Abstract: A method of programming a storage device includes determining, at a controller of the storage device, that a first program mode of a plurality of program modes is to be entered in response to first information, wherein the first information includes a parameter associated with temperature, power consumption or input/output workload, and changing, using the controller, a program ratio of a first programming and a second programming of the storage device in the first program mode.

Abstract: The present invention relates to an acid salt of tolterodine with superior stabililty and useful as a transdermal drug delivery system. More specifically, the present invention relates to a novel acid salt of tolterodine with superior stabililty to the conventional acid salts of tolterodine, which is useful as a pharmaceutical composition for the treatment of overactive bladder and can be formulated into a transdermal drug delivery system.

Abstract: Disclosed herein is a shock absorber for damping vibration transmitted to a vehicle according to a road state. The shock absorber includes a cylinder and a piston valve disposed within the cylinder and connected to a piston rod. The piston rod includes a hollow chamber formed within the piston rod, a floating piston disposed within the hollow chamber to move up and down and to divide the hollow chamber into upper and lower chambers, and a moving mechanism formed in the hollow chamber to move an operating fluid to upper and lower portions of the floating piston. The shock absorber can change a damping force according to a displacement of the piston rod, thereby improving driving comfort and stability of the vehicle.

Abstract: A self leveling shock absorber includes a base shell, an inner tube in the base shell, having a low pressure chamber between the shell and the inner tube, a piston rod in the inner tube and having a hollow portion with an upper portion closed, a piston valve coupled to the piston rod, dividing space in the inner tube into rebound and compression chambers. An outer tube installed to a lower portion of the inner tube having a high pressure chamber and a gas chamber between the shell and the outer tube. A diaphragm divides the high pressure chamber from the gas chamber. A body valve is installed to a lower end of the inner tube to control flow of fluid between the low pressure chamber and the high pressure chamber, and a pump rod is provided having a hollow portion and one end installed to the body valve and another end inserted into the hollow portion of the piston rod. A relief valve is positioned under the pump rod.

Abstract: Disclosed herein is a shock absorber for damping vibration transmitted to a vehicle according to a road state. The shock absorber includes a cylinder and a piston valve disposed within the cylinder and connected to a piston rod to divide the cylinder into a first chamber and a second chamber. The shock absorber further includes a hollow chamber formed within the piston rod, a floating piston disposed within the hollow chamber to move up and down and to divide the hollow chamber into upper and lower chambers, first and second orifices formed in upper and lower ends of the hollow chamber and connected to the first and second chambers, respectively, and a resistance changing mechanism configured to cooperate with the floating piston and change a fluid resistance with respect to the floating piston where the resistance changing mechanism cooperates therewith.

Abstract: The present invention relates to an acid salt of tolterodine with superior stabililty and useful as a transdermal drug delivery system. More specifically, the present invention relates to a novel acid salt of tolterodine with superior stabililty to the conventional acid salts of tolterodine, which is useful as a pharmaceutical composition for the treatment of overactive bladder and can be formulated into a transdermal drug delivery system.

Abstract: The present invention relates to a lyophilized pharmaceutical composition for injection having superior storage stability comprising a taxoid, and a method thereof. More specifically, the present invention relates to a lyophilized pharmaceutical composition for injection having improved solubility and stability of dilution compared to the conventional preparations by dissolving a water-insoluble taxoid in distilled water added with a hydrophilic polymer such as hydroxypropylmethyl cellulose (HPMC), polyethylene glycol (PEG) or polyvinylpyrrolidone (PVP) cyclodextrin (CD), and lyophilizing the mixture and a method thereof.

Abstract: The present invention relates to a method for optical resolution of amlodipines by using isopropanol solvent and optically active O,O?-dibenzoyl tartaric acid as chiral reagent. More particularly, the present invention relates to a method comprising (a) obtaining (R)- or (S)-amlodipine dibenzoyl tartrate salt or solvate thereof by reacting (R,S)-amlodipines with optically active O,O?-dibenzoyl tartaric acid in isopropanol solvent, and (b) treating the (R)- or (S)-amlodipine salt with a base, thus obtaining optically active amlodipine.

Abstract: The present invention relates to a sibutramine-containing inclusion complex having superior storage stability, and particularly to a pharmaceutically stable inclusion complex suitable for the drug formulation, which prepared by reacting a sibutramine (N,N-dimethyl-1-[1-(4-chlorophenyl)-cyclobutyl]-3-methylbutylamine) of Formula 1 and beta-cyclodextrin in a predetermined ratio, its preparation method and a pharmaceutical composition comprising the same.

Abstract: The present invention relates to a process for the preparation of S-(+)-clopidogrel by an optical resolution and, more particularly, to a process for the preparation of S-(+)-clopidogrel represented by the following formula 1 with high optical purity by converting a clopidogrel racemic carboxylic acid into a diastereomeric salt using a (+)-cinchonine for optical resolution, extracting an S-(+)-clopidogrel carboxylic acid from the diastereomeric salt using a suitable solvent under an acidic condition and then reacting the S-(+)-clopidogrel carboxylic acid with methanol.

Abstract: The present invention relates to salts of a pyrrolopyrimidinone derivative having superior PDE-5 inhibition activity and a process for preparing the same. More particularly, the present invention relates to a crystalline acid addition salt prepared by reacting a pyrrolopyrimidinone derivative with an acid selected from gentisic acid, maleic acid, citric acid, fumaric acid and tartaric acid. With no hygroscopic property and superior long-term storage stability, photostability and thermal stability, the salts of the pyrrolopyrimidinone derivative are appropriate to be prepared into medications and, with superior PDE-5 inhibition activity, are useful for the treatment and prevention of erectile dysfunction, pulmonary arterial hypertension, chronic obstructive pulmonary disease, benign prostatic hypertrophy and lower urinary tract diseases.

Abstract: The invention relates to novel pyridine derivatives having an inhibitory effect on production of cytokines, which are involved in inflammatory responses, thus suggesting its usefulness as therapeutic agents for treating diseases related to inflammation, immune, chronic inflammation as well as an agent having an anti-inflammatory and analgesic effect. Further, this invention relates to a method of manufacturing the same and a pharmaceutical composition containing the same.

Abstract: A self leveling shock absorber includes a base shell, an inner tube in the base shell, having a low pressure chamber between the shell and the inner tube, a piston rod in the inner tube and having a hollow portion with an upper portion closed, a piston valve coupled to the piston rod, dividing space in the inner tube into rebound and compression chambers. An outer tube installed to a lower portion of the inner tube having a high pressure chamber and a gas chamber between the shell and the outer tube. A diaphragm divides the high pressure chamber from the gas chamber. A body valve is installed to a lower end of the inner tube to control flow of fluid between the low pressure chamber and the high pressure chamber, and a pump rod is provided having a hollow portion and one end installed to the body valve and another end inserted into the hollow portion of the piston rod. A relief valve is positioned under the pump rod.

Abstract: The present invention relates to a stable pharmaceutical composition for injection containing docetaxel and a method of preparing the same. More particularly, the present invention relates to a pharmaceutical composition for injection containing docetaxel having better storage stability than conventional medications, which is prepared by dissolving docetaxel, a water-insoluble compound, in distilled water after mixing it with cyclodextrin (CD) and a water-soluble polymer such as hydroxypropyl methylcellulose (HPMC), polyethylene glycol (PEG) or polyvinylpyrrolidone (PVP) and lyophilizing the mixture, and a method of preparing the same.

Abstract: A method of manufacturing thermosets such as epoxy resins includes adding expandable hollow microspheres, which expand with temperature as shown in the accompanying graph, to the base thermoset components in the liquid phase and applying heat treatment to the mixture so formed causing the micropsheres to expand during or after curing of the thermoset. This results in a toughening mechanism caused by compressive residual stress around the microspheres which significantly increases the specific fracture energy of the epoxy resin.

Abstract: Disclosed herein is a shock absorber for damping vibration transmitted to a vehicle according to a road state. The shock absorber includes a cylinder and a piston valve disposed within the cylinder and connected to a piston rod to divide the cylinder into a first chamber and a second chamber. The shock absorber further includes a hollow chamber formed within the piston rod, a floating piston disposed within the hollow chamber to move up and down and to divide the hollow chamber into upper and lower chambers, first and second orifices formed in upper and lower ends of the hollow chamber and connected to the first and second chambers, respectively, and a resistance changing mechanism configured to cooperate with the floating piston and change a fluid resistance with respect to the floating piston where the resistance changing mechanism cooperates therewith.

Abstract: Disclosed herein is a shock absorber for damping vibration transmitted to a vehicle according to a road state. The shock absorber includes a cylinder and a piston valve disposed within the cylinder and connected to a piston rod to divide the cylinder into a first chamber and a second chamber. The piston rod includes a hollow chamber formed within the piston rod, first and second orifices formed in upper and lower ends of the hollow chamber and connected to the first and second chambers, respectively, a floating piston disposed within the hollow chamber to move up and down and to divide the hollow chamber into upper and lower chambers, and a moving mechanism formed in the hollow chamber to move an operating fluid to upper and lower portions of the floating piston. The shock absorber can change a damping force according to a displacement of the piston rod, thereby improving driving comfort and stability of the vehicle.

Abstract: Disclosed are agents that inhibit histone deacetylase. More specifically, the present invention relates to novel hydroxamic acid derivatives or pharmaceutically acceptable salts thereof for anticancer agents or other therapeutic agents based on their histone deacetylase inhibitory activity.

Abstract: The present invention relates to a process for the preparation of optically pure amlodipine gentisate, more particularly to a continuous process for the preparation of optically pure amlodipine gentisate with good yield and high optical purity. The processes can be preformed by first reacting racemic (R,S)-amlodipine and optically pure O,O?-dibenzoyltartaric acid in the presence of a solvent including isopropanol to prepare (R)- or (S)-amlodipine dibenzoyltartarate diastereomer or a solvate thereof, treating the prepared amlodipine diastereomeric salt or a solvate thereof with a base and then finally adding gentisic acid.

Abstract: The present invention relates to a method for optical resolution of amlodipines by using isopropanol solvent and optically active O,O?-dibenzoyl tartaric acid as chiral reagent. More particularly, the present invention relates to a method comprising (a) obtaining (R)— or (S)-amlodipine dibenzoyl tartrate salt or solvate thereof by reacting (R,S)-amlodipines with optically active O,O?-dibenzoyl tartaric acid in isopropanol solvent, and (b) treating the (R)— or (S)-amlodipine salt with a base, thus obtaining optically active amlodipine.