Abstract: A dispensing package for a spreadable personal care product and its respective methods for dispensing the product. The dispensing package comprises a reusable dispenser, a replaceable cartridge and optionally a top cap. The reusable dispenser comprises a tubular body and a telescopic actuator. The telescopic actuator comprises a hand wheel, a leading screw, a tubular screw and an elevator. The replaceable cartridge comprises a push plate. The telescopic actuator is able to engage with the push plate of the replaceable cartridge to deliver the personal care product such that a top surface of the elevator telescopes with a bottom surface of the push plate of the replaceable cartridge.

Abstract: The hybrid measurement system includes an evanescent prism coupling spectroscopy (EPCS) sub-system and a light-scattering polarimetry (LSP) sub-system. The EPCS sub-system includes an EPCS light source optically coupled to an EPCS detector system through an EPCS coupling prism. The LSP sub-system includes an LSP light source optically coupled to an optical compensator, which in turn is optically coupled to a LSP detector system via a LSP coupling prism. A support structure supports the EPCS and LSP coupling prisms to define a coupling prism assembly, which supports the two prisms at a measurement location. Stress measurements made using the EPCS and LSP sub-systems are combined to fully characterize the stress properties of a transparent chemically strengthened substrate. Methods of processing the EPCS and LSP measurements to improve measurement accuracy are also disclosed.

Abstract: The present disclosure relates to systems, devices and methods for receiving biosensor data acquired by a medical device, e.g., relating to glucose concentration values, and controlling the access and distribution of that data. In some embodiments, systems and methods are disclosed for monitoring glucose levels, displaying data relating to glucose values and metabolic health information, and controlling distribution of glucose data between applications executing on a computer, such as a smart phone. In some embodiments, systems and methods are disclosed for controlling access to medical data such as continuously monitored glucose levels, synchronizing health data relating to glucose levels between multiple applications executing on a computer, and/or encrypting data.

Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Abstract: Disclosed herein are light guide plates (100, 100?, 100?) comprising a transparent substrate (110) having an edge surface (150), a light emitting first major surface (160), and an opposing second major surface (170); and a polymeric film (120) disposed on at least one of the first (160) and second (170) major surfaces of the transparent substrate, wherein the polymeric film (120) comprises a plurality of microstructures (130) and/or a plurality of light extraction features. At least one light source (140) may be coupled to the edge surface (150) of the transparent substrate (110). Display and lighting devices comprising such light guide plates are further disclosed, as well as methods for manufacturing such light guide plates.

Abstract: The prism-coupling systems and methods include using a prism-coupling system to collect initial TM and TE mode spectra of a chemically strengthened article having a refractive index profile with a near-surface spike region and a deep region. The prism-coupling system has a light source configured to generate sequential measurement light beams or reflected light beams having different measurement wavelengths. The different measurement wavelengths generate different TM and TE mode spectra. The light source can include multiple light-emitting elements and optical filters or a broadband light source and optical filters. The optical filters can be sequentially inserted into either the input optical path or the output optical path of the prism-coupling system.

Abstract: This disclosure provides methods, apparatuses, wireless nodes and computer-readable mediums for wireless communications. In one aspect, a method is provide for dynamic selection and triggering of uplink (UL) transmission (TX) modes. A method that may be performed by an access point (AP) includes dynamically selecting an UL single user (SU) TX mode, an UL multiple user (MU) multiple input multiple output (MIMO) TX mode, or an UL orthogonal frequency division multiple access (OFDMA) TX mode. The AP communicates with one or more stations (STAs) based on the dynamically selected UL TX mode.

Abstract: The present disclosure relates to systems, devices and methods for receiving biosensor data acquired by a medical device, e.g., relating to glucose concentration values, and controlling the access and distribution of that data. In some embodiments, systems and methods are disclosed for monitoring glucose levels, displaying data relating to glucose values and metabolic health information, and controlling distribution of glucose data between applications executing on a computer, such as a smart phone. In some embodiments, systems and methods are disclosed for controlling access to medical data such as continuously monitored glucose levels, synchronizing health data relating to glucose levels between multiple applications executing on a computer, and/or encrypting data.

Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.

Abstract: Systems and methods for interactive site resource management are disclosed. In certain embodiments, the system and method collects and accesses local geospatially-referenced landscape and site survey data in the field as facilitated by selectable content views, the gathered landscape and site survey data synthesized with baseline geospatially-referenced landscape and site survey data. In one aspect, the synthesized landscape and site geospatially-referenced survey data may be used by a project lead or authority agent, to create a landscape and/or site report, an authorized development plan, a master landscape and/or site survey, and/or as-built development plans. In certain embodiments, the synthesized landscape site survey data is presented as an augmented reality display.

Abstract: A method and apparatus for automated particulate extraction from solid parts is disclosed herein, which comprises a test tank (42) and a liquid cleaning medium (46) for washing a test part (48). The principle advantages offered by this invention include the ability to verify that the test tank (42) has met a required tank clean threshold (102) as specified by a percentage reduction of contaminants (78) through the use of a liquid quality sensor (76) which repeatedly measures the contamination level of a liquid cleaning medium (46) exiting the test tank (42). Type I and Type II sampling error are eliminated by verifying that the liquid cleaning medium (46) passing from the test tank (42) has measured contaminants (78) reaching both a maximum value (98) and then falling below a specified tank clean threshold (102) prior to ending the cleaning cycle.

Abstract: This disclosure provides systems, methods and apparatus, including computer programs encoded on computer storage media, for adjusting a packet duration for triggered uplink (UL) transmissions to an access point (AP) from one or more stations (STAs). In one aspect, the AP may estimate an amount of data that a STA has queued for UL transmission and select the packet duration based on the estimated amount of queued UL data. The AP may transmit a trigger frame that solicits UL data from the STA and indicates the selected packet duration. In response, the AP may receive an UL packet from the STA and determine an amount of UL data queued in the STA based on the UL packet. In some implementations, the AP may selectively adjust the packet duration for UL transmissions based on the UL packet, the determined amount of UL data queued in the STA, or both.

Abstract: Polypeptides, viruses, methods and compositions provided herein are useful for the selective elimination of senescent cells. Method aspects include methods for inducing apoptosis in a senescent cell comprising administering to the cell a polynucleotide, virus, host cell, or pharmaceutical composition described herein. Other methods include expressing a pro-apoptotic gene in a senescent cell comprising administering to the cell the polynucleotide, virus, or pharmaceutical composition as described herein.

Abstract: This invention is based on the discovery that many lung diseases associated with aging are mediated at least in part by cells bearing a senescent phenotype. Senescent cells accumulate with age, and express factors that contribute to the pathophysiology of age related conditions. The severity of age-related conditions typically correlates with the abundance of senescent cells: thus, clearing senescent cells can help abrogate the condition: providing symptomatic relief, and potentially inhibiting disease progression. In accordance with this invention, a family of Bcl protein inhibitors has been developed for the treatment of lung diseases. These senolytic agents have an appropriate dose and specificity profile to be effective in the clinical management of previously intractable pulmonary diseases.

Abstract: A library of heterocyclic compounds has been screened to identify particular compounds that have high inhibitory capacity for the Bcl family of regulatory proteins. Compounds identified as Bcl antagonists have been further screened to select pharmaceutical agents with both high potency and high specificity for eliminating senescent cells in comparison with replicative or quiescent cells of the same tissue type. Particular structures are identified in this disclosure that eliminate senescent cells with an EC50 in the nanomole range and a specificity around or above 100-fold. In accordance with this invention, heterocyclic compounds provided in this disclosure can be formulated for the treatment of a range of age-related conditions caused or mediated by senescent cells. Such conditions are exemplified by ophthalmic conditions, pulmonary conditions, and osteoarthritis.

Abstract: Disclosed herein are compounds that are effective for treatment of various disease states. Dosing includes both single administration and regimens of cycling dosages.

Abstract: Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

Abstract: Systems, apparatuses, and methods for performing efficient video compression are disclosed. A video processing system includes a transmitter sending a video stream over a wireless link to a receiver. The transmitter includes a processor and an encoder. The processor generates rendered blocks of pixels of a video frame, and when the processor predicts a compression level for a given region of the video frame is different from a compression level for immediately neighboring blocks, the processor generates side information. The side information identifies a location of the given region in the video frame and a type of content that causes the compression level differences. The processor sends the rendered video information and the side information as accompanying metadata to the encoder. The encoder updates encoding parameters based on the received side information, and compresses the rendered given region based on the updated encoding parameters.

Abstract: Systems, apparatuses, and methods for performing efficient video transmission are disclosed. In a video processing system, a transmitter identifies multiple planes in a scene. The transmitter renders and compresses each of the multiple planes with a combination of a corresponding compression level and a resolution, which is different from a combination of compression level and resolution of any other plane. For each plane, the transmitter inserts, in multi-plane information, data such as identification of the plane, a location in the video frame for the plane, and one or more of a resolution and compression level for the plane. The transmitter conveys the rendered and compressed planes along with the multi-plane information to a receiver. The receiver decodes each of the planes and insets each of the planes on any lower resolution planes of the multiple planes.