Abstract: In an embodiment, an object of the present invention is to provide a double-stranded nucleic acid complex having a novel structure. In an embodiment, the present invention relates to a nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein said first nucleic acid strand: (1) is capable of hybridizing to at least a part of a target transcriptional product; (2) has an antisense effect on the target transcriptional product; and (3) is a gapmer comprising a central region, and a 5? wing region and a 3? wing region, said second nucleic acid strand comprises at least one sugar-unmodified central region (first exposed region) consisting of one sugar-unmodified ribonucleoside or two or three contiguous sugar-unmodified ribonucleosides linked by an internucleoside bond, which is or are complementary to a part of said first nucleic acid strand, and said first nucleic acid strand is annealed to said second nucleic acid strand.

Abstract: One embodiment relates to a vehicle control unit. The vehicle control unit includes a metallic base body and an electronic control unit which is attached to the base body. The electronic control unit includes a housing which is attached to an attaching surface of the base body and a control circuit board which is housed in the housing. A heat radiation portion is provided on the attaching surface so as to be inserted into the housing. The heat radiation portion is brought into abutment with the control circuit board via a heat conducting member. And, a heat conducting member holding portion is formed in the housing so as to hold the heat conducting member with respect to the heat radiation portion.

Abstract: An onboard system that reduces a mental pressure on a driver includes a remaining amount detector that detects a remaining amount of a power source remaining in a vehicle, a lighting detector that detects that a low power source indicator provided in the vehicle lights up, a lighting remaining amount storage unit that stores, as a lighting remaining amount, the remaining power source amount detected by the remaining amount detector at a timing at which the lighting detector detects the lighting of the low power source indicator, a notification remaining amount detector that detects a remaining power source amount larger by a predetermined amount than the lighting remaining amount stored in the lighting remaining amount storage unit, and a notifier that notifies information for promoting supply of the power source after the remaining power source amount larger than the lighting remaining amount by the predetermined amount is detected before the lighting remaining amount is detected.

Abstract: An onboard system that reduces a mental pressure on a driver includes a remaining amount detector that detects a remaining amount of a power source remaining in a vehicle, a lighting detector that detects that a low power source indicator provided in the vehicle lights up, a lighting remaining amount storage unit that stores, as a lighting remaining amount, the remaining power source amount detected by the remaining amount detector at a timing at which the lighting detector detects the lighting of the low power source indicator, a notification remaining amount detector that detects a remaining power source amount larger by a predetermined amount than the lighting remaining amount stored in the lighting remaining amount storage unit, and a notifier that notifies information for promoting supply of the power source after the remaining power source amount larger than the lighting remaining amount by the predetermined amount is detected before the lighting remaining amount is detected.

Abstract: The present invention provides a compound having a lysine specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, Alzheimer's disease, Parkinson's disease or Huntington's disease, and the like. The present invention relates to a compound represented by the formula wherein A is a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s); B is a benzene ring optionally having further substituent(s); R1, R2 and R3 are each independently a hydrogen atom, a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s); A and R1 are optionally bonded to each other to form, together with the adjacent nitrogen atom, a cyclic group optionally having substituent(s); and R2 and R3 are optionally bonded to each other to form, together with the adjacent nitrogen atom, a cyclic group optionally having substituent(s), or a salt thereof.

Abstract: The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for cancer, and central nervous system diseases, and the like.

Abstract: The present provides a pyridazine compound having an inhibiting effect on Stearoyl-CoA desaturase (SCD) (in particular, SCD1). The present provides a compound represented by formula (where each symbol is as defined as in the Specification) or a salt thereof.

Abstract: One embodiment relates to a vehicle control unit. The vehicle control unit includes a metallic base body and an electronic control unit which is attached to the base body. The electronic control unit includes a housing which is attached to an attaching surface of the base body and a control circuit board which is housed in the housing. A heat radiation portion is provided on the attaching surface so as to be inserted into the housing. The heat radiation portion is brought into abutment with the control circuit board via a heat conducting member. And, a heat conducting member holding portion is formed in the housing so as to hold the heat conducting member with respect to the heat radiation portion.

Abstract: The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for cancer, and central nervous system diseases, and the like.

Abstract: The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for cancer, and central nervous system diseases, and the like.

Abstract: The present invention provides a compound having a lysine specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, Alzheimer's disease, Parkinson's disease or Huntington's disease, and the like. The present invention relates to a compound represented by the formula wherein A is a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s); B is a benzene ring optionally having further substituent(s); R1, R2 and R3 are each independently a hydrogen atom, a hydrocarbon group optionally having substituent(s), or a heterocyclic group optionally having substituent(s); A and R1 are optionally bonded to each other to form, together with the adjacent nitrogen atom, a cyclic group optionally having substituent(s); and R2 and R3 are optionally bonded to each other to form, together with the adjacent nitrogen atom, a cyclic group optionally having substituent(s), or a salt thereof.

Abstract: The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for cancer, and central nervous system diseases, and the like.

Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with MEK that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.

Abstract: The present invention aims to provide a novel pyrazole derivative and a pharmaceutical agent containing the same.

Abstract: Compounds, pharmaceutical compositions, kits and methods are provided for use with MEK that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.

Abstract: A document carrier sheet is provided with a support sheet having a support surface on which a document is supported. The document carrier sheet is also provided with a transparent sheet attached to the support sheet and permitting the document to be held on the support surface, with an image on the document being covered. The support surface of the support sheet has a different color from that of the document.

Abstract: A production evaluation managing system in a factory including facilities in a plurality of production processes from materials to products and a means for evaluating the products based on at least one of inspection and testing characterized by comprising a network connecting the facilities in respective production processes with the evaluating means, and a means for collecting through the network field data of the facility in a production process pertaining to the production of a product corresponding to the information of evaluation results, based on the information of evaluation results of the products outputted from the evaluating means.

Abstract: A document carrier sheet is provided with a support sheet having a support surface on which a document is supported. The document carrier sheet is also provided with a transparent sheet attached to the support sheet and permitting the document to be held on the support surface, with an image on the document being covered. The support surface of the support sheet has a different color from that of the document.

Abstract: The present invention is directed to detecting information such as characters or the like formed on a form using fluorescent ink without using any special components such as a light source for emitting ultraviolet light, an optical filter for intercepting transmission of ultraviolet light, or the like. When visible light which is emitted by fluorescent ink excited upon being irradiated with ultraviolet rays is detected by an image sensor, a level of the output photoelectrically converted by the image sensor is saturated and assures a level higher than white level as white reference, so that information such as characters or the like formed on a form using fluorescent ink can be acquired.