Patents by Inventor Ned M. Weinshenker

Ned M. Weinshenker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7232805
    Abstract: The present invention provides a cobalamin-drug conjugate suitable for the treatment of tumor related diseases. Cobalamin is indirectly covalently bound to an anti-tumor drug via a cleavable linker and one or more optional spacers. Cobalamin is covalently bound to a first spacer or the cleavable linker via the 5?-OH of the cobalamin ribose ring. The drug is bound to a second spacer of the cleavable linker via an existing or added functional group on the drug. After administration, the conjugate forms a complex with transcobalamin (any of its isoforms). The complex then binds to a receptor on a cell membrane and is taken up into the cell. Once in the cell, an intracellular enzyme cleaves the conjugate thereby releasing the drug. Depending upon the structure of the conjugate, a particular class or type of intracellular enzyme affects the cleavage. Due to the high demand for cobalamin in growing cells, tumor cells typically take up a higher percentage of the conjugate than do normal non-growing cells.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: June 19, 2007
    Assignee: Inflabloc Pharmaceuticals, Inc.
    Inventors: Ned M. Weinshenker, Frederick G. West, Barbara A. Araneo, Weiping Li
  • Publication number: 20040121991
    Abstract: The present invention is related to acute therapeutic uses of dehydroepiandrosterone (DHEA) congeners. These uses include methods for treating or preventing ulcers which comprise administering to a subject either at risk or in need thereof having an ulcer a therapeutic amount of DHEA congener.
    Type: Application
    Filed: May 22, 2003
    Publication date: June 24, 2004
    Inventors: Barbara A. Araneo, Ned M. Weinshenker, John R. Gebhard
  • Patent number: 5068226
    Abstract: Cyclodextrins and especially ionic cyclodextrin derivatives facilitate the iontophoretic delivery of pharmaceutically active agents.
    Type: Grant
    Filed: April 30, 1990
    Date of Patent: November 26, 1991
    Assignee: Cyclex, Inc.
    Inventors: Ned M. Weinshenker, William P. O'Neill
  • Patent number: 5068227
    Abstract: Cyclodextrins can be coupled to biorecognition molecules such as antibodies. The cyclodextrins so coupled provide a cavity or complexation zone into which active agents such as labels, drugs and the like may be incorporated. The active agent forms a noncovalently bonded inclusion complex within the cavity of the cyclodextrin. It remains associated with the cyclodextrin and the coupled biorecognition molecule and thus can be delivered to the other half of the biospecific recognition pair. A process for producing these materials is also disclosed. The process includes the steps of activating a primary hydroxyl site on a cyclodextrin; linking a biorecognition molecule to the activated primary hydroxyl site on the cyclodextrin in either a direct covalent linkage or through a covalently linked spacer; and introducing a guest molecule (active agent) into the cavity of the derivatized cyclodextrin to form an inclusion complex.
    Type: Grant
    Filed: January 18, 1989
    Date of Patent: November 26, 1991
    Assignee: Cyclex, Inc.
    Inventor: Ned M. Weinshenker
  • Patent number: 4532128
    Abstract: Polymeric quaternary ammonium compounds having recurring vinylbenzyl ammonium units are disclosed. The quaternary ammonium units preferably have 2 alkyl substituents of 1 to 4 carbons and 1 alkyl substituent of 4 to 12 carbons. These materials have antimicrobial properties and are particularly useful for preserving ophthalmic solutions.
    Type: Grant
    Filed: September 17, 1984
    Date of Patent: July 30, 1985
    Assignee: Dynapol
    Inventors: Bernard G. Sheldon, Robert E. Wingard, Jr., Ned M. Weinshenker, Daniel J. Dawson
  • Patent number: 4482680
    Abstract: Polymeric quaternary ammonium compounds having recurring vinylbenzyl ammonium units are disclosed. The quaternary ammonium units preferably have 2 alkyl substituents of 1 to 4 carbons and 1 alkyl substituent of 4 to 12 carbons. These materials have antimicrobial properties and are particularly useful for preserving ophthalmic solutions.
    Type: Grant
    Filed: April 13, 1983
    Date of Patent: November 13, 1984
    Assignee: Dynapol
    Inventors: Bernard G. Sheldon, Robert E. Wingard, Jr., Ned M. Weinshenker, Daniel J. Dawson
  • Patent number: 4381185
    Abstract: Water-fast printing of paper stock using a colorant solution containing water-soluble polymeric dyes is accomplished by a three step process. Step 1 is selecting a paper stock characterized as containing at least 250 ppm by weight of cation, particularly a polyvalent metal cation (especially Ca.sup.2+ or Al.sup.3+). In step 2, a colorant solution is applied to the paper. This solution is water-based, containing up to 30 wt % of an organic paper-penetrating agent (such as an alkanol), and at least 500 ppm of one or more anionic group-possessing polymeric colorants. In step 3, the solvent is exhausted by either evaporation (which may be aided by the application of heat) or diffusion into the paper stock, or by a combination of both.
    Type: Grant
    Filed: June 9, 1981
    Date of Patent: April 26, 1983
    Assignee: Dynapol
    Inventors: Sally A. Swanson, Ned M. Weinshenker, Robert E. Wingard, Jr., Daniel J. Dawson
  • Patent number: 4115545
    Abstract: Novel alkyl diethers of prostaglandins of the formula; ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.6 are hydrogen when Y is a single bond and R.sub.2 and R.sub.6 are absent when Y is a double bond; R.sub.3 is keto, ##STR2## R'.sub.9 is hydrogen or lower alkyl; R'.sub.10 is lower alkyl; R'.sub.11 is lower alkyl; Z.sub.1 is cis or trans --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; Z.sub.2 is trans --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; X is a single bond or a double bond and X is a single bond when R.sub.4 and R.sub.5 are hydrogen; Y is a single bond or a double bond; n is 1 to 5, m is 0 to 4; and the non-toxic salts. The prostaglandin ethers possess valuable pharmacological properties as modifiers of smooth muscle activity, gastric secretion, blood pressure, lipolysis and the reproductive system. The compounds also induce labor and menses and they can be used for the relief of asthma and nasal congestion.
    Type: Grant
    Filed: August 11, 1977
    Date of Patent: September 19, 1978
    Assignee: Alza Corporation
    Inventors: Ned M. Weinshenker, Niels H. Anderson
  • Patent number: 4098829
    Abstract: Polymeric hydroquinones of the structure ##STR1## WHEREIN N IS FROM 3 TO 10,000 INCLUSIVE AND R and R' independently are hydrogen or a lower alkyl, are disclosed, as is the preparation and the use of such materials, especially as nonabsorbable polymeric antioxidants for edible materials.
    Type: Grant
    Filed: May 19, 1977
    Date of Patent: July 4, 1978
    Assignee: Dynapol
    Inventors: Ned M. Weinshenker, James A. Dale
  • Patent number: 4055593
    Abstract: Novel alkyl diethers of prostaglandins of the formula; ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.6 are hydrogen when Y is a single bond and R.sub.2 and R.sub.6 are absent when Y is a double bond; R.sub.3 is keto, ##STR2## R.sub.4 is hydrogen or ##STR3## R'.sub.9 is hydrogen or lower alkyl; R'.sub.10 is lower alkyl; R'.sub.11 is lower alkyl; Z.sub.1 is cis or trans --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; Z.sub.2 is trans --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; X is a single bond or a double bond and X is a single bond when R.sub.4 and R.sub.5 are hydrogen; Y is a single bond or a double bond; n is 1 to 5, m is 0 to 4; and the non-toxic salts. The prostaglandin ethers possess valuable pharmacological properties as modifiers of smooth muscle activity, gastric secretion, blood pressure, lipolysis and the reproductive system. The compounds also induce labor and menses and they can be used for the relief of asthma and nasal congestion.
    Type: Grant
    Filed: April 23, 1975
    Date of Patent: October 25, 1977
    Assignee: Alza Corporation
    Inventors: Ned M. Weinshenker, Niels H. Andersen
  • Patent number: 4055604
    Abstract: Insoluble polymeric organotin hydrides of the formula: ##STR1## WHEREIN P represents an organic polymer backbone; R and R.sub.1 each represent a hydrogen atom, a lower alkyl group of 1 to 5 carbon atoms, an aryl group of 6 to 10 carbon atoms, or an alkaryl or aralkyl group of from 7 to 10 carbon atoms; and n is a positive number greater than 1 are disclosed. Such polymeric organotin hydrides are useful as reagents for reducing organic compounds such as organic halides, ketones, and aldehydes without the difficult problem of removing dissolved or dispersed tin impurities from the reduced compounds.
    Type: Grant
    Filed: January 28, 1976
    Date of Patent: October 25, 1977
    Assignee: Dynapol
    Inventor: Ned M. Weinshenker
  • Patent number: 4054676
    Abstract: Polymeric hydroquinones of the structure ##STR1## , wherein n is from 3 to 10,000 inclusive and R and R' independently are hydrogen or a lower alkyl, are disclosed, as is the preparation and the use of such materials, especially as nonabsorbable polymeric antioxidants for edible materials.
    Type: Grant
    Filed: December 4, 1974
    Date of Patent: October 18, 1977
    Assignee: Dynapol
    Inventors: Ned M. Weinshenker, James A. Dale
  • Patent number: 4025535
    Abstract: Flavanones represented by the formula ##STR1## wherein R is a lower alkyl of from one to three carbon atoms inclusive, n is an integer of from one to three inclusive and M is hydrogen or a physiologically acceptable metal cation, are disclosed. These materials are themselves useful as dietetic sweeteners as well as being direct intermediates for the preparation of useful dihydrochalcone sweeteners.
    Type: Grant
    Filed: February 13, 1976
    Date of Patent: May 24, 1977
    Assignee: Dynapol Corporation
    Inventors: Guy A. Crosby, Grant E. DuBois, Ned M. Weinshenker
  • Patent number: 4000201
    Abstract: Organic liquids subject to oxidative decomposition, such as ethers, are stabilized against such decomposition by the addition of particulate, insoluble solid polymer resin to which is covalently bonded a plurality of oxidation active groups.
    Type: Grant
    Filed: October 4, 1974
    Date of Patent: December 28, 1976
    Assignee: Dynapol Corporation
    Inventor: Ned M. Weinshenker
  • Patent number: 3996199
    Abstract: Phenolic polymers formed by the reaction of divinylbenzene with a mixture of hydroxyanisole, tertiary butylhydroquinone, tertiary butyl phenol and bisphenol A (and optionally para-cresol) under condensation conditions in the presence of a phenol ortho alkylation catalyst are disclosed. These materials find use as oil-soluble antioxidants especially for edibles.
    Type: Grant
    Filed: February 17, 1976
    Date of Patent: December 7, 1976
    Assignee: Dynapol Corporation
    Inventors: Ned M. Weinshenker, Leonard A. Bunes, Roman Davis
  • Patent number: 3975334
    Abstract: Insoluble polymeric organotin hydrides of the formula: ##EQU1## wherein P represents an organic polymer backbone; R and R.sub.1 each represent a hydrogen atom, a lower alkyl group of 1 to 5 carbon atoms, an aryl group of 6 to 10 carbon atoms, or an alkaryl or aralkyl group of from 7 to 10 carbon atoms; and n is a positive number greater than 1 are disclosed. Such polymeric organotin hydrides are useful as reagents for reducing organic compounds such as organic halides, ketones, and aldehydes without the different problem of removing dissolved or dispersed tin impurities from the reduced compounds.
    Type: Grant
    Filed: May 8, 1974
    Date of Patent: August 17, 1976
    Assignee: Dynapol
    Inventor: Ned M. Weinshenker
  • Patent number: 3974299
    Abstract: A group of novel dihydrochalcone compounds represented by the formula ##SPC1##Wherein R is a lower alkyl or from one to three carbon atoms inclusive, n is an integer of from one to three inclusive and M is a physiologically acceptable metal cation, are disclosed. These materials are useful as dietetic sweeteners.
    Type: Grant
    Filed: March 24, 1975
    Date of Patent: August 10, 1976
    Assignee: Dynapol
    Inventors: Guy A. Crosby, Grant E. Dubois, Ned M. Weinshenker
  • Patent number: 3959190
    Abstract: A polymeric sulfide oxidation reagent comprising a cross-linked polymeric resin carrying a plurality of lower alkyl sulfide groups, its preparation and its use as a co-reactant for the oxidation of primary and secondary alcohols are disclosed.
    Type: Grant
    Filed: June 17, 1974
    Date of Patent: May 25, 1976
    Assignee: Dynapol
    Inventor: Ned M. Weinshenker
  • Patent number: 3941886
    Abstract: The invention concerns a novel crystalline racemate, 9.alpha. , 11.alpha. , 15(S)-trihydroxy-5-cis,13-trans-prostadienoic acid. The racemate can be administered in pharmaceutical dosage forms or from a drug delivery device at a programmed rate for producing smooth muscle stimulation, termination of pregnancy, induction of labor or induction of menses.
    Type: Grant
    Filed: April 17, 1975
    Date of Patent: March 2, 1976
    Assignee: Alza Corporation
    Inventor: Ned M. Weinshenker
  • Patent number: 3940438
    Abstract: The invention concerns a novel crystalline racemate, 9.alpha.,11.alpha.,15(S)-trihydroxy-5-cis,13-trans-prostadienoic acid. The racemate can be administered in pharmaceutical dosage forms or from a drug delivery device at a programmed rate for producing smooth muscle stimulation, termination of pregnancy, induction of labor or induction of menses.
    Type: Grant
    Filed: September 21, 1973
    Date of Patent: February 24, 1976
    Assignee: Alza Corporation
    Inventor: Ned M. Weinshenker