Patents by Inventor Nathan Zygraich

Nathan Zygraich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Temperature sensitive strain of bovine viral diarrhoea virus
    Patent number: 4714678
    Abstract: Disclosed is a temperature - sensitive (ts) mutant of bovine viral diarrhoea (BVD) virus which shows a considerably limited replication ability at the animal body temperature. The mutant is prepared by reacting wild-type BVD with a chemical mutagen such as nitrous acid. The mutant virous is advantageously used in vaccine compositions because it is capable of inducing immunity in bovines without causing serious side effects.
    Type: Grant
    Filed: July 31, 1986
    Date of Patent: December 22, 1987
    Assignee: SmithKline-RIT
    Inventors: Jean-Claude Delgoffe, Michele Lobmann, Nathan Zygraich
  • Temperature sensitive strains of bovine viral diarrhoea virus, preparation thereof and vaccines containing them
    Patent number: 4618493
    Abstract: A live bovine viral diarrhoea (BVD) virus vaccine capable of producing immunity in bovines without causing significant side effects comprising a temperature sensitive (ts) mutant of BVD virus which is obtained by mutating a strain of BVD virus with nitrous acid. The temperature sensitive mutants show a replication ability considerably limited at the animal body temperature of 39.5.degree. C. The vaccine may be combined with other live bovine vaccines such as respiratory virus vaccines and then administered to bovines.
    Type: Grant
    Filed: October 13, 1982
    Date of Patent: October 21, 1986
    Assignee: SmithKline-RIT
    Inventors: Jean-Claude Delgoffe, Michele Lobmann, Nathan Zygraich
  • Methods of vaccinating humans against rotavirus infection
    Patent number: 4341763
    Abstract: The invention relates to rotavirus vaccines for man and to methods of using them.The vaccines comprise an effective dose of bovine rotavirus which is either attenuated or inactivated.The invention comprises a method of immunizing human beings against human rotavirus infections by administering said vaccines by intramuscular, oral or nasal route; it further comprises a method of immunizing infants by boosting their mother with said vaccines prior to the birth of said infants.
    Type: Grant
    Filed: March 10, 1981
    Date of Patent: July 27, 1982
    Assignee: SmithKline-Rit
    Inventor: Nathan Zygraich
  • Live Newcastle disease virus vaccine
    Patent number: 4235876
    Abstract: The invention relates to an avian vaccine and to the preparation thereof.The vaccine according to the invention is a Newcastle disease virus vaccine. Its active ingredient is the P/77/8 NDV strain.The vaccine of the invention is useful in the prevention of Newcastle disease by administration to chickens in the form of an aerosol.
    Type: Grant
    Filed: April 24, 1978
    Date of Patent: November 25, 1980
    Assignee: SmithKline-Rit
    Inventors: Jacqueline Gits, Nathan Zygraich
  • Live Newcastle disease virus vaccines
    Patent number: 4053583
    Abstract: The improved live Newcastle disease virus vaccines of the invention contain a cold or cold and temperature-sensitive strain of Newcastle disease virus obtained by U.V. or nitrous acid mutation. The vaccines are administered to chickens in the form of an aerosol.
    Type: Grant
    Filed: March 1, 1976
    Date of Patent: October 11, 1977
    Assignee: SmithKline Corporation
    Inventors: Jacqueline Gits, Nathan Zygraich
  • Live brovine adenovirus vaccines, preparation thereof and method of vaccination using them
    Patent number: 3962424
    Abstract: The invention relates to live virus vaccines containing temperature-sensitive mutant strains of bovine Adenovirus, the cut-off temperature of said mutant strain being comprised between 39.degree. and 40.degree. C.The invention also relates to the induction of said temperature-sensitive mutant strains and to a vaccination method by intranasal administration of the obtained vaccines.
    Type: Grant
    Filed: August 13, 1975
    Date of Patent: June 8, 1976
    Assignee: Recherche et Industrie Therapeutiques (R.I.T.)
    Inventors: Nathan Zygraich, Constant Huygelen