Patents by Inventor Narasimhan Mani

Narasimhan Mani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160346227
    Abstract: The present invention provides immediate release and modified release oral dosage forms. Specifically, the invention provides modified and immediate release pharmaceutical dosage forms containing memantine that exhibit an enhanced release profile and provide reliable absorption. The dosage forms may be used to treat mild, moderate or severe Alzheimer's disease or neuropathic pain.
    Type: Application
    Filed: August 11, 2016
    Publication date: December 1, 2016
    Inventors: Mahendria G. Dedhiya, Suneel K. Rastogi, Anil Chhettry, Narasimhan Mani, Niranjan Rao, Antonia Periclou
  • Publication number: 20150258042
    Abstract: The present invention provides immediate release and modified release oral dosage forms. Specifically, the invention provides modified and immediate release pharmaceutical dosage forms containing memantine that exhibit an enhanced release profile and provide reliable absorption. The dosage forms may be used to treat mild, moderate or severe Alzheimer's disease or neuropathic pain.
    Type: Application
    Filed: May 27, 2015
    Publication date: September 17, 2015
    Inventors: Mahendra G. DEDHIYA, Suneel K. RASTOGI, Anil CHHETTRY, Narasimhan MANI, Niranjan RAO, Antonia PERICLOU
  • Publication number: 20130302430
    Abstract: The present invention provides immediate release and modified release oral dosage forms. Specifically, the invention provides modified and immediate release pharmaceutical dosage forms containing memantine that exhibit an enhanced release profile and provide reliable absorption. The dosage forms may be used to treat mild, moderate or severe Alzheimer's disease or neuropathic pain.
    Type: Application
    Filed: July 17, 2013
    Publication date: November 14, 2013
    Inventors: Mahendra G. DEDHIYA, Suneel K. RASTOGI, Anil CHHETTRY, Narasimhan MANI, Niranjan RAO, Antonia PERICLOU
  • Publication number: 20130011474
    Abstract: The present invention provides immediate release and modified release oral dosage forms. Specifically, the invention provides modified and immediate release pharmaceutical dosage forms containing memantine that exhibit an enhanced release profile and provide reliable absorption. The dosage forms may be used to treat mild, moderate or severe Alzheimer's disease or neuropathic pain.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: FOREST LABORATORIES HOLDINGS LTD.
    Inventors: Mahendra G. DEDHIYA, Suneel K. RASTOGI, Anil CHHETTRY, Narasimhan MANI, Antonia PERICLOU, Niranjan Rao
  • Patent number: 8257746
    Abstract: Tannate compositions containing active pharmaceutical ingredients to be used for treating nausea, vomiting, pain, convulsions, and insomnia and manufacturing processes for preparing the tannate compositions.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: September 4, 2012
    Assignee: Pernix Therapeutics, LLC
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Publication number: 20120201889
    Abstract: The present invention provides immediate release and modified release oral dosage forms. Specifically, the invention provides modified and immediate release pharmaceutical dosage forms containing memantine that exhibit an enhanced release profile and provide reliable absorption. The dosage forms may be used to treat mild, moderate or severe Alzheimer's disease or neuropathic pain.
    Type: Application
    Filed: February 15, 2012
    Publication date: August 9, 2012
    Applicant: Forest Laboratories Holdings Ltd.
    Inventors: Mahendra G. Dedhiya, Suneel K. Rastogi, Anil Chhettry, Narasimhan Mani, Antonia Periclou, Niranjan Rao
  • Publication number: 20110288079
    Abstract: Tannate compositions containing active pharmaceutical ingredients to be used for treating nausea, vomiting, pain, convulsions, and insomnia and manufacturing processes for preparing the tannate compositions.
    Type: Application
    Filed: July 28, 2011
    Publication date: November 24, 2011
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan ManI
  • Patent number: 8012506
    Abstract: Tannate compositions containing active pharmaceutical ingredients to be used for treating nausea, vomiting, pain, convulsions, and insomnia and manufacturing processes for preparing the tannate compositions.
    Type: Grant
    Filed: August 9, 2006
    Date of Patent: September 6, 2011
    Assignee: Pernix Therapeutics, LLC
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Patent number: 7786168
    Abstract: The present invention relates to pharmaceutical compositions of gabapentin tannate in solid dosage form, processes for production of those compositions and methods of use of those compositions. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. The process may utilize either natural or synthetic tannic acid.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: August 31, 2010
    Assignee: Kiel Laboratories, Inc.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Patent number: 7550628
    Abstract: The present invention provides a novel process for preparation of the tannate salt of gabapentin for human and veterinary pharmaceutical use. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. However, the prior art neither discloses nor suggests the preparation of gabapentin tannate. The process for preparing gabapentin tannate includes the mixing of gabapentin and tannic acid together in the presence of one or more solvents. The method may further include the step of selecting the one or more solvents from a group consisting of purified water, ethanol, glycerin, propylene glycol, diethylether, methylene chloride, acetone, isopropyl alcohol and mixtures thereof. The process may also include the steps of isolating and purifying the tannate salt. This may be accomplished by filtration, drying, centrifugation and lyophilization. The process may utilize either natural or synthetic tannic acid.
    Type: Grant
    Filed: March 22, 2004
    Date of Patent: June 23, 2009
    Assignee: Kiel Laboratories, Inc.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Patent number: 7456312
    Abstract: The present invention relates to pharmaceutical compositions of gabapentin tannate in solid dosage form, processes for production of those compositions and methods of use of those compositions. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. The process may utilize either natural or synthetic tannic acid.
    Type: Grant
    Filed: March 22, 2004
    Date of Patent: November 25, 2008
    Assignee: Kiel Laborities, Inc.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Publication number: 20080242728
    Abstract: The present invention relates to pharmaceutical compositions of gabapentin tannate in solid dosage form, processes for production of those compositions and methods of use of those compositions. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. The process may utilize either natural or synthetic tannic acid.
    Type: Application
    Filed: June 13, 2008
    Publication date: October 2, 2008
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Patent number: 7390922
    Abstract: The present invention relates to pharmaceutical compositions of gabapentin tannate, processes for production of those compositions and methods of use of those compositions. The present invention provides a novel process for preparation of the tannate salt of gabapentin in liquid or semi-solid dosage form for human and veterinary pharmaceutical use. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. The process may utilize either natural or synthetic tannic acid.
    Type: Grant
    Filed: March 22, 2004
    Date of Patent: June 24, 2008
    Assignee: Kiel Laboratories, Inc.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Publication number: 20080125453
    Abstract: Compositions of tannate salts of phenylephrine, pyrilamine, and dextromethorphan produced by a method that allows for the in-situ conversions and incorporation of the tannate salts in a single dosage form. The conversion process includes dissolving salts of phenylephrine, pyrilamine, and dextromethorphan in a solvent and mixing with a dispersing agent and tannic acid to generate tannate salts. The tannate salts may be further processed without further purification or isolation to single dosage forms, such as tablets and suspension.
    Type: Application
    Filed: February 8, 2008
    Publication date: May 29, 2008
    Applicant: TIBER LABORATORIES, LLC
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Patent number: 7273623
    Abstract: An active pharmaceutical ingredient is combined with tannic acid to form a tannate salt complex of the active ingredient. The active ingredient tannate salt complex without isolation or purification is then blended with pharmaceutically acceptable excipients to form a granulate which is processed into a tablet or capsule to generate a therapeutic solid dosage form.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: September 25, 2007
    Assignee: Kiel Laboratories, Inc.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Publication number: 20070196472
    Abstract: Compositions of tannate salts of phenylephrine and pyrilamine produced by a method that allows for the in-situ conversion and incorporation of the tannate salts in a single dosage form. The conversion process includes dissolving a salts of phenylephrine and pyrilamine in a solvent and mixing with a dispersing agent and tannic acid to generate tannate salts. The tannate salts may be further processed to single dosage forms, such as tablets and suspensions.
    Type: Application
    Filed: April 18, 2007
    Publication date: August 23, 2007
    Inventors: Jeffrey Kiel, H. Thomas, Narasimhan Mani
  • Publication number: 20070112075
    Abstract: The present invention relates to stable pharmaceutical formulations of escitalopram and bupropion and their use for the treatment a central nervous system disorder, such as a mood disorder (e.g., major depressive disorder) or an anxiety disorder (e.g., general anxiety disorder, social anxiety disorder, post traumatic stress disorder, or panic disorder).
    Type: Application
    Filed: October 16, 2006
    Publication date: May 17, 2007
    Applicant: Forest Laboratories, Inc.
    Inventors: Mahendra Dedhiya, Anil Chhettry, Narasimhan Mani
  • Publication number: 20070065512
    Abstract: The present invention provides immediate release and modified release oral dosage forms. Specifically, the invention provides modified and immediate release pharmaceutical dosage forms containing memantine that exhibit an enhanced release profile and provide reliable absorption. The dosage forms may be used to treat mild, moderate or severe Alzheimer's disease or neuropathic pain.
    Type: Application
    Filed: June 14, 2006
    Publication date: March 22, 2007
    Applicant: Forest Laboratories, Inc.
    Inventors: Mahendra Dedhiya, Suneel Rastogi, Anil Chhettry, Narasimhan Mani, Antonia Periclou, Niranjan Rao
  • Publication number: 20070020332
    Abstract: Tannate compositions containing active pharmaceutical ingredients to be used for treating nausea, vomiting, pain, convulsions, and insomnia and manufacturing processes for preparing the tannate compositions.
    Type: Application
    Filed: August 9, 2006
    Publication date: January 25, 2007
    Inventors: Jeffrey Kiel, H. Thomas, Narasimhan Mani
  • Patent number: 7094429
    Abstract: An active ingredient from the group of an antihistamine, a decongestant, an antitussive or anticholinergic is dissolved in a suitable solvent and added to a dispersion of tannic acid in water to form the tannate salt complex of the active ingredient. The active ingredient tannate salt complex without isolation or purification is then added to a liquid or semi-solid medium composed of thickening, suspending, coloring, sweetening and flavoring agents, with stirring. Thereafter, preservatives, pH-adjusting and anti-caking agents in a suitable solvent are mixed with the liquid or semi-solid medium to generate a therapeutic dosage form.
    Type: Grant
    Filed: August 19, 2004
    Date of Patent: August 22, 2006
    Assignee: Kiel Laboratories, Inc.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani