Patents by Inventor Neelu Kaila

Neelu Kaila has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolo[2,3-D]pyrimidine derivatives
    Patent number: 9035074
    Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: May 19, 2015
    Assignee: Pfizer Inc.
    Inventors: Matthew Frank Brown, Ashley Edward Fenwick, Mark Edward Flanagan, Andrea Gonzales, Timothy Allan Johnson, Neelu Kaila, Mark J. Mitton-Fry, Joseph Walter Strohbach, Ruth E. TenBrink, John David Trzupek, Rayomand Jal Unwalla, Michael L. Vazquez, Mihir D. Parikh
  • PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES
    Publication number: 20140243312
    Abstract: Described herein are pyrrolo{2,3-d}pyrimidine derivatives, their use as Janus Kinase (JAK) inhibitors, and pharmaceutical compositions containing them.
    Type: Application
    Filed: February 19, 2014
    Publication date: August 28, 2014
    Applicant: Pfizer Inc.
    Inventors: Matthew Frank Brown, Ashley Edward Fenwick, Mark Edward Flanagan, Andrea Gonzales, Timothy Allan Johnson, Neelu Kaila, Mark J. Mitton-Fry, Joseph Walter Strohbach, Ruth E. TenBrink, John David Trzupek, Rayomand Jal Unwalla, Michael L. Vazquez
  • Methods and compositions for selectin inhibition
    Patent number: 7994333
    Abstract: The present invention relates to the field of anti-inflammatory substances, and more particularly to novel compounds that act as antagonists of the mammalian adhesion proteins known as selectins. In some embodiments, methods for treating selectin mediated disorders are provided which include administration of compound of Formula I: wherein the constituent variables are defined herein.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: August 9, 2011
    Assignee: Wyeth LLC
    Inventors: Neelu Kaila, Silvano L. Debarnardo, Kristin M. Janz, Raymond T. Camphausen, Patricia Ward Bedard, Adrian Huang
  • INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS
    Publication number: 20110105509
    Abstract: Disclosed are compounds of Formula (I): which are useful as antagonists of the CRTH2 receptors. Pharmaceutical compositions containing compounds of Formula (I) and the use of compounds of Formula (I) to treat diseases or disorders that are responsive to inhibition of the binding of endogenous ligands to the CRTH2 receptor are also disclosed. Methods for preparing and using these compounds are further described.
    Type: Application
    Filed: November 3, 2010
    Publication date: May 5, 2011
    Applicant: Wyeth, LLC
    Inventors: Neelu Kaila, Eddine Saiah, Bruce Christopher Follows, Adrian Huang, Kristin Marie Janz, Michael Dennis Lowe, Alessandro Fabio Moretto, Jennifer Romanic Thomason, Tarek Suhayl Mansour, Cara Margaret May Williams
  • Methods and Compositions for Selectin Inhibition
    Publication number: 20090076077
    Abstract: The present invention relates to the field of anti-inflammatory substances, and more particularly to novel compounds that act as antagonists of the mammalian adhesion proteins known as selecting. In some embodiments, methods for treating selectin mediated disorders are provided which include administration of compound of Formula I: wherein the constituent variables are defined herein.
    Type: Application
    Filed: November 11, 2008
    Publication date: March 19, 2009
    Applicant: Wyeth
    Inventors: Neelu Kaila, Silvano L. Debernardo, Kristin M. Janz, Raymond T. Camphausen, Patricia W. Bedard
  • Methods and Compositions for Selectin Inhibition
    Publication number: 20090069564
    Abstract: The present invention relates to the field of anti-inflammatory substances, and more particularly to novel compounds that act as antagonists of the mammalian adhesion proteins known as selectins. In some embodiments, methods for treating selectin mediated disorders are provided which include administration of compound of Formula I: wherein the constituent variables are defined herein.
    Type: Application
    Filed: November 7, 2008
    Publication date: March 12, 2009
    Applicant: Wyeth
    Inventors: Neelu Kaila, Silvano L. Debernardo, Kristin M. Janz, Raymond T. Camphausen, Patricia W. Bedard, Adrian Huang
  • Methods and compositions for selectin inhibition
    Patent number: 7465799
    Abstract: The present invention relates to the field of anti-inflammatory substances, and more particularly to novel compounds that act as antagonists of the mammalian adhesion proteins known as selectins. In some embodiments, methods for treating selectin mediated disorders are provided which include administration of compound of Formula I: wherein the constituent variables are defined herein.
    Type: Grant
    Filed: November 9, 2004
    Date of Patent: December 16, 2008
    Assignee: Wyeth
    Inventors: Neelu Kaila, Silvano L. Debernardo, Kristin M. Jantz, Raymond T. Camphausen, Patricia W. Bedard
  • Methods and compositions for selectin inhibition
    Patent number: 7465798
    Abstract: The present invention relates to the field of anti-inflammatory substances, and more particularly to novel compounds that act as antagonists of the mammalian adhesion proteins known as selectins. In some embodiments, methods for treating selectin mediated disorders are provided which include administration of compound of Formula I: wherein the constituent variables are defined herein.
    Type: Grant
    Filed: November 9, 2004
    Date of Patent: December 16, 2008
    Assignee: Wyeth
    Inventors: Neelu Kaila, Silvano L. Debernardo, Kristin M. Jantz, Raymond T. Camphausen, Patricia W. Bedard, Adrian Huang
  • Methods and Compositions for Selectin Inhibition
    Publication number: 20080255192
    Abstract: The present teachings relate to novel compounds of formula I: wherein the constituent variables are as defined herein. Compounds of the present teachings can act as antagonists of the mammalian adhesion proteins known as selecting. Methods for treating or preventing selectin-mediated disorders are provided, which include administration of these compounds in a therapeutically effective amount.
    Type: Application
    Filed: March 28, 2008
    Publication date: October 16, 2008
    Applicant: Wyeth
    Inventors: Neelu Kaila, Kristin Marie Janz, Adrian Huang, Alessandro Fabio Moretto, Patricia Ward Bedard
  • 4,6-diamino-[1,7]naphthyridine-3-carbonitrile inhibitors of Tpl2 kinase and methods of making and using the same
    Patent number: 7432279
    Abstract: The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5r6, m and n are defined as described herein. The invention also provides methods of making the compounds of formula (I), and methods of treating inflammatory diseases, such as rheumatoid arthritis, in a mammal comprising administering a therapeutically effective amount of a compound of formula (I) to the mammal.
    Type: Grant
    Filed: May 18, 2006
    Date of Patent: October 7, 2008
    Assignee: Wyeth
    Inventors: Neal Jeffrey Green, Lori Krim Gavrin, Neelu Kaila, Yonghan Hu, Kristin Marie Janz, Jennifer R. Thomason, Ariamala Gopalsamy, Steve Y. Tam, Lih-Ling Lin, John William Cuozzo, Dennis William Powell
  • Methods and Compositions for Selectin Inhibition
    Publication number: 20080242700
    Abstract: The present teachings relate to compounds of formula I: wherein the constituent variables are defined herein. Compounds of the present teachings can act as antagonists of the mammalian adhesion proteins known as selecting. Methods for treating selectin mediated disorders are provided, which include administration of these compounds in a therapeutically effective amount.
    Type: Application
    Filed: March 28, 2008
    Publication date: October 2, 2008
    Applicant: Wyeth
    Inventors: Neelu Kaila, Adrian Huang, Patricia Ward Bedard
  • 4,6-diamino-[1,7]naphthyridine-3-carbonitrile inhibitors of Tpl2 kinase and methods of making and using the same
    Publication number: 20060276498
    Abstract: The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, m and n are defined as described herein. The invention also provides methods of making the compounds of formula (I), and methods of treating inflammatory diseases, such as rheumatoid arthritis, in a mammal comprising administering a therapeutically effective amount of a compound of formula (I) to the mammal.
    Type: Application
    Filed: May 18, 2006
    Publication date: December 7, 2006
    Applicant: Wyeth
    Inventors: Neal Green, Lori Gavrin, Neelu Kaila, Yonghan Hu, Kristin Janz, Jennifer Thomason, Ariamala Gopalsamy, Steve Tam, Lih-Ling Lin, John Cuozzo, Dennis Powell
  • 3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same
    Publication number: 20060264460
    Abstract: The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, m and n are defined as described herein. The invention also provides methods of making the compounds of formula (I), and methods of treating inflammatory diseases, such as rheumatoid arthritis, in a mammal comprising administering a therapeutically effective amount of a compound of formula (I) to the mammal.
    Type: Application
    Filed: May 18, 2006
    Publication date: November 23, 2006
    Applicant: Wyeth
    Inventors: Neal Green, Yonghan Hu, Neelu Kaila, Kristin Janz, Jennifer Thomason, Huan-Qiu Li, Rajeev Hotchandani, Junjun Wu, Ariamala Gopalsamy, Steve Tam, Lih-Ling Lin, John Cuozzo, Satenig Guler, Adrian Huang, Jeffrey condon
  • Inhibitors of phospholipase enzymes
    Patent number: 6916841
    Abstract: Novel compounds are disclosed which inhibit the activity of phospholipase enzymes in a mammal, particularly cytosolic phospholipase A2. Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclosed.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: July 12, 2005
    Assignee: Genetics Institute, LLC
    Inventors: Jasbir S. Seehra, Neelu Kaila, John C. McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang
  • Methods and compositions for selectin inhibition
    Publication number: 20050101568
    Abstract: The present invention relates to the field of anti-inflammatory substances, and more particularly to novel compounds that act as antagonists of the mammalian adhesion proteins known as selectins. In some embodiments, methods for treating selectin mediated disorders are provided which include administration of compound of Formula I: wherein the constituent variables are defined herein.
    Type: Application
    Filed: November 9, 2004
    Publication date: May 12, 2005
    Applicant: Wyeth
    Inventors: Neelu Kaila, Silvano Debernardo, Kristin Janz, Raymond Camphausen, Patricia Bedard
  • Methods and compositions for selectin inhibition
    Publication number: 20050101569
    Abstract: The present invention relates to the field of anti-inflammatory substances, and more particularly to novel compounds that act as antagonists of the mammalian adhesion proteins known as selectins. In some embodiments, methods for treating selectin mediated disorders are provided which include administration of compound of Formula I: wherein the constituent variables are defined herein.
    Type: Application
    Filed: November 9, 2004
    Publication date: May 12, 2005
    Applicant: Wyeth
    Inventors: Neelu Kaila, Silvano Debernardo, Kristin Janz, Raymond Camphausen, Patricia Bedard, Adrian Huang
  • Inhibitors of phospholipase enzymes
    Patent number: 6828344
    Abstract: Novel compounds are disclosed which inhibit the activity of phospholipase enzymes, particularly cytosolic phospholipase A2. Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclosed.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: December 7, 2004
    Assignee: Genetics Institute, LLC
    Inventors: Jasbir S. Seehra, Neelu Kaila, John McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang
  • Inhibitors of phospholipase enzymes
    Patent number: 6630496
    Abstract: This invention provides substituted indole and indoline compounds useful in inhibiting phospholipase activity, particularly including cytosolic phospholipase A2 (cPLA2) activity, as well as pharmaceutical compositions containing the compounds and methods of using them to treat various maladies, including pain and inflammatory conditions.
    Type: Grant
    Filed: August 24, 2000
    Date of Patent: October 7, 2003
    Assignee: Genetics Institute LLC
    Inventors: Jasbir S. Seehra, Neelu Kaila, John C. McKew, Jean E. Bemis, YiBin Xiang, Lihren Chen
  • Inhibitors of phospholipase enzymes
    Publication number: 20030153751
    Abstract: Novel compounds are disclosed which inhibit the activity of phospholipase enzymes in a mammal, particularly cytosolic phospholipase A2. Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclosed.
    Type: Application
    Filed: May 8, 2002
    Publication date: August 14, 2003
    Applicant: American Home Products Corporation
    Inventors: Jasbir S. Seehra, Neelu Kaila, John C. McKew, Frank Lovering, Jean E. Bemis, YiBin Xiang