Abstract: A compound represented by the general formula (1) or a salt thereof, which has a superior IRAK-4 inhibitory activity, and is useful as active ingredients of medicaments for prophylactic treatment and/or therapeutic treatment of diseases relating to IRAK-4 inhibition.

Abstract: An NC automatic lathe including abase board, a headstock provided with a main spindle and so arranged as to move in a direction of Z1 axis, a back attachment provided with a sub spindle which is so arranged as to be opposed to the headstock, the back attachment being so arranged as to move in directions of Z2 axis, X2 axis and Y2 axis, a guide bush, a first turret tool post arranged at a side of the guide bush so as to move in directions of X1 axis and Y1 axis, a second turret tool post arranged at a side of the guide bush so as to move in directions of Z3 axis, X3 axis and Y3 axis, and a fixed back machining tool unit arranged at a position offset with respect to at least one of the first turret tool post and second turret tool post, to the back attachment in a direction of Z axis, and provided with tool holding portions in at least two rows and two lines in directions of X axis and Y axis.

Abstract: An NC automatic lathe including abase board, a headstock provided with a main spindle and so arranged as to move in a direction of Z1 axis, a back attachment provided with a sub spindle which is so arranged as to be opposed to the headstock, the back attachment being so arranged as to move in directions of Z2 axis, X2 axis and Y2 axis, a guide bush, a first turret tool post arranged at a side of the guide bush so as to move in directions of X1 axis and Y1 axis, a second turret tool post arranged at a side of the guide bush so as to move in directions of Z3 axis, X3 axis and Y3 axis, and a fixed back machining tool unit arranged at a position offset with respect to at least one of the first turret tool post and second turret tool post, to the back attachment in a direction of Z axis, and provided with tool holding portions in at least two rows and two lines in directions of X axis and Y axis.

Abstract: Disclosed are a 2,3-dihydrobenzofuran derivative represented by formula (1) or a salt thereof, a method for producing the same, and use thereof: ##STR1## wherein R.sup.1 represents a hydrogen atom or a lower alkyl group; R.sup.2 represents a naphthyl group, a pyridyl group, a furyl group or a thienyl group; n is an integer of from 2 to 6; A represents a carbonyl group or a sulfonyl group; and * represents an asymmetric carbon atom. The 2,3-dihydrobenzofuran derivatives of the present invention and the non-toxic salts thereof have a strong affinity for serotonin 1A receptors. Therefore, are useful as pharmaceutical composition containing the 2,3-dihydrobenzofuran derivatives and the non-toxic salts thereof are especially useful for treating a serotonergic neuron-related disease, such as anxiety, depression, eating disorder, high blood pressure, emesis (including emesis induced by motion sickness, space sickness, dizziness and drug, etc.) and the like.