Abstract: [Problems] To provide a chemically modified siRNA that has improved stability against RNase enzymes and selectively exhibits silencing of FUS P525L mutation which is a causative gene of ALS. [Solution] Provided is a chemically modified siRNA comprising a sense strand and an antisense strand, or a salt thereof, wherein: the antisense strand includes a complementary or substantially complementary region in a portion of a mRNA that codes FUS P525L mutation protein; the complementary region has a nucleotide length of 19 to 21; and the siRNA contains at least one substitution selected from the group consisting of a 2?-F-nucleotide, a 2?-OMe-nucleotide, a nucleotide in which a 2?-O atom and a 4?-O atom are bridged by methylene, a 2?-deoxynucleotide, and a phosphorothioate bond that forms an internucleotide bond.

Abstract: An output gear of the differential apparatus includes a gear member and an operating member capable of being integrally rotatably engaged with the gear member via the cam portion. The cam portion includes a gear protrusion on the gear member, an operating protrusion on the operating member, and cam surfaces respectively provided on opposing surfaces of the gear protrusion and the operating protrusion. A corner portion on a tip side of at least one of the gear protrusion and the operating protrusion is provided with a retreating portion.

Abstract: An image display method includes a determination step, a generation step, and a display step. A processor refers to a reference model indicating a figure expanding two-dimensionally or three-dimensionally in a three-dimensional space including two or more points and determines whether or not a positional relationship between each of the two or more points and the reference model meets a condition that is set in advance in the determination step. The processor generates an image and differentiates a display state of a pixel corresponding to a first point from a display state of a pixel corresponding to a second point in the generation step. The first point meets the condition, and the second point does not meet the condition. The processor displays the image on a display in the display step.

Abstract: An image-processing method includes a measurement step, an index calculation step, a comparison step, and a selection step. A processor measures a distance at each of two or more points in one or more images of a subject in the measurement step. The processor calculates a first index or a second index on the basis of the distance in the index calculation step. The processor compares the first index or the second index with a threshold value in the comparison step. The processor selects at least one image included in the one or more images in the selection step when the first index is greater than the threshold value or the second index is less than the threshold value.

Abstract: A capacitor that includes: a metal base material; a dielectric layer on the metal base material; a conductive layer on the dielectric layer; an oxide layer between the metal base material and the dielectric layer; and an oxygen barrier layer between the oxide layer and the dielectric layer, wherein the oxide layer includes: a first oxidized region containing a metal of the metal base material; and a second oxidized region containing an atom of the oxygen barrier layer and a metal of the metal base material, and a thickness of the first oxidized region is 3 nm or less and is 0% to 50% of a thickness of the second oxidized region.

Abstract: A backside-illumination solid-state image pickup apparatus and a backside-illumination solid-state image-pickup-apparatus manufacturing method, an image pickup apparatus, and electronic equipment that are configured to make it possible to reduce manufacturing costs. A diced memory circuit and logic circuit are laid out in a horizontal direction, are embedded and flattened by using an oxide film, and are stacked so as to be enclosed in a plane direction under a solid-state image pickup element. The present disclosure can be applied to an image pickup apparatus.

Abstract: A flush toilet includes a reservoir tank, a bowl, a rim spout port, a discharge trap conduit, a jet spout port configured to spout flush water toward an inlet of the discharge trap conduit, a jet water conduit configured to supply the flush water from the reservoir tank to the jet spout port, and a discharge device configured to supply or stop supplying the flush water to the jet water conduit, wherein the flush water is spouted at a first flow rate from the jet spout port when the discharge device is driven and the flush water in the reservoir tank flows into the jet water conduit and, after spouting of the first flow rate ends, the flush water is spouted at a second flow rate from the jet spout port due to the flush water retained in the jet water conduit flowing toward the jet spout port.

Abstract: The present invention provides a therapeutic agent for refractory viral infections, etc., which is capable of reducing or eliminating cccDNA from hepatocytes. The therapeutic agent for refractory viral infections according to the present invention is characterized by comprising a complex encapsulating poly-I or a poly-I analog and poly-C or a poly-C analog within a drug carrier useful for drug delivery into cells, wherein the surface of the carrier is conjugated with a molecule imparting the ability to accumulate in hepatocytes.

Abstract: An image compression device includes an extraction unit configured to extract a protection target region from an image, the protection target region being a region including a protection target of personal information; and a compression unit configured to compress the image by compressing the protection target region at a compression ratio higher than a compression ratio for a region other than the protection target region in the image.

Abstract: A water wheel includes a casing to carry a fluid flow through an inside of the casing, a pipe extending in the inside of the casing, a rotor unit having a shaft to be inserted in the inside of the casing, and a support. The shaft is directed toward the pipe. The rotor unit is detachably attached to the casing from outside. The support supports the rotor unit at a predetermined position relative to the pipe when the rotor unit is attached to the casing. A hydraulic power generation device includes the water wheel and a generator driven by the water wheel. A hydraulic power generation system includes the hydraulic power generation device and a flow path with the hydraulic power generation employed in the flow path.

Abstract: A user terminal 10 of one embodiment is operated by a user. The user terminal 10 includes a usage amount acquisition unit 12 configured to acquire information indicating an amount of usage of the user terminal 10 by the user in a predetermined period, and a control unit 13 configured to reduce operability of the user terminal 10 when the amount of usage exceeds a predetermined threshold value.

Abstract: A user terminal 10 according to one embodiment is a user terminal configured to be able to execute a plurality of applications set in advance as targets for use limit. The user terminal (10) includes: a setting unit (11) configured to set a weight according to an application to each of a plurality of applications; a calculation unit (13) configured to calculate a degree of a user's use of the user terminal (10) on the basis of a use amount and a weight of the application used by the user in a predetermined period; and a display control unit (14) configured to hinder the user's use of the user terminal (10) by executing control of screen display of the user terminal (10) in a case in which the degree of use exceeds a predetermined threshold.

Abstract: A user terminal (10) according to one embodiment includes: a notification unit (11) configured to perform a notification for the user using at least one of a sound or a vibration; and a control unit (14) configured to control operations of the notification unit (11). The control unit (14) causes the notification unit (11) to execute a dummy notification not including details of which the user is to be notified at a predetermined notification timing separately from a regular notification including details of which the user is to be notified. The notification unit (11) sets a sound level or a vibration intensity of the dummy notification to be lower than a sound level or a vibration intensity of the regular notification.

Abstract: Conventional porous membranes have a mesh structure having a relatively large pore diameter in order to improve the removability of a relatively large component such as a virus. When a contaminative liquid to be filtered is filtered, contaminants are easily accumulated in the porous membranes, clogging or the like occurs in the porous membranes, and contamination of the porous membranes easily occurs. Accordingly, an object is to provide a porous membrane having high contamination resistance and high-precision removability. To achieve the object, provided is a porous membrane including, in at least one surface, a surface portion spanning 10 ?m in thickness from the surface, being denser than an inner portion, and having a removal rate T of dextran having a weight-average molecular weight of 40,000 Da of 60 to 95%, in which a number of surface pores per unit area observed on the surface of the surface portion is 200 pores/?m2 to 2,000 pores/?m2.

Abstract: A shock absorber is provided. The shock absorber of the present invention includes a shock absorber main body, a damping passage, a primary damping force generation component, and a secondary damping force generation component. The shock absorber main body has an outer tube and a rod and is stretchable. The damping passage communicates operating chambers with each other provided in the shock absorber main body. The primary and secondary damping force generation components are provided in series with the damping passage. The secondary damping force generation component includes a secondary valve, an annular facing portion, and a valve stopper. The annular facing portion faces the secondary valve with an annular gap between the annular facing portion and the secondary valve. The valve stopper has elasticity to allow bending, and when the secondary valve bends and comes in contact with the valve stopper, restricts the secondary valve from bending.

Abstract: Disclosed is a method for measuring activated partial thromboplastin time, the method comprising: mixing: a blood sample; a first reagent comprising an ellagic acid compound and a compound represented by Formula (I); and a second regent comprising a calcium ion; and measuring activated partial thromboplastin time using the mixture prepared in the mixing step, wherein the compound represented by Formula (I) is shown below wherein X is a hydrogen atom, —(C?O)—Y, or —(C?O)—OZ, Y is a hydroxyl group, a hydrogen atom, a linear or branched alkyl group having a carbon number of 1 or more and 6 or less, or a phenyl group, and Z is an alkali metal.

Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.

Abstract: Provided is an iron-based soft magnetic powder that may be used in producing a dust core having a low iron loss. The iron-based soft magnetic powder has a crystallinity of 10% or less, volume-based median circularity (C50) of 0.85 or more, and when heated to 400° C. at a heating rate of 3° C./min and held at 400° C. for 20 min in a nitrogen atmosphere, then allowed to naturally cool to room temperature, number density of Cu clusters in the powder of 1.00×103/?m3 or more and 1.00×106/m3 or less, and average Cu concentration of the Cu clusters of 30.0 at % or more.

Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.

Abstract: A microneedle sheet according to one embodiment includes: a sheet body having a main surface; and at least one microneedle formed on the sheet body and lying along the main surface. Each of the at least one microneedle has a base positioned on a first side of the sheet body and a tip oriented toward a second side of the sheet body that is opposite to the first side. A first portion of the sheet body is bent from the first side, whereby the microneedle positioned in the first portion is raised from the main surface and the raised microneedle is applied to skin.