Patents by Inventor Nanibhushan Dattagupta

Nanibhushan Dattagupta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8691508
    Abstract: Contemplated systems and methods allow analysis of multiple and distinct patient samples using a labeling scheme that entirely avoids carry-over of a label or reagent to the analytic platform, typically an addressable solid phase. In preferred aspects, a hybridization portion, a fluorophore, and/or a quencher are removed by a 5?-3?-exonuclease activity of a polymerase from a reporter oligonucleotide to so remove the oligonucleotide from the pool of molecules that bind to the solid phase and/or or to provide signal differentiation by removal of a fluorophore or quencher.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: April 8, 2014
    Assignee: Autogenomics, Inc.
    Inventor: Nanibhushan Dattagupta
  • Publication number: 20110065589
    Abstract: Individual patient- and disease-specific test results are obtained from a mixture of one or more distinct tests from multiple combined and distinct patient samples or reactions. In an especially preferred aspect, multiple reaction products from oligonucleotides having unique identifier portions are prepared or received from a clinician and combined for hybridization on a chip. Test results are deconvoluted using a deconvolution table in which associative data are employed to provide access to the individual patient- and disease-specific test results.
    Type: Application
    Filed: December 13, 2007
    Publication date: March 17, 2011
    Inventor: Nanibhushan Dattagupta
  • Publication number: 20110033846
    Abstract: Contemplated systems and methods allow analysis of multiple and distinct patient samples using a labeling scheme that entirely avoids carry-over of a label or reagent to the analytic platform, typically an addressable solid phase. In preferred aspects, a hybridization portion, a fluorophore, and/or a quencher are removed by a 5?-3?-exonuclease activity of a polymerase from a reporter oligonucleotide to so remove the oligonucleotide from the pool of molecules that bind to the solid phase and/or or to provide signal differentiation by removal of a fluorophore or quencher.
    Type: Application
    Filed: December 13, 2007
    Publication date: February 10, 2011
    Inventor: Nanibhushan Dattagupta
  • Publication number: 20060073475
    Abstract: This invention relates generally to compositions and methods for detection of pathogenic bacteria that express extracellular chaperonin proteins. In one embodiment, it relates to Mycobacterium tuberculosis (Mtb) detection and provides for novel probes for a specific and sensitive diagnostic test for Mycobacterium tuberculosis complex (TBC) that hybridize with the groEL-1 gene. Arrays comprising the novel probes immobilized on a support for hybridization analysis and methods for TBC detection using the probes are also provided.
    Type: Application
    Filed: August 9, 2002
    Publication date: April 6, 2006
    Inventors: Nanibhushan Dattagupta, Ketan Shah
  • Patent number: 7009041
    Abstract: A method, composition and kit for synthesizing multiple copies of a target nucleic acid sequence autocatalytically under conditions of substantially constant temperature, ionic strength, and pH are provided in which multiple RNA copies of the target sequence autocatalytically generate additional copies using a mixture of blocked and unblocked primers and/or promoter-primers to initiate DNA and RNA synthesis, preferably with reduced non-specific product formation. The invention is useful for generating copies of a nucleic acid target sequence for purposes that include assays to quantitate specific nucleic acid sequences in clinical, environmental, forensic and similar samples, cloning and generating probes.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 7, 2006
    Assignee: Gen-Probe Incorporated
    Inventors: Sherrol H. McDonough, Daniel L. Kacian, Nanibhushan Dattagupta, Diane L. McAllister, Philip W. Hammond, Thomas B. Ryder
  • Patent number: 6696255
    Abstract: This invention relates generally to nucleic acid hybridization analysis. More specifically, oligonucleotide probes containing hairpin structures, or arrays of such oligonucleotide probes immobilized on a solid support, that are suitable for hybridization analysis are provided. Methods for nucleic acid hybridization analysis using the probes or array of immobilized probes are also provided.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: February 24, 2004
    Assignee: Applied Gene Technologies, Inc.
    Inventor: Nanibhushan Dattagupta
  • Publication number: 20040009574
    Abstract: This invention relates generally to Group B streptococci (GBS) Streptococcus agalactiae detection. More specifically, the present invention provides for novel probes for a specific and sensitive diagnostic test of GBS. These GBS-specific probes hybridize with the capsular polysaccharide synthesis (cps) gene. Arrays comprising the probes immobilized on a support for hybridization analysis and methods for GBS detection using the probes are also provided.
    Type: Application
    Filed: July 9, 2002
    Publication date: January 15, 2004
    Inventors: Nanibhushan Dattagupta, Ketan Shah
  • Publication number: 20040009482
    Abstract: This invention relates generally to Group B streptococci (GBS) Streptococcus agalactiae detection. More specifically, the present invention provides for novel probes for a specific and sensitive diagnostic test of GBS. These GBS-specific probes hybridize with the the surface immunogenic protein (sip) gene. Arrays comprising the probes immobilized on a support for hybridization analysis and methods for GBS detection using the probes are also provided.
    Type: Application
    Filed: July 9, 2002
    Publication date: January 15, 2004
    Inventors: Nanibhushan Dattagupta, Ketan Shah
  • Publication number: 20030219755
    Abstract: This invention relates to methods of signal amplification in nucleic acid hybridization reactions without the use of direct amplification of the target sequence. More particularly, it relates to methods of detecting target nucleic acids in samples such that detection is accomplished via probe-target and target-target hybridization. In one aspect, the present invention relates to methods of detecting genomic target nucleic acids such that the signal is amplified via formation of target-probe complexes.
    Type: Application
    Filed: May 24, 2002
    Publication date: November 27, 2003
    Inventor: Nanibhushan Dattagupta
  • Publication number: 20030219757
    Abstract: This invention relates generally to Mycobacterium tuberculosis complex (TBC) detection. More specifically, the present invention provides for novel IS6110 probes for a direct, specific and sensitive diagnostic test of tuberculosis (TB). These probes hybridize with the IS6110 DNA sequence that is believed to be present only in the Mycobacterium tuberculosis complex (TBC). Arrays comprising the novel IS6110 probes immobilized on a support for hybridization analysis and methods for TBC detection using the probes or arrays of immobilized probes are also provided.
    Type: Application
    Filed: May 24, 2002
    Publication date: November 27, 2003
    Inventors: Nanibhushan Dattagupta, I-Shiou Hwang
  • Publication number: 20030211532
    Abstract: The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the invention provides for methods and combinations for analyzing nucleic acids in a plurality of samples using a plurality of detectably different signature labels and a probe that is hybridizable to each of the target nucleic acids. The invention also provides for a method for quantifying a nucleic acid by analyzing the amount of a label, e.g., a photoactivatable label, attached to the target nucleic acid.
    Type: Application
    Filed: June 9, 2003
    Publication date: November 13, 2003
    Inventor: Nanibhushan Dattagupta
  • Patent number: 6620586
    Abstract: The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the invention provides for methods and combinations for analyzing nucleic acids in a plurality of samples using a plurality of detectably different signature labels and a probe that is hybridizable to each of the target nucleic acids. The invention also provides for a method for quantifying a nucleic acid by analyzing the amount of a label, e.g., a photoactivatable label, attached to the target nucleic acid.
    Type: Grant
    Filed: February 20, 2001
    Date of Patent: September 16, 2003
    Assignee: Applied Gene Technologies, Inc.
    Inventor: Nanibhushan Dattagupta
  • Publication number: 20030165963
    Abstract: This invention relates generally to nucleic acid hybridization analysis. More specifically, an oligonucleotide probe for hybridization analysis is provided, which probe comprises a nucleotide sequence that forms a hairpin structure having a double stranded segment and a single stranded loop, wherein at least a portion of said nucleotide sequences located within said double stranded segment and a portion of said nucleotide sequence located within said single stranded loop collectively form a region that is complementary to a target nucleotide sequence to be hybridized with. Arrays comprising the hairpin probes immobilized on a solid support and methods for nucleic acid hybridization analysis using the probes or array of immobilized probes are also provided. Methods for transcribing and/or amplifying a probe DNA sequence using a hairpin probe are further provided.
    Type: Application
    Filed: February 13, 2003
    Publication date: September 4, 2003
    Inventor: Nanibhushan Dattagupta
  • Patent number: 6596489
    Abstract: This invention relates generally to nucleic acid hybridization analysis. More specifically, a method for detecting a point mutation in a DNA strand is provided, which method uses, inter alia, a test nucleic acid strand complementary to a target DNA strand, said nucleic acid strand comprises a sufficient number of ribonucleotide residues that span the position of said point mutation to be detected to form a target DNA strand/test nucleic acid strand duplex and RNase H cleavage of said target DNA strand/test nucleic acid strand duplex. Kits and arrays for detecting a point mutation in a DNA strand comprising test nucleic acid strand comprising a sufficient number of ribonucleotide residues that span the position of said point mutation to be detected are also provided.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: July 22, 2003
    Assignee: Applied Gene Technologies
    Inventors: Nanibhushan Dattagupta, Ta-Chien Tseng
  • Patent number: 6596490
    Abstract: This invention relates generally to nucleic acid hybridization analysis. More specifically, an oligonucleotide probe for hybridization analysis is provided, which probe comprises a nucleotide sequence that forms a hairpin structure having a double stranded segment and a single stranded loop, wherein at least a portion of said nucleotide sequences located within said double stranded segment and a portion of said nucleotide sequence located within said single stranded loop collectively form a region that is complementary to a target nucleotide sequence to be hybridized with. Arrays comprising the hairpin probes immobilized on a solid support and methods for nucleic acid hybridization analysis using the probes or array of immobilized probes are also provided. Methods for transcribing and/or amplifying a probe DNA sequence using a hairpin probe are further provided.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: July 22, 2003
    Assignee: Applied Gene Technologies, Inc.
    Inventor: Nanibhushan Dattagupta
  • Publication number: 20030082607
    Abstract: This invention relates generally to nucleic acid hybridization analysis. More specifically, oligonucleotide probes containing hairpin structures, or arrays of such oligonucleotide probes immobilized on a solid support, that are suitable for hybridization analysis are provided. Methods for nucleic acid hybridization analysis using the probes or array of immobilized probes are also provided.
    Type: Application
    Filed: September 9, 2002
    Publication date: May 1, 2003
    Inventor: Nanibhushan Dattagupta
  • Publication number: 20020142309
    Abstract: This invention relates generally to nucleic acid hybridization analysis. More specifically, an oligonucleotide probe for hybridization analysis is provided, which probe comprises a nucleotide sequence that forms a hairpin structure having a double stranded segment and a single stranded loop, wherein at least a portion of said nucleotide sequences located within said double stranded segment and a portion of said nucleotide sequence located within said single stranded loop collectively form a region that is complementary to a target nucleotide sequence to be hybridized with. Arrays comprising the hairpin probes immobilized on a solid support and methods for nucleic acid hybridization analysis using the probes or array of immobilized probes are also provided. Methods for transcribing and/or amplifying a probe DNA sequence using a hairpin probe are further provided.
    Type: Application
    Filed: March 30, 2001
    Publication date: October 3, 2002
    Inventor: Nanibhushan Dattagupta
  • Publication number: 20020142308
    Abstract: This invention relates generally to nucleic acid hybridization analysis. More specifically, a method for detecting a point mutation in a DNA strand is provided, which method uses, inter alia, a test nucleic acid strand complementary to a target DNA strand, said nucleic acid strand comprises a sufficient number of ribonucleotide residues that span the position of said point mutation to be detected to form a target DNA strand/test nucleic acid strand duplex and RNase H cleavage of said target DNA strand/test nucleic acid strand duplex. Kits and arrays for detecting a point mutation in a DNA strand comprising test nucleic acid strand comprising a sufficient number of ribonucleotide residues that span the position of said point mutation to be detected are also provided.
    Type: Application
    Filed: March 30, 2001
    Publication date: October 3, 2002
    Inventors: Nanibhushan Dattagupta, Ta-Chien Tseng
  • Patent number: RE38960
    Abstract: Methods for amplifying target nucleic acid sequences using a nucleic acid polymerase lacking 5? exonuclease activity and a set of oligonucleotide primers. Preferably, a primer array is used. The primer array contains two sets of primers. One set contains at least two complementary primers. The other set contains at least two sense primers. Using the described methods amplification can be carried out under essentially constant environmental conditions without the requirement for exonuclease activity or restriction endonuclease activity.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: January 31, 2006
    Assignee: Gen-Probe Incorporated
    Inventors: Nanibhushan Dattagupta, Paul Douglas Stull, Marc Spingola, Daniel Louis Kacian
  • Patent number: RE39007
    Abstract: Methods for amplifying target nucleic acid sequences using a nucleic acid polymerase lacking 5? exonuclease activity and a set of oligonucleotide primers. Preferably, a primer array is used. The primer array contains two sets of primers. One set contains at least two complementary primers. The other set contains at least two sense primers. Using the described methods amplification can be carried out under essentially constant environmental conditions without the requirement for exonuclease activity or restriction endonu- clease activity.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: March 7, 2006
    Assignee: Gen-Probe Incorporated
    Inventors: Nanibhushan Dattagupta, Paul Douglas Stull, Marc Spingola, Daniel Louis Kacian