Patents by Inventor Neera Jain

Neera Jain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230330742
    Abstract: A twin roll casting system includes a pair of counter-rotating casting rolls, a casting roll controller is configured to adjust at least one process control setpoint for the casting rolls in response to control signals. A cast strip sensor measures at least one parameter of the cast strip. A controller receives measurement signals from the cast strip sensor provides control signals to the casting roll controller. The controller is a data-driven model comprising a database of state-input pairs; and executes the following steps at each time step: measure a state-input similarity between a new state observation and samples, assign a weight to each consequent output of samples based on the similarity measured, and sum the weighted outputs and predict an output of a new state observation. The controller is configured to provide the control signals to the casting roll controller based on the predicted output of the new state observation.
    Type: Application
    Filed: April 14, 2023
    Publication date: October 19, 2023
    Inventors: Jianqi RUAN, Robert Gerard NOONING, JR., Ivan David PARKES, Walter Blejde, Neera Jain SUNDARAM, George T.C. CHIU
  • Publication number: 20220379372
    Abstract: A twin roll casting system includes a pair of counter-rotating casting rolls having an adjustable nip therebetween, a casting roll controller configured to adjust the nip between the casting rolls in response to control signals; a cast strip sensor measuring a parameter of the cast strip and generating strip measurement signals; and an iterative learning control (ILC) controller receiving the strip measurement signals and providing control signals to the casting roll controller. The ILC controller includes a fault detection algorithm receiving the control signals and the strip measurement signals and generating a fault detection signal indicating when a fault condition is detected and an iterative learning control algorithm to generate the control signals. The fault detection algorithm indicates a fault condition when it detects the control signal exceeding an upper control saturation threshold or the ILC controller operating a state that is not guaranteed as stable.
    Type: Application
    Filed: October 28, 2020
    Publication date: December 1, 2022
    Inventors: Florian Maurice Browne, III, George T.C. CHIU, Neera Jain SUNDARAM, Harold Bradley REES
  • Publication number: 20220289749
    Abstract: The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.
    Type: Application
    Filed: May 26, 2022
    Publication date: September 15, 2022
    Inventors: Neera Jain, Weiwen Ying, Dinesh U. Chimmanamada, Junyi Zhang, Amit Kale
  • Patent number: 11377447
    Abstract: The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: July 5, 2022
    Assignee: MADRIGAL PHARMACEUTICALS, INC.
    Inventors: Neera Jain, Weiwen Ying, Dinesh U. Chimmanamada, Junyi Zhang, Amit Kale
  • Patent number: 11135647
    Abstract: A twin roll casting system where the casting rolls have a nip between the casting rolls, each roller having a circumference and a rotational period. The casting roll controller adjusts the nip between the casting rolls in response to control signals. The sensor measures at least one parameter of the cast strip. The ILC controller receives strip measurement signals from the sensor and provides control signals to the casting roll controller. The ILC controller includes an ILC control algorithm to generate the control signals based on the strip measurement signals and a time delay estimate based on circumference, rotational period, and a length of cast strip between the nip and the sensor to compensate for an elapsed time from the cast strip exiting the nip to being measured by the cast strip sensor.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: October 5, 2021
    Assignee: NUCOR CORPORATION
    Inventors: Florian Maurice Browne, III, George T. C. Chiu, Neera Jain Sundaram, Harold Bradley Rees
  • Patent number: 11083728
    Abstract: The present invention provides, in part, compositions comprising an inhibitor of cyclin-dependent kinase 7 (CDK7) and sulfobutyl ether-?-cyclodextrin. Also provided are methods of using a disclosed composition for treating proliferative diseases. The present invention also provides methods of making disclosed compositions.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: August 10, 2021
    Assignee: Syros Pharmaceuticals, Inc.
    Inventor: Neera Jain
  • Publication number: 20200239472
    Abstract: The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.
    Type: Application
    Filed: June 19, 2018
    Publication date: July 30, 2020
    Inventors: Neera Jain, Weiwen Ying, Dinesh U. Chimmanamada, Junyi Zhang, Amit Kale
  • Publication number: 20200108067
    Abstract: The present invention provides, in part, compositions comprising an inhibitor of cyclin-dependent kinase 7 (CDK7) and sulfobutyl ether-?-cyclodextrin. Also provided are methods of using a disclosed composition for treating proliferative diseases. The present invention also provides methods of making disclosed compositions.
    Type: Application
    Filed: April 3, 2018
    Publication date: April 9, 2020
    Inventor: Neera Jain
  • Publication number: 20200009644
    Abstract: A twin roll casting system where the casting rolls have a nip between the casting rolls, each roller having a circumference and a rotational period. The casting roll controller adjusts the nip between the casting rolls in response to control signals. The sensor measures at least one parameter of the cast strip. The ILC controller receives strip measurement signals from the sensor and provides control signals to the casting roll controller. The ILC controller includes an ILC control algorithm to generate the control signals based on the strip measurement signals and a time delay estimate based on circumference, rotational period, and a length of cast strip between the nip and the sensor to compensate for an elapsed time from the cast strip exiting the nip to being measured by the cast strip sensor.
    Type: Application
    Filed: September 16, 2019
    Publication date: January 9, 2020
    Inventors: Florian Maurice BROWNE, III, George T.C. CHIU, Neera Jain SUNDARAM, Harold Bradley REES
  • Patent number: 10449603
    Abstract: A twin roll casting system where the casting rolls have a nip between the casting rolls, each roller having a circumference and a rotational period. The casting roll controller adjusts the nip between the casting rolls in response to control signals. The sensor measures at least one parameter of the cast strip. The ILC controller receives strip measurement signals from the sensor and provides control signals to the casting roll controller. The ILC controller includes an ILC control algorithm to generate the control signals based on the strip measurement signals and a time delay estimate based on circumference, rotational period, and a length of cast strip between the nip and the sensor to compensate for an elapsed time from the cast strip exiting the nip to being measured by the cast strip sensor.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: October 22, 2019
    Assignee: NUCOR CORPORATION
    Inventors: Florian Maurice Browne, III, George T. C. Chiu, Neera Jain Sundaram, Harold Bradley Rees
  • Publication number: 20190091761
    Abstract: A twin roll casting system where the casting rolls have a nip between the casting rolls, each roller having a circumference and a rotational period. The casting roll controller adjusts the nip between the casting rolls in response to control signals. The sensor measures at least one parameter of the cast strip. The ILC controller receives strip measurement signals from the sensor and provides control signals to the casting roll controller. The ILC controller includes an ILC control algorithm to generate the control signals based on the strip measurement signals and a time delay estimate based on circumference, rotational period, and a length of cast strip between the nip and the sensor to compensate for an elapsed time from the cast strip exiting the nip to being measured by the cast strip sensor.
    Type: Application
    Filed: September 21, 2018
    Publication date: March 28, 2019
    Inventors: Florian Maurice BROWNE, III, George T. C. CHIU, Neera Jain SUNDARAM, Harold Bradley REES
  • Publication number: 20180339058
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Application
    Filed: July 30, 2018
    Publication date: November 29, 2018
    Applicant: Wyeth Holdings LLC
    Inventors: Arthur KUNZ, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
  • Patent number: 9625196
    Abstract: A method for controlling an operation of a vapor compression system (VCS) determines values of measured outputs of the operation of the VCS that include performance and constrained outputs. The method determines states of the VCS using an estimator model of the VCS defining a relationship between the states of the VCS, control inputs and controlled outputs, such that a difference between outputs predicted using the estimator model and the measured outputs asymptotically approaches zero. The states of the VCS include a main state representing the operation of the VCS and an auxiliary state representing the effect of unknown disturbances on each measured output of the VCS. The control inputs for controlling the operation of the VCS are determined using a prediction model, such that the constrained output satisfies the constraints, and a difference between the performance output and the value of the setpoint asymptotically approaches zero.
    Type: Grant
    Filed: June 9, 2014
    Date of Patent: April 18, 2017
    Assignee: Mitsubishi Electric Research Laboratories, Inc.
    Inventors: Dan Burns, Neera Jain, Christopher Laughman, Stefano Di Cairano, Scott Bortoff
  • Publication number: 20160303252
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Application
    Filed: May 3, 2016
    Publication date: October 20, 2016
    Applicant: Wyeth Holdings LLC
    Inventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
  • Patent number: 9351986
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: May 31, 2016
    Assignee: WYETH HOLDINGS LLC
    Inventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis DiJoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
  • Publication number: 20150354877
    Abstract: A method for controlling an operation of a vapor compression system (VCS) determines values of measured outputs of the operation of the VCS that include performance and constrained outputs. The method determines states of the VCS using an estimator model of the VCS defining a relationship between the states of the VCS, control inputs and controlled outputs, such that a difference between outputs predicted using the estimator model and the measured outputs asymptotically approaches zero. The states of the VCS include a main state representing the operation of the VCS and an auxiliary state representing the effect of unknown disturbances on each measured output of the VCS. The control inputs for controlling the operation of the VCS are determined using a prediction model, such that the constrained output satisfies the constraints, and a difference between the performance output and the value of the setpoint asymptotically approaches zero.
    Type: Application
    Filed: June 9, 2014
    Publication date: December 10, 2015
    Inventors: Dan Burns, Neera Jain, Christopher Laughman, Stefano Di Cairano, Scott Bortoff
  • Publication number: 20150150851
    Abstract: Provided is a pharmaceutical composition comprising a pharmaceutically acceptable organic solvent, a pharmaceutically acceptable surfactant, and a compound according to the following formula: wherein the variables are defined herein. Optionally, the pharmaceutical composition further comprises a co-solvent. Also provided is a method of using the pharmaceutical composition disclosed herein for the treatment of a patient in need thereof.
    Type: Application
    Filed: February 5, 2015
    Publication date: June 4, 2015
    Inventors: Neera Jain, Suresh R. Babu, Shweta Kotecha, Hong Yang
  • Patent number: 8835611
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: September 16, 2014
    Assignee: Wyeth Holdings LLC
    Inventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Paul David Robbins, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Andrew George Popplewell
  • Publication number: 20140235835
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Application
    Filed: March 7, 2014
    Publication date: August 21, 2014
    Applicant: WYETH HOLDINGS LLC
    Inventors: ARTHUR KUNZ, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell
  • Patent number: 8747857
    Abstract: Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
    Type: Grant
    Filed: November 3, 2003
    Date of Patent: June 10, 2014
    Assignee: Wyeth Holdings LLC
    Inventors: Arthur Kunz, Justin Keith Moran, Joseph Thomas Rubino, Neera Jain, Eugene Joseph Vidunas, John McLean Simpson, Nishith Merchant, John Francis Dijoseph, Mark Edward Ruppen, Nitin Krishnaji Damle, Paul David Robbins, Andrew George Popplewell