Patents by Inventor Nicholas Ktistakis

Nicholas Ktistakis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7820803
    Abstract: The invention relates to immobilized phosphatidic acid probes which can be used to identify important proteins for signal transduction, housekeeping and diagnosis.
    Type: Grant
    Filed: August 23, 2001
    Date of Patent: October 26, 2010
    Inventors: Len Stephens, Phillip Thomas Hawkins, Andrew Bruce Holmes, Maria Manifava, Ze-Yi Lim, Nicholas Ktistakis, Johannes Wilhelmus John Fitzgerald Thuring
  • Publication number: 20040072244
    Abstract: Probes comprising an immobilised Phosphatidic Acid attached onto a solid support are described, for example, as shown in formula I and V: (a) the linker consists of aryl, heteroaryl, alkyl with possible heteroatoms and/or unsaturations, preferably chains of (CH2)n, with n=8-20, most preferably n=11; (b) the heteroatom X maybe O, S, or most preferably NH; (c) the functional group (FG) is a carbonyl from a carboxylate (thiolo)ester, or, most preferably an amide; (d) the R-substituent carries an aryl, alkyl group, or a combination, preferably R=CmH2m+1, m=8-20, m=16 optimal; (e) the ion M represents any cation, preferably Na+, NH4+; (f) unsaturations are allowed, such as in an arachidonyl side chain and (g) =solid support with attachment to functional group, where: R=aryl, alkyl group, or a combination, preferably R=CmH2m+1, m=8-20, m=16 is optimal.
    Type: Application
    Filed: August 28, 2003
    Publication date: April 15, 2004
    Inventors: Len Stephens, Phillip Thomas Hawkins, Andrew Bruce Holmes, Maria Manifava, Ze-Yi Lim, Nicholas Ktistakis, Johannes Wilhelmus John Fitzgerald Thuring