Abstract: One embodiment provides for a method of determining application display persistence on a wearable electronic device, the method comprising receiving an application programming interface (API) call from an application to perform an action on the wearable electronic device; beginning a session on the wearable electronic device in response to determining that the API call is associated with the beginning of a session; determining, based on the application, a persistence level to apply to the application; flagging the application associated with the session as persistent; and displaying a persistent application at a next activation of the wearable electronic device in place of a default application associated with the wearable electronic device.

Abstract: The present invention relates to compositions comprising one or more active agents that selectively modulate the expression of two or more genes, for example at the post-transcription level, that are involved in fibrosis and/or inflammatory conditions. Also provided are methods of using such compositions for treating fibrotic diseases, as well as other diseases including inflammatory diseases and cancer.

Abstract: Efficiently identifying transactions processed by a software application, such as a server application is disclosed. In one embodiment, transactions are identified by applying a set of rules to communications between a client and server to determine whether certain patterns are in the communications. For example, the rules may look for some combination of parameters in the transactions. As a particular example, the rules may be used to look for parameters in HTTP requests. The rules are organized in a way that allows efficient processing. For example, the rules may be organized based on the frequency with which the parameters are expected to occur in the transactions and the frequency with which each transaction is expected to occur. The rules may be updated if the expected frequencies deviate from actual frequencies, such that the rules can be organized for more efficient processing.

Abstract: Efficiently identifying transactions processed by a software application, such as a server application is disclosed. In one embodiment, transactions are identified by applying a set of rules to communications between a client and server to determine whether certain patterns are in the communications. For example, the rules may look for some combination of parameters in the transactions. As a particular example, the rules may be used to look for parameters in HTTP requests. The rules are organized in a way that allows efficient processing. For example, the rules may be organized based on the frequency with which the parameters are expected to occur in the transactions and the frequency with which each transaction is expected to occur. The rules may be updated if the expected frequencies deviate from actual frequencies, such that the rules can be organized for more efficient processing.

Abstract: The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of a mammalian tumor to a chemotherapeutic agent, comprising a means for the isolation of protein or RNA from the tumor, a SPARC protein or RNA detection and quantification means, control RNAs, and rules for predicting the response of the tumor based on the level of SPARC protein or RNA in tumor.

Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.

Abstract: The invention provides isoquinoline, quinoline, and quinazoline derivatives to treat a variety of disorders, diseases and pathologic conditions, and more specifically to the use of isoquinoline, quinoline, and quinazoline derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds to the treatment of hyperproliferative diseases and pathologic angiogenesis.

Abstract: The invention provides multiparametric anti-SPARC antibody-based techniques for predicting the response to chemotherapy.

Abstract: The invention provides SPARC binding antibodies that target disease sites, in particular, tumors and uses thereof to diagnose and treat diseases, in particular, cancerous tumors.

Abstract: The invention provides anti-SPARC antibody-based techniques for predicting a response to chemotherapy.

Abstract: The invention provides Triazine derivatives and further provides methods of using these compounds to modulate protein kinases and for treating diseases and conditions mediated by protein kinases.

Abstract: The invention provides methods for predicting or determining the response of a mammalian tumor to a chemotherapeutic agent and for treating a mammalian tumor comprising detecting and quantifying the SPARC protein or RNA in a sample isolated from the mammal. The invention further provides kit for predicting the response of a mammalian tumor to a chemotherapeutic agent, comprising a means for the isolation of protein or RNA from the tumor, a SPARC protein or RNA detection and quantification means, control RNAs, and rules for predicting the response of the tumor based on the level of SPARC protein or RNA in tumor.

Abstract: The present invention relates to compositions comprising one or more active agents that selectively modulate the expression of two or more genes, for example at the post-transcription level, that are involved in fibrosis and/or inflammatory conditions. Also provided are methods of using such compositions for treating fibrotic diseases, as well as other diseases including inflammatory diseases and cancer.

Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.

Abstract: The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.

Abstract: The invention provides compositions and methods which exploit the discovery of the SPARC carboxy angiogenic domain.

Abstract: The invention provides compositions and methods which exploit the discovery of the SPARC carboxy angiogenic domain.

Abstract: The invention provides multiparametric anti-SPARC antibody-based techniques for treating cancers as well as determining prognosis and predicting the response to therapy, including chemotherapy, radiotherapy, surgical therapy and combination therapies.

Abstract: The invention relates to nucleic acid aptamers having the ability to bind human SPARC protein (osteonectin) with specificity. The invention also relates to compositions including such aptamers, as well as methods of identifying such aptamers. The invention further relates to methods for using such aptamers in treating and diagnosing proliferative diseases such as, e.g., cancer.