Abstract: A method for determining a sentiment associated with an entity includes inputting a plurality of texts associated with the entity, labeling seed words in the plurality of texts as positive or negative, determining a score estimate for the plurality of words based on the labeling, re-enumerating paths of the plurality of words and determining a number of sentiment alternations, determining a final score for the plurality of words using only paths whose number of alternations is within a threshold, converting the final scores to corresponding z-scores for each of the plurality of words, and outputting the sentiment associated with the entity.

Abstract: Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.

Abstract: A method for real-time reconstruction is provided. The method includes receiving a sparse signal sequence one at a time and performing compressed sensing on the sparse signal sequence in a manner which causally estimates a time sequence of spatially sparse signals and generates a real-time reconstructed signal. Recursive algorithms provide for causally reconstructing a time sequence of sparse signals from a greatly reduced number of linear projection measurements.

Abstract: The present invention relates to the regeneration, reconstruction, repair, augmentation or replacement of organs or tissue structures using scaffolds and autologous cells that are not derived from such organs or tissues.

Abstract: A pharmaceutical composition for the oral or parenteral administration of a compound of Formula (I) comprising an oil in water emulsion, wherein the oil phase comprises the free base of or a pharmaceutically acceptable salt thereof of a compound of Formula (I), and one or more surfactants which are soluble in the oil phase and/or the aqueous phase. The emulsion optionally contains one or more excipients that are soluble in the oil phase and/or the aqueous phase, such as pH modifying agents such as buffers, osmolality/tonicity modifying agents, emulsifying agents, water-soluble polymers, and preservatives. The compound of Formula (I) can be formulated as a solid material and stored until needed. Kits for forming the emulsion are provided. Prior to administration, the solid material can be reconstituted in an aqueous medium to form the emulsion.

Abstract: Biocompatible, resorbable medical implants and related methods are disclosed in which the implant can be made of a collagen matrix for filling a space after partial or total resection of the trapezium bone of the wrist. The resorbable medical implant can include a plurality of surface projections, and the collagen matrix can be folded or spirally wound about itself to form a spiral roll.

Abstract: A method for determining a sentiment associated with an entity includes inputting a plurality of texts associated with the entity, labeling seed words in the plurality of texts as positive or negative, determining a score estimate for the plurality of words based on the labeling, re-enumerating paths of the plurality of words and determining a number of sentiment alternations, determining a final score for the plurality of words using only paths whose number of alternations is within a threshold, converting the final scores to corresponding z-scores for each of the plurality of words, and outputting the sentiment associated with the entity.

Abstract: Biocompatible synthetic or natural scaffolds are provided for the reconstruction, repair, augmentation or replacement of organs or tissue structures in a patient in need of such treatment. The scaffolds are shaped to conform to at least a part of the organ or tissue structure and may be seeded with one or more cell populations. Inserts, receptacles and ports are also provided for the attachment of tubular vessels to the neo-organ scaffolds. The seeded scaffolds are implanted into the patient at the site in need of treatment to form an organized organ or tissue structure. The scaffolds may be used to form organs or tissues, such as bladders, urethras, valves, and blood vessels.

Abstract: Bioreactors are used in neo-organ production to allow for an appropriate environment for the maintenance of healthy culturing conditions from pre-wetting to shipment of the neo-organ. The closed system “all-in-one bioreactor” is designed to allow for minimal exposure of the scaffold to the open air in order to maintain sterility. The design allows for the same container to be utilized for sterilization, pre-wetting, cell seeding, medium exchange, and shipment. The “all-in-one” bioreactor also remains completely closed after the urothelial cell seeding step to the implantation at the clinical site. This allows for sufficient time for release testing to occur so the neo-organ can be implanted into the patient.

Abstract: A method is provided for making a parenteral dosage form of a pharmaceutical agent which includes (a) providing particles of a pharmaceutical agent; (b) blending the particles with particles of at least one bulking agent to form a first powder blend, which does not include a surfactant; (c) milling the first powder blend to form a milled blend which comprises microparticles or nanoparticles of the pharmaceutical agent; and (d) reconstituting the milled blend with a liquid vehicle, which includes at least one surfactant, for parenteral administration. A method also is provided which includes (a) providing particles of a pharmaceutical agent; (b) blending these particles with particles of an excipient to form a first blend; and (c) milling the first blend to form a milled blend that includes microparticles or nanoparticles, which exhibits a greater dispersibility, wettability, and suspendability as compared to the particles of step (a) or the first blend.