Patents by Inventor Neil P. King

Neil P. King has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210380641
    Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using synthetic nanostructures are disclosed herein.
    Type: Application
    Filed: November 9, 2018
    Publication date: December 9, 2021
    Inventors: Gabriel BUTTERFIELD, Marc Joseph LAJOIE, Neil P. KING, David BAKER, Daniel ELLIS
  • Patent number: 11192926
    Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: December 7, 2021
    Assignees: University of Washington, Institute for Research in Biomedicine
    Inventors: Neil P. King, David Baker, Brooke Nickerson, Lance Joseph Stewart, Laurent Perez, Antonio Lanzavecchia, Jessica Marcandalli
  • Publication number: 20200392187
    Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.
    Type: Application
    Filed: April 3, 2018
    Publication date: December 17, 2020
    Inventors: Neil P. KING, David BAKER, Brooke NICKERSON, Lance Joseph STEWART, Laurent PEREZ, Antonio LANZAVECCHIA, Jessica MARCANDALLI
  • Publication number: 20200140493
    Abstract: Disclosed herein are modified capsid proteins comprising a capsid forming protein, a membrane binding element and an ESCRT-recruiting element, wherein at least one of the membrane binding element and the ESCRT-recruiting element is heterologous to the capsid forming protein. Disclosed are capsids comprising a plurality of modified capsid proteins. Disclosed are multimeric assemblies comprising a plurality of capsids within a membrane. Also disclosed are modified non-enveloped viruses comprising a capsid wherein the capsid comprises a plurality of modified capsid proteins, wherein the plurality of modified capsid proteins comprise a capsid forming protein, a membrane binding element and an ESCRT-recruiting element, wherein at least one of the membrane binding element and the ESCRT-recruiting element is heterologous to the modified capsid protein, wherein the capsid forming protein is a capsid forming protein of a non-enveloped virus.
    Type: Application
    Filed: October 25, 2019
    Publication date: May 7, 2020
    Inventors: Jörg Philip Votteler, Wesley I. Sundquist, Neil P. King
  • Publication number: 20190352639
    Abstract: The application discloses multimeric assemblies packaging one or more active component and their use to carry out nucleic acid regulation or gene editing.
    Type: Application
    Filed: February 12, 2018
    Publication date: November 21, 2019
    Inventors: Marc Joseph LAJOIE, Elizabeth Erin GRAY, Neil P. KING, Daniel Brewster STETSON, David BAKER, Katherine DaPRON
  • Patent number: 10421789
    Abstract: The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRC01 and/or improve binding to germline VRC01 and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRC01 epitope and surroundings.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: September 24, 2019
    Assignees: University of Washington, Center for Commercialization, The Scripps Research Institute, International AIDS Vaccine Initiative
    Inventors: Po-Ssu Huang, Joseph Graham Jardine, Sergey V. Menis, William Ray Schief, Neil P. King
  • Publication number: 20190284242
    Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
    Type: Application
    Filed: May 31, 2019
    Publication date: September 19, 2019
    Inventors: David BAKER, Jacob B. BALE, Neil P. KING, William H. SHEFFLER, Daniel ELLIS
  • Patent number: 10351603
    Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: July 16, 2019
    Assignee: University of Washington
    Inventors: David Baker, Jacob B. Bale, Neil P. King, William H. Sheffler, Daniel Ellis
  • Publication number: 20190194262
    Abstract: The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRC01 and/or improve binding to germline VRC01 and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRC01 epitope and surroundings.
    Type: Application
    Filed: March 4, 2019
    Publication date: June 27, 2019
    Inventors: Po-Ssu Huang, Joseph Graham Jardine, Sergey V. Menis, William Ray Schief, Neil P. King
  • Patent number: 10221217
    Abstract: The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRC01 and/or improve binding to germline VRC01 and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRC01 epitope and surroundings.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: March 5, 2019
    Assignees: University of Washington, Center for Commercialization, The Scripps Research Institute, International AIDS Vaccine Initiative
    Inventors: Po-Ssu Huang, Joseph Graham Jardine, Sergey V. Menis, William Ray Schief, Neil P. King
  • Publication number: 20170218029
    Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
    Type: Application
    Filed: April 18, 2017
    Publication date: August 3, 2017
    Inventors: David BAKER, Jacob B. BALE, Neil P. KING, William H. SHEFFLER, Daniel ELLIS
  • Patent number: 9630994
    Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: April 25, 2017
    Assignee: University of Washington
    Inventors: David Baker, Jacob B. Bale, Neil P. King, William H. Sheffler, Daniel Ellis
  • Publication number: 20160185825
    Abstract: The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRC01 and/or improve binding to germline VRC01 and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRC01 epitope and surroundings.
    Type: Application
    Filed: December 22, 2015
    Publication date: June 30, 2016
    Inventors: Po-Ssu Huang, Joseph Graham Jardine, Sergey V. Menis, William Ray Schief, Neil P. King
  • Publication number: 20160122392
    Abstract: Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.
    Type: Application
    Filed: November 3, 2015
    Publication date: May 5, 2016
    Inventors: David BAKER, Jacob B. BALE, Neil P. KING, William H. SHEFFLER, Daniel ELLIS
  • Publication number: 20140322269
    Abstract: The invention relates to an engineered outer domain (eOD) of HIV gp120 and mutants thereof and methods of making and using the same. The mutant eODs may be advantageous for the elicitation of CD4-binding site (CD4bs)-directed broadly-neutralizing antibodies (bnAbs) and/or improve binding to mature VRC01 and/or improve binding to germline VRC01 and the germlines of other VH1-2 derived broadly-neutralizing antibodies. The mutant eODs may also include glycan-masking mutations on eOD. The present invention also includes fusions of eOD to various protein multimers to enhance immunogenicity as well as the design of cocktails of different eODs that represent the full diversity of HIV sequences within the VRC01 epitope and surroundings.
    Type: Application
    Filed: April 11, 2014
    Publication date: October 30, 2014
    Applicants: University of Washington, International AIDS Vaccine Initiative, The Scripps Research Institute
    Inventors: Po-Ssu Huang, Joseph Graham Jardine, Sergey V. Menis, William Ray Schief, JR., Neil P. King