Patents by Inventor Naoko Senda

Naoko Senda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10846849
    Abstract: The present invention provides a method and an apparatus for analyzing a cell state, cell death in particular, in an interior of a spheroid non-invasively and quantitatively when the spheroid is cultured. More specifically, the present invention provides a method and an apparatus for analyzing a cell state by implementing optical imaging of a spheroid by using an optical instrument characterized by a high resolution and analyzing the internal structure of the spheroid.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: November 24, 2020
    Assignee: Hitachi High-Tech Corporation
    Inventors: Naoko Senda, Toshinari Sakurai
  • Publication number: 20200308530
    Abstract: Provided is a method for non-invasively and quantitatively determining multilayerization and differentiation when culturing a cell sheet. Provided is a method for determining a cell state by imaging a cell sheet by using an optical instrument characterized by having a high resolution, and then analyzing the inner structure thereof.
    Type: Application
    Filed: June 12, 2020
    Publication date: October 1, 2020
    Applicant: HITACHI HIGH-TECH CORPORATION
    Inventors: Naoko Senda, Kentaro Osawa
  • Publication number: 20200277609
    Abstract: A method of optimizing a synthesis reaction condition for a compound which is synthesized through one or a plurality of reaction steps, the method including: controlling the expression amount of at least one enzyme among one or a plurality of enzymes in the reaction steps by using a wild type and/or a mutant of a promoter; and measuring the synthesis amount of a target compound.
    Type: Application
    Filed: February 11, 2020
    Publication date: September 3, 2020
    Inventors: Ruolan ZHANG, Hirokazu NISHIDA, Naoko SENDA
  • Patent number: 10717962
    Abstract: Provided is a method for non-invasively and quantitatively determining multilayerization and differentiation when culturing a cell sheet. Provided is a method for determining a cell state by imaging a cell sheet by using an optical instrument characterized by having a high resolution, and then analyzing the inner structure thereof.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: July 21, 2020
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Naoko Senda, Kentaro Osawa
  • Publication number: 20200040374
    Abstract: Provided is a method for detecting a microorganism in a test sample containing cells, including a step of adding the sample to a microorganism culture medium, a step of culturing the microorganism culture medium containing the sample, a step of sampling a part of the culture medium at a predetermined time, a step of acquiring the ATP level of the sampled culture medium, and a step of detecting the microorganism in the sample based on the change of the ATP level over time.
    Type: Application
    Filed: March 11, 2019
    Publication date: February 6, 2020
    Inventors: Chihiro MANRI, Hideyuki NODA, Naoko SENDA
  • Publication number: 20190244349
    Abstract: The present invention provides a method and an apparatus for analyzing a cell state, cell death in particular, in an interior of a spheroid non-invasively and quantitatively when the spheroid is cultured. More specifically, the present invention provides a method and an apparatus for analyzing a cell state by implementing optical imaging of a spheroid by using an optical instrument characterized by a high resolution and analyzing the internal structure of the spheroid.
    Type: Application
    Filed: June 16, 2016
    Publication date: August 8, 2019
    Applicant: Hitachi High-Technologies Corporation
    Inventors: Naoko SENDA, Toshinari SAKURAI
  • Patent number: 10087409
    Abstract: Provided is a cell culturing vessel for holding and culturing cells. It has a first vessel that stores a culture medium and cells or only a culture medium, a second vessel that is placed above the first vessel and stores a culture medium and cells or only a culture medium, a main vessel that holds the first vessel and houses the second vessel, and a lid member that engages with the main vessel. The main vessel has a pressing member that fixes and holds the first vessel in the main vessel and the second vessel is eccentrically held in the first vessel by the pressing member.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: October 2, 2018
    Assignee: Hitachi, Ltd.
    Inventors: Masaharu Kiyama, Guangbin Zhou, Ryota Nakajima, Takayuki Nozaki, Naoko Senda, Shizu Matsuoka
  • Patent number: 9862921
    Abstract: There is provided a method for noninvasively evaluating the cell state (proliferation, multi-layering, and differentiation) of a cell sheet as a mimic tissue at the time of culturing the cell sheet. The method is characterized in that an analysis of an amino acid is conducted with the use of the culture supernatant of a cell sheet to monitor a change in the concentration of any amino acid selected from a group of 5-species of amino acids (Ile, Val, Ser, Leu, and Ala), thereby making a determination.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: January 9, 2018
    Assignee: Hitachi High-Technologies Corporation
    Inventors: Naoko Senda, Yoko Inoue, Hiroaki Nakagawa, Akihiro Shimase, Ryota Nakajima, Kazumichi Imai, Shizu Takeda
  • Publication number: 20170159004
    Abstract: Provided is a method for non-invasively and quantitatively determining multilayerization and differentiation when culturing a cell sheet. Provided is a method for determining a cell state by imaging a cell sheet by using an optical instrument characterized by having a high resolution, and then analyzing the inner structure thereof.
    Type: Application
    Filed: June 22, 2015
    Publication date: June 8, 2017
    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Naoko Senda, Kentaro Osawa
  • Patent number: 9638510
    Abstract: An optical measurement apparatus has a light source that emits a laser beam that is branched into signal light and reference light. An objective lens condenses the signal light on a measurement target to cause the measurement target to be irradiated; and a condensing position of the signal light is scanned in an optical axis direction. An interference optical system combines the signal light reflected or scattered from the measurement target with the reference light, and generates a plurality of interfering light beams having phase relationships different from one another that are detected by photodetectors. The detection signals are output as electrical signals; and a signal processing unit performs a predetermined arithmetic operation on the plurality of detection signals. The signal processing unit subtracts reflection light components from a predetermined portion of the measurement target from the plurality of detection signals or signals generated using the detection signals.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: May 2, 2017
    Assignee: HITACHI—LG DATA STORAGE, INC.
    Inventors: Kentaro Osawa, Naoko Senda, Daisuke Tomita
  • Patent number: 9593935
    Abstract: A clear image of a measurement target in optical coherence tomography (OCT) is obtained while suppressing influence of reflected light from a specific portion. Included are a laser beam source, a beam splitter that splits a laser beam into a signal beam and reference beam; an objective lens that focuses the signal beam onto a measurement target in a container, a unit that moves the signal beam focus position, an objective lens that focuses the reference beam, a reflecting mirror, a flat plate arranged between the objective lens and reflecting mirror, and interference optics that combine the signal beam reflected by the measurement target with the reference beam reflected by the reflecting mirror and having passed through the objective lens. Three or more interference beams with different phases, and photodetectors that detect the interference beams are generated, and two of the objective lenses are the same lenses.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: March 14, 2017
    Assignee: Hitachi-LG Data Storage, Inc.
    Inventors: Kentaro Osawa, Naoko Senda, Daisuke Tomita
  • Publication number: 20160122702
    Abstract: There is provided a method for noninvasively evaluating the cell state (proliferation, multi-layering, and differentiation) of a cell sheet as a mimic tissue at the time of culturing the cell sheet. The method is characterized in that an analysis of an amino acid is conducted with the use of the culture supernatant of a cell sheet to monitor a change in the concentration of any amino acid selected from a group of 5-species of amino acids (Ile, Val, Ser, Leu, and Ala), thereby making a determination.
    Type: Application
    Filed: June 17, 2014
    Publication date: May 5, 2016
    Inventors: Naoko SENDA, Yoko INOUE, Hiroaki NAKAGAWA, Akihiro SHIMASE, Ryota NAKAJIMA, Kazumichi IMAI, Shizu TAKEDA
  • Publication number: 20160054113
    Abstract: A clear image of a measurement target in optical coherence tomography (OCT) is obtained while suppressing influence of reflected light from a specific portion. Included are a laser beam source, a beam splitter that splits a laser beam into a signal beam and reference beam; an objective lens that focuses the signal beam onto a measurement target in a container, a unit that moves the signal beam focus position, an objective lens that focuses the reference beam, a reflecting mirror, a flat plate arranged between the objective lens and reflecting mirror, and interference optics that combine the signal beam reflected by the measurement target with the reference beam reflected by the reflecting mirror and having passed through the objective lens. Three or more interference beams with different phases, and photodetectors that detect the interference beams are generated, and two of the objective lenses are the same lenses.
    Type: Application
    Filed: July 9, 2015
    Publication date: February 25, 2016
    Inventors: Kentaro OSAWA, Naoko SENDA, Daisuke TOMITA
  • Publication number: 20150260503
    Abstract: An optical measurement apparatus has a light source that emits a laser beam that is branched into signal light and reference light. An objective lens condenses the signal light on a measurement target to cause the measurement target to be irradiated; and a condensing position of the signal light is scanned in an optical axis direction. An interference optical system combines the signal light reflected or scattered from the measurement target with the reference light, and generates a plurality of interfering light beams having phase relationships different from one another that are detected by photodetectors. The detection signals are output as electrical signals; and a signal processing unit performs a predetermined arithmetic operation on the plurality of detection signals. The signal processing unit subtracts reflection light components from a predetermined portion of the measurement target from the plurality of detection signals or signals generated using the detection signals.
    Type: Application
    Filed: February 3, 2015
    Publication date: September 17, 2015
    Inventors: Kentaro Osawa, Naoko Senda, Daisuke Tomita
  • Publication number: 20150231628
    Abstract: The present invention provides a biological sample packaging container including: a sample storage container having a recessed part; a lid member that seals the upper surface of the sample storage container; and at least one gasket that is provided on the rear surface of the lid member or on the upper surface of the sample storage container, wherein: the sample storage container has a function of holding a biological sample therein; the lid member includes a first lid member provided with flow channel tubes that allow liquid and gas to be moved between the sample storage container and the outside, and a second lid member having no flow channel tubes; and the sample storage container is configured in such a manner that the first lid member and the second lid member can be replaced by each other.
    Type: Application
    Filed: September 11, 2012
    Publication date: August 20, 2015
    Applicant: Hitachi, Ltd.
    Inventors: Takayuki Nozaki, Masaharu Kiyama, Guangbin Zhou, Shizu Matsuoka, Ryota Nakajima, Naoko Senda
  • Publication number: 20150218503
    Abstract: Provided is a cell culturing vessel for holding and culturing cells. It has a first vessel that stores a culture medium and cells or only a culture medium, a second vessel that is placed above the first vessel and stores a culture medium and cells or only a culture medium, a main vessel that holds the first vessel and houses the second vessel, and a lid member that engages with the main vessel. The main vessel has a pressing member that fixes and holds the first vessel in the main vessel and the second vessel is eccentrically held in the first vessel by the pressing member.
    Type: Application
    Filed: September 26, 2012
    Publication date: August 6, 2015
    Applicant: Hitachi, Ltd.
    Inventors: Masaharu Kiyama, Guangbin Zhou, Ryota Nakajima, Takayuki Nozaki, Naoko Senda, Shizu Matsuoka
  • Publication number: 20150072401
    Abstract: In a closed system culture vessel to be used in an automated culture apparatus, some of the ports perform both liquid supply and gas supply functions. Culture medium is thereby made to flow always in one direction. The culture vessel is also configured so that, in the complete culture medium exchange process and the effluent recovery process for analyzing culture medium components, waste liquid medium does not get mixed into fresh culture medium.
    Type: Application
    Filed: March 29, 2012
    Publication date: March 12, 2015
    Inventors: Takayuki Nozaki, Guangbin Zhou, Ryota Nakajima, Shizu Matsuoka, Toyoshige Kobayashi, Naoko Senda