Patents by Inventor Ned M. Weinshenker
Ned M. Weinshenker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7232805Abstract: The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker and one or more optional spacers. Cobalamin is covalently bound to a first spacer or the cleavable linker via the 5?-OH of the cobalamin ribose ring. The drug is bound to a second spacer of the cleavable linker via an existing or added functional group on the drug. After administration, the conjugate forms a complex with transcobalamin (any of its isoforms). The complex then binds to a receptor on a cell membrane and is taken up into the cell. Once in the cell, an intracellular enzyme cleaves the conjugate thereby releasing the drug. Depending upon the structure of the conjugate, a particular class or type of intracellular enzyme affects the cleavage. Due to the high demand for cobalamin in growing cells, tumor cells typically take up a higher percentage of the conjugate than do normal non-growing cells.Type: GrantFiled: September 10, 2003Date of Patent: June 19, 2007Assignee: Inflabloc Pharmaceuticals, Inc.Inventors: Ned M. Weinshenker, Frederick G. West, Barbara A. Araneo, Weiping Li
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Publication number: 20040121991Abstract: The present invention is related to acute therapeutic uses of dehydroepiandrosterone (DHEA) congeners. These uses include methods for treating or preventing ulcers which comprise administering to a subject either at risk or in need thereof having an ulcer a therapeutic amount of DHEA congener.Type: ApplicationFiled: May 22, 2003Publication date: June 24, 2004Inventors: Barbara A. Araneo, Ned M. Weinshenker, John R. Gebhard
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Patent number: 5068227Abstract: Cyclodextrins can be coupled to biorecognition molecules such as antibodies. The cyclodextrins so coupled provide a cavity or complexation zone into which active agents such as labels, drugs and the like may be incorporated. The active agent forms a noncovalently bonded inclusion complex within the cavity of the cyclodextrin. It remains associated with the cyclodextrin and the coupled biorecognition molecule and thus can be delivered to the other half of the biospecific recognition pair. A process for producing these materials is also disclosed. The process includes the steps of activating a primary hydroxyl site on a cyclodextrin; linking a biorecognition molecule to the activated primary hydroxyl site on the cyclodextrin in either a direct covalent linkage or through a covalently linked spacer; and introducing a guest molecule (active agent) into the cavity of the derivatized cyclodextrin to form an inclusion complex.Type: GrantFiled: January 18, 1989Date of Patent: November 26, 1991Assignee: Cyclex, Inc.Inventor: Ned M. Weinshenker
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Patent number: 5068226Abstract: Cyclodextrins and especially ionic cyclodextrin derivatives facilitate the iontophoretic delivery of pharmaceutically active agents.Type: GrantFiled: April 30, 1990Date of Patent: November 26, 1991Assignee: Cyclex, Inc.Inventors: Ned M. Weinshenker, William P. O'Neill
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Patent number: 4532128Abstract: Polymeric quaternary ammonium compounds having recurring vinylbenzyl ammonium units are disclosed. The quaternary ammonium units preferably have 2 alkyl substituents of 1 to 4 carbons and 1 alkyl substituent of 4 to 12 carbons. These materials have antimicrobial properties and are particularly useful for preserving ophthalmic solutions.Type: GrantFiled: September 17, 1984Date of Patent: July 30, 1985Assignee: DynapolInventors: Bernard G. Sheldon, Robert E. Wingard, Jr., Ned M. Weinshenker, Daniel J. Dawson
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Patent number: 4482680Abstract: Polymeric quaternary ammonium compounds having recurring vinylbenzyl ammonium units are disclosed. The quaternary ammonium units preferably have 2 alkyl substituents of 1 to 4 carbons and 1 alkyl substituent of 4 to 12 carbons. These materials have antimicrobial properties and are particularly useful for preserving ophthalmic solutions.Type: GrantFiled: April 13, 1983Date of Patent: November 13, 1984Assignee: DynapolInventors: Bernard G. Sheldon, Robert E. Wingard, Jr., Ned M. Weinshenker, Daniel J. Dawson
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Patent number: 4381185Abstract: Water-fast printing of paper stock using a colorant solution containing water-soluble polymeric dyes is accomplished by a three step process. Step 1 is selecting a paper stock characterized as containing at least 250 ppm by weight of cation, particularly a polyvalent metal cation (especially Ca.sup.2+ or Al.sup.3+). In step 2, a colorant solution is applied to the paper. This solution is water-based, containing up to 30 wt % of an organic paper-penetrating agent (such as an alkanol), and at least 500 ppm of one or more anionic group-possessing polymeric colorants. In step 3, the solvent is exhausted by either evaporation (which may be aided by the application of heat) or diffusion into the paper stock, or by a combination of both.Type: GrantFiled: June 9, 1981Date of Patent: April 26, 1983Assignee: DynapolInventors: Sally A. Swanson, Ned M. Weinshenker, Robert E. Wingard, Jr., Daniel J. Dawson
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Patent number: 4115545Abstract: Novel alkyl diethers of prostaglandins of the formula; ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.6 are hydrogen when Y is a single bond and R.sub.2 and R.sub.6 are absent when Y is a double bond; R.sub.3 is keto, ##STR2## R'.sub.9 is hydrogen or lower alkyl; R'.sub.10 is lower alkyl; R'.sub.11 is lower alkyl; Z.sub.1 is cis or trans --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; Z.sub.2 is trans --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; X is a single bond or a double bond and X is a single bond when R.sub.4 and R.sub.5 are hydrogen; Y is a single bond or a double bond; n is 1 to 5, m is 0 to 4; and the non-toxic salts. The prostaglandin ethers possess valuable pharmacological properties as modifiers of smooth muscle activity, gastric secretion, blood pressure, lipolysis and the reproductive system. The compounds also induce labor and menses and they can be used for the relief of asthma and nasal congestion.Type: GrantFiled: August 11, 1977Date of Patent: September 19, 1978Assignee: Alza CorporationInventors: Ned M. Weinshenker, Niels H. Anderson
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Patent number: 4098829Abstract: Polymeric hydroquinones of the structure ##STR1## WHEREIN N IS FROM 3 TO 10,000 INCLUSIVE AND R and R' independently are hydrogen or a lower alkyl, are disclosed, as is the preparation and the use of such materials, especially as nonabsorbable polymeric antioxidants for edible materials.Type: GrantFiled: May 19, 1977Date of Patent: July 4, 1978Assignee: DynapolInventors: Ned M. Weinshenker, James A. Dale
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Patent number: 4055604Abstract: Insoluble polymeric organotin hydrides of the formula: ##STR1## WHEREIN P represents an organic polymer backbone; R and R.sub.1 each represent a hydrogen atom, a lower alkyl group of 1 to 5 carbon atoms, an aryl group of 6 to 10 carbon atoms, or an alkaryl or aralkyl group of from 7 to 10 carbon atoms; and n is a positive number greater than 1 are disclosed. Such polymeric organotin hydrides are useful as reagents for reducing organic compounds such as organic halides, ketones, and aldehydes without the difficult problem of removing dissolved or dispersed tin impurities from the reduced compounds.Type: GrantFiled: January 28, 1976Date of Patent: October 25, 1977Assignee: DynapolInventor: Ned M. Weinshenker
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Patent number: 4055593Abstract: Novel alkyl diethers of prostaglandins of the formula; ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.6 are hydrogen when Y is a single bond and R.sub.2 and R.sub.6 are absent when Y is a double bond; R.sub.3 is keto, ##STR2## R.sub.4 is hydrogen or ##STR3## R'.sub.9 is hydrogen or lower alkyl; R'.sub.10 is lower alkyl; R'.sub.11 is lower alkyl; Z.sub.1 is cis or trans --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; Z.sub.2 is trans --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; X is a single bond or a double bond and X is a single bond when R.sub.4 and R.sub.5 are hydrogen; Y is a single bond or a double bond; n is 1 to 5, m is 0 to 4; and the non-toxic salts. The prostaglandin ethers possess valuable pharmacological properties as modifiers of smooth muscle activity, gastric secretion, blood pressure, lipolysis and the reproductive system. The compounds also induce labor and menses and they can be used for the relief of asthma and nasal congestion.Type: GrantFiled: April 23, 1975Date of Patent: October 25, 1977Assignee: Alza CorporationInventors: Ned M. Weinshenker, Niels H. Andersen
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Patent number: 4054676Abstract: Polymeric hydroquinones of the structure ##STR1## , wherein n is from 3 to 10,000 inclusive and R and R' independently are hydrogen or a lower alkyl, are disclosed, as is the preparation and the use of such materials, especially as nonabsorbable polymeric antioxidants for edible materials.Type: GrantFiled: December 4, 1974Date of Patent: October 18, 1977Assignee: DynapolInventors: Ned M. Weinshenker, James A. Dale
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Patent number: 4025535Abstract: Flavanones represented by the formula ##STR1## wherein R is a lower alkyl of from one to three carbon atoms inclusive, n is an integer of from one to three inclusive and M is hydrogen or a physiologically acceptable metal cation, are disclosed. These materials are themselves useful as dietetic sweeteners as well as being direct intermediates for the preparation of useful dihydrochalcone sweeteners.Type: GrantFiled: February 13, 1976Date of Patent: May 24, 1977Assignee: Dynapol CorporationInventors: Guy A. Crosby, Grant E. DuBois, Ned M. Weinshenker
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Patent number: 4000201Abstract: Organic liquids subject to oxidative decomposition, such as ethers, are stabilized against such decomposition by the addition of particulate, insoluble solid polymer resin to which is covalently bonded a plurality of oxidation active groups.Type: GrantFiled: October 4, 1974Date of Patent: December 28, 1976Assignee: Dynapol CorporationInventor: Ned M. Weinshenker
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Patent number: 3996199Abstract: Phenolic polymers formed by the reaction of divinylbenzene with a mixture of hydroxyanisole, tertiary butylhydroquinone, tertiary butyl phenol and bisphenol A (and optionally para-cresol) under condensation conditions in the presence of a phenol ortho alkylation catalyst are disclosed. These materials find use as oil-soluble antioxidants especially for edibles.Type: GrantFiled: February 17, 1976Date of Patent: December 7, 1976Assignee: Dynapol CorporationInventors: Ned M. Weinshenker, Leonard A. Bunes, Roman Davis
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Patent number: 3975334Abstract: Insoluble polymeric organotin hydrides of the formula: ##EQU1## wherein P represents an organic polymer backbone; R and R.sub.1 each represent a hydrogen atom, a lower alkyl group of 1 to 5 carbon atoms, an aryl group of 6 to 10 carbon atoms, or an alkaryl or aralkyl group of from 7 to 10 carbon atoms; and n is a positive number greater than 1 are disclosed. Such polymeric organotin hydrides are useful as reagents for reducing organic compounds such as organic halides, ketones, and aldehydes without the different problem of removing dissolved or dispersed tin impurities from the reduced compounds.Type: GrantFiled: May 8, 1974Date of Patent: August 17, 1976Assignee: DynapolInventor: Ned M. Weinshenker
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Patent number: 3974299Abstract: A group of novel dihydrochalcone compounds represented by the formula ##SPC1##Wherein R is a lower alkyl or from one to three carbon atoms inclusive, n is an integer of from one to three inclusive and M is a physiologically acceptable metal cation, are disclosed. These materials are useful as dietetic sweeteners.Type: GrantFiled: March 24, 1975Date of Patent: August 10, 1976Assignee: DynapolInventors: Guy A. Crosby, Grant E. Dubois, Ned M. Weinshenker
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Patent number: 3959190Abstract: A polymeric sulfide oxidation reagent comprising a cross-linked polymeric resin carrying a plurality of lower alkyl sulfide groups, its preparation and its use as a co-reactant for the oxidation of primary and secondary alcohols are disclosed.Type: GrantFiled: June 17, 1974Date of Patent: May 25, 1976Assignee: DynapolInventor: Ned M. Weinshenker
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Patent number: 3941886Abstract: The invention concerns a novel crystalline racemate, 9.alpha. , 11.alpha. , 15(S)-trihydroxy-5-cis,13-trans-prostadienoic acid. The racemate can be administered in pharmaceutical dosage forms or from a drug delivery device at a programmed rate for producing smooth muscle stimulation, termination of pregnancy, induction of labor or induction of menses.Type: GrantFiled: April 17, 1975Date of Patent: March 2, 1976Assignee: Alza CorporationInventor: Ned M. Weinshenker
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Patent number: 3940438Abstract: The invention concerns a novel crystalline racemate, 9.alpha.,11.alpha.,15(S)-trihydroxy-5-cis,13-trans-prostadienoic acid. The racemate can be administered in pharmaceutical dosage forms or from a drug delivery device at a programmed rate for producing smooth muscle stimulation, termination of pregnancy, induction of labor or induction of menses.Type: GrantFiled: September 21, 1973Date of Patent: February 24, 1976Assignee: Alza CorporationInventor: Ned M. Weinshenker