
    Type: Application
    Filed: April 17, 2015
    Publication date: June 29, 2017
    Inventors: Simon Geir Møller, Aisling Dunne, Nam-Hai Chua
  • Patent number: 9650644
    Abstract: The present invention relates to the field of plant molecular biology and gene silencing. More particularly, the present invention relates to gene silencing of Sugar-dependent 1 (JcSDP1) in Jatropha curcas. JcSDP1 encodes a patatin-domain triacylglyerol lipase. Silencing of JcSDP1 enhances seed oil accumulation in J. curcas.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: May 16, 2017
    Assignee: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Nam-Hai Chua, Mi Jung Kim, Seong Wook Yang
  • Publication number: 20160115494
    Abstract: The present invention relates to transcriptional gene activation. More specifically, the present invention relates to the methylation of the gene body using inverted repeat RNAs which results in the activation of gene expression without changing the tempo-spatial regulatory patterns of the gene expression.
    Type: Application
    Filed: October 27, 2014
    Publication date: April 28, 2016
    Applicant: THE ROCKEFELLER UNIVERSITY
    Inventors: Nam-Hai CHUA, Shulin DENG
  • Publication number: 20160010097
    Abstract: The present invention relates to the field of plant molecular biology and gene silencing. More particularly, the present invention relates to gene silencing of Sugar-dependent 1 (JcSDP1) in Jatropha curcas. JcSDP1 encodes a patatin-domain triacylglyerol lipase. Silencing of JcSDP1 enhances seed oil accumulation in J. curcas.
    Type: Application
    Filed: February 25, 2014
    Publication date: January 14, 2016
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Nam-Hai CHUA, Mi Jung KIM, Seong Wook YANG
  • Publication number: 20150329860
    Abstract: The present invention relates to transcriptional gene silencing (TGS) of endogenes in plants, plant tissue and plant cells. More specifically, the present invention relates to nucleic acid constructs that are capable of more effectively silencing genes of interest, such as endogenes, in plants, plant tissue and plant cells by TGS. The present invention further relates to methods of more effectively reducing endogenous gene expression in plants, plant tissues or plant cells by TGS using the nucleic acid constructs of the invention.
    Type: Application
    Filed: December 17, 2013
    Publication date: November 19, 2015
    Applicant: THE ROCKEFELLER UNIVERSITY
    Inventors: Nam-Hai CHUA, Qiwen NIU, Shulin DENG
  • Publication number: 20150252375
    Abstract: The present invention relates to transcriptional gene silencing (TGS) of endogenes in plants, plant tissue and plant cells. More specifically, the present invention relates to nucleic acid constructs that are capable of TGS of endogenes in plants, plant tissue and plant cells. The present invention further relates to methods of reducing endogenous gene expression in plants, plant tissues or plant cells by TGS using the nucleic acid constructs of the invention.
    Type: Application
    Filed: August 27, 2013
    Publication date: September 10, 2015
    Applicant: THE ROCKEFELLER UNIVERSITY
    Inventors: Nam-Hai Chua, Shulin Deng, Hongzheng Dai, Qi-Wen Niu, Huan Wang, Catalina Arenas Huertero
  • Publication number: 20150159157
    Abstract: The invention provides methods and compositions useful in target sequence suppression, target sequence validation and target sequence down regulation. The invention provides polynucleotide constructs useful for gene silencing or RNA down regulation, as well as cells, plants and seeds comprising the polynucleotides. The invention also provides a method for using microRNA to silence a target sequence or to down regulate RNA.
    Type: Application
    Filed: February 20, 2015
    Publication date: June 11, 2015
    Applicant: THE ROCKEFELLER UNIVERSITY
    Inventors: Jose L. REYES-TABOADA, Xiuren ZHANG, Takashi SOYANO, Nam-Hai CHUA, Qi-Wen NIU, Shih-Shun LIN
  • Publication number: 20150074853
    Abstract: The present invention relates to the field of plant molecular biology, more particularly cotton WRINKLED 1-like (WREL) genes. More specifically, the present invention relates to cotton WRIL genes whose products act as transcription factors of genes involved in fatty acid biosynthesis. The present invention also relates to methods of increasing cotton fiber length in cotton. In one embodiment, the methods involve modulating the level of activity of an enzyme involved in a fatty acid biosynthesis in the host cotton cell and/or culturing the host cotton cell. In another embodiment, the methods involve the manipulation of transcription factors which can regulate an enzyme involved in fatty acid biosynthesis.
    Type: Application
    Filed: April 19, 2012
    Publication date: March 12, 2015
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Nam-Hai Chua, Jian Ye, Jing Qu
  • Publication number: 20150074847
    Abstract: The present invention provides compositions and methods for enhancing protein stability in transgenic plants. The compositions are nucleic acid constructs which encode fusion proteins, fusion proteins, transgenic plant cells and transgenic plants. A fusion protein in accordance with the present invention comprises a protein of interest and a UBA1 or UBA2 domain of an Arabidopsis RAD23 protein. The methods use the nucleic acid constructs to produce fusion proteins in transgenic plant cells or transgenic plants. The fusion proteins have greater stability than the protein of interest and have the same function as the proteins of interest.
    Type: Application
    Filed: March 13, 2013
    Publication date: March 12, 2015
    Applicant: THE ROCKEFELLER UNIVERSITY
    Inventors: Nam-Hai Chua, In Cheol Jang, Qiwen Niu, Shulin Deng
  • Patent number: 8975471
    Abstract: The invention provides methods and compositions useful in target sequence suppression, target sequence validation and target sequence down regulation. The invention provides polynucleotide constructs useful for gene silencing or RNA down regulation, as well as cells, plants and seeds comprising the polynucleotides. The invention also provides a method for using microRNA to silence a target sequence or to down regulate RNA.
    Type: Grant
    Filed: October 12, 2005
    Date of Patent: March 10, 2015
    Assignee: The Rockefeller University
    Inventors: Jose L. Reyes Taboada, Xiuren Zhang, Takashi Soyano, Nam-Hai Chua, Qi-Wen Niu, Shih-Shun Lin
  • Publication number: 20150033414
    Abstract: The present invention relates to the field of modifying Jatropha branching, flowering time, fruiting and seed setting. More specifically, the present invention relates to a method for control and optimization of Jatropha curcas flowering time, fruiting and seed production by manipulating one gene from Jatropha. The present invention can be used in various Jatropha breeding efforts.
    Type: Application
    Filed: February 27, 2013
    Publication date: January 29, 2015
    Applicant: TEMASEK LIFE SCIENCES LABORATORY LIMITED
    Inventors: Nam-Hai Chua, Jian Ye, Yun-Feng Geng, Bipei Zhang
  • Patent number: 8921655
    Abstract: The present invention relates to the field of functional analysis of Jatropha genes on a genomic scale. More specifically, the present invention relates to a method for high-throughtput functional analysis of Jatropha curcas genes on a genomic scale using virus-induced gene silencing. The method involves use of the tobacco rattle virus (TRV).
    Type: Grant
    Filed: December 16, 2009
    Date of Patent: December 30, 2014
    Assignee: Joil (S) Pte Ltd.
    Inventors: Jian Ye, Nam Hai Chua, Jing Qu
  • Patent number: 8852928
    Abstract: The present invention relates generally to chemical-inducible system and to methods of use in transgenic animals. More specifically, the present invention relates to a chimeric transcription factor that binds to a ligand and functions in ligand-dependent manner to induce expression of genes of interest under the control of a synthetic operator-promoter sequence. The expression of genes of interest can be tightly controlled by adding or removing the ligand.
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: October 7, 2014
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Alexander Emelyanov, Sergey Parinov, Nam-Hai Chua
  • Patent number: 8853493
    Abstract: The invention relates to the functional analysis of genes in cotton by employing the Virus Induced Gene Silencing (VIGS) method. More specifically this method induces gene silencing in cotton with the help of the Tobacco Rattle Virus (TRV) vectors RNA1 and RNA2 and phenotypic effects on the cotton plant can be analysed Moreover this invention also provides transient expression vector TRV RNA2 in order to transiently express genes in cotton plants and plant tissue under the influence of a strong subgenomic promoter.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: October 7, 2014
    Assignee: Temasek Life Sciences Laboratory Limited
    Inventors: Jian Ye, Nam Hai Chua, Jing Qu, Yun Feng Geng, Yun Ping Bu
  • Patent number: 8686223
    Abstract: The present invention relates to methods for the regeneration and Agrobacterium-mediated transformation of plants in the genera of Jatropha, more specifically, in Jatropha curcas.
    Type: Grant
    Filed: July 3, 2012
    Date of Patent: April 1, 2014
    Assignee: Joil (S) Pte Ltd.
    Inventors: Hui Zhu Mao, Jian Ye, Nam Hai Chua
  • Patent number: 8609418
    Abstract: The present invention relates to methods for the regeneration and Agrobacterium-mediated transformation of plants in the genera of Jatropha, more specifically, in Jatropha curcas.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: December 17, 2013
    Assignee: Joil (S) Pte Ltd.
    Inventors: Hui Zhu Mao, Jian Ye, Nam Hai Chua
  • Patent number: 8586824
    Abstract: A group of genes including GhCIR1 from cotton (Gossypium hirsutum), and AtCIR1 and AtCIR2 from Arabidopsis thaliana promote shoot regeneration in plants even in the absence of cytokinin. In the presence of cytokinin, the genes significantly improve transformation efficiency. The genes can be used as an enhancer as well as a selectable marker of transformation in plants. The proteins encoded by the novel genes have a homeodomain (HD) at the N-terminus and a highly divergent domain at the C-terminus. The proteins share a common structural motif.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: November 19, 2013
    Assignee: Temasek Life Sciences Laboratory
    Inventors: Lianghui Ji, Lin Cai, Nam-Hai Chua