Abstract: A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.

Abstract: A barrier structure, a battery module including the barrier structure, and a method of assembling the battery module are provided. The barrier structure includes a plurality of first sidewalls oriented in a first direction, and a plurality of second sidewalls oriented in a second direction. The plurality of first sidewalls interlock with the plurality of second sidewalls to form a grid structure comprising a plurality of cells, each having an open-ended top and an open-ended bottom and configured to be arranged around a cylindrical section of at least one of a plurality of battery cells. The battery module includes a plurality of cylindrical battery cells arranged in a predetermined pattern and a barrier structure for separating the battery cells.

Abstract: An isolator for an aircraft fuel tank configured to separate an electrically conductive internal panel of the fuel tank from an electrically conductive pipe that passes through the panel. The isolator includes: a plurality of first attachment points for attaching the isolator to the panel, a plurality of second attachment points for attaching the isolator to the pipe, and an aperture defined by an outer wall and extending from a first side of the isolator to a second side of the isolator. The aperture is configured to receive the pipe in use, wherein the isolator is formed of a non-electrically conductive material.

Abstract: A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.

Abstract: A system for predicting one or more analytes based on outputs from thin film gas sensors is provided. The system may comprise an electronic nose (e-nose). The e-nose may comprise the gas sensors and a first processor. The system may further comprise a second processor. The second processor may be configured to receive the output from each of the gas sensors, evaluate a prediction accuracy using an evaluation parameter of each of a plurality of models which are trained and tested and select a model from among the plurality of models to deploy based on a comparison of the evaluation parameter for each of the plurality of models and use the same. The second processor may also receive, an output of each of the gas sensors caused by unknown one or more analytes; and predict, using the deployed model, the one or more analytes that causes the output.

Abstract: A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.

Abstract: An isolator for an aircraft fuel tank configured to separate an electrically conductive internal panel of the fuel tank from an electrically conductive pipe that passes through the panel. The isolator includes: a plurality of first attachment points for attaching the isolator to the panel, a plurality of second attachment points for attaching the isolator to the pipe, and an aperture defined by an outer wall and extending from a first side of the isolator to a second side of the isolator. The aperture is configured to receive the pipe in use, wherein the isolator is formed of a non-electrically conductive material.

Abstract: An isolator for an aircraft fuel tank configured to separate an electrically conductive internal panel of the fuel tank from an electrically conductive pipe that passes through the panel. The isolator includes: a plurality of first attachment points for attaching the isolator to the panel, a plurality of second attachment points for attaching the isolator to the pipe, and an aperture defined by an outer wall and extending from a first side of the isolator to a second side of the isolator. The aperture is configured to receive the pipe in use, wherein the isolator is formed of a non-electrically conductive material.

Abstract: An isolator for an aircraft fuel tank configured to separate an electrically conductive internal panel of the fuel tank from an electrically conductive pipe that passes through the panel. The isolator includes: a plurality of first attachment points for attaching the isolator to the panel, a plurality of second attachment points for attaching the isolator to the pipe, and an aperture defined by an outer wall and extending from a first side of the isolator to a second side of the isolator. The aperture is configured to receive the pipe in use, wherein the isolator is formed of a non-electrically conductive material.

Abstract: A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.

Abstract: A bleed air duct joint insulation means is disclosed in which a leak vent comprises valve means.

Abstract: An exhaust silencer for the air conditioning system of an aircraft is disclosed.

Abstract: The present invention relates to a method of treating or prophlaxis of a respiratory tract illness in a subject comprising administering to said subject a composition comprising Bifidobacterium lactis BL04 and/or fermentation product of Bifidobacterium lactis BL04 and/or a cell lysate of Bifidobacterium lactis BL04.

Abstract: A bleed air duct joint insulation means is disclosed in which a leak vent comprises valve means.

Abstract: An exhaust silencer for the air conditioning system of an aircraft is disclosed.