Patents by Inventor Naoto Minamino
Naoto Minamino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220196681Abstract: The present invention is intended to provide a novel biomarker for detecting arteriosclerosis-related disease or for evaluating the stage of progression of arteriosclerosis, and specifically, the present invention relates to a marker for detecting arteriosclerosis-related disease or for evaluating the stage of progression of arteriosclerosis, comprising an NPC2 (Niemann-Pick disease type C2) protein and/or an IGFBP7 (Insulin-like growth factor-binding protein 7) protein.Type: ApplicationFiled: March 29, 2019Publication date: June 23, 2022Applicants: Eiken Kagaku Kabushiki Kaisha, National Cerebral and Cardiovascular CenterInventors: Naoto MINAMINO, Hiroaki YAGI, Mitsuhiro NISHIGORI, Hatsue UEDA, Hitoshi MATSUDA, Yusuke MURAKAMI
-
Publication number: 20220178945Abstract: The present invention is intended to provide a novel biomarker capable of detecting aortic aneurysm with high sensitivity, and specifically, the present invention relates to a detection marker of aortic aneurysm, comprising an NPC2 (Niemann-Pick disease type C2) protein and/or an IGFBP7 (Insulin-like growth factor-binding protein 7) protein.Type: ApplicationFiled: March 29, 2019Publication date: June 9, 2022Applicants: EIKEN KAGAKU KABUSHIKI KAISHA, NATIONAL CEREBRAL AND CARDIOVASCULAR CENTERInventors: Naoto MINAMINO, Hiroaki YAGI, Mitsuhiro NISHIGORI, Hatsue UEDA, Hitoshi MATSUDA, Yusuke MURAKAMI
-
Publication number: 20130260480Abstract: The present invent ion provides a new method and kit tor determining the overload or atrium or ventricle in a subject, comprising at least a step of measuring levels of proBNP-108 in a sample from the subject. The disclosed methods and kits are useful, for example, in the diagnosis, prevention and/or treatment of cardiac diseases, particularly heart failure, aortic stenosis, aortic regurgitation, mitral stenosis, mitral regurgitation, and atrial fibrillation.Type: ApplicationFiled: April 5, 2013Publication date: October 3, 2013Applicants: President of National Cardiovascular Center, Shionogi & Co., Ltd.Inventors: Toshio Nishikimi, Naoto Minamino
-
Publication number: 20120021431Abstract: The present invention provides a new method and kit for determining the overload of atrium or ventricle in a subject comprising at least a step of measuring levels of proBNP-108 in a sample from the subject. The disclosed methods and kits are useful, for example, in the diagnosis, prevention and/or treatment of cardiac diseases, particularly heat failure, aortic stenosis, aortic regurgitation, mitral stenosis, mitral regurgitation, and atrial fibrillation.Type: ApplicationFiled: February 25, 2011Publication date: January 26, 2012Applicants: PRESIDENT OF NATIONAL CARDIOVASCULAR CENTER, SHIONOGI & CO., LTD.Inventors: Toshio Nishikimi, Naoto Minamino
-
Publication number: 20100248255Abstract: The present invention provides novel peptides with circulation-modulating activity. These peptides are useful as circulation-modulating agents and vasopressors because of their circulation-modulating activity, and can be used for treating diseases of the circulatory system such as myocardial infarction, ischemic heart disease, cerebral infarction, or the like.Type: ApplicationFiled: July 28, 2006Publication date: September 30, 2010Applicants: KYOWA HAKKO KOGYO CO., LTD, JAPAN AS REPRESENTED BY THE PRESIDENT OF NATIONAL CARDIOVASCULAR CENTER, OSAKA UNIVERSITYInventors: Motoo Yamasaki, Noriyuki Takahashi, Naoto Minamino, Kazuki Sasaki, Toshifumi Takao, Yoshinori Satomi
-
Publication number: 20100075343Abstract: The present invention provides novel peptides with energy-modulating activity or circulatory function-modulating activity. The peptides of the present invention have energy-modulating activity or circulatory function-modulating activity and thus are useful for treating food consumption disorders and diseases of the circulatory system.Type: ApplicationFiled: November 29, 2007Publication date: March 25, 2010Inventors: Motoo Yamasaki, Noriyuki Takahashi, Naoto Minamino, Kazuki Sasaki, Toshifumi Takao, Yoshinori Satomi, Yoichi Ueta
-
Publication number: 20090105464Abstract: A physiologically active polypeptide derived from human brain and a DNA fragment comprising the base sequence encoding the polypeptide are disclosed. The polypeptide possesses excellent smooth muscle relaxation activity, diuretic or natriuretic activity, and vasodepressor activity, and is thus useful as a medicine for curing circulation diseases, e.g. cardiac edema, nephric edema, hepatic edema, pulmonary edema, hypertension, congestive heart failure, and acute and chronic renal failure.Type: ApplicationFiled: April 19, 2007Publication date: April 23, 2009Applicants: DAIICHI PURE CHEMICALS CO., LTD., DAIICHI PHARMACEUTICAL CO., LTD., Hisayuki MatsuoInventors: Tetsuji Sudoh, Keiji Maekawa, Naoto Minamino, Kenji Kangawa, Hisayuki Matsuo, Atsushi Izumi, Mika Takashima
-
Patent number: 7211380Abstract: A physiologically active polypeptide derived from human brain and a DNA fragment comprising the base sequence encoding the polypeptide are disclosed. The polypeptide possesses excellent smooth muscle relaxation activity, diuretic or natriuretic activity, and vasodepressor activity, and is thus useful as a medicine for curing circulation diseases, e.g. cardiac edema, nephric edema, hepatic edema, pulmonary edema, hypertension, congestive heat failure, and acute and chronic renal failure.Type: GrantFiled: February 7, 1994Date of Patent: May 1, 2007Assignees: Shionogi & Co., Ltd.Inventors: Tetsuji Sudoh, Keiji Maekawa, Naoto Minamino, Kenji Kangawa, Hisayuki Matsuo, Atsushi Izumi, Mika Takashima
-
Publication number: 20050256302Abstract: It is intended to provide novel and useful proteins which are expressed in the central nerve system and act on a calcitonin receptor, genes thereof and medicinal compositions containing the same.Type: ApplicationFiled: May 28, 2003Publication date: November 17, 2005Applicants: Japan Science and Technology Agency, Japan as Represented by Presedent of the NationalInventors: Naoto Minamino, Takeshi Katafuchi
-
Publication number: 20030162710Abstract: A physiologically active polypeptide derived from human brain and a DNA fragment comprising the base sequence encoding the polypeptide are disclosed. The polypeptide possesses excellent smooth muscle relaxation activity, diuretic or natriuretic activity, and vasodepressor activity, and is thus useful as a medicine for curing circulation diseases, e.g. cardiac edema, nephric edema, hepatic edema, pulmonary edema, hypertension, congestive heat failure, and acute and chronic renal failure.Type: ApplicationFiled: January 3, 2003Publication date: August 28, 2003Applicant: DAIICHI PURE CHEMICALS CO., LTD.Inventors: Tetsuji Sudoh, Keiji Maekawa, Naoto Minamino, Kenji Kangawa, Hisayuki Matsuo, Atsushi Izumi, Mika Takashima
-
Publication number: 20020086843Abstract: A physiologically active polypeptide derived from human brain and a DNA fragment comprising the base sequence encoding the polypeptide are disclosed. The polypeptide possesses excellent smooth muscle relaxation activity, diuretic or natriuretic activity, and vasodepressor activity, and is thus useful as a medicine for curing circulation diseases, e.g. cardiac edema, nephric edema, hepatic edema, pulmonary edema, hypertension, congestive heat failure, and acute and chronic renal failure.Type: ApplicationFiled: July 11, 2001Publication date: July 4, 2002Applicant: Daiichi Pure Chemicals Co., Ltd.Inventors: Tetsuji Sudoh, Keiji Maekawa, Naoto Minamino, Kenji Kangawa, Hisayuki Matsuo, Atsushi Izumi, Mika Takashima
-
Patent number: 6034231Abstract: The gene of a human CNP (human C-type natriuretic peptide), as well as the hCNP precursor protein that is encoded by said gene. The hCNP precursor is represented by the following amino acid sequence.Met His Leu Ser Gln Leu Leu Ala Cys Ala - Leu Leu Leu Thr Leu Leu Ser Leu Arg Pro - Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys - Val Pro Arg Thr Pro Pro Ala Glu Glu Leu - Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln - Lys Lys Gly Asp Lys Ala Pro Gly Gly Gly - Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg - Leu Leu Arg Asp Leu Arg Val Asp Thr Lys - Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln - Glu His Pro Asn Ala Arg Lys Tyr Lys Gly - Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys - Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser - Met Ser Gly Leu Gly Cys.The hCNP precursor and its derivatives are novel and have natriuretic and hypotensive activities.Type: GrantFiled: September 26, 1991Date of Patent: March 7, 2000Assignee: Suntory LimitedInventors: Shoji Tanaka, Kayoko Fuchimura, Yasunori Tawaragi, Hisayuki Matsuo, Kenji Kanagawa, Naoto Minamino
-
Patent number: 6020168Abstract: The gene and cDNA of a procine derived CNP (C-type natriuretic peptide), and a procine derived CNP precursor protein and derivatives thereof are disclosed. The proceine derivative CNP precursor is represented by the following amino acid sequence:Met His Leu Ser Gln Leu Leu Ala Cys Ala - Leu Leu Leu Thr Leu Leu Ser Leu Arg Pro - Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys - Val Pro Arg Thr Pro Pro Gly Glu Glu Val - Ala Glu Pro Gln Ala Ala Gly Gly Gly Gln - Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly - Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg - Leu Leu Arg Asp Leu Arg Val Asp Thr Lys - Ser Arg Ala Ala Trp Ala Arg Leu Leu His - Glu His Pro Asn Ala Arg Lys Tyr Lys Gly - Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys - Phe Gly Leu Lys Leu Asp Arg Ile Gly SerThese derivatives are novel and have natriuretic and hypotensive activities.Type: GrantFiled: July 12, 1991Date of Patent: February 1, 2000Assignees: Suntory Limited, Hisayuki MatsuoInventors: Hisayuki Matsuo, Kenji Kangawa, Naoto Minamino, Shoji Tanaka, Kayoko Fuchimura, Yasunori Tawaragi
-
Patent number: 5340920Abstract: A peptide composed of 53 amino acid residues represented by the following amino acid sequence: (see SEQ ID NO: 1) ##STR1## and derivatives thereof represented by the following amino acid sequence: (see SEQ ID NO: 2) ##STR2## wherein X is as shown in the specification, are disclosed. These polypeptides are novel and have natriuretic and hypotensive actions.Type: GrantFiled: July 12, 1991Date of Patent: August 23, 1994Assignee: Hisayuki MatsuoInventors: Hisayuki Matsuo, Kenji Kangawa, Naoto Minamino
-
Patent number: 5338830Abstract: A novel peptide that exhibits a natriuretic action and a vasodepressor activity, and hence, that is applicable as a diagnostic reagent. The novel peptide is manufactured by the procedure of genetic engineering as well as by the methods of purification from chicken brains or by chemical synthesis.Type: GrantFiled: September 4, 1991Date of Patent: August 16, 1994Assignees: Suntory Limited, Hisayuki MatsuoInventors: Hisayuki Matsuo, Kenji Kangawa, Naoto Minamino
-
Patent number: 5336759Abstract: A novel peptide that exhibits a natriuretic action and a vasodepressor activity, and hence, that is applicable for a diagnostic reagent. The novel peptide is manufactured by tile procedure of genetic engineering as well as by the methods of purification from frog brains or by chemical synthesis.Type: GrantFiled: September 4, 1991Date of Patent: August 9, 1994Assignees: Suntory Limited, Hisayuki MatsuoInventors: Hisayuki Matsuo, Kenji Kangawa, Naoto Minamino
-
Patent number: 4904763Abstract: Disclosed herein is a physiologically-active peptide represented by the following general formula (I): ##STR1## wherein X means H or H-Asp-Ser-Gly- and Y denotes -Asn-Val-Leu-Arg-Arg-Tyr-OH, -Asn-Val-Leu-Arg-Arg-OH, -Asn-Val-Leu-Arg-Tyr-OH, -Asn-Val-Leu-Arg-OH, -Asn-Val-Leu-OH or -Asn-Ser-Phe-Arg-Tyr-OH, or a salt thereof.Type: GrantFiled: June 17, 1988Date of Patent: February 27, 1990Assignees: Daiichi Pure Chemicals Co., Ltd., Hisayuki MatsuoInventors: Hisayuki Matsuo, Kenji Kangawa, Naoto Minamino, Tetsuji Sudoh, Atsushi Izumi, Mitsutaka Isogai